\u3ci\u3ePsychology in the Schools, School Psychology Review, School Psychology Quarterly\u3c/i\u3e and \u3ci\u3eJournal of Educational and Psychological Consultation\u3c/i\u3e Editors Collaborate to Chart School Psychology’s Past, Present, and “Futures”

For the first time in the history of school psychology, four editors of journals with a school psychology readership are collaborating to offer our field extensive coverage of the recently held School Psychology Futures conference and to continue discussion on a variety of topics relevant to the professional practice of school psychology. This introduction briefly describes the special journal issues that will be or have been offered in Psychology in the Schools (PITS), School Psychology Review (SPR), School Psychology Quarterly (SPQ), and Journal of Educational and Psychological Consultation (JEPC)on topics related to the conference. This information is provided in an effort to offer our readers a Futures link across a variety of journals and organizations, including both the Division of School Psychology of the American Psychological Association (APA) and the National Association of School Psychologists (NASP). This introduction, which will be reprinted at the beginning of all of our special issues, establishes a context for the Futures conference by discussing the promise (and practice) of school psychology in our ever changing, vibrant, but problem-saturated society. We hope you will join us in using these vital resources to help chart new Futures for school psychology

Predictability of variable solar-terrestrial coupling

In October 2017, the Scientific Committee on Solar-Terrestrial Physics (SCOSTEP) Bureau established a committee for the design of SCOSTEP's Next Scientific Programme (NSP). The NSP committee members and authors of this paper decided from the very beginning of their deliberations that the predictability of the Sun-Earth System from a few hours to centuries is a timely scientific topic, combining the interests of different topical communities in a relevant way. Accordingly, the NSP was christened PRESTO - PREdictability of the variable Solar-Terrestrial cOupling. This paper presents a detailed account of PRESTO; we show the key milestones of the PRESTO roadmap for the next 5 years, review the current state of the art and discuss future studies required for the most effective development of solar-terrestrial physics.Peer reviewe

Predictability of variable solar-terrestrial coupling

In October 2017, the Scientific Committee on Solar-Terrestrial Physics (SCOSTEP) Bureau established a committee for the design of SCOSTEP's Next Scientific Programme (NSP). The NSP committee members and authors of this paper decided from the very beginning of their deliberations that the predictability of the Sun-Earth System from a few hours to centuries is a timely scientific topic, combining the interests of different topical communities in a relevant way. Accordingly, the NSP was christened PRESTO -PREdictability of the variable Solar-Terrestrial cOupling. This paper presents a detailed account of PRESTO; we show the key milestones of the PRESTO roadmap for the next 5 years, review the current state of the art and discuss future studies required for the most effective development of solar-terrestrial physics.Fil: Daglis, Ioannis A.. Hellenic Space Center; Grecia. Universidad Nacional y Kapodistriaca de Atenas; GreciaFil: Chang, Loren C.. National Central University; ChinaFil: Dasso, Sergio Ricardo. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Gopalswamy, Nat. NASA Goddard Space Flight Center; Estados UnidosFil: Khabarova, Olga V.. Russian Academy Of Sciences; RusiaFil: Kilpua, Emilia. University of Helsinki; FinlandiaFil: Lopez, Ramon. University of Texas; Estados UnidosFil: Marsh, Daniel. National Center for Atmospheric Research; Estados Unidos. University of Leeds; Reino UnidoFil: Matthes, Katja. Geomar-Helmholtz Centre for Ocean Research Kiel; Alemania. Christian Albrechts Universitat Zu Kiel; AlemaniaFil: Nandy, Dibyendu. Indian Institute Of Science Education And Research Kolkata; IndiaFil: Seppälä, Annika. University of Otago; Nueva ZelandaFil: Shiokawa, Kazuo. Nagoya University; JapónFil: Thiéblemont, Rémi. Université Pierre et Marie Curie; FranciaFil: Zong, Qiugang. Peking University; Chin

Evaluating how agent methodologies support the specification of the normative environment through the development process

[EN] Due to the increase in collaborative work and the decentralization of processes in many domains, there is an expanding demand for large-scale, flexible and adaptive software systems to support the interactions of people and institutions distributed in heterogeneous environments. Commonly, these software applications should follow specific regulations meaning the actors using them are bound by rights, duties and restrictions. Since this normative environment determines the final design of the software system, it should be considered as an important issue during the design of the system. Some agent-oriented software engineering methodologies deal with the development of normative systems (systems that have a normative environment) by integrating the analysis of the normative environment of a system in the development process. This paper analyses to what extent these methodologies support the analysis and formalisation of the normative environment and highlights some open issues of the topic.This work is partially supported by the PROMETEOII/2013/019, TIN2012-36586-C03-01, FP7-29493, TIN2011-27652-C03-00, CSD2007-00022 projects, and the CASES project within the 7th European Community Framework Program under the grant agreement No 294931.Garcia Marques, ME.; Miles, S.; Luck, M.; Giret Boggino, AS. (2014). Evaluating how agent methodologies support the specification of the normative environment through the development process. Autonomous Agents and Multi-Agent Systems. 1-20. https://doi.org/10.1007/s10458-014-9275-zS120Cossentino, M., Hilaire, V., Molesini, A., & Seidita, V. (Eds.). (2014). Handbook on agent-oriented design processes (Vol. VIII, 569 p. 508 illus.). Berlin: Springer.Akbari, O. (2010). A survey of agent-oriented software engineering paradigm: Towards its industrial acceptance. Journal of Computer Engineering Research, 1, 14–28.Argente, E., Botti, V., Carrascosa, C., Giret, A., Julian, V., & Rebollo, M. (2011). An abstract architecture for virtual organizations: The THOMAS approach. Knowledge and Information Systems, 29(2), 379–403.Argente, E., Botti, V., & Julian, V. (2009). GORMAS: An organizational-oriented methodological guideline for open MAS. In Proceedings of AOSE’09 (pp. 440–449).Argente, E., Botti, V., & Julian, V. (2009). Organizational-oriented methodological guidelines for designing virtual organizations. In Distributed computing, artificial intelligence, bioinformatics, soft computing, and ambient assisted living. Lecture Notes in Computer Science (Vol. 5518, pp. 154–162).Boella, G., Pigozzi, G., & van der Torre, L. (2009). Normative systems in computer science—Ten guidelines for normative multiagent systems. In G. Boella, P. Noriega, G. Pigozzi, & H. Verhagen (Eds.), Normative multi-agent systems, number 09121 in Dagstuhl seminar proceedings.Boella, G., Torre, L., & Verhagen, H. (2006). Introduction to normative multiagent systems. Computational and Mathematical Organization Theory, 12(2–3), 71–79.Bogdanovych, A., Esteva, M., Simoff, S., Sierra, C., & Berger, H. (2008). A methodology for developing multiagent systems as 3d electronic institutions. In M. Luck & L. Padgham (Eds.), Agent-Oriented Software Engineering VIII (Vol. 4951, pp. 103–117). Lecture Notes in Computer Science. Berlin: Springer.Boissier, O., Padget, J., Dignum, V., Lindemann, G., Matson, E., Ossowski, S., Sichman, J., & Vazquez-Salceda, J. (2006). Coordination, organizations, institutions and norms in multi-agent systems. LNCS (LNAI) (Vol. 3913).Bordini, R. H., Fisher, M., Visser, W., & Wooldridge, M. (2006). Verifying multi-agent programs by model checking. In Autonomous agents and multi-agent systems (Vol. 12, pp. 239–256). Hingham, MA: Kluwer Academic Publishers.Botti, V., Garrido, A., Giret, A., & Noriega, P. (2011). The role of MAS as a decision support tool in a water-rights market. In Post-proceedings workshops AAMAS2011 (Vol. 7068, pp. 35–49). Berlin: Springer.Breaux, T. (2009). Exercising due diligence in legal requirements acquisition: A tool-supported, frame-based approach. In Proceedings of the IEEE international requirements engineering conference (pp. 225–230).Breaux, T. D., & Baumer, D. L. (2011). Legally reasonable security requirements: A 10-year ftc retrospective. Computers and Security, 30(4), 178–193.Breaux, T. D., Vail, M. W., & Anton, A. I. (2006). Towards regulatory compliance: Extracting rights and obligations to align requirements with regulations. In Proceedings of the 14th IEEE international requirements engineering conference, RE ’06 (pp. 46–55). Washington, DC: IEEE Computer Society.Bresciani, P., Perini, A., Giorgini, P., Giunchiglia, F., & Mylopoulos, J. (2004). Tropos: An agent-oriented software development methodology. Autonomous Agents and Multi-Agent Systems, 8(3), 203–236.Cardoso, H. L., & Oliveira, E. (2008). A contract model for electronic institutions. In COIN’07: Proceedings of the 2007 international conference on Coordination, organizations, institutions, and norms in agent systems III (pp. 27–40).Castor, A., Pinto, R. C., Silva, C. T. L. L., & Castro, J. (2004). Towards requirement traceability in tropos. In WER (pp. 189–200).Chopra, A., Dalpiaz, F., Giorgini, P., & Mylopoulos, J. (2009). Modeling and reasoning about service-oriented applications via goals and commitments. ICST conference on digital business.Cliffe, O., Vos, M., & Padget, J. (2006). Specifying and analysing agent-based social institutions using answer set programming. In O. Boissier, J. Padget, V. Dignum, G. Lindemann, E. Matson, S. Ossowski, J. Sichman, & J. Vázquez-Salceda (Eds.), Coordination, organizations, institutions, and norms in multi-agent systems. Lecture Notes in Computer Science (Vol. 3913, pp. 99–113). Springer. Berlin.Criado, N., Argente, E., Garrido, A., Gimeno, J. A., Igual, F., Botti, V., Noriega, P., & Giret, A. (2011). Norm enforceability in Electronic Institutions? In Coordination, organizations, institutions, and norms in agent systems VI (Vol. 6541, pp. 250–267). Springer.Dellarocas, C., & Klein, M. (2001). Contractual agent societies. In R. Conte & C. Dellarocas (Eds.), Social order in multiagent systems (Vol. 2, pp. 113–133)., Multiagent Systems, Artificial Societies, and Simulated Organizations New York: Springer.DeLoach, S. A. (2008). Developing a multiagent conference management system using the o-mase process framework. In Proceedings of the international conference on agent-oriented software engineering VIII (pp. 168–181).DeLoach, S. A., & Garcia-Ojeda, J. C. (2010). O-mase; a customisable approach to designing and building complex, adaptive multi-agent systems. International Journal of Agent-Oriented Software Engineering, 4(3), 244–280.DeLoach, S. A., Padgham, L., Perini, A., Susi, A., & Thangarajah, J. (2009). Using three aose toolkits to develop a sample design. International Journal Agent-Oriented Software Engineering, 3, 416–476.Dignum, F., Dignum, V., Thangarajah, J., Padgham, L., & Winikoff, M. (2007). Open agent systems? Eighth international workshop on agent oriented software engineering (AOSE) in AAMAS07.Dignum, V. (2003). A model for organizational interaction:based on agents, founded in logic. PhD thesis, Utrecht University.Dignum, V., Meyer, J., Dignum, F., & Weigand, H. (2003). Formal specification of interaction in agent societies. Formal approaches to agent-based systems (Vol. 2699).Dignum, V., Vazquez-Salceda, J., & Dignum, F. (2005). Omni: Introducing social structure, norms and ontologies into agent organizations. In R. Bordini, M. Dastani, J. Dix, & A. Seghrouchni (Eds.)Programming multi-agent systems. Lecture Notes in Computer Science (Vol. 3346, pp. 181–198). Berlin: Springer.d’Inverno, M., Luck, M., Noriega, P., Rodriguez-Aguilar, J., & Sierra, C. (2012). Communicating open systems, 186, 38–94.Elsenbroich, C., & Gilbert, N. (2014). Agent-based modelling. In Modelling norms (pp. 65–84). Dordrecht: Springer.Esteva, M., Rosell, B., Rodriguez, J. A., & Arcos, J. L. (2004). AMELI: An agent-based middleware for electronic institutions. In AAMAS04 (pp. 236–243).Fenech, S., Pace, G. J., & Schneider, G. (2009). Automatic conflict detection on contracts. In Proceedings of the 6th international colloquium on theoretical aspects of computing, ICTAC ’09 (pp. 200–214).Garbay, C., Badeig, F., & Caelen, J. (2012). Normative multi-agent approach to support collaborative work in distributed tangible environments. In Proceedings of the ACM 2012 conference on computer supported cooperative work companion, CSCW ’12 (pp. 83–86). New York, NY: ACM.Garcia, E., Giret, A., & Botti, V. (2011). Regulated open multi-agent systems based on contracts. In Information Systems Development (pp. 243–255).Garcia, E., Tyson, G., Miles, S., Luck, M., Taweel, A., Staa, T. V., & Delaney, B. (2012). An analysis of agent-oriented engineering of e-health systems. In 13th international eorkshop on sgent-oriented software engineering (AOSE-AAMAS).Garcia, E., Tyson, G., Miles, S., Luck, M., Taweel, A., Staa, T. V., and Delaney, B. (2013). Analysing the Suitability of Multiagent Methodologies for e-Health Systems. In Agent-Oriented Software Engineering XIII, volume 7852, pages 134–150. Springer-Verlag.Garrido, A., Giret, A., Botti, V., & Noriega, P. (2013). mWater, a case study for modeling virtual markets. In New perspectives on agreement technologies (Vol. Law, Gover, pp. 563–579). Springer.Gteau, B., Boissier, O., & Khadraoui, D. (2006). Multi-agent-based support for electronic contracting in virtual enterprises. IFAC Symposium on Information Control Problems in Manufacturing (INCOM), 150(3), 73–91.Hollander, C. D., & Wu, A. S. (2011). The current state of normative agent-based systems. Journal of Artificial Societies and Social Simulation, 14(2), 6.Hsieh, F.-S. (2005). Automated negotiation based on contract net and petri net. In E-commerce and web technologies. Lecture Notes in Computer Science (Vol. 3590, pp. 148–157).Kollingbaum, M., Jureta, I. J., Vasconcelos, W., & Sycara, K. (2008). Automated requirements-driven definition of norms for the regulation of behavior in multi-agent systems. In Proceedings of the AISB 2008 workshop on behaviour regulation in multi-agent systems, Aberdeen, Scotland, U.K., April 2008.Li, T., Balke, T., Vos, M., Satoh, K., & Padget, J. (2013). Detecting conflicts in legal systems. In Y. Motomura, A. Butler, & D. Bekki (Eds.), New Frontiers in Artificial Intelligence (Vol. 7856, pp. 174–189)., Lecture Notes in Computer Science Berlin Heidelberg: Springer.Lomuscio, A., Qu, H., & Solanki, M. (2010) Towards verifying contract regulated service composition. Journal of Autonomous Agents and Multi-Agent Systems (pp. 1–29).Lopez, F., Luck, M., & d’Inverno, M. (2006). A normative framework for agent-based systems. Computational and Mathematical Organization Theory, 12, 227–250.Lpez, F. y, Luck, M., & dInverno, M. (2006). A normative framework for agent-based systems. Computational and Mathematical Organization Theory, 12(2–3), 227–250.Mader, P., & Egyed, A. (2012). Assessing the effect of requirements traceability for software maintenance. In 28th IEEE International Conference on Software Maintenance (ICSM) (pp. 171–180), Sept 2012.Mao, X., & Yu, E. (2005). Organizational and social concepts in agent oriented software engineering. In AOSE IV. Lecture Notes in Artificial Intelligence (Vol. 3382, pp. 184–202).Meyer, J.-J. C., & Wieringa, R. J. (Eds.). (1993). Deontic logic in computer science: Normative system specification. Chichester, UK: Wiley.Okouya, D., & Dignum, V. (2008). Operetta: A prototype tool for the design, analysis and development of multi-agent organizations (demo paper). In AAMAS (pp. 1667–1678).Malone, T. W., Smith J. B., & Olson, G. M. (2001). Coordination theory and collaboration technology. Mahwah, NJ: Lawrence Erlbaum Associates.Oren, N., Panagiotidi, S., Vázquez-Salceda, J., Modgil, S., Luck, M., & Miles, S. (2009). Towards a formalisation of electronic contracting environments. COIN (pp. 156–171).Osman, N., Robertson, D., & Walton, C. (2006). Run-time model checking of interaction and deontic models for multi-agent systems. In AAMAS ’06: Proceedings of the fifth international joint conference on Autonomous agents and multiagent systems (pp. 238–240). New York, NY: ACM.Pace, G., Prisacariu, C., & Schneider, G. (2007). Model checking contracts a case study. In Automated technology for verification and analysis. Lecture Notes in Computer Science (Vol. 4762, pp. 82–97).Rotolo, A., & van der Torre, L. (2011). Rules, agents and norms: Guidelines for rule-based normative multi-agent systems. RuleML Europe, 6826, 52–66.Saeki, M., & Kaiya, H. (2008). Supporting the elicitation of requirements compliant with regulations. In CAiSE ’08 (pp. 228–242).Siena, A., Mylopoulos, J., Perini, A., & Susi, A. (2009). Designing law-compliant software requirements. In Proceedings of the 28th international conference on conceptual modeling, ER ’09 (pp. 472–486).Singh, M. P. Commitments in multiagent systems: Some history, some confusions, some controversies, some prospects.Solaiman, E., Molina-Jimenez, C., & Shrivastav, S. (2003). Model checking correctness properties of electronic contracts. In Service-oriented computing—ICSOC 2003. Lecture Notes in Computer Science (Vol. 2910, pp. 303–318). Berlin: Springer.Telang, P. R., & Singh, M. P. (2009). Conceptual modeling: Foundations and applications. Enhancing tropos with commitments (pp. 417–435).Vázquez-Salceda, J., Confalonieri, R., Gomez, I., Storms, P., Nick Kuijpers, S. P., & Alvarez, S. (2009). Modelling contractually-bounded interactions in the car insurance domain. DIGIBIZ 2009.Viganò, F., & Colombetti, M. (2007). Symbolic model checking of institutions. In ICEC (pp. 35–44).Walton, C. D. (2007). Verifiable agent dialogues. Journal of Applied Logic, 5(2):197–213, Logic-Based Agent Verification.Winkler, S., & Pilgrim, J. (2010). A survey of traceability in requirements engineering and model-driven development. Software and Systems Modeling (SoSyM), 9(4), 529–565.Wooldridge, M., Fisher, M., Huget, M., & Parsons, S. (2002). Model checking multi-agent systems with mable. In AAMAS02 (pp. 952–959). ACM

Overview of recent TJ-II stellarator results

The main results obtained in the TJ-II stellarator in the last two years are reported. The most important topics investigated have been modelling and validation of impurity transport, validation of gyrokinetic simulations, turbulence characterisation, effect of magnetic configuration on transport, fuelling with pellet injection, fast particles and liquid metal plasma facing components. As regards impurity transport research, a number of working lines exploring several recently discovered effects have been developed: the effect of tangential drifts on stellarator neoclassical transport, the impurity flux driven by electric fields tangent to magnetic surfaces and attempts of experimental validation with Doppler reflectometry of the variation of the radial electric field on the flux surface. Concerning gyrokinetic simulations, two validation activities have been performed, the comparison with measurements of zonal flow relaxation in pellet-induced fast transients and the comparison with experimental poloidal variation of fluctuations amplitude. The impact of radial electric fields on turbulence spreading in the edge and scrape-off layer has been also experimentally characterized using a 2D Langmuir probe array. Another remarkable piece of work has been the investigation of the radial propagation of small temperature perturbations using transfer entropy. Research on the physics and modelling of plasma core fuelling with pellet and tracer-encapsulated solid-pellet injection has produced also relevant results. Neutral beam injection driven Alfvénic activity and its possible control by electron cyclotron current drive has been examined as well in TJ-II. Finally, recent results on alternative plasma facing components based on liquid metals are also presentedThis work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under Grant Agreement No. 633053. It has been partially funded by the Ministerio de Ciencia, Inovación y Universidades of Spain under projects ENE2013-48109-P, ENE2015-70142-P and FIS2017-88892-P. It has also received funds from the Spanish Government via mobility grant PRX17/00425. The authors thankfully acknowledge the computer resources at MareNostrum and the technical support provided by the Barcelona S.C. It has been supported as well by The Science and Technology Center in Ukraine (STCU), Project P-507F

Four-month incidence of suicidal thoughts and behaviors among healthcare workers after the first wave of the Spain COVID-19 pandemic

[EN] Healthcare workers (HCW) are at high risk for suicide, yet little is known about the onset of suicidal thoughts and behaviors (STB) in this important segment of the population in conjunction with the COVID-19 pandemic. We conducted a multicenter, prospective cohort study of Spanish HCW active during the COVID-9 pandemic. A total of n = 4809 HCW participated at baseline (May–September 2020; i.e., just after the first wave of the pandemic) and at a four-month follow-up assessment (October–December 2020) using web-based surveys. Logistic regression assessed the individual- and population-level associations of separate proximal (pandemic) risk factors with four-month STB incidence (i.e., 30-day STB among HCW negative for 30-day STB at baseline), each time adjusting for distal (pre-pandemic) factors. STB incidence was estimated at 4.2% (SE = 0.5; n = 1 suicide attempt). Adjusted for distal factors, proximal risk factors most strongly associated with STB incidence were various sources of interpersonal stress (scaled 0–4; odds ratio [OR] range = 1.23–1.57) followed by personal health-related stress and stress related to the health of loved ones (scaled 0–4; OR range 1.30–1.32), and the perceived lack of healthcare center preparedness (scaled 0–4; OR = 1.34). Population-attributable risk proportions for these proximal risk factors were in the range 45.3–57.6%. Other significant risk factors were financial stressors (OR range 1.26–1.81), isolation/quarantine due to COVID-19 (OR = 1.53) and having changed to a specific COVID-19 related work location (OR = 1.72). Among other interventions, our findings call for healthcare systems to implement adequate conflict communication and resolution strategies and to improve family-work balance embedded in organizational justice strategies.S

Problematic Facebook use and problematic video gaming as mediators of relationship between impulsivity and life satisfaction among female and male gamers

Over the past few decades, many new technologies have emerged, such as portable computers, the internet and smartphones, which have contributed to improving the lives of individuals. While the benefits of these new technologies are overwhelmingly positive, negative consequences are experienced by a minority of individuals. One possible negative aspect of new technologies is their problematic use due to impulsive use which may lead to lower life satisfaction. The present study investigated the mediating role of problematic video gaming (PVG) and problematic Facebook use (PFU) in the relationship between impulsivity dimensions and life satisfaction as well as the relationship between impulsivity dimensions and problematic behaviors. Additionally, the potential impact of gender differences was also examined. The study comprised 673 gamers (391 females) aged 17–38 years (M = 21.25 years, SD = 2.67) selected from 1365 individuals who completed an offline survey. PFU was assessed using the Facebook Intrusion Scale, and PVG was assessed using the nine-item Internet Gaming Disorder Scale–Short-Form (IGDS9-SF). Impulsivity dimensions such as attention, cognitive instability, motor, perseverance, self-control, and cognitive complexity were assessed using the Barratt Impulsiveness Scale (BIS-11), and life satisfaction was assessed using the Satisfaction With Life Scale (SWLS). Depending on the specific impulsivity dimension, findings showed both positive and negative relationships between impulsivity and life satisfaction. Attention and perseverance subtypes of impulsivity were primarily associated with problematic behaviors. Additionally, cognitive complexity was associated with PFU among female gamers, whereas cognitive instability was associated with PVG among male gamers. Additionally, PVG was primarily associated with lower life satisfaction. However, there was no mediation effects between impulsivity dimensions and life satisfaction via PFU or PVG. These findings provide a better understanding of the relationship between problematic behaviors, life satisfaction, and impulsivity among gamers and the differences between male and female gamers

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic