47 research outputs found
Regional Pollution due to Biomass Burning in South America
The present study analyses a low level jet event that occurred inconjunction with biomass burning and focuses on the impact onsoutheastern South America. The aerosol transport is analyzed usingoutputs of the CATT-BRAMS modeling system. The relationships betweenthe low level jet and the smoke plume pattern and concentrations are shown.The present study analyses a low level jet event that occurred inconjunction with biomass burning and focuses on the impact onsoutheastern South America. The aerosol transport is analyzed usingoutputs of the CATT-BRAMS modeling system. The relationships betweenthe low level jet and the smoke plume pattern and concentrations are shown
Binding of smoothelin-like 1 to tropomyosin and calmodulin is mutually exclusive and regulated by phosphorylation
Avaliação da influência de condições meteorológicas na ocorrência e manutenção de um episódio prolongado com altas concentrações de ozônio sobre a região metropolitana de São Paulo
British Romanticism and the Global Climate
As a result of developments in the meteorological and geological sciences, the Romantic period saw the gradual emergence of attempts to understand the climate as a dynamic global system that could potentially be affected by human activity. This chapter examines textual responses to climate disruption cause by the Laki eruption of 1783 and the Tambora eruption of 1815. During the Laki haze, writers such as Horace Walpole, Gilbert White, and William Cowper found in Milton a powerful way of understanding the entanglements of culture and climate at a time of national and global crisis. Apocalyptic discourse continued to resonate during the Tambora crisis, as is evident in eyewitness accounts of the eruption, in the utopian predictions of John Barrow and Eleanor Anne Porden, and in the grim speculations of Byron’s ‘Darkness’. Romantic writing offers a powerful analogue for thinking about climate change in the Anthropocene
Negative teacher behaviors in the classroom : Linking students’ and teachers’ perspectives.
Application of immobilized ATP to the study of NLRP inflammasomes
The NLRP proteins are a subfamily of the NOD-like receptor (NLR) innate immune sensors that possess an ATP-binding NACHT domain. As the most well-studied member, NLRP3 can initiate the assembly process of a multiprotein complex, termed the inflammasome, upon detection of a wide range of microbial products and endogenous danger signals and results in the activation of pro-caspase-1, a cysteine protease that regulates multiple host defense pathways including cytokine maturation. Dysregulated NLRP3 activation contributes to inflammation and the pathogenesis of several chronic diseases, and the ATP-binding properties of NLRPs are thought to be critical for inflammasome activation. In light of this, we examined the utility of immobilized ATP matrices in the study of NLRP inflammasomes. Using NLRP3 as the prototypical member of the family, P-linked ATP Sepharose was determined to be a highly-effective capture agent. In subsequent examinations, P-linked ATP Sepharose was used as an enrichment tool to enable the effective profiling of NLRP3-biomarker signatures with selected reaction monitoring-mass spectrometry (SRM-MS). Finally, ATP Sepharose was used in combination with a fluorescence-linked enzyme chemoproteomic strategy (FLECS) screen to identify potential competitive inhibitors of NLRP3. The identification of a novel benzo[d]imidazol-2-one inhibitor that specifically targets the ATP-binding and hydrolysis properties of the NLRP3 protein implies that ATP Sepharose and FLECS could be applied other NLRPs as well.Canadian Institutes of Health Research - Foundation Schem