153 research outputs found
Etude socio-économique et technologique de la production du poisson fermenté et séché (Guedj) au Sénégal
Cette étude aborde les aspects socio-économiques et technologiques relatifs à l’un des maillons très important de la pêche maritime qui est la transformation du poisson en guedj ou poisson fermenté et séché. En effet, une enquête diagnostique menée à travers trois zones de production au Sénégal (Dakar, Thiès et Fatick), combinée aux données de la bibliographie et des entretiens avec les acteurs, ont permis de faire ressortir un certain nombre d’enjeux. L’étude a montré que cette activité assurée à 80% par des femmes, génère beaucoup d’emplois et de revenus, que le prix de vente fluctue entre 1000 et 3500 frs CFA.kg-1 et par conséquent qu’une grande productrice peut gagner en moyenne jusqu’à 400000 frs CFA par mois. Cependant, malgré son importance économique, elle est confrontée à d’énormes difficultés liées à la manutention, au manque d’infrastructures et de stockage adéquates et aux techniques de transformation rudimentaires utilisées. Par ailleurs, l’analyse physicochimique et microbiologique réalisée sur des échantillons prélevés dans les sites de production et de vente laisse apparaître la nécessité d’appliquer rigoureusement les bonnes pratiques de fabrication et d’hygiène afin d’améliorer la qualité sanitaire du guedj, qui fait de plus en plus l’objet de demande du marché extérieur.Mots clés : Guedj, poisson fermenté, méthode traditionnelle, étude de filière, qualité, Sénégal
Compositionality, stochasticity and cooperativity in dynamic models of gene regulation
We present an approach for constructing dynamic models for the simulation of
gene regulatory networks from simple computational elements. Each element is
called a ``gene gate'' and defines an input/output-relationship corresponding
to the binding and production of transcription factors. The proposed reaction
kinetics of the gene gates can be mapped onto stochastic processes and the
standard ode-description. While the ode-approach requires fixing the system's
topology before its correct implementation, expressing them in stochastic
pi-calculus leads to a fully compositional scheme: network elements become
autonomous and only the input/output relationships fix their wiring. The
modularity of our approach allows to pass easily from a basic first-level
description to refined models which capture more details of the biological
system. As an illustrative application we present the stochastic repressilator,
an artificial cellular clock, which oscillates readily without any cooperative
effects.Comment: 15 pages, 8 figures. Accepted by the HFSP journal (13/09/07
The Milky Way: An Exceptionally Quiet Galaxy; Implications for the formation of spiral galaxies
[Abridged]We compare both the Milky Way and M31 galaxies to local external
disk galaxies within the same mass range, using their relative locations in the
planes formed by V_flat versus M_K, j_disk, and the average Fe abundance of
stars in the galaxy outskirts. We find, for all relationships, that the MW is
systematically offset by ~ 1 sigma, showing a significant deficiency in stellar
mass, in angular momentum, in disk radius and [Fe/H] in the stars in its
outskirts at a given V_flat. On the basis of their location in the M_K, V_flat,
and R_d volume, the fraction of spirals like the MW is 7+/-1%, while M31
appears to be a "typical'' spiral. Our Galaxy appears to have escaped any
significant merger over the last ~10 Gyrs which may explain why it is deficient
by a factor 2 to 3 in stellar mass, angular momentum and outskirts metallicity
and then, unrepresentative of the typical spiral. As with M31, most local
spirals show evidence for a history shaped mainly by relatively recent merging.
We conclude that the standard scenario of secular evolution is generally unable
to reproduce the properties of most (if not all) spiral galaxies. However, the
so-called "spiral rebuilding'' scenario proposed by Hammer et al. 2005 is
consistent with the properties of both distant galaxies and of their
descendants - the local spirals.Comment: 14 pages, 6 figures, to appear in Ap
The MACHO Project 9 Million Star Color-Magnitude Diagram of the Large Magellanic Cloud
We present a 9 million star color-magnitude diagram (9M CMD) of the LMC bar.
The 9M CMD reveals a complex superposition of different age and metallicity
stellar populations, with important stellar evolutionary phases occurring over
3 orders of magnitude in number density. First, we count the non-variable
supergiants, the associated Cepheids, and measure the effective temperatures
defining the instability strip. Lifetime predictions of stellar evolution
theory are tested, with implications for the origin of low-luminosity Cepheids.
The highly-evolved AGB stars have a bimodal distribution in brightness, which
we interpret as discrete old populations (>1 Gyr). The faint AGB may be
metal-poor and very old. We identify the clusters NGC 411 and M3 as templates
for the admixture of old stellar populations. However, there are indications
that the old and metal-poor field population has a red HB morphology: the RR
Lyraes lie on the red edge of the instability strip, the AGB-bump is very red,
and the ratio of AGB-bump stars to RR Lyraes is quite large. If the HB second
parameter is age, the old and metal-poor field population likely formed after
the oldest clusters. Lifetime predictions of stellar evolution theory lead us
to associate a significant fraction of the red HB clump giants with the same
old and metal-poor population producing the RR Lyraes and the AGB-bump. In this
case, compared to the age-dependent luminosity predictions of stellar evolution
theory, the red HB clump is too bright relative to the RR Lyraes and AGB-bump.
Last, the surface density profile of RR Lyraes is fit by an exponential,
favoring a disk-like rather than spheroidal distribution. We conclude that the
age of the LMC disk is probably similar to the age of the Galactic disk.
(ABRIDGED)Comment: to appear in the Astronomical Journal, 49 pages, 12 figures,
aaspp4.st
Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates
© 2020 Elsevier B.V. Objective: Overweight and obesity are major risk factors for Type 2 Diabetes Mellitus (T2DM), cardiovascular disease (CVD) and cancer. Genetic predisposition has been shown to play a key role in obesity, and genome-wide association studies (GWAS) have identified multiple loci linked with obesity in various ethnic groups. The aim of this study was to validate the reported genetic variants associated with obesity and overweight in a young UAE Arab population. Methods: Twenty-two associated single nucleotide polymorphisms (SNPs) at 11 loci (FTO, MC4R, TMEM18, KCTD15, MTCH2, SH2B1, TFAP2B, GNPDA2, NEGR1, PCSK1 and BDNF) were studied in 392 controls and 318 overweight/obese young Emiratis (aged 18–35 years). Results: After adjusting for age and smoking, rs3751812 of the FTO gene was associated with overweight/obesity in male participants (p-value \u3c 0.016), while SNPs rs17782313, rs571312 of the MC4R gene and rs12463617 of the TMEM18 gene were significantly associated with overweight/obesity in female participants (p-value = 0.001, 0.028, 0.044, respectively). Follow-up association tests and logistic regression revealed the contribution of the FTO rs3751812 and MC4R rs571213 SNPs to the risk of overweight/obesity after adjusting for age, sex and smoking (p-value = 0.044, 0.049, respectively). In addition, the FTO rs3751812 was associated with the risk of overweight/obesity after adjusting for the effect of other markers (rs17782313, rs571312, rs2867125, rs6548238 and rs12463617) (p-value = 0.035). A significant gene-gene interaction was seen between FTO, MCR4 and TMEM18 (p-value = 0.013). Conclusions: Our data demonstrates that rs3751812 of the FTO gene is the key SNP associated with risk of overweight/obesity among the young UAE Arab population, in alignment with previous findings. Our results also indicate that the identified genes stratify with sex and risk of overweight/obesity. In addition to their direct association with overweight/obesity, rs17782313 and rs571312, as well as rs2867125 and rs6548238, may have a modifying effect on the risk of overweight/obesity caused by the rs3751812. Population-specific, sex-specific genetic profiling is important in understanding the heritability of obesity
Control of star formation by supersonic turbulence
Understanding the formation of stars in galaxies is central to much of modern
astrophysics. For several decades it has been thought that stellar birth is
primarily controlled by the interplay between gravity and magnetostatic
support, modulated by ambipolar diffusion. Recently, however, both
observational and numerical work has begun to suggest that support by
supersonic turbulence rather than magnetic fields controls star formation. In
this review we outline a new theory of star formation relying on the control by
turbulence. We demonstrate that although supersonic turbulence can provide
global support, it nevertheless produces density enhancements that allow local
collapse. Inefficient, isolated star formation is a hallmark of turbulent
support, while efficient, clustered star formation occurs in its absence. The
consequences of this theory are then explored for both local star formation and
galactic scale star formation. (ABSTRACT ABBREVIATED)Comment: Invited review for "Reviews of Modern Physics", 87 pages including 28
figures, in pres
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
Aims/hypothesis: harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians. Methods: All studies published on the association between -rs9939609 (or proxy [r > 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes. Results: The -rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 × 10), overweight by 1.13-fold/allele (p = 1.0 × 10) and type 2 diabetes by 1.15-fold/allele (p = 5.5 × 10). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p = 6.6 × 10). The -rs9939609 minor allele increased BMI by 0.26 kg/m2 per allele (p = 2.8 × 10), WHR by 0.003/allele (p = 1.2 × 10), and body fat percentage by 0.31%/allele (p = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12–20%) than South Asians (30–33%), the effect of variation on obesity-related traits and type 2 diabetes was similar in the two populations. Conclusions/interpretation: is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, is also associated with type 2 diabetes independently of BMI. Electronic supplementary material The online version of this article (doi:10.1007/s00125-011-2370-7) contains peer-reviewed but unedited supplementary material, which is available to authorised users
Association between depression, anxiety and weight change in young adults
Background To investigate whether there are bi-directional associations between anxiety and mood disorders and body mass index (BMI) in a cohort of young adults. Methods We analysed data from the 2004–2006 (baseline) and 2009–2011 (follow-up) waves of the Childhood Determinants of Adult Health study. Lifetime DSM-IV anxiety and mood disorders were retrospectively diagnosed with the Composite International Diagnostic Interview. Potential mediators were individually added to the base models to assess their potential role as a mediator of the associations. Results In males, presence of mood disorder history at baseline was positively associated with BMI gain (β = 0.77, 95% CI: 0.14–1.40), but baseline BMI was not associated with subsequent risk of mood disorder. Further adjustment for covariates, including dietary pattern, physical activity, and smoking reduced the coefficient (β) to 0.70 (95% CI: 0.01–1.39), suggesting that the increase in BMI was partly mediated by these factors. In females, presence of mood disorder history at baseline was not associated with subsequent weight gain, however, BMI at baseline was associated with higher risk of episode of mood disorder (RR per kg/m2: 1.04, 95% CI: 1.01–1.08), which was strengthened (RR per kg/m2 = 1.07, 95% CI: 1.00–1.15) after additional adjustment in the full model. There was no significant association between anxiety and change in BMI and vice-versa. Conclusion The results do not suggest bidirectional associations between anxiety and mood disorders, and change in BMI. Interventions promoting healthy lifestyle could contribute to reducing increase in BMI associated with mood disorder in males, and excess risk of mood disorder associated with BMI in females
Erythroid-Specific Transcriptional Changes in PBMCs from Pulmonary Hypertension Patients
Gene expression profiling of peripheral blood mononuclear cells (PBMCs) is a powerful tool for the identification of surrogate markers involved in disease processes. The hypothesis tested in this study was that chronic exposure of PBMCs to a hypertensive environment in remodeled pulmonary vessels would be reflected by specific transcriptional changes in these cells.The transcript profiles of PBMCs from 30 idiopathic pulmonary arterial hypertension patients (IPAH), 19 patients with systemic sclerosis without pulmonary hypertension (SSc), 42 scleroderma-associated pulmonary arterial hypertensio patients (SSc-PAH), and 8 patients with SSc complicated by interstitial lung disease and pulmonary hypertension (SSc-PH-ILD) were compared to the gene expression profiles of PBMCs from 41 healthy individuals. Multiple gene expression signatures were identified which could distinguish various disease groups from controls. One of these signatures, specific for erythrocyte maturation, is enriched specifically in patients with PH. This association was validated in multiple published datasets. The erythropoiesis signature was strongly correlated with hemodynamic measures of increasing disease severity in IPAH patients. No significant correlation of the same type was noted for SSc-PAH patients, this despite a clear signature enrichment within this group overall. These findings suggest an association of the erythropoiesis signature in PBMCs from patients with PH with a variable presentation among different subtypes of disease.In PH, the expansion of immature red blood cell precursors may constitute a response to the increasingly hypoxic conditions prevalent in this syndrome. A correlation of this erythrocyte signature with more severe hypertension cases may provide an important biomarker of disease progression
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