525 research outputs found
Spin states of asteroids in the Eos collisional family
Eos family was created during a catastrophic impact about 1.3 Gyr ago.
Rotation states of individual family members contain information about the
history of the whole population. We aim to increase the number of asteroid
shape models and rotation states within the Eos collision family, as well as to
revise previously published shape models from the literature. Such results can
be used to constrain theoretical collisional and evolution models of the
family, or to estimate other physical parameters by a thermophysical modeling
of the thermal infrared data. We use all available disk-integrated optical data
(i.e., classical dense-in-time photometry obtained from public databases and
through a large collaboration network as well as sparse-in-time individual
measurements from a few sky surveys) as input for the convex inversion method,
and derive 3D shape models of asteroids together with their rotation periods
and orientations of rotation axes. We present updated shape models for 15
asteroids and new shape model determinations for 16 asteroids. Together with
the already published models from the publicly available DAMIT database, we
compiled a sample of 56 Eos family members with known shape models that we used
in our analysis of physical properties within the family. Rotation states of
asteroids smaller than ~20 km are heavily influenced by the YORP effect, whilst
the large objects more or less retained their rotation state properties since
the family creation. Moreover, we also present a shape model and bulk density
of asteroid (423) Diotima, an interloper in the Eos family, based on the
disk-resolved data obtained by the Near InfraRed Camera (Nirc2) mounted on the
W.M. Keck II telescope.Comment: Accepted for publication in ICARUS Special Issue - Asteroids: Origin,
Evolution & Characterizatio
Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review
Ulcerative colitis (UC) is part of the inflammatory bowels diseases, and moderate to severe UC patients can be treated with anti-tumour necrosis α monoclonal antibodies, including infliximab (IFX). Even though treatment of UC patients by IFX has been in place for over a decade, many gaps in modelling of IFX PK in this population remain. This is even more true for acute severe UC (ASUC) patients for which early prediction of IFX pharmacokinetic (PK) could highly improve treatment outcome. Thus, this review aims to compile and analyse published population PK models of IFX in UC and ASUC patients, and to assess the current knowledge on disease activity impact on IFX PK. For this, a semi-systematic literature search was conducted, from which 26 publications including a population PK model analysis of UC patients receiving IFX therapy were selected. Amongst those, only four developed a model specifically for UC patients, and only three populations included severe UC patients. Investigations of disease activity impact on PK were reported in only 4 of the 14 models selected. In addition, the lack of reported model codes and assessment of predictive performance make the use of published models in a clinical setting challenging. Thus, more comprehensive investigation of PK in UC and ASUC is needed as well as more adequate reports on developed models and their evaluation in order to apply them in a clinical setting
SOPHIE velocimetry of Kepler transit candidates XII. KOI-1257 b: a highly eccentric three-month period transiting exoplanet
In this paper we report a new transiting warm giant planet: KOI-1257 b. It
was first detected in photometry as a planet-candidate by the
space telescope and then validated thanks to a radial velocity follow-up with
the SOPHIE spectrograph. It orbits its host star with a period of 86.647661 d
3 s and a high eccentricity of 0.772 0.045. The planet transits the
main star of a metal-rich, relatively old binary system with stars of mass of
0.99 0.05 Msun and 0.70 0.07 Msun for the primary and secondary,
respectively. This binary system is constrained thanks to a self-consistent
modelling of the transit light curve, the SOPHIE radial
velocities, line bisector and full-width half maximum (FWHM) variations, and
the spectral energy distribution. However, future observations are needed to
confirm it. The PASTIS fully-Bayesian software was used to validate the nature
of the planet and to determine which star of the binary system is the transit
host. By accounting for the dilution from the binary both in photometry and in
radial velocity, we find that the planet has a mass of 1.45 0.35 Mjup,
and a radius of 0.94 0.12 Rjup, and thus a bulk density of 2.1
1.2 g.cm. The planet has an equilibrium temperature of 511 50 K,
making it one of the few known members of the warm-jupiter population. The
HARPS-N spectrograph was also used to observe a transit of KOI-1257 b,
simultaneously with a joint amateur and professional photometric follow-up,
with the aim of constraining the orbital obliquity of the planet. However, the
Rossiter-McLaughlin effect was not clearly detected, resulting in poor
constraints on the orbital obliquity of the planet.Comment: 39 pages, 17 figures, accepted for publication in Astronomy &
Astrophysic
Investigation on the role of red fox in tuberculosis maintenance community ¿ second opus: experimental infection with a virulent field Mycobacterium bovis strain
Trabajo presentado al: 69th Wildlife Disease Association and 14th European Wildlife Disease Association Conference. Cuenca, Spain. p. 135. 31 agosto-2 septiembre
Technical developments for computed tomography on the CENBG nanobeam line
The use of ion microbeams as probes for computedtomography has proven to be a powerful tool for the three-dimensional characterization of specimens a few tens of micrometers in size. Compared to other types of probes, the main advantage is that quantitative information about mass density and composition can be obtained directly, using specific reconstruction codes. At the Centre d’Etudes Nucléaires de Bordeaux Gradignan (CENBG), this technique was initially developed for applications in cellular biology. However, the observation of the cell ultrastructure requires a sub-micron resolution. The construction of the nanobeamline at the Applications Interdisciplinaires des Faisceaux d’Ions en Region Aquitaine (AIFIRA) irradiation facility has opened new perspectives for such applications.
The implementation of computedtomography on the nanobeamline of CENBG has required a careful design of the analysis chamber, especially microscopes for precise sample visualization, and detectors for scanning transmission ion microscopy (STIM) and for particle induced X-ray emission (PIXE). The sample can be precisely positioned in the three directions X, Y, Z and a stepper motor coupled to a goniometer ensures the rotational motion. First images of 3D tomography were obtained on a reference sample containing microspheres of certified diameter, showing the good stability of the beam and the sample stage, and the precision of the motion
The field high-amplitude SX Phe variable BL Cam: results from a multisite photometric campaign. II. Evidence of a binary - possibly triple - system
Short-period high-amplitude pulsating stars of Population I ( Sct
stars) and II (SX Phe variables) exist in the lower part of the classical
(Cepheid) instability strip. Most of them have very simple pulsational
behaviours, only one or two radial modes being excited. Nevertheless, BL Cam is
a unique object among them, being an extreme metal-deficient field
high-amplitude SX Phe variable with a large number of frequencies. Based on a
frequency analysis, a pulsational interpretation was previously given. aims
heading (mandatory) We attempt to interpret the long-term behaviour of the
residuals that were not taken into account in the previous Observed-Calculated
(O-C) short-term analyses. methods heading (mandatory) An investigation of the
O-C times has been carried out, using a data set based on the previous
published times of light maxima, largely enriched by those obtained during an
intensive multisite photometric campaign of BL Cam lasting several months.
results heading (mandatory) In addition to a positive (161 3) x 10
yr secular relative increase in the main pulsation period of BL Cam, we
detected in the O-C data short- (144.2 d) and long-term ( 3400 d)
variations, both incompatible with a scenario of stellar evolution. conclusions
heading (mandatory) Interpreted as a light travel-time effect, the short-term
O-C variation is indicative of a massive stellar component (0.46 to 1
M_{\sun}) with a short period orbit (144.2 d), within a distance of 0.7 AU
from the primary. More observations are needed to confirm the long-term O-C
variations: if they were also to be caused by a light travel-time effect, they
could be interpreted in terms of a third component, in this case probably a
brown dwarf star ( 0.03 \ M_{\sun}), orbiting in 3400 d at a
distance of 4.5 AU from the primary.Comment: 7 pages, 5 figures, accepted for publication in A&
Asteroids' physical models from combined dense and sparse photometry and scaling of the YORP effect by the observed obliquity distribution
The larger number of models of asteroid shapes and their rotational states
derived by the lightcurve inversion give us better insight into both the nature
of individual objects and the whole asteroid population. With a larger
statistical sample we can study the physical properties of asteroid
populations, such as main-belt asteroids or individual asteroid families, in
more detail. Shape models can also be used in combination with other types of
observational data (IR, adaptive optics images, stellar occultations), e.g., to
determine sizes and thermal properties. We use all available photometric data
of asteroids to derive their physical models by the lightcurve inversion method
and compare the observed pole latitude distributions of all asteroids with
known convex shape models with the simulated pole latitude distributions. We
used classical dense photometric lightcurves from several sources and
sparse-in-time photometry from the U.S. Naval Observatory in Flagstaff,
Catalina Sky Survey, and La Palma surveys (IAU codes 689, 703, 950) in the
lightcurve inversion method to determine asteroid convex models and their
rotational states. We also extended a simple dynamical model for the spin
evolution of asteroids used in our previous paper. We present 119 new asteroid
models derived from combined dense and sparse-in-time photometry. We discuss
the reliability of asteroid shape models derived only from Catalina Sky Survey
data (IAU code 703) and present 20 such models. By using different values for a
scaling parameter cYORP (corresponds to the magnitude of the YORP momentum) in
the dynamical model for the spin evolution and by comparing synthetics and
observed pole-latitude distributions, we were able to constrain the typical
values of the cYORP parameter as between 0.05 and 0.6.Comment: Accepted for publication in A&A, January 15, 201
Early psychological care of the French victims of the Costa Concordia shipwreck
Most of the French passengers who survived the shipwreck of the cruise ship Costa Concordia were repatriatedfrom Italy to Marseille, one of the stopovers of the cruise. The shipwreck happened during the nightof 13th–14th January 2012 and entailed the forced evacuation of 4195 passengers and crewmembers.Thirty-two persons died and 2 others are still reported missing. The massive and unexpected inflow of402 French citizens in the port of Marseille required the quick setting up of welcome facilities, not only tosolve logistical problems, but also to address psychological and sometimes even medical problems. ThePrehospital Psychological Emergency Service (CUMP) and the Prehospital Emergency Medical Service(SAMU) of Marseille examined 196 persons in total, and were able to avoid a great number of emergencyadmissions deemed necessary because of difficult psychological situations (death, missing or lost persons,acute stress). The objective of this report is to rapidly present the emergency committee as a whole andto describe in more detail the work that the CUMP accomplished during the 36 hours necessary to takecharge of the majority of the French passengers of the Costa Concordia.Most of the French passengers who survived the shipwreck of the cruise ship Costa Concordia were repatriatedfrom Italy to Marseille, one of the stopovers of the cruise. The shipwreck happened during the nightof 13th–14th January 2012 and entailed the forced evacuation of 4195 passengers and crewmembers.Thirty-two persons died and 2 others are still reported missing. The massive and unexpected inflow of402 French citizens in the port of Marseille required the quick setting up of welcome facilities, not only tosolve logistical problems, but also to address psychological and sometimes even medical problems. ThePrehospital Psychological Emergency Service (CUMP) and the Prehospital Emergency Medical Service(SAMU) of Marseille examined 196 persons in total, and were able to avoid a great number of emergencyadmissions deemed necessary because of difficult psychological situations (death, missing or lost persons,acute stress). The objective of this report is to rapidly present the emergency committee as a whole andto describe in more detail the work that the CUMP accomplished during the 36 hours necessary to takecharge of the majority of the French passengers of the Costa Concordia
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