849 research outputs found

    Kann die 18F-FDG-PET/CT-Untersuchung die Panendoskopie zur Detektion von synchronen Zweitkarzinomen ersetzen?

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    Ziel der Arbeit war es, die Wertigkeit der 18F-FDG-PET/ CT-Untersuchung bezßglich synchroner Zweitkarzinome im Vergleich mit der Panendoskopie beim initialen Staging zu untersuchen. 311 Patienten wurden mit beiden Untersuchungsmethoden abgeklärt. Als Referenz galt die zytologische, histologische und/oder klinische oder radiologische Untersuchung. Die Prävalenz fßr synchrone Zweitkarzinome betrug mit der Panendoskopie 4,5%, während die Prävalenz mittels PET/ CT-Untersuchung 6,1% betrug. Die Sensitivität fßr die Panendoskopie betrug 74%, die Spezifität 99,7%, der positiv prädiktive Wert 93% und der negativ prädiktive Wert 98%. Die Sensitivität fßr die PET/CT-Untersuchung betrug 100%, die Spezifität 95,7% der positiv prädiktive Wert 59% und der negativ prädiktive Wert 100%. Die PET/CT-Untersuchung scheint der Panendoskopie ßberlegen zu sein. Bei bezßglich synchroner Zweitkarzinome unauffälligem PET/CT kann die Panendoskopie auf die Endoskopie und Beurteilung des Primärtumors beschränkt werden kann. Aufgrund der hohen Kosten und der grossen Anzahl falsch positiver Resultate, welche durch das PET/CT generiert werden, empfehlen wir die Durchfßhrung dieser Untersuchung nur bei fortgeschrittenen Tumoren mit der Frage nach Fernmetastasen. Die Panendoskopie bleibt weiterhin der Goldstandar

    Combining Monte Carlo generators with next-to-next-to-leading order calculations: event reweighting for Higgs boson production at the LHC

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    We study a phenomenological ansatz for merging next-to-next-to-leading order (NNLO) calculations with Monte Carlo event generators. We reweight them to match bin-integrated NNLO differential distributions. To test this procedure, we study the Higgs boson production cross-section at the LHC, for which a fully differential partonic NNLO calculation is available. We normalize PYTHIA and MC@NLO Monte Carlo events for Higgs production in the gluon fusion channel to reproduce the bin integrated NNLO double differential distribution in the transverse momentum and rapidity of the Higgs boson. These events are used to compute differential distributions for the photons in the pp \to H \to \gamma \gamma decay channel, and are compared to predictions from fixed-order perturbation theory at NNLO. We find agreement between the reweighted generators and the NNLO result in kinematic regions where we expect a good description using fixed-order perturbation theory. Kinematic boundaries where resummation is required are also modeled correctly using this procedure. We then use these events to compute distributions in the pp \to H \to W^+W^- \to l^+l^- \nu\bar{\nu} channel, for which an accurate description is needed for measurements at the LHC. We find that the final state lepton distributions obtained from PYTHIA are not significantly changed by the reweighting procedure.Comment: 18 pages, 14 fig

    NNLO QCD predictions for the H -> WW -> l l nu nu signal at the LHC

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    We present a first computation of the NNLO QCD cross section at the LHC for the production of four leptons from a Higgs boson decaying into W bosons. We study the cross section for a Higgs boson mass Mh = 165 GeV; around this value a Standard Model Higgs boson decays almost exclusively into W-pairs. We apply all nominal experimental cuts on the final state leptons and the associated jet activity and study the magnitude of higher-order effects up to NNLO on all kinematic variables which are constrained by experimental cuts. We find that the magnitude of the higher-order corrections varies significantly with the signal selection cuts. As a main result we give the value of the cross section at NNLO with all selection cuts envisaged for the search for the Higgs boson.Comment: typos corrected, version accepted in JHE

    Social corrections act as a double-edged sword by reducing the perceived accuracy of false and real news in the UK, Germany, and Italy

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    This is the final version. Available from Nature Research via the DOI in this record. Data availability: All shareable data are found on the online OSF repository at https://osf.io/jhwfgCode availability: All the code including reproducible analyses are found on the online OSF repository at https://osf.io/4hjcf for data relating to the UK, https://osf.io/yvdj4 for Italy, and https:// osf.io/jhwfg Germany.Corrective or refutational posts from ordinary users on social media have the potential to improve the online information ecosystem. While initial evidence of these social corrections is promising, a better understanding of the effects across different topics, formats, and audiences is needed. In three pre-registered experiments (N = 1944 UK, N = 2467 Italy, N = 2210 Germany) where respondents completed a social media post assessment task with false and true news posts on various topics (e.g., health, climate change, technology), we find that social corrections reduce perceived accuracy of and engagement with false news posts. We also find that social corrections that flag true news as false decrease perceived accuracy of and engagement with true news posts. We did not find evidence to support moderation of these effects by correction strength, anti-expert sentiments, cognitive reflection capacities, or susceptibility to social influence. While social corrections can be effective for false news, they may also undermine belief in true news.British AcademyDavidson Colleg

    Radiation hardness qualification of PbWO4 scintillation crystals for the CMS Electromagnetic Calorimeter

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    This is the Pre-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2010 IOPEnsuring the radiation hardness of PbWO4 crystals was one of the main priorities during the construction of the electromagnetic calorimeter of the CMS experiment at CERN. The production on an industrial scale of radiation hard crystals and their certification over a period of several years represented a difficult challenge both for CMS and for the crystal suppliers. The present article reviews the related scientific and technological problems encountered

    Predictors of enhancing human physical attractiveness: Data from 93 countries

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    People across the world and throughout history have gone to great lengths to enhance their physical appearance. Evolutionary psychologists and ethologists have largely attempted to explain this phenomenon via mating preferences and strategies. Here, we test one of the most popular evolutionary hypotheses for beauty-enhancing behaviors, drawn from mating market and parasite stress perspectives, in a large cross-cultural sample. We also test hypotheses drawn from other influential and non-mutually exclusive theoretical frameworks, from biosocial role theory to a cultural media perspective. Survey data from 93,158 human participants across 93 countries provide evidence that behaviors such as applying makeup or using other cosmetics, hair grooming, clothing style, caring for body hygiene, and exercising or following a specific diet for the specific purpose of improving one physical attractiveness, are universal. Indeed, 99% of participants reported spending >10 min a day performing beauty-enhancing behaviors. The results largely support evolutionary hypotheses: more time was spent enhancing beauty by women (almost 4 h a day, on average) than by men (3.6 h a day), by the youngest participants (and contrary to predictions, also the oldest), by those with a relatively more severe history of infectious diseases, and by participants currently dating compared to those in established relationships. The strongest predictor of attractiveness-enhancing behaviors was social media usage. Other predictors, in order of effect size, included adhering to traditional gender roles, residing in countries with less gender equality, considering oneself as highly attractive or, conversely, highly unattractive, TV watching time, higher socioeconomic status, right-wing political beliefs, a lower level of education, and personal individualistic attitudes. This study provides novel insight into universal beauty-enhancing behaviors by unifying evolutionary theory with several other complementary perspectives.info:eu-repo/semantics/publishedVersio

    Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

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    A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE
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