73 research outputs found
Relational Contracts with Subjective Peer Evaluations
- Author
- --
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- --
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- A Field
- A Ishihara
- A Mukherjee
- Arijit Mukherjee
- B Holmstr�m
- C Bull
- C Ittner
- C Rose
- D Barron
- D Campbell
- D Fedor
- D Fudenberg
- D Gromb
- D Nilsen
- E Ben-Porath
- F Moers
- F Yammarino
- G Baker
- G Calzolari
- G Ellison
- G May
- I Andrew
- J Chan
- J Cr�mer
- J Deb
- J Harrington
- J Kim
- J Levin
- J Xie
- J.-J La�ont
- James Malcomson
- Jin Li
- Joyee Deb
- K Wexley
- L Carmichael
- L Maestri
- L Marx
- L Rayo
- L Telser
- M Budman
- M Ederhof
- M Edwards
- M Eswaran
- M Kandori
- M Kandori
- M Peiperl
- M Rajan
- O Kval�y
- P Fleckinger
- P Mabe
- R Heneman
- R Simons
- S Board
- S Lippert
- S Scott
- T Baldenius
- W B Macleod
- W Fuchs
- Y.-F Fong
- Y.-K Che
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Genetic Predictions of Prion Disease Susceptibility in Carnivore Species Based on Variability of the Prion Gene Coding Region
- Author
- A Bencsik
- A Brun
- A Maj
- A Mange
- AH Nalls
- AN Hamir
- AN Hamir
- B Bratberg
- B Caughey
- B Iulini
- B Sweeting
- C B-Rao
- C Plinston
- CE Krumm
- CJ Sigurdson
- CS Jennelle
- DA Lysek
- DA Lysek
- DM Heisey
- E Flechsig
- F Wopfner
- GR Pearson
- H Bueler
- HM Schatzl
- I Laffont-Proust
- I Vorberg
- J Slate
- J Wan
- JC Bartz
- JC Manson
- Jon M. Arnemo
- K Kaneko
- Karen A. Griffin
- L Westergard
- L Wik
- Lauren Campbell
- M Eiden
- M Polymenidou
- MA Menotti-Raymond
- Mark D. Zabel
- ME Chase-Topping
- Michael A. Tranulis
- Michael W. Miller
- MM Hilbe
- MM Leggett
- Morten Tryland
- MW Miller
- Paula Stewart
- PJ Robinson
- PP Liberski
- RD Harrington
- RM Anderson
- RM Barron
- S Lezmi
- S Mead
- S Peletto
- S Young
- Simon Girling
- SJ O’Brien
- Susan Skogtvedt
- T Baron
- TD Kurt
- W Goldmann
- W Goldmann
- Wilfred Goldmann
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2012
- Field of study
Mammalian species vary widely in their apparent susceptibility to prion diseases. For example, several felid species developed prion disease (feline spongiform encephalopathy or FSE) during the bovine spongiform encephalopathy (BSE) epidemic in the United Kingdom, whereas no canine BSE cases were detected. Whether either of these or other groups of carnivore species can contract other prion diseases (e.g. chronic wasting disease or CWD) remains an open question. Variation in the host-encoded prion protein (PrP(C)) largely explains observed disease susceptibility patterns within ruminant species, and may explain interspecies differences in susceptibility as well. We sequenced and compared the open reading frame of the PRNP gene encoding PrP(C) protein from 609 animal samples comprising 29 species from 22 genera of the Order Carnivora; amongst these samples were 15 FSE cases. Our analysis revealed that FSE cases did not encode an identifiable disease-associated PrP polymorphism. However, all canid PrPs contained aspartic acid or glutamic acid at codon 163 which we propose provides a genetic basis for observed susceptibility differences between canids and felids. Among other carnivores studied, wolverine (Gulo gulo) and pine marten (Martes martes) were the only non-canid species to also express PrP-Asp163, which may impact on their prion diseases susceptibility. Populations of black bear (Ursus americanus) and mountain lion (Puma concolor) from Colorado showed little genetic variation in the PrP protein and no variants likely to be highly resistant to prions in general, suggesting that strain differences between BSE and CWD prions also may contribute to the limited apparent host range of the latter
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
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- Afolabi D.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
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- C Beazley
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- C Clulow
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- C Demetriou
- C Dennis
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- C Kaye
- C Lynch
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- C Stuart
- C Summers
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- Caroline Abernathy
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- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
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- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
- D Purohit
- D Raynard
- D Salutous
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- D Scaletta
- D Shaw
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- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
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- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
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- H Moore
- H Parker
- H Pearson
- H Prady
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- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
- I Otahal
- I Otahal
- I Turner-Bone
- I Welters
- I White
- I Wynter
- Ilaria Meloni
- Immacolata Andolfo
- Isabella Zanella
- J Allan
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- J Caterson
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- J Egan
- J Fernandez Roman
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- Janie F Shelton
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- Johnny Millar
- Jorge Esparza-Gordillo
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- L Zitter
- Lance C W Turtle
- Laura Bergantini
- Laura Di Sarno
- Laura Marsh
- Laura Merson
- Law Andrew
- Leonardo Croci
- Lia Crotti
- Ling Lowell
- Lisa Norman
- Lorenzo Salerni
- Lorna Donnelly
- Louise Cullum
- Louise Macgillivray
- Louise Sigfrid
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Luisa Tavecchia
- M Abdelrazik
- M Al-Moasseb
- M Balasubramaniam
- M Bates
- M Bellamy
- M Birt
- M Blunt
- M Bokhari
- M Bolton
- M Brady
- M Breekes
- M Brett
- M Bromley
- M Bruce
- M Brunton
- M Burton
- M Callaghan
- M Carmody
- M Carnahan
- M Casey
- M Caswell
- M Chablani
- M Clapham
- M Clark
- M Clark
- M Coulding
- M Croft
- M Cunningham
- M Davey
- M Davies
- M Davies
- M Edward
- M Elhassan
- M Elsaadany
- M Faulkner
- M Forsey
- M Frise
- M Gellamucho
- M Gill
- M Gummadi
- M Halkes
- M Harkins
- M Hill
- M Hobrok
- M Holland
- M Home
- M Hussain
- M Jackson
- M K Phull
- M Kent
- M Khan
- M Latif
- M Leigh
- M Lopez Martinez
- M Lyons
- M MacMahon
- M Male
- M Marani
- M Margarson
- M Marotti
- M Matharu
- M McLaughlin
- M McPhail
- M Meredith
- M Mpelembue
- M Msiska
- M Mulcahy
- M Mupudzi
- M Nauman Akhtar
- M Newton
- M Oblak
- M Odam
- M Ostermann
- M Patel
- M Peiu
- M Penacerrada
- M Peters
- M Popescu
- M Poulaka
- M Purewal
- M Raj
- M Robinson
- M Sangombe
- M Shankar-Hari
- M Sim
- M Slaughter
- M Smith
- M Smith
- M Spivey
- M T Hijazi
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Templeton
- M Thankachen
- M Thirumaran
- M Thomas
- M Tolson
- M Usher
- M Varghese
- M Verlander
- M Vertue
- M Watters
- M White
- M Wiles
- M Williams
- M Wills
- M Woodruff
- M Young
- Maaike Swets
- Mahdad Noursadeghi
- Manu Shankar-Hari
- Marco Castori
- Marco Feri
- Marco Gori
- Marco Mandalà
- Marco Sita
- Margherita Baldassarri
- Mari E K Niemi
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Eugenia Quiros-Roldan
- Maria Palmieri
- Maria Zambon
- Marie Connor
- Mario Capasso
- Mario U Mondelli
- Marta Corridi
- Maslove David
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Girardis
- Massimo Palmarini
- Massimo Vaghi
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Mattia Cordioli
- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
- McAuley Danny
- Meera Chand
- Meynert Alison
- Michelle Girvan
- Millar Jonathan
- Mirella Bruttini
- Miriana D'Alessandro
- Montgomery Hugh
- Moore Shona C
- Moutsianas Loukas
- Murphy Lee
- Murray Wham
- N Ahmad
- N Bandla
- N Baxter
- N Boyle
- N Capps
- N Clarke
- N Crisp
- N Davidson
- N Dormand
- N Grau
- N Harris
- N Jacques
- N Keenan
- N Lancaster
- N Love
- N MacCallum
- N Michalak-Glinska
- N Motherwell
- N Muchenje
- N Nikitas
- N Pathan
- N Pattison
- N Proudfoot
- N Rea
- N Richardson
- N Rodden
- N Roe
- N Rogers
- N Runciman
- N Schumacher
- N Schunki
- N Slawson
- N Staines
- N Thomson
- N Truman
- N White
- Nichol Alistair
- Nicholas Parkinson
- Nicholas Price
- Nicky Day
- Nicola Picchiotti
- O Adanini
- O Akinkugbe
- O Ezeobu
- O Jones
- O Kelsall
- O Mercer
- O Mitchelmore
- O Olufuwa
- O Prysyazhna
- O Zongo
- Oosthuyzen Wilna
- Openshaw Peter J M
- P Alexander
- P Anderson
- P Bamford
- P Barry
- P Boyle
- P Clark
- P Coghlan
- P Doble
- P Donnison
- P Ebano
- P Gondo
- P Grant
- P Harding
- P Henderson
- P Hutton
- P Jackson
- P MacGoey
- P May
- P McConnell
- P Mercer
- P O'Brien
- P O'Neil
- P Parkinson
- P Parsons
- P Paul
- P Polgarova
- P Ranga
- P Rice
- P Rogers
- P Saunderson
- P Shanmugasundaram
- P Springle
- P Szedlak
- P Turner
- P Williams
- Pairo-Castineira Erola
- Pamela Raggi
- Paola Magro
- Paolo Cameli
- Paolo Piacentini
- Parkinson Nick
- Pasko Dorota
- Patrick Sulem
- Patrizia Zucchi
- Paul Finernan
- Paul Klenerman
- Pereira Alexandre C
- Peter W Horby
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pietro Pinoli
- Ponting Chris P
- Porteous David J
- R Astin-Chamberlain
- R Barber
- R Baruah
- R Bi
- R Bolton
- R Bowles
- R Boyle
- R Bradley
- R Campbell
- R Campbell
- R Chan
- R Charlesworth
- R Clark
- R Crawley
- R Crowe
- R Cusack
- R Davies
- R Doonan
- R Flanagan
- R Gascoyne
- R Girach
- R Gomez
- R Griffiths
- R Hall
- R Hamill
- R Haq
- R Harford
- R Harper
- R Herdman-Grant
- R Howle
- R Jacob
- R Jha
- R Johnson
- R Jones
- R Joy
- R Kanu
- R Kapoor
- R Kausar
- R Khade
- R Kitson
- R Kumar
- R Lean
- R Lim
- R Loosley
- R Lorusso
- R M Genetu
- R Marshall
- R O'Leary
- R Paramsothy
- R Parker
- R Partridge
- R Penn
- R Pepermans Saluzzio
- R Pollard
- R Price
- R Prout
- R Pugh
- R Raobaikady
- R Reece-Anthony
- R Rikunenko
- R Rojo
- R Saha
- R Sandhu
- R Shaw
- R Shokkar
- R Simms
- R Stead
- R Stewart
- R Sundaram
- R Tully
- R Tutton
- R Vincent
- R Walker
- R Wilcox
- R Wolf-Roberts
- R Worner
- R Wulandari
- Rachel Law
- Raffaele Scala
- Rawlik Konrad
- Renieri
- Renzo Scaggiante
- Richard Clark
- Richard S Tedder
- Richmond Anne
- Riinu Pius
- Rita Perna
- Roberta Russo
- Ross Hendry
- Rossella Tita
- Rowan Kathy
- Russell Clark D
- Ruth Armstrong
- Ruth Lyons
- Ryan S Thwaites
- S Agrawal
- S Allen
- S Allibone
- S Anderson
- S Archer
- S Bano
- S Bean
- S Beavis
- S Bell
- S Bennett
- S Benyon
- S Bird
- S Blowes
- S Board
- S Bonner
- S Brett
- S Buckley
- S Campos
- S Cathcart
- S Chapman
- S Charlton
- S Cherian
- S Chukkambotla
- S Clamp
- S Clark
- S Clements
- S Coetzee
- S Cole
- S Cornell
- S Cutler
- S Dale
- S Donlon
- S Farnell-Ward
- S Fowler
- S Garrioch
- S Gibson
- S Gopal
- S Greer
- S Gurung Rai
- S Henderson
- S Hierons
- S Hope
- S Humphreys
- S Hussain
- S Jenkins
- S Jhanji
- S Jones
- S Jose
- S Joseph
- S Kaul
- S Keenan
- S Keith
- S Kennedy-Hay
- S Kimber
- S Kumar
- S Laha
- S Latham
- S Leaver
- S Lee
- S Leggett
- S MacFadyen
- S Manna
- S Marriott
- S Masuko
- S McIvor
- S McKechnie
- S Melling
- S Mellor
- S Mepham
- S Metherell
- S Mitchard
- S Mohamed Ally
- S Monnery
- S Moore
- S Morrison
- S Moultrie
- S Mtuwa
- S Mulla
- S Munt
- S Murdoch
- S O'Sullivan
- S Packham
- S Patch
- S Pearson
- S Pitts
- S Preston
- S Purvis
- S Quaid
- S Ray
- S Roche
- S Rose
- S Rundell
- S Salmi
- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
- S Sousa Arias
- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Design and assembly of SPT-3G cold readout hardware
- Author
- Ade Peter A. R.
- Ahmed Z.
- Anderson A. J.
- Austermann J. E.
- Avva J. S.
- Barron D.
- Bender A. N.
- Benson B. A.
- Carlstrom J. E.
- Carter F. W.
- Cecil T.
- Chang C. L.
- Cliche J. F.
- Cukierman A.
- de Haan T.
- Denison E. V.
- Ding J.
- Dobbs M. A.
- Dutcher D.
- Elleflot T.
- Everett W.
- Foster A.
- Gannon R. N.
- Gilbert A.
- Groh J. C.
- Halverson N. W.
- Harke-Hosemann A. H.
- Harrington N. L.
- Hasegawa M.
- Hattori K.
- Henning J. W.
- Hilton G. C.
- Holzapfel W. L.
- Hori Y.
- Huang N.
- Irwin K. D.
- Jeong O. B.
- Jonas M.
- Khaire T.
- Kofman A. M.
- Korman M.
- Kubik D.
- Kuhlmann S.
- Kuo C. L.
- Lee A. T.
- Lowitz A. E.
- Meyer S. S.
- Montgomery J.
- Nadolski A.
- Natoli T.
- Nguyen H.
- Nishino H.
- Noble G. I.
- Novosad V.
- Padin S.
- Pan Z.
- Pearson J.
- Posada C. M.
- Rahlin A.
- Rotermund K.
- Ruhl J. E.
- Saunders L. J.
- Sayre J. T.
- Shirley I.
- Shirokoff E.
- Smecher G.
- Sobrin J. A.
- Stark A. A.
- Story K. T.
- Suzuki A.
- Tang Q. Y.
- Thakur R. Basu
- Thompson K. L.
- Tucker C.
- Vale L. R.
- Vanderlinde K.
- Vieira J. D.
- Wang G.
- Whitehorn N.
- Yefremenko V.
- Yoon K. W.
- Young M. R.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 24/05/2018
- Field of study
The third-generation upgrade to the receiver on the South Pole Telescope, SPT-3G, was installed at the South Pole during the 2016–2017 austral summer to measure the polarization of the cosmic microwave background. Increasing the number of detectors by a factor of 10 to ∼16,000
∼16,000
required the multiplexing factor to increase to 68 and the bandwidth of the frequency-division readout electronics to span 1.6–5.2 MHz. This increase necessitates low-thermal conductance, low-inductance cryogenic wiring. Our cold readout system consists of planar thin-film aluminum inductive–capacitive resonators, wired in series with the detectors, summed together, and connected to 4K SQUIDs by 10−μm
10−μm
-thick niobium–titanium (NbTi) broadside-coupled striplines. Here, we present an overview of the cold readout electronics for SPT-3G, including assembly details and characterization of electrical and thermal properties of the system. We report, for the NbTi striplines, values of R≤10 −4 Ω
R≤10−4Ω
, L=21±1 nH
L=21±1 nH
, and C=1.47±.02 nF
C=1.47±.02 nF
. Additionally, the striplines’ thermal conductivity is described by kA=6.0±0.3 T 0.92±0.04 μW mm K −1
kA=6.0±0.3 T0.92±0.04 μW mm K−1
. Finally, we provide projections for cross talk induced by parasitic impedances from the stripline and find that the median value of percentage cross talk from leakage current is 0.22 and 0.09%
0.09%
from wiring impedance
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial
- Author
- Abano N
- Abbott L
- Abbott W
- Abdul-Hamid A
- Abdul-Saheb M
- Abousleiman Y
- Abubakar S
- Adedoyin T
- Adie K
- Affley B
- Ahlquist K
- Ahmad N
- Ahmed A
- Ahmed S
- Ahmed Z
- Al Hussayni S
- Al-Samarrai N
- Alam I
- Alam S
- Ali A
- Ali K
- Allen C
- Allen J
- Allison J
- Allsop H
- Allsop L
- Almadenboyle C
- Alvares W
- Alwis L
- Alwis L
- Amero J
- Amis E
- Amlani S
- Amor K
- Anazodo C
- Anderson R
- Andrews J
- Anjum T
- Annamalai A
- Annison F
- Anthony A
- Appiatse G
- Archer J
- Argandona L
- Arif S
- Armer C
- Armstrong L
- Aruldoss P
- Arundell L-L
- Ashcroft P
- Asokanathan A
- Aubrey B
- Augustin M
- Auld G
- Austin D
- Awolesi J
- Ayer J
- Azim A
- Badiani B
- Bahk A
- Bailey D
- Bailey L
- Bakawala R
- Baker J
- Baker P
- Balami J
- Balasubramanian V
- Balian L
- Ball J
- Ball L
- Balogun I
- Bamford E
- Bamford J
- Banaras A
- Barber M
- Barbon E
- Barcroft H
- Barker J
- Barron C
- Barron L
- Barry A
- Barugh A
- Bate J
- Bateman G
- Bates M
- Bathula R
- Beadle H
- Beadling T
- Beard R
- Beardmore C
- Bedford C
- Bedford E
- Begum Y
- Bell A
- Bell J
- Bell J
- Bell S
- Bell S
- Bellfield R
- Benford A
- Bent C
- Benton L
- Beranova E
- Beranova E
- Besley S
- Bhalla A
- Bhandari M
- Bharaj K
- Bhargava M
- Bhattad M
- Bhome G
- Billingham S
- Birns J
- Black T
- Blackburn J
- Blackburn R
- Blair G
- Blane S
- Blight A
- Blight A
- Bloom S
- Board J
- Board S
- Bohannan E
- Bokhari M
- Bolton M
- Bond K
- Booth C
- Booth L
- Borley J
- Borley J
- Boulton A
- Boulton R
- Bower R
- Bowers R
- Bowie E
- Bowler H
- Bowring A
- Box C
- Bradfield S
- Bradshaw E
- Brady M
- Brammer S
- Bray H
- Breeds J
- Brewer C
- Brezitski M
- Bridger H
- Brighouse-Johnson C
- Brodie C
- Brodie F
- Brookes L
- Brotheridge S
- Brotherton L
- Broughton D
- Brown C
- Brown E
- Brown L
- Brown P
- Brown R
- Brown S
- Bruce D
- Buchan R
- Buchanan D
- Buckley C
- Bunworth K
- Burgess D
- Burgess L
- Burgess S
- Burgoyne J-R
- Burn I
- Burn M
- Burnip R
- Burns A
- Burns E
- Burova M
- Burton H
- Burton K
- Butler A
- Butler D
- Butler F
- Butler R
- Butler S
- Butt G
- Bwalya A
- Byrne A
- Cageao J
- Cain R
- Caine S
- Cairns F
- Cannon E
- Cape A
- Carpenter M
- Carpio R
- Carr L
- Carson S
- Carter T
- Cartwright B
- Cassidy T
- Cattermole E
- Causley C
- Ceccarelli D
- Chadbourn I
- Chadha D
- Chakrabarti A
- Chamberlain A
- Chan K
- Chandler S
- Chandrasena D
- Chaplin S
- Chapman N
- Chapman R
- Chapter T
- Charles B
- Chatterjee K
- Chattha N
- Chauhan M
- Chembala J
- Cheripelli B
- Chesser D
- Chin Y-M
- Chinery E
- Chohan O
- Chopra N
- Choy L
- Christie D
- Christie M
- Christmas N
- Chun Y
- Clark Brown P
- Clarke B
- Clarke C
- Clarke N
- Clarke R
- Clarke S
- Clarkson E
- Claydon F
- Clayton S
- Clements C
- Cloud G
- Cluckie G
- Coburn I
- Cohen D
- Collas D
- Collins K
- Collins S
- Colwill D
- Connell L
- Constantin C
- Cook A
- Cook P
- Cook S
- Cooke D
- Cooper L
- Cooper M
- Cooper P
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- Corbett T
- Corrigan P
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- Cox C
- Cox P
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- Crause J
- Crawford P
- Creeden R
- Crisp S
- Crofts M
- Cron N
- Croome V
- Crothers S
- Crowther H
- Cuddy S
- Cuenoud L
- Culbert A
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- Culmsee C
- Cunningham J
- Cunningham J
- Curtis J
- Curwen R
- Cusack E
- Cvoro V
- Dabbagh S
- Dainty A
- Dakin K
- Dangri P
- Daniel D
- Darnbrook G
- Das S
- Datta P
- Davenport S
- Davey R
- David A
- David O
- David O
- Davies Y
- Davis F
- Davy M
- Day D
- Day N
- Dayal S
- De Bruijn S
- De Michele Hock L
- Dealing S
- Deary A
- Dellafera D
- Denham L
- Denic H
- Dennett K
- Dennis M
- Denny L
- Deveciana A
- Devine J
- Devitt N
- Dhakal M
- Dhar S
- Dickinson C
- Dickson C
- Dima S
- Dimartino V
- Dinsmore L
- Dixon L
- Dodd E
- Dodsworth K
- Donaldson D
- Donaldson D
- Donaldson F
- Donaldson S
- Donne C
- Donninson M
- Doughty L
- Douglas E
- Douris G
- Dow L
- Dowling T
- Doyle C
- Doyle D
- Drake M
- Drever J
- Drew J
- Driver E
- Drummond G
- Dsouza M
- Dube J
- Duberley S
- Duckett T
- Duffy J
- Duffy M
- Duggan C
- Dunn G
- Dunn S
- Dunne A
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- Duran B
- Durman H
- Dutta D
- Duty S
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- Dymond H
- Dynan K
- Earnshaw P
- Eastwood MJ
- Edmunds T
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- Edwards B
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- Elitova S
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- Erumere E
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.
Methods
FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762.
Findings
Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839–1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26–6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38–2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months.
Interpretation
Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function.
Funding
UK Stroke Association and NIHR Health Technology Assessment Programme
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Conscious Motivations of Adolescent Visual Artists and Creative Writers: Similarities and Differences
- Author
- Allport G. W.
- Amabile T.
- Arts Council of New Zealand
- Austen-Leigh W.
- Barbot B.
- Barron F.
- Barron F.
- Christina S. Chin-Newman
- Csikszentmihali R.
- Csikszentmihalyi M.
- David M. Harrington
- Freud S.
- Getzels J. W.
- Gopnik A.
- Harrington D. M.
- Kastenbaum R.
- Ludwig A. M.
- Maslow A. H.
- Mathews N. M.
- O’Brian P.
- Rank O.
- Renwald J.
- Rothenberg A.
- Runco M. A.
- Scott D.
- Shaw J. A.
- Stein M. I.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains
- Author
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- Field of study
Is Crowdsourcing Useful for Enhancing Innovation and Learning Outcomes in Culinary and Hospitality Education?
- Author
- Airey D.
- Allen Booz
- Awazu Y.
- Barron P.
- Bitner M. J.
- Cooper R. G.
- Cooper R. G.
- Crawford C. M.
- Creswell J. W.
- Danneels E.
- Dooley R. S.
- Feltenstein T.
- Forbes D. P.
- Ghauri P. N.
- Gressgård L.
- Harrington R. J.
- Harrington R. J.
- Harrington R. J.
- Harrington R. J.
- Hegarty J. A.
- Hellsten M.
- Johnson K.
- Kelly A. Way
- Meiren T.
- Michael C. Ottenbacher
- Miles M. B.
- Morrison A.
- Müller K. F.
- Ottenbacher M.
- Ottenbacher M.
- Ottenbacher M.
- Ottenbacher M.
- Ottenbacher M.
- Ottenbacher M.
- Paul P.
- Robert J. Harrington
- Sawyer K.
- Simons T.
- Strauss A.
- Sulkowski N. B.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
- …