Acquired hemophilia as first manifestation of breast carcinoma in a man under long-term spironolactone therapy.

A 69-year-old man under long-term spironolactone therapy (16 years) was hospitalized with spontaneous hematoma on the trunk and extremities. Coagulation studies disclosed an acquired hemophilia that was successfully treated with human factor VIII for a few days and immunosuppressive agents for several months. Physical examination revealed bilateral gynecomastia and an upper left quadrant breast nodule. Complete staging was unremarkable. Complete left mastectomy was performed. Histopathology showed invasive ductal carcinoma, expressing positivity for estrogen and progesterone receptors. The acquired hemophilia was considered to be a paraneoplasic syndrome. The question of a linkage between long-term spironolactone therapy and breast carcinoma is discussed

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

High-energy spin-density-wave correlated fluctuations in paramagnetic Cr + 5 at. % V

Measurements of the magnetic fluctuations, termed spin-density-wave (SDW) paramagnons, in the nearly antiferromagnetic alloy Cr + 5 at.%V are extended up in energy to about 80 MeV. These fluctuating spin-spin correlations occur at incommensurate positions, corresponding to the SDW wavevector Q. Their characteristic energy is at least an order of magnitude larger than that of the magnetic fluctuations seen in the paramagnetic phase of pure Cr, but their intensity is more than two orders of magnitude smaller. We find that the dynamic susceptibility decreases by about 50% between temperature T = 10K and 300K

Eye lens monitoring programme for medical staff involved in fluoroscopy guided interventional procedures in Switzerland.

Epidemiological studies indicate that radiation damages to the eye lens occurs at lower dose values than previously considered (Worgul et al., 2007; Chodick et al., 2008; Ciraj-Bjelac et al., 2010; Rehani et al., 2011; Vano et al., 2010) [1-5]. The International Commission on Radiological Protection lowered the equivalent dose limit value for the eye lens to 20 mSv/year (ICRP, n.d.) [6]. This new limit has been incorporated into the revised Swiss legislation [7]. Prior this change, it was agreed that if the effective dose limit was respected it would implicitly imply the respect of the limit to the eye lens, for penetrating radiation. The concept had to be reviewed in the light of necessary application of the new eye lens dose limit. The new Swiss legislation proposes to use the value of H <sub>p</sub> (0.07) measured over the protective apron to estimate the eye lens dose. This study aims to investigate the validity of this approach for medical staff during fluoroscopy guided procedures. The results show that the ratio between thorax and eye lens doses varies greatly from one medical speciality to another, but also between surgeons within the same speciality. Moreover, for a given physician, the ratio varied over the periods of surveillance. Those variations confirmed the crucial influence of external parameters related to experience, practice and workload. The surveillance method is appropriate for most of the procedures performed in the department included in this study. Nevertheless, for the particular configuration in urology, the respect of the effective dose limit measured by the routine dosimetry does not allow direct compliance with the dose limit to the eye lens, unless appropriate protective eye wear gear are worn

Le bilinguisme, représentations sociales, discours et contextes

International audienc

Le bilinguisme, représentations sociales, discours et contextes

International audienc

Can CRRA Preferences Explain CAPM-Anomalies in the Cross-Section of Stock Returns?

A large number of empirical studies find evidence for systematic deviations from the CAPM. The CAPM tends to understate the returns on low-beta stocks and overstate the returns on high-beta stocks, which means that the security market line is too steep. Other well-documented anomalies are the size premium and the value premium. The CAPM is a special case of the consumption-based CAPM. This study addresses the question whether the consumption-based CAPM with constant relative risk aversion preferences can explain CAPM-anomalies. An example of an economy with power utility and lognormal returns is examined that can be solved in closed form. The model leads to a security market line that is flatter than in the CAPM and generates a size and a value premium. The comparative statics suggest that cross-sectional anomalies and the equity premium puzzle are of a very similar nature