Valeur de l’examen extemporane en pathologie thyroïdienne

OBJECTIF : Etudier la valeur de l’examen extemporané dans la pathologie thyroidienne et identifier ses limitesMATERIELS ET METHODES : Notre étude est rétrospective incluant 800 examens extemporanés réalisés sur des pièces de résectionthyroïdienne colligés dans notre service sur une période de 12 ans (2000-2011).Les résultats ont été comparés à ceux del’examen anatomopathologique définitif.RESULTATS : Les résultats étaient concordants dans 96,5%, discordants dans 3,5 %. La sensibilité de l’examen extemporané toustypes confondus était de 78 % et la spécificité de 100 %CONCLUSION : Notre étude a montré une spécificité parfaite de l’examen extemporané cependant l’interprétation difficile des lésionsthyroïdiennes d’architecture vésiculaire expliquent une sensibilité de 78 %.Mots Clés : Thyroïdectomie, examen extemporanOBJECTIVE: To assess the value of frozen-section examination in thyroid surgery and evaluate its limitationsPATIENTS AND METHODES: This retrospective study examined the results of 800 frozen-sections of thyroid specimens analysedover the 12 –year period (2000-2011). Their results were compared with definitive anatomo-pathological examinationRESULTS :Frozen-section diagnosis was concordant with subsequent histopathological examination in 96,5% ,discordant in 3,5%.The global specificity of frozen section analysis for all histological subtypes was 100 % and its sensitivity was 78 %.CONCLUSION: This study shows the good specificity of frozen section .Discordances between frozen-section and definitive diagnosiswas associated with microfllicular lesions wich explain the sensibility of 78%Key Words: Thyroid surgery, frozen section examinatio

Perception of Subject Matter Experts (SMEs) on various curation and preservation techniques for the development of natural history gallery in Malaysia: a qualitative study

Preserving animal’s body or part of the animals have become an important and wellknown conservation medium to ensure that the future generations are still able to enjoy the biodiversity and all the incredible species that live within it. This paper aims to present a qualitative study on perception and preference of subject matter experts (SMEs) on various curation and preservation methods that is suitable for certain animals for the development of Natural History Gallery. Interview with the SMEs were done by using semi-structured questionnaire and prior to this, permission were gained from the respondents by signing the Informed Consent Form (ICF). The findings suggest that the preservation methods of specimens ultimately depend on the purpose of specimens collected, either to be preserved as research specimens or exhibition specimens. The information gained form this study will be valuable as directive for the development of natural history gallery in Malaysia

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important role as effector agents of the innate immune system. The AMP era was born more than 6 decades ago when the first cationic cyclic peptide antibiotics, namely polymyxins and tyrothricin, found their way into clinical use. Due to the good clinical experience in the treatment of, for example, infections of mucus membranes as well as the subsequent understanding of mode of action, AMPs are now considered for treatment of inflammatory skin diseases and for improving healing of infected wounds. Based on the preclinical findings, including pathobiochemistry and molecular medicine, targeted therapy strategies are developed and first results indicate that AMPs influence processes of diseased skin. Importantly, in contrast to other antibiotics, AMPs do not seem to propagate the development of antibiotic-resistant micro-organisms. Therefore, AMPs should be tested in clinical trials for their efficacy and tolerability in inflammatory skin diseases and chronic wounds. Apart from possible fields of application, these peptides appear suited as an example of the paradigm of translational medicine for skin diseases which is today seen as a `two-way road' - from bench to bedside and backwards from bedside to bench. Copyright (c) 2012 S. Karger AG, Base

Cultura de Inovação: Conceitos e Modelos Teóricos

This study portrays the state of the art in scientific literature on the culture of innovation, with the objective of characterizing its meaning and especially describing different theoretical models that seek to understand how it occurs in an organizational environment. To enrich the analysis, research results show the relationship between organizational culture and innovation. The literature review was carried out in 2011 using the following databases: Coordination for the Improvement of Higher Education Personnel (CAPES), Proquest and Directory of Open Access Journals (DOAJ). The keywords used were the expression culture of innovation and the joint terms culture and innovation, only full articles were included in the research. Culture of innovation articles that were cited in the papers identified in the literature search were also considered. The analysis consisted of 40 articles, based on the predefined criteria, and showed that this is a topic of interest for researchers in different world regions. It is a complex theme determined by factors with a systemic character. There is a predominance of quantitative research and strong evidence of a relationship between organizational culture and innovation, which requires further research to test the theoretical models proposed by these different authors

Green process innovation: Where we are and where we are going

Environmental pollution has worsened in the past few decades, and increasing pressure is being put on firms by different regulatory bodies, customer groups, NGOs and other media outlets to adopt green process innovations (GPcIs), which include clean technologies and end-of-pipe solutions. Although considerable studies have been published on GPcI, the literature is disjointed, and as such, a comprehensive understanding of the issues, challenges and gaps is lacking. A systematic literature review (SLR) involving 80 relevant studies was conducted to extract seven themes: strategic response, organisational learning, institutional pressures, structural issues, outcomes, barriers and methodological choices. The review thus highlights the various gaps in the GPcI literature and illuminates the pathways for future research by proposing a series of potential research questions. This study is of vital importance to business strategy as it provides a comprehensive framework to help firms understand the various contours of GPcI. Likewise, policymakers can use the findings of this study to fill in the loopholes in the existing regulations that firms are exploiting to circumvent taxes and other penalties by locating their operations to emerging economies with less stringent environmental regulations.publishedVersio

Digital supply chain management in the videogames industry: a systematic literature review

As industries mature, they rely more heavily on supply chain management (SCM) to ensure effective operations leading to greater levels of organisational performance. SCM has been widely covered in many industrial areas and, in line with other burgeoning sectors such as Tourism, an industry focus provides the opportunity to look in-depth at the context-based factors that affect SCM. Developments in digital distribution and rapid technological innovations have resulted in an increased focus on Digital Supply Chains (DSCs), which bring about significant changes to how consumers, customers, suppliers, and manufacturers interact, affecting supply chain design and processes. Through a systematic review of the Videogames Industry Supply Chain Management literature, which serves as a pertinent contextual example of a DSC, we look at how supply chains are affected by structural, market and technological change, such as increased platformisation, disintermediation and the proliferation of digital distribution. We distil these findings into a new research agenda, which identifies themes in line with extant DSC research, provides a series of relevant practice recommendations and identifies opportunities for future research