En kvalitativ studie av Kommunens psykiske helsetilbud for barn og unge i et minoritetsperspektiv : «Vi må være mer synlige og gi av oss selv»

Master's thesis MIKA. VID Specialized University, Stavanger, May 2021En målsetning til velferdsstaten er likeverdige helsetjenester som hensyntar at alle barn og familier har ulike ønsker og behov. Regjeringen og barneombudet har et økt fokus på barn og unges psykiske helse, uten at det fremkommer spesifikke tiltak rettet mot barn og familier med innvandrerbakgrunn. Frykt for barnevern, tabu rundt psykisk helse og manglende kunnskap om velferdssystemet i Norge forhindrer at mange barn og familier med minoritetsbakgrunn får hjelp i form av tidlig innsats. Denne oppgaven ønsker å belyse at det kreves forskjellige fremgangsmåter for å oppnå likeverdige tjenester for alle i samfunnet.submittedVersio

The isolated perfused human skin flap model: A missing link in skin penetration studies?

Manuscript. Published version available in http://dx.doi.org/10.1016/j.ejps.2016.10.003 Development of effective (trans)dermal drug delivery systems requires reliable skinmodels to evaluate skin drug penetration. The isolated perfused human skin flap remainsmetabolically active tissue for up to 6 h during in vitro perfusion. We introduce the isolated perfused human skin flap as a close-to-in vivo skin penetration model. To validate the model's ability to evaluate skin drug penetration the solutions of a hydrophilic (calcein) and a lipophilic (rhodamine) fluorescence marker were applied. The skin flaps were perfused with modified Krebs- Henseleit buffer (pH 7.4). Infrared technology was used to monitor perfusion and to select a well-perfused skin area for administration of the markers. Flap perfusion and physiological parameters were maintained constant during the 6 h experiments and the amount of markers in the perfusate was determined. Calcein was detected in the perfusate, whereas rhodamine was not detectable. Confocal images of skin cross-sections shoved that calcein was uniformly distributed through the skin, whereas rhodamine accumulated in the stratum corneum. For comparison, the penetration of both markers was evaluated on ex vivo human skin, pig skin and cellophanemembrane. The proposed perfused flapmodel enabled us to distinguish between the penetrations of the two markers and could be a promising close-to-in vivo tool in skin penetration studies and optimization of formulations destined for skin administratio

Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge

Accepted manuscript version, licensed CC BY-NC-ND 4.0. Published version available at https://doi.org/10.1016/j.ejps.2018.10.005.The topical administration of exogenous human epidermal growth factor (hEGF) is a promising approach for improved chronic wound therapy. To develop therapeutically superior hEGF formulation, we prepared hEGF-containing neutral (NDLs), cationic (CDLs) and anionic (ADLs) deformable liposomes (DLs), respectively, since it is expected that the liposomal surface charge can affect both the liposomal physicochemical properties, their skin penetration potential and therapeutic efficacy of liposome-associated drug. All prepared liposomes were of similar size (300–350 nm) with high hEGF load (~80% entrapment efficacy). Among the studied DLs, ADLs were found to be most promising for sustained release of hEGF, as assessed in vitro using the polyamide membrane. Ex vivo studies revealed that all DLs were excellent systems for skin therapy with hEGF and no penetration of hEGF through the full thickness human skin was detected. ADLs provided a depot exhibiting the highest hEGF retention onto the human skin surface. ADLs also revealed enhanced mitogenic activities in human fibroblasts compared to both NDLs and CDLs after 48 hrs treatment. Moreover, hEGF-containing ADLs significantly enhanced mitogenic activity in fibroblast as compared to activity of hEGF solution (positive control). Similar trends were observed in human keratinocytes after 24 hrs of treatment. We proved that the liposomal surface charge affects the therapeutic potential of hEGF-containing liposomes. hEGF-containing ADLs can be a promising nanosystem-based formulation for localized therapy of chronic wounds

Growth, yield and fruit quality of tomato Solanum lycopersicum L grown in sewage-based compost in a semi-hydroponic cultivation system

Purpose: Due to environmental concerns, there is a demand to reduce the use of peat as a growing medium for horticultural crops. Simultaneously, there is an interest to recycle organic waste materials in the form of compost. This study aimed to document effects on growth, yield, and fruit quality of tomato plants when cultivated in a sewage digestate-based compost in a subirrigation container system. Materials and methods: The compost used in this experiment consisted of 30% hygienised sewage digestate from biogas extraction and 70% garden waste. The treatments were 100% compost, a peat mix and mixtures of the two in 25/75, 50/50 and 75/25 ratios. Results and conclusion: Considering the contrast in chemical and physical properties of the treatments, variations in growth, yield and quality were expected. The plants differed in leaf area and number of leaves, but there were no differences in yield or quality of the tomato fruits. It is assumed that this is in great part due to the remediating effects of subirrigation with an ideal nutrient solution, and the use of pre-established plants. Further research should focus on benefits of this cultivation system for use in sustainable horticulture in combination with recycled organic waste.publishedVersio

MIMRES – Integrering som samskaping i distriktskommuner: Forskningsrapport fra et utviklings- og innovasjonsprosjekt i kommunene Vågå, Sel og Nordre Land

I denne rapporten presenteres det forskningsarbeidet som er gjort i prosjektet «Flyktninger som ressurser» som har pågått i tre distriktskommuner i perioden 2016-2019. Målet med prosjektet var å se på muligheter for bedre samarbeid og samordning mellom ulike aktører som er berørt av eller involvert i integreringsarbeid i kommunen. Rapporten dokumenterer og analyserer funn som er gjort og som er presentert i tre delnotater. Delnotatene er basert på intervjuer med flyktningene, arbeidsgivere og tjenesteapparatet i de tre kommunene. Forskningen er finansiert av NAV FoU-midler og har pågått i perioden mars 2017 til januar 2019NAV Fo

Effects of cod intake in pregnancy on iodine nutrition and infant development: study protocol for Mommy’s Food - a randomized controlled trial

Background Iodine is a key component of thyroid hormones that are critical for normal development of the brain and nervous system in utero. Recent results indicate that two thirds of pregnant women in Europe have sub-optimal iodine nutrition. In Norway, milk and seafood are the most important dietary iodine sources and contributes to about 80% of the intake. Method Two-armed randomized trial where 137 pregnant women were randomized to either receiving cod twice weekly, or continue with habitual diet for 16 weeks (pregnancy week 20–36). Socioeconomic- and demographic factors, dietary information and biological (urine, blood, and hair) samples are collected pre- and post-intervention, and at six weeks, three-, six-, and eleven months postpartum. Biological samples (urine, blood, and hair) of the infant are collected at six weeks, three-, six-, and eleven months postnatal. Child development is assessed by The Bayley Scale of Infant and Toddler Development, 3rd edition, at eleven months, and by parent report on the Ages and Stages Questionnaire, 3rd edition, and Ages and Stages Questionnaire: Social Emotional at three-, six-, and eleven months. Discussion The Mommy’s Food study will provide knowledge on changes in iodine nutrition when consuming iodine rich fish during pregnancy and contribute to the understanding of the impact of iodine status in pregnancy on infant neurodevelopment.publishedVersio

Randomized implementation of a primary human papillomavirus testing-based cervical cancer screening protocol for women 34 to 69 years in Norway

Background: Cervical cancer screening programs are facing a programmatic shift where screening protocol based on human papillomavirus testing (HPV-Screening protocol) is replacing the liquid-based cytology (LBC-Screening protocol). For safe technology transfer within the nationwide screening programme in Norway, HPV-Screening protocol was implemented randomized to compare the real-world effectiveness of HPV-Screening protocol and LBC-Screening protocol at the first screening round. Methods: Among 302,295 women ages 34 to 69 years scheduled to attend screening from February 2015 to June 2017, 157,447 attended. A total of 77,207 were randomly allocated to the HPV-Screening protocol and 80,240 were allocated to the LBC-Screening protocol. All women were followed up for 18 months. Results: The HPV-Screening protocol resulted in a relative increase of 60% in the detection of cervical intraepithelial neoplasia (CIN) grade 2 or worse [risk ratio (RR) = 1.6, 95% confidence interval (CI) = 1.5–1.7], 40% in CIN grade 3 or worse (RR = 1.4, 95% CI = 1.3–1.6), 40% in cancer (RR = 1.4, 95% CI = 1.0–2.1), and 60% in colposcopy referrals (RR = 1.6, 95% CI = 1.5–1.6) compared with LBC-Screening. The performance of both protocols was age dependent, being more effective in women ages under 50 years. Conclusions: The HPV-Screening protocol was well accepted by women in Norway and detected more CIN2, CIN3, and cancers compared with the LBC-Screening protocol. Impact: A randomized implementation of the HPV-Screening protocol with real-world assessment enabled a gradual, quality assured, and safe technology transition. HPV-based screening protocol may further be improved by using HPV genotyping and age-specific referral algorithms.publishedVersio

Fatty fish intake and cognitive function: FINS-KIDS, a randomized controlled trial in preschool children

Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children. The purpose of the trial was to investigate whether an increased intake of fatty fish compared to meat improves cognitive function in children 4–6 years old.publishedVersio