The direct and indirect effects of corruption on motor vehicle crash deaths.

Recent empirical research has found that there is an inverted U-shaped or Kuznets relationship between income and motor vehicle crash (MVC) deaths, such that MVC deaths increase as national income increases and decrease after reaching a critical level. Corruption has been identified as one of the underlying factors that could affect this relationship, primarily by undermining institutional development and effective enforcement schemes. The total effect of corruption can be decomposed into two components, a direct and an indirect effect. The direct effect measures the immediate impact of corruption on MVC deaths by undermining effective enforcement and regulations, while the indirect effect captures the impact of corruption on hindering increases in per capita income and the consequent impact of reduced income on MVC deaths. By influencing economic growth, corruption can lead to an increase or decrease in MVC deaths depending on the income level. Using data from 60 countries between 1982 and 2003, these effects are estimated using linear panel and fixed effects negative binomial models. The estimation results suggest that corruption has different direct effects for less developed and highly developed countries. It has a negative (decreasing) effect on MVC deaths for less developed countries and a positive (increasing) effect on MVC deaths for highly developed countries. For highly developed countries, the total effect is positive at lower per capita income levels, but decreases with per capita income and becomes negative at per capita income levels of about US$ 38,248. For less developed countries, the total effect is negative within the sample range and decreases with increased per capita income. In summary, the results of this study suggest that reduction of corruption is likely a necessary condition to effectively tackle road safety problems

Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake

In this paper a review of the application of four different techniques (a version of the similarity transformation approach for autonomous uncontrolled systems, a non-differential input/output observable normal form approach, the characteristic set differential algebra and a recent algebraic input/output relationship approach) to determine the structural identifiability of certain in vitro nonlinear pharmacokinetic models is provided. The Organic Anion Transporting Polypeptide (OATP) substrate, Pitavastatin, is used as a probe on freshly isolated animal and human hepatocytes. Candidate pharmacokinetic non-linear compartmental models have been derived to characterise the uptake process of Pitavastatin. As a prerequisite to parameter estimation, structural identifiability analyses are performed to establish that all unknown parameters can be identified from the experimental observations available

GRB 081028 and its late-time afterglow re-brightening

‘The definitive version is available at www3.interscience.wiley.com '. Copyright Royal Astronomical SocietySwift captured for the first time a smoothly rising X-ray re-brightening of clear non-flaring origin after the steep decay in a long gamma-ray burst (GRB): GRB 081028. A rising phase is likely present in all GRBs but is usually hidden by the prompt tail emission and constitutes the first manifestation of what is later to give rise to the shallow decay phase. Contemporaneous optical observations reveal a rapid evolution of the injection frequency of a fast cooling synchrotron spectrum through the optical band, which disfavours the afterglow onset (start of the forward shock emission along our line of sight when the outflow is decelerated) as the origin of the observed re-brightening. We investigate alternative scenarios and find that the observations are consistent with the predictions for a narrow jet viewed off-axis. The high on-axis energy budget implied by this interpretation suggests different physical origins of the prompt and (late) afterglow emission. Strong spectral softening takes place from the prompt to the steep decay phase: we track the evolution of the spectral peak energy from the γ-rays to the X-rays and highlight the problems of the high latitude and adiabatic cooling interpretations. Notably, a softening of both the high and low spectral slopes with time is also observed. We discuss the low on-axis radiative efficiency of GRB 081028 comparing its properties against a sample of Swift long GRBs with secure Eγ,iso measurements.Peer reviewe

Substructures in lens galaxies: PG1115+080 and B1555+375, two fold configurations

We study the anomalous flux ratio which is observed in some four-image lens systems, where the source lies close to a fold caustic. In this case two of the images are close to the critical curve and their flux ratio should be equal to unity, instead in several cases the observed value differs significantly. The most plausible solution is to invoke the presence of substructures, as for instance predicted by the Cold Dark Matter scenario, located near the two images. In particular, we analyze the two fold lens systems PG1115+080 and B1555+375, for which there are not yet satisfactory models which explain the observed anomalous flux ratios. We add to a smooth lens model, which reproduces well the positions of the images but not the anomalous fluxes, one or two substructures described as singular isothermal spheres. For PG1115+080 we consider a smooth model with the influence of the group of galaxies described by a SIS and a substructure with mass $\sim 10^{5} M_{\odot}$ as well as a smooth model with an external shear and one substructure with mass $\sim 10^{8} M_{\odot}$ . For B1555+375 either a strong external shear or two substructures with mass $\sim 10^{7} M_{\odot}$ reproduce the data quite well.Comment: 26 pages, updated bibliography, Accepted for publication in Astrophysics & Space Scienc

Critical phenomena in Newtonian gravity

We investigate the stability of self-similar solutions for a gravitationally collapsing isothermal sphere in Newtonian gravity by means of a normal mode analysis. It is found that the Hunter series of solutions are highly unstable, while neither the Larson-Penston solution nor the homogeneous collapse one have an analytic unstable mode. Since the homogeneous collapse solution is known to suffer the kink instability, the present result and recent numerical simulations strongly support a proposition that the Larson-Penston solution will be realized in astrophysical situations. It is also found that the Hunter (A) solution has a single unstable mode, which implies that it is a critical solution associated with some critical phenomena which are analogous to those in general relativity. The critical exponent $\gamma$ is calculated as $\gamma\simeq 0.10567$. In contrast to the general relativistic case, the order parameter will be the collapsed mass. In order to obtain a complete picture of the Newtonian critical phenomena, full numerical simulations will be needed.Comment: 25 pages, 7 figures, accepted for publication in Physical Review

Exclusive Queueing Process with Discrete Time

In a recent study [C Arita, Phys. Rev. E 80, 051119 (2009)], an extension of the M/M/1 queueing process with the excluded-volume effect as in the totally asymmetric simple exclusion process (TASEP) was introduced. In this paper, we consider its discrete-time version. The update scheme we take is the parallel one. A stationary-state solution is obtained in a slightly arranged matrix product form of the discrete-time open TASEP with the parallel update. We find the phase diagram for the existence of the stationary state. The critical line which separates the parameter space into the regions with and without the stationary state can be written in terms of the stationary current of the open TASEP. We calculate the average length of the system and the average number of particles

Generalized empty-interval method applied to a class of one-dimensional stochastic models

In this work we study, on a finite and periodic lattice, a class of one-dimensional (bimolecular and single-species) reaction-diffusion models which cannot be mapped onto free-fermion models. We extend the conventional empty-interval method, also called {\it interparticle distribution function} (IPDF) method, by introducing a string function, which is simply related to relevant physical quantities. As an illustration, we specifically consider a model which cannot be solved directly by the conventional IPDF method and which can be viewed as a generalization of the {\it voter} model and/or as an {\it epidemic} model. We also consider the {\it reversible} diffusion-coagulation model with input of particles and determine other reaction-diffusion models which can be mapped onto the latter via suitable {\it similarity transformations}. Finally we study the problem of the propagation of a wave-front from an inhomogeneous initial configuration and note that the mean-field scenario predicted by Fisher's equation is not valid for the one-dimensional (microscopic) models under consideration.Comment: 19 pages, no figure. To appear in Physical Review E (November 2001

Supergravity from a Massive Superparticle and the Simplest Super Black Hole

We describe in superspace a theory of a massive superparticle coupled to a version of two dimensional N=1 dilaton supergravity. The (1+1) dimensional supergravity is generated by the stress-energy of the superparticle, and the evolution of the superparticle is reciprocally influenced by the supergravity. We obtain exact superspace solutions for both the superparticle worldline and the supergravity fields. We use the resultant non-trivial compensator superfield solution to construct a model of a two-dimensional supersymmetric black hole.Comment: Latex, 27 pages, minor typos corrected and reference adde

A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.Peer reviewedPublisher PD