High Level Synthesis of Neural Network Chips

This thesis investigates the development of a silicon compiler dedicated to generate Application-Specific Neural Network Chips (ASNNCs) from a high level C-based behavioural specification language. The aim is to fully integrate the silicon compiler with the ESPRIT II Pygmalion neural programming environment. The integration of these two tools permits the translation of a neural network application specified in nC, the Pygmalion's C-based neural programming language, into either binary (for simulation) or silicon (for execution in hardware). Several applications benefit from this approach, in particular the ones that require real-time execution, for which a true neural computer is required. This research comprises two major parts: extension of the Pygmalion neural programming environment, to support automatic generation of neural network chips from the nC specification language; and implementation of the high level synthesis part of the neural silicon compiler. The extension of the neural programming environment has been developed to adapt the nC language to hardware constraints, and to provide the environment with a simulation tool to test in advance the performance of the neural chips. Firstly, new hardware-specific requisites have been incorporated to nC. However, special attention has been taken to avoid transforming nC into a hardware-oriented language, since the system assumes minimum (or even no) knowledge of VLSI design from the application developer. Secondly, a simulator for neural network hardware has been developed, which assesses how well the generated circuit will perform the neural computation. Lastly, a hardware library of neural network models associated with a target VLSI architecture has been built. The development of the neural silicon compiler focuses on the high level synthesis part of the process. The goal of the silicon compiler is to take nC as the input language and automatically translate it into one or more identical integrated circuits, which are specified in VHDL (the IEEE standard hardware description language) at the register transfer level. The development of the high level synthesis comprises four major parts: firstly, compilation and software-like optimisations of nC; secondly, transformation of the compiled code into a graph-based internal representation, which has been designed to be the basis for the hardware synthesis; thirdly, further transformations and hardware-like optimisations on the internal representation; and finally, creation of the neural chip's data path and control unit that implement the behaviour specified in nC. Special attention has been devoted to the creation of optimised hardware structures for the ASNNCs employing both phases of neural computing on-chip: recall and learning. This is achieved through the data path and control synthesis algorithms, which adopt a heuristic approach that targets the generated hardware structure of the neural chip in a specific VLSI architecture, namely the Generic Neuron. The viability, concerning the effective use of silicon area versus speed, has been evaluated through the automatic generation of a VHDL description for the neural chip employing the Back Propagation neural network model. This description is compared with the one created manually by a hardware designer

A Near-Infrared L Band Survey of the Young Embedded Cluster NGC 2024

We present the results of the first sensitive L band (3.4 micron) imaging study of the nearby young embedded cluster NGC 2024. Two separate surveys of the cluster were acquired in order to obtain a census of the circumstellar disk fraction in the cluster. From an analysis of the JHKL colors of all sources in our largest area, we find an infrared excess fraction of > 86%. The JHKL colors suggest that the infrared excesses arise in circumstellar disks, indicating that the majority of the sources which formed in the NGC 2024 cluster are currently surrounded by, and likely formed with circumstellar disks. The excess fractions remain very high, within the errors, even at the faintest L magnitudes from our deeper surveys suggesting that disks form around the majority of the stars in very young clusters such as NGC 2024 independent of mass. From comparison with published JHKL observations of Taurus, we find the K - L excess fraction in NGC 2024 to be consistent with a high initial incidence of circumstellar disks in both NGC 2024 and Taurus. Because NGC 2024 represents a region of much higher stellar density than Taurus, this suggests that disks may form around most of the YSOs in star forming regions independent of environment. We find a relatively constant JHKL excess fraction with increasing cluster radius, indicating that the disk fraction is independent of location in the cluster. In contrast, the JHK excess fraction increases rapidly toward the central region of the cluster, and is most likely due to contamination of the K band measurements by bright nebulosity in the central regions of the cluster. We identify 45 candidate protostellar sources in the central regions of the NGC 2024 cluster, and find a lower limit on the protostellar phase of early stellar evolution of 0.4 - 1.4 X 10^5 yr, similar to that in Taurus.Comment: 37 pages, 8 figures, 3 tables, To appear in the Astronomical Journa

Tuneable molecular doping of corrugated graphene

Density functional theory (DFT) modeling of the physisorption of four different types of molecules (toluene, bromine dimmer, water and nitrogen dioxide) over and above graphene ripples has been performed. For all types of molecules changes of charge transfer and binding energies in respect to flat graphene is found. The changes in electronic structure of corrugated graphene and turn of {\pi}-orbitals of carbon atoms in combination with chemical structure of adsorbed molecules are proposed as the causes of difference with the perfect graphene case and variety of adsorption properties of different types of the molecules. Results of calculation suggest that the tops of the ripples are more attractive for large molecules and valley between ripples for small molecules. Stability of molecules on the ripples and energy barriers for migration over flat and corrugated graphene is also discussed.Comment: 15 pages, 5 figures, accepted in Surface Scienc

Graphene: Status and Prospects

Graphene is a wonder material with many superlatives to its name. It is the thinnest material in the universe and the strongest ever measured. Its charge carriers exhibit giant intrinsic mobility, have the smallest effective mass (it is zero) and can travel micrometer-long distances without scattering at room temperature. Graphene can sustain current densities 6 orders higher than copper, shows record thermal conductivity and stiffness, is impermeable to gases and reconciles such conflicting qualities as brittleness and ductility. Electron transport in graphene is described by a Dirac-like equation, which allows the investigation of relativistic quantum phenomena in a bench-top experiment. What are other surprises that graphene keeps in store for us? This review analyses recent trends in graphene research and applications, and attempts to identify future directions in which the field is likely to develop.Comment: pre-edited version of the review published in Science Please note that only 40 references are allowed by the magazine. Sorr

Rainbow Research: Challenges and Recommendations for Sexual Orientation and Gender Identity and Expression (SOGIE) Survey Design

A growing number of people around the world identify, in some way, as Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ+); yet, these voices are noticeably absent from nonprofit research. To address issues of equity and the historic marginalization of LGBTQ+ people both societally and in the nonprofit sector, this manuscript seeks to answer the following questions: Why is it important to include sexual orientation and gender identity and expression (SOGIE) survey questions in nonprofit surveys? What are best practices for including SOGIE survey questions in nonprofit research? We present LGBTQ+ inclusive research strategies and suggested questions for inclusive SOGIE survey design. Though this article focuses primarily on surveying LGBTQ+ populations, it can also be instructive for general population surveys

Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols

Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. Here we used electron microscopy and lipidomics to characterize defects in Fatp4-/- mice. Mutants showed lamellar body, corneocyte lipid envelope, and cornified envelope abnormalities. Lipidomics identified two lipids previously speculated to be present in mouse epidermis, sphingosine β-hydroxyceramide and monoacylglycerol; mutants displayed decreased proportions of these and the two ceramide classes that carry ultralong-chain, amide-linked fatty acids (FAs) thought to be critical for barrier function, unbound ω-O-acylceramide and bound ω-hydroxyceramide, the latter constituting the major component of the corneocyte lipid envelope. Other abnormalities included elevated amounts of sphingosine α-hydroxyceramide, phytosphingosine non-hydroxyceramide, and 1-O-acylceramide. Acyl chain length alterations in ceramides also suggested roles for FATP4 in esterifying saturated non-hydroxy and β-hydroxy FAs with at least 25 carbons and saturated or unsaturated ω-hydroxy FAs with at least 30 carbons to CoA. Our lipidomic analysis is the most thorough such study of the Fatp4-/- mouse skin barrier to date, providing information about how FATP4 can contribute to barrier function by regulating fatty acyl moieties in various barrier lipids

Aplicaciones ergonomicas para la mejoria del rendimiento de los brigadistas de incendios forestales

El presente estudio se generó como parte de un proyecto financiado por una agencia estatal denominada FONDEF, con el apoyo de cinco grandes empresas forestales. Su objetivo principal fue conocer la respuesta humana en el combate de incendios forestales, con el fin de contribuir a la organización de  programas de combate del fuego seguros y eficientes.Para cumplir con los objetivos específicos, fue necesario efectuar estudios en incendios y en  construcción de líneas de fuego. En los incendios se midió la respuesta fisiológica impuesta por la exposición a calor y el trabajo físico, registrándose continuamente la frecuencia cardíaca de los brigadistas. Se midieron también las temperaturas de bulbo seco, húmedo y de globo, la pendiente del terreno, las características del combustible, el estado del incendio y la calidad y el rendimiento,  obtenidos en brigadistas combatiendo el fuego en 605 ocasiones. Por su parte,  los ensayos de construcción de línea se llevaron a cabo  para establecer, bajo condiciones controladas, el efecto de las pausas y relevos.

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis.

Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. Here, we investigated ASC-exosomes' effects on skin barrier restoration by analyzing protein and lipid contents. We found that subcutaneous injection of ASC-exosomes in an oxazolone-induced dermatitis model remarkably reduced trans-epidermal water loss, while enhancing stratum corneum (SC) hydration and markedly decreasing the levels of inflammatory cytokines such as IL-4, IL-5, IL-13, TNF-α, IFN-γ, IL-17, and TSLP, all in a dose-dependent manner. Interestingly, ASC-exosomes induced the production of ceramides and dihydroceramides. Electron microscopic analysis revealed enhanced epidermal lamellar bodies and formation of lamellar layer at the interface of the SC and stratum granulosum with ASC-exosomes treatment. Deep RNA sequencing analysis of skin lesions demonstrated that ASC-exosomes restores the expression of genes involved in skin barrier, lipid metabolism, cell cycle, and inflammatory response in the diseased area. Collectively, our results suggest that ASC-exosomes effectively restore epidermal barrier functions in AD by facilitating the de novo synthesis of ceramides, resulting in a promising cell-free therapeutic option for treating AD