243 research outputs found
Asteroseismology with the WIRE satellite. I. Combining Ground- and Space-based Photometry of the Delta Scuti Star Epsilon Cephei
We have analysed ground-based multi-colour Stromgren photometry and
single-filter photometry from the star tracker on the WIRE satellite of the
delta scuti star Epsilon Cephei. The ground-based data set consists of 16
nights of data collected over 164 days, while the satellite data are nearly
continuous coverage of the star during 14 days. The spectral window and noise
level of the satellite data are superior to the ground-based data and this data
set is used to locate the frequencies. However, we can use the ground-based
data to improve the accuracy of the frequencies due to the much longer time
baseline. We detect 26 oscillation frequencies in the WIRE data set, but only
some of these can be seen clearly in the ground-based data. We have used the
multi-colour ground-based photometry to determine amplitude and phase
differences in the Stromgren b-y colour and the y filter in an attempt to
identify the radial degree of the oscillation frequencies. We conclude that the
accuracies of the amplitudes and phases are not sufficient to constrain
theoretical models of Epsilon Cephei. We find no evidence for rotational
splitting or the large separation among the frequencies detected in the WIRE
data set. To be able to identify oscillation frequencies in delta scuti stars
with the method we have applied, it is crucial to obtain more complete coverage
from multi-site campaigns with a long time baseline and in multiple filters.
This is important when planning photometric and spectroscopic ground-based
support for future satellite missions like COROT and KEPLER.Comment: 13 pages, 12 figures, 4 tables. Fig. 4 reduced in quality. Accepted
by A&
A semi-automatic procedure for abundance determination of A- and F-type stars
A variety of physical processes leading to different types of pulsations and
chemical compositions is observed among A- and F-type stars. To investigate the
underlying mechanisms responsible for these processes in stars with similar
locations in the H-R diagram, an accurate abundance determination is needed,
among others. Here, we describe a semi-automatic procedure developed to
determine chemical abundances of various elements ranging from helium to
mercury for this type of stars. We test our procedure on synthetic spectra,
demonstrating that our procedure provides abundances consistent with the input
values, even when the stellar parameters are offset by reasonable observational
errors. For a fast-rotating star such as Vega, our analysis is consistent with
those carried out with other plane-parallel model atmospheres. Simulations show
that the offsets from the input abundances increase for stars with low
inclination angle of about 4 degrees. For this inclination angle, we also show
that the distribution of the iron abundance found in different regions is
bimodal. Furthermore, the effect of rapid rotation can be seen in the peculiar
behaviour of the H_beta line.Comment: accepted for publication in MNRAS, contains 6 tables and 8 figure
A new interferometric study of four exoplanet host stars : {\theta} Cygni, 14 Andromedae, {\upsilon} Andromedae and 42 Draconis
Studying exoplanet host stars is of the utmost importance to establish the
link between the presence of exoplanets around various types of stars and to
understand the respective evolution of stars and exoplanets.
Using the limb-darkened diameter (LDD) obtained from interferometric data, we
determine the fundamental parameters of four exoplanet host stars. We are
particularly interested in the F4 main-sequence star, {\theta} Cyg, for which
Kepler has recently revealed solar-like oscillations that are unexpected for
this type of star. Furthermore, recent photometric and spectroscopic
measurements with SOPHIE and ELODIE (OHP) show evidence of a quasi-periodic
radial velocity of \sim150 days. Models of this periodic change in radial
velocity predict either a complex planetary system orbiting the star, or a new
and unidentified stellar pulsation mode.
We performed interferometric observations of {\theta} Cyg, 14 Andromedae,
{\upsilon} Andromedae and 42 Draconis for two years with VEGA/CHARA (Mount
Wilson, California) in several three-telescope configurations. We measured
accurate limb darkened diameters and derived their radius, mass and temperature
using empirical laws.
We obtain new accurate fundamental parameters for stars 14 And, {\upsilon}
And and 42 Dra. We also obtained limb darkened diameters with a minimum
precision of \sim 1.3%, leading to minimum planet masses of Msini=5.33\pm 0.57,
0.62 \pm 0.09 and 3.79\pm0.29 MJup for 14 And b, {\upsilon} And b and 42 Dra b,
respectively. The interferometric measurements of {\theta} Cyg show a
significant diameter variability that remains unexplained up to now. We propose
that the presence of these discrepancies in the interferometric data is caused
by either an intrinsic variation of the star or an unknown close companion
orbiting around it.Comment: 10 pages + 2 pages appendix, 16 figures, accepted for publication in
A&
Evaluation of Microorganisms Cultured from Injured and Repressed Tissue Regeneration Sites in Endangered Giant Aquatic Ozark Hellbender Salamanders
Investigation into the causes underlying the rapid, global amphibian decline provides critical insight into the effects of changing ecosystems. Hypothesized and confirmed links between amphibian declines, disease, and environmental changes are increasingly represented in published literature. However, there are few long-term amphibian studies that include data on population size, abnormality/injury rates, disease, and habitat variables to adequately assess changes through time. We cultured and identified microorganisms isolated from abnormal/injured and repressed tissue regeneration sites of the endangered Ozark Hellbender, Cryptobranchus alleganiensis bishopi, to discover potential causative agents responsible for their significant decline in health and population. This organism and our study site were chosen because the population and habitat of C. a. bishopi have been intensively studied from 1969–2009, and the abnormality/injury rate and apparent lack of regeneration were established. Although many bacterial and fungal isolates recovered were common environmental organisms, several opportunistic pathogens were identified in association with only the injured tissues of C.a. bishopi. Bacterial isolates included Aeromonas hydrophila, a known amphibian pathogen, Granulicetella adiacens, Gordonai terrae, Stenotrophomonas maltophilia, Aerococcus viridans, Streptococcus pneumoniae and a variety of Pseudomonads, including Pseudomonas aeruginosa, P. stutzeri, and P. alcaligenes. Fungal isolates included species in the genera Penicillium, Acremonium, Cladosporium, Curvularia, Fusarium, Streptomycetes, and the Class Hyphomycetes. Many of the opportunistic pathogens identified are known to form biofilms. Lack of isolation of the same organism from all wounds suggests that the etiological agent responsible for the damage to C. a. bishopi may not be a single organism. To our knowledge, this is the first study to profile the external microbial consortia cultured from a Cryptobranchid salamander. The incidence of abnormalities/injury and retarded regeneration in C. a. bishopi may have many contributing factors including disease and habitat degradation. Results from this study may provide insight into other amphibian population declines
Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse
Alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-HT) production, storage and signaling have long been associated with autism. The 5-HT transporter gene (HTT, SERT, SLC6A4) has received considerable attention as a potential risk locus for autism-spectrum disorders, as well as disorders with overlapping symptoms, including obsessive-compulsive disorder (OCD). Here, we review our efforts to characterize rare, nonsynonymous polymorphisms in SERT derived from multiplex pedigrees carrying diagnoses of autism and OCD and present the initial stages of our effort to model one of these variants, Gly56Ala, in vivo. We generated a targeting vector to produce the Gly56Ala substitution in the Slc6a4 locus by homologous recombination. Following removal of a neomycin resistance selection cassette, animals exhibiting germline transmission of the Ala56 variant were bred to establish a breeding colony on a 129S6 background, suitable for initial evaluation of biochemical, physiological and behavioral alterations relative to SERT Gly56 (wildtype) animals. SERT Ala56 mice were achieved and exhibit a normal pattern of transmission. The initial growth and gross morphology of these animals is comparable to wildtype littermate controls. The SERT Ala56 variant can be propagated in 129S6 mice without apparent disruption of fertility and growth. We discuss both the opportunities and challenges that await the physiological/behavioral analysis of Gly56Ala transgenic mice, with particular reference to modeling autism-associated traits
Nicotinic receptors
Regulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including depression, anxiety, schizophrenia and Parkinson’s disorders. There is also a great amount of evidence indicating that 5-HT signalling may affect the reinforcing properties of drugs of abuse by the interaction and modulation of dopamine (DA) function. This chapter is focused on one of the more addictive drugs, nicotine. It is widely recognised that the effects of nicotine are strongly associated with the stimulatory action it exhibits on mesolimbic DAergic function. We outline the role of 5-HT and its plethora of receptors, focusing on 5-HT2 subtypes with relation to their involvement in the neurobiology of nicotine addiction. We also explore the novel pharmacological approaches using 5-HT agents for the treatment of nicotine dependence. Compelling evidence shows that 5-HT2C receptor agonists may be possible therapeutic targets for smoking cessation, although further investigation is required.peer-reviewe
Current and prospective pharmacological targets in relation to antimigraine action
Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with vascular receptors, a fact that has raised concerns about their cardiovascular safety. In the past, α-adrenoceptor agonists (ergotamine, dihydroergotamine, isometheptene) were used. The last two decades have witnessed the advent of 5-HT1B/1D receptor agonists (sumatriptan and second-generation triptans), which have a well-established efficacy in the acute treatment of migraine. Moreover, current prophylactic treatments of migraine include 5-HT2 receptor antagonists, Ca2+ channel blockers, and β-adrenoceptor antagonists. Despite the progress in migraine research and in view of its complex etiology, this disease still remains underdiagnosed, and available therapies are underused. In this review, we have discussed pharmacological targets in migraine, with special emphasis on compounds acting on 5-HT (5-HT1-7), adrenergic (α1, α2, and β), calcitonin gene-related peptide (CGRP 1 and CGRP2), adenosine (A1, A2, and A3), glutamate (NMDA, AMPA, kainate, and metabotropic), dopamine, endothelin, and female hormone (estrogen and progesterone) receptors. In addition, we have considered some other targets, including gamma-aminobutyric acid, angiotensin, bradykinin, histamine, and ionotropic receptors, in relation to antimigraine therapy. Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
The human body hosts an enormous abundance and diversity of microbes, which perform a range of essential and beneficial functions. Our appreciation of the importance of these microbial communities to many aspects of human physiology has grown dramatically in recent years. We know, for example, that animals raised in a germ-free environment exhibit substantially altered immune and metabolic function, while the disruption of commensal microbiota in humans is associated with the development of a growing number of diseases. Evidence is now emerging that, through interactions with the gut-brain axis, the bidirectional communication system between the central nervous system and the gastrointestinal tract, the gut microbiome can also influence neural development, cognition and behaviour, with recent evidence that changes in behaviour alter gut microbiota composition, while modifications of the microbiome can induce depressive-like behaviours. Although an association between enteropathy and certain psychiatric conditions has long been recognized, it now appears that gut microbes represent direct mediators of psychopathology. Here, we examine roles of gut microbiome in shaping brain development and neurological function, and the mechanisms by which it can contribute to mental illness. Further, we discuss how the insight provided by this new and exciting field of research can inform care and provide a basis for the design of novel, microbiota-targeted, therapies.GB Rogers, DJ Keating, RL Young, M-L Wong, J Licinio, and S Wesseling
The evolution of Ap stars
The many peculiarities of Ap stars (not only chemical ones, but also magnetic field and slow rotation) may vary during the main-sequence evolution of these stars. We review here briefly the evidences found in the last thirty years for such evolution, with an emphasis on the more recent research. The position in the HR diagram of low mass Ap stars with a significant surface magnetic field (as measured by us) is reviewed as well
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