Simultaneous measurements of magnetotail dynamics by IMP spacecraft

Changes in tail energy density during substorms in the magnetotail are given. In addition to plasma sheet thinnings seen prior to substorm onsets, a gradual decrease in plasma beta was detected in the deep tail which precedes onset and the more prominent plasma disappearance that typically accompanies it. The frequency of thinnings and the regions over which they occurred indicate that drastic changes in plasma sheet thickness are common features of substorms which occur at all locations across the tail

Reply to comment by H. Hasegawa on "Evolution of Kelvin-Helmholtz activity on the dusk flank magnetopause"

We demonstrate, on experimental grounds, that the justifications for the comment by Hasegawa [2009], hereinafter H09, on work done by Foullon et al. [2008], hereinafter F08, are not well founded

On the multispacecraft determination of periodic surface wave phase speeds and wavelengths

Observations of surface waves on the magnetopause indicate a wide range of phase velocities and wavelengths. Their multispacecraft analysis allows a more precise determination of wave characteristics than ever before and reveal shortcomings of approximations to the phase speed that take a predetermined fraction of the magnetosheath speed or the average flow velocity in the boundary layer. We show that time lags between two or more spacecraft can give a qualitative upper estimate, and we confirm the unreliability of flow approximations often used by analyzing a few cases. Using two‐point distant magnetic field observations and spectral analysis of the tailward magnetic field component, we propose an alternative method to estimate the wavelength and phase speed at a single spacecraft from a statistical fit to the data at the other site

MeV magnetosheath ions energized at the bow shock

A causal relationship between midlatitude magnetosheath energetic ions and bow shock magnetic geometry was previously established for ion energy up to 200 keV e−1 for the May 4, 1998, storm event. This study demonstrates that magnetosheath ions with energies above 200 keV up to 1 MeV simply extend the ion spectrum to form a power law tail. Results of cross-correlation analysis suggest that these ions also come directly from the quasi-parallel bow shock, not the magnetosphere. This is confirmed by a comparison of energetic ion fluxes simultaneously measured in the magnetosheath and at the quasi-parallel bow shock when both regions are likely connected by the magnetic field lines. We suggest that ions are accelerated at the quasi-parallel bow shock to energies as high as 1 MeV and subsequently transported into the magnetosheath during this event

Clinical effectiveness and cost-effectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluation

Background: Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is characterised by hyper-secretion of growth hormone (GH) and insulin-like growth factor I (IGF-1). It is associated with reduced life expectancy, cardiovascular problems, a variety of insidiously progressing detrimental symptoms and metabolic malfunction. Treatments include surgery, radiotherapy and pharmacotherapy. Pegvisomant (PEG) is a genetically engineered GH analogue licensed as a third or fourth line option when other treatments have failed to normalise IGF-1 levels. Methods: Evidence about effectiveness and cost-effectiveness of PEG was systematically reviewed. Data were extracted from published studies and used for a narrative synthesis of evidence. A decision analytical economic model was identified and modified to assess the cost-effectiveness of PEG. Results: One RCT and 17 non-randomised studies were reviewed for effectiveness. PEG substantially reduced and rapidly normalised IGF-1 levels in the majority of patients, approximately doubled GH levels, and improved some of the signs and symptoms of the disease. Tumour size was unaffected at least in the short term. PEG had a generally safe adverse event profile but a few patients were withdrawn from treatment because of raised liver enzymes. An economic model was identified and adapted to estimate the lower limit for the cost-effectiveness of PEG treatment versus standard care. Over a 20 year time horizon the incremental cost-effectiveness ratio was pound81,000/QALY and pound212,000/LYG. To reduce this to pound30K/QALY would require a reduction in drug cost by about one third. Conclusion: PEG is highly effective for improving patients' IGF-1 level. Signs and symptoms of disease improve but evidence is lacking about long term effects on improved signs and symptoms of disease, quality of life, patient compliance and safety. Economic evaluation indicated that if current standards (UK) for determining cost-effectiveness of therapies were to be applied to PEG it would be considered not to represent good value for money

Stepwise tailward retreat of magnetic reconnection: THEMIS observations of an auroral substorm

Auroral stepwise poleward expansions were clarified by investigating a multiple‐onset substorm that occurred on 27 February 2009. Five successive auroral brightenings were identified in all‐sky images, occurring at approximately 10 min intervals. The first brightening was a faint precursor. The second brightening had a wide longitude; thus, it represented the Akasofu substorm onset. Other brightenings expanded poleward; thus, they were interpreted to be auroral breakups. These breakups occurred stepwise; that is, later breakups were initiated at higher latitudes. Corresponding reconnection signatures were studied using Time History of Events and Macroscale Interactions during Substorms (THEMIS) satellite observations between 8 and 24 RE down the magnetotail. The Akasofu substorm onset was not accompanied by a clear reconnection signature in the tail. In contrast, the three subsequent auroral breakups occurred simultaneously (within a few minutes) with three successive fast flows at 24 RE; thus, these were interpreted to be associated with impulsive reconnection episodes. These three fast flows consisted of a tailward flow and two subsequent earthward flows. The flow reversal at the second breakup indicated that a tailward retreat of the near‐Earth reconnection site occurred during the substorm expansion phase. In addition, the earthward flow at the third breakup was consistent with the classic tailward retreat near the end of the expansion phase; therefore, the tailward retreat is likely to have occurred in a stepwise manner. We interpreted the stepwise characteristics of the tailward retreat and poleward expansion to be potentially associated by a stepwise magnetic flux pileup.Key PointsAuroral stepwise poleward expansions were associated with reconnection stepwise tailward retreatThis spatially stepwise association is consequence of magnetic flux pileupThe stepwise association resolved objections to the Hones poleward leap conceptPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146463/1/jgra52608.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146463/2/jgra52608_am.pd

Direct Dark Matter Search using CCDs

There is currently vast evidence for Dark Matter (DM) from astronomical observations. However, in spite of tremendous efforts by large experimental groups, there is no confirmed direct detection of the dark matter in our galaxy. Recent experimental results and theoretical developments suggest the possibility of a DM particle with mass below 10 GeV, such a particle would escape most of the direct searches due to the large thresholds for the detection of nuclear recoils typically used. In this work we study the possibility of a new Dark Matter search with an unprecedented low threshold for the detection of nuclear recoils using high-resistivity CCD detectors (hr-CCD). Due to their extremely low readout noise and the relatively large active mass, these detectors present a unique opportunity in this field.Comment: paper presented at the Taup2009 Conferenc