410 research outputs found
Basic concepts in quantum computation
Section headings: 1 Qubits, gates and networks 2 Quantum arithmetic and
function evaluations 3 Algorithms and their complexity 4 From interferometers
to computers 5 The first quantum algorithms 6 Quantum search 7 Optimal phase
estimation 8 Periodicity and quantum factoring 9 Cryptography 10 Conditional
quantum dynamics 11 Decoherence and recoherence 12 Concluding remarksComment: 37 pages, lectures given at les Houches Summer School on "Coherent
Matter Waves", July-August 199
Isolating a light Higgs boson from the di-photon background at the LHC
We compute the QCD corrections to the gluon fusion subprocess gg to gamma
gamma, which forms an important component of the background to the search for a
light Higgs boson at the LHC. We study the dependence of the improved pp to
gamma gamma X background calculation on the factorization and renormalization
scales, on various choices for photon isolation cuts, and on the rapidities of
the photons. We also investigate ways to enhance the statistical significance
of the Higgs signal in the di-photon channel.Comment: Additional reference included, 17 pages, 16 figure files, revte
Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition
Purpose: Poor prognosis in triple-negative breast cancer (TNBC) is due to an aggressive phenotype and lack of biomarker-driven targeted therapies. Overexpression of cyclin E and phosphorylated-CDK2 are correlated with poor survival in TNBC patients, and the absence of CDK2 desensitizes cells to inhibition of Wee1 kinase, a key cell cycle regulator. We hypothesize that cyclin E expression can predict response to therapies, which include the Wee1 kinase inhibitor, AZD1775. Experimental Design: Mono and combination therapies with AZD1775 were evaluated in TNBC cell lines and multiple patient derived xenograft (PDX) models with different cyclin E expression profiles. The mechanism(s) of cyclin E-mediated replicative stress were investigated following cyclin E induction or CRISPR/Cas9 knockout by a number of assays in multiple cells lines. Results: Cyclin E overexpression (1) is enriched in TNBCs with high recurrence rates, (2) sensitizes TNBC cell lines and PDX models to AZD1775, (3) leads to CDK2-dependent activation of DNA replication stress pathways and (4) increases Wee1 kinase activity. Moreover, treatment of cells with either CDK2 inhibitors or carboplatin leads to transient transcriptional induction of cyclin E (in cyclin E-low tumors) and result in DNA replicative stress. Such drug mediated cyclin E induction in TNBC cells and PDX models sensitizes them to AZD1775 in a sequential treatment combination strategy. Conclusions: Cyclin E is a potential biomarker of response (1) for AZD1775 as monotherapy in cyclin E high TNBC tumors and (2) for sequential combination therapy with CDK2 inhibitor or carboplatin followed by AZD1775 in cyclin E low TNBC tumors
Phylogenetic and morphotaxonomic revision of Ramichloridium and allied genera
The phylogeny of the genera Periconiella, Ramichloridium,
Rhinocladiella and Veronaea was explored by means of partial
sequences of the 28S (LSU) rRNA gene and the ITS region (ITS1, 5.8S rDNA and
ITS2). Based on the LSU sequence data, ramichloridium-like species segregate
into eight distinct clusters. These include the Capnodiales
(Mycosphaerellaceae and Teratosphaeriaceae), the
Chaetothyriales (Herpotrichiellaceae), the Pleosporales, and
five ascomycete clades with uncertain affinities. The type species of
Ramichloridium, R. apiculatum, together with R. musae,
R. biverticillatum, R. cerophilum, R. verrucosum, R. pini, and three new
species isolated from Strelitzia, Musa and forest soil,
respectively, reside in the Capnodiales clade. The human-pathogenic
species R. mackenziei and R. basitonum, together with R.
fasciculatum and R. anceps, cluster with Rhinocladiella
(type species: Rh. atrovirens, Herpotrichiellaceae,
Chaetothyriales), and are allocated to this genus. Veronaea
botryosa, the type species of the genus Veronaea, also resides
in the Chaetothyriales clade, whereas Veronaea simplex
clusters as a sister taxon to the Venturiaceae (Pleosporales), and is
placed in a new genus, Veronaeopsis. Ramichloridium
obovoideum clusters with Carpoligna pleurothecii (anamorph:
Pleurothecium sp., Chaetosphaeriales), and a new combination
is proposed in Pleurothecium. Other ramichloridium-like clades
include R. subulatum and R. epichloës (incertae sedis,
Sordariomycetes), for which a new genus, Radulidium is
erected. Ramichloridium schulzeri and its varieties are placed in a
new genus, Myrmecridium (incertae sedis, Sordariomycetes).
The genus Pseudovirgaria (incertae sedis) is introduced to
accommodate ramichloridium-like isolates occurring on various species of rust
fungi. A veronaea-like isolate from Bertia moriformis with
phylogenetic affinity to the Annulatascaceae (Sordariomycetidae) is
placed in a new genus, Rhodoveronaea. Besides
Ramichloridium, Periconiella is also polyphyletic.
Thysanorea is introduced to accommodate Periconiella papuana
(Herpotrichiellaceae), which is unrelated to the type species, P.
velutina (Mycosphaerellaceae)
Electroweak Symmetry Breaking at the LHC
One of the major goals of the Large Hadron Collider is to probe the
electroweak symmetry breaking mechanism and the generation of the masses of the
elementary particles. We review the physics of the Higgs sector in the Standard
Model and some of its extensions such as supersymmetric theories and models of
extra dimensions. The prospects for discovering the Higgs particles at the LHC
and the study of their fundamental properties are summarised.Comment: 27 pages, 45 figures, uses LaTeX (insa.sty). Invited review for
volume on LHC physics to celebrate the Platinum Jubilee of the Indian
National Science Academy, edited by Amitava Datta, Biswarup Mukhopadhyaya and
Amitava Raychaudhuri. Expanded the acronym in the title in the annoncement.
No other change in the text or reference
A Study of Strange Particles Produced in Neutrino Neutral Current Interactions in the NOMAD Experiment
Results of a detailed study of strange particle production in neutrino
neutral current interactions are presented using the data from the NOMAD
experiment. Integral yields of neutral strange particles (K0s, Lambda,
Lambda-bar) have been measured. Decays of resonances and heavy hyperons with an
identified K0s or Lambda in the final state have been analyzed. Clear signals
corresponding to K* and Sigma(1385) have been observed. First results on the
measurements of the Lambda polarization in neutral current interactions have
been obtained.Comment: Accepted for publication in Nuclear Physics B as a rapid
communicatio
Search for the exotic resonance in the NOMAD experiment
A search for exotic Theta baryon via Theta -> proton +Ks decay mode in the
NOMAD muon neutrino DIS data is reported. The special background generation
procedure was developed. The proton identification criteria are tuned to
maximize the sensitivity to the Theta signal as a function of xF which allows
to study the Theta production mechanism. We do not observe any evidence for the
Theta state in the NOMAD data. We provide an upper limit on Theta production
rate at 90% CL as 2.13 per 1000 of neutrino interactions.Comment: Accepted to European Physics Journal
Opportunistic, human-pathogenic species in the Herpotrichiellaceae are phenotypically similar to saprobic or phytopathogenic species in the Venturiaceae
Although morphologically similar, species of Cladophialophora
(Herpotrichiellaceae) were shown to be phylogenetically distinct from
Pseudocladosporium (Venturiaceae), which was revealed to be
synonymous with the older genus, Fusicladium. Other than being
associated with human disorders, species of Cladophialophora were
found to also be phytopathogenic, or to occur as saprobes on organic material,
or in water, fruit juices, or sports drinks, along with species of
Exophiala. Caproventuria and Metacoleroa were
confirmed to be synonyms of Venturia, which has Fusicladium
(= Pseudocladosporium) anamorphs. Apiosporina, based on
A. collinsii, clustered basal to the Venturia clade, and
appears to represent a further synonym. Several species with a
pseudocladosporium-like morphology in vitro represent a sister clade
to the Venturia clade, and are unrelated to Polyscytalum.
These taxa are newly described in Fusicladium, which is
morphologically close to Anungitea, a heterogeneous genus with
unknown phylogenetic affinity. In contrast to the
Herpotrichiellaceae, which were shown to produce numerous
synanamorphs in culture, species of the Venturiaceae were
morphologically and phylogenetically more uniform. Several new species and new
combinations were introduced in Cladophialophora, Cyphellophora
(Herpotrichiellaceae), Exophiala, Fusicladium, Venturia
(Venturiaceae), and Cylindrosympodium (incertae
sedis)
Final NOMAD results on nu_mu->nu_tau and nu_e->nu_tau oscillations including a new search for nu_tau appearance using hadronic tau decays
Results from the nu_tau appearance search in a neutrino beam using the full
NOMAD data sample are reported. A new analysis unifies all the hadronic tau
decays, significantly improving the overall sensitivity of the experiment to
oscillations. The "blind analysis" of all topologies yields no evidence for an
oscillation signal. In the two-family oscillation scenario, this sets a 90%
C.L. allowed region in the sin^2(2theta)-Delta m^2 plane which includes
sin^2(2theta)<3.3 x 10^{-4} at large Delta m^2 and Delta m^2 < 0.7 eV^2/c^4 at
sin^2(2theta)=1. The corresponding contour in the nu_e->nu_tau oscillation
hypothesis results in sin^2(2theta)<1.5 x 10^{-2} at large Delta m^2 and Delta
m^2 < 5.9 eV^2/c^4 at sin^2(2theta)=1. We also derive limits on effective
couplings of the tau lepton to nu_mu or nu_e.Comment: 46 pages, 16 figures, Latex, to appear on Nucl. Phys.
Search for heavy neutrinos mixing with tau neutrinos
We report on a search for heavy neutrinos (\nus) produced in the decay
D_s\to \tau \nus at the SPS proton target followed by the decay \nudecay in
the NOMAD detector. Both decays are expected to occur if \nus is a component
of .\
From the analysis of the data collected during the 1996-1998 runs with
protons on target, a single candidate event consistent with
background expectations was found. This allows to derive an upper limit on the
mixing strength between the heavy neutrino and the tau neutrino in the \nus
mass range from 10 to 190 . Windows between the SN1987a and Big Bang
Nucleosynthesis lower limits and our result are still open for future
experimental searches. The results obtained are used to constrain an
interpretation of the time anomaly observed in the KARMEN1 detector.\Comment: 20 pages, 7 figures, a few comments adde
- …