Aplicación de electroencefalografía digital a la evaluación de la estabilidad en visión binocular

El trabajo aplica la instrumentación de registro de la actividad cortical mediante EEG digital. Nos hemos familiarizado con el manejo de dicha instrumentación y hemos diseñado un instrumento relacionado con la visión binocular. Tras ello se realizó un experimento para encontrar el alcance de estas técnicas para valorar la estabilidad en la visión binocular. El trabajo concluye con un análisis y discusión de los resultados obtenidos

Revisión bibliográfica sobre el tratamiento quirúrgico de la hernia inguinal a propósito de un caso. Actualización de las técnicas laparoscópica preperitoneal transabdominal y totalmente extraperitoneal.

La hernia inguinal, en la actualidad, es una de las patologías más prevalentes en la población. Y aunque se han descrito diversos factores que favorecen su aparición, su etiología sigue siendo una incógnita. Entre sus factores intrínsecos más importantes destacan la edad avanzada, el sexo masculino, el índice de masa corporal bajo y algunas patologías pulmonares, frente a los factores extrínsecos como una baja actividad física. Para poder entender la cirugía reparatoria de la hernia inguinal es imprescindible el estudio de sus diversas estructuras anatómicas, especialmente los músculos abdominales y el conducto inguinal. Existen una gran diversidad de clasificaciones respecto de la hernia inguinal, pero la más aceptada es la clasificación de Gilbert. La cirugía de la hernia inguinal sigue siendo una de las más practicadas en el mundo occidental. A lo largo de la historia ha ido evolucionando con diferentes modalidades técnicas pero siempre con la misma base reparatoria. Y aunque durante muchos años la técnica de Lichstenstein ha sido la técnica quirúrgica más empleada por los cirujanos, hoy en día cada vez se está avanzando más gracias a la cirugía laparoscópica. <br /

Evolución histórica de las enfermedades causadas por micobacterias no pigmentadas de crecimiento rápido en un Hospital Universitario

Non-pigmented rapidly growing mycobacteria (NPRGM) are a group of organisms of increasing interest due to the growing number of potential patients and the difficulties for a proper treatment in many of them. However, the evolution of these diseases in a long period of time and its evolutionary changes has been described only in a scanty number of reports. Material and methods. We performed a retrospective study between January 1st 2004 and December 31st 2017 in order to evaluate the clinical significance and types of diseases caused by NPRGM. Patients with isolates of NPRGM during this period were selected for the study, and clinical charts were reviewed using a predefined protocol. Results. During this period we identified 59 patients (76 clinical samples) with isolates of NPRGM, with 12 cases of clinical disease and one patient with doubtful significance (including 6 respiratory tract infections, 2 catheter infections, 1 skin and soft tissue infection, 1 disseminated infection, 1 conjunctivitis, 1 prosthetic joint infection and 1 mastitis). Fifty percent of M. chelonae isolates, 37.5% of M. abscessus isolates and 23.33% of M. fortuitum isolates were clinically significant. None of the isolates of other species were significant. Conclusions. Most isolates in respiratory samples were contaminants/colonizations. M. abscessus was the main etiological agent in respiratory syndromes, whereas M. chelonae and M. fortuitum were more frequently associated with other infections, especially clinical devices and skin and soft tissue infections.Las micobacterias no pigmentadas de crecimiento rápido (MNPCR) son un grupo de organismos de interés creciente debido al número cada vez mayor de pacientes potenciales y a las dificultades en el tratamiento. Sin embargo, el número de estudios que analizan la evolución de estos casos a lo largo de un periodo de tiempo largo es escaso. Material and métodos. Se realizó un estudio retrospectivo entre el 1 de enero de 2004 y el 31 de diciembre de 2017 para evaluar el significado clínico y los tipos de enfermedades causados por MNPCR. Se seleccionaron para ello aquellos pacientes con aislamientos de MNPCR, y se revisaron las historias clínicas mediante un protocolo predefinido. Resultados. Se identificaron 59 pacientes (76 muestras) con aislamientos de MNPCR, de los cuales 12 presentaron enfermedad y uno tuvo un significado dudoso (incluyendo 6 infecciones respiratorias, 2 infecciones asociadas a catéter, 1 infección de piel y partes blandas, 1 infección diseminada, 1 conjuntivitis, 1 infección de prótesis osteoarticular y 1 mastitis). El 50 % de los aislamientos de Mycobacterium chelonae, el 37,5 % de Mycobacterium abscessus y el 23,33 % de Mycobacterium fortuitum fueron clínicamente significativos. Ninguno de los aislamientos de otras especies fue significativo La mayoría de los aislamientos de muestras respiratorias resultaron ser contaminantes/ colonizaciones. M. abscessus fue el principal agente etiológico en las infecciones respiratorias, mientras que M. chelonae y M. fortuitum fueron asociados con mayor frecuencia a otras infecciones, especialmente infecciones de piel y partes blandas e infecciones asociadas a dispositivos biomédico

El Diseño: 7 visiones transversales

El diseño ha evolucionado de manera sorprendente en las últimos años gracias a la tecnología, potenciando diferentes disciplinas y especializaciones en las que influyen aspectos técnicos y de percepción de la imagen. El trabajo de los diseñadores demanda por tanto unos conocimientos de dominio de códigos y contexto. Este volumen centra sus capítulos en siete áreas convergentes tratadas con voluntad didáctica: la gestión del diseño, el diseño de productos, el diseño para la imprenta, la estética en el diseño, el diseño para la web, el diseño publicitario y finalmente la identidad visual corporativa. El diseño, 7 visiones transversales, se dirige a estudiantes y personas que se inician en el mundo del diseño, por lo que se trata de una publicación básica y fundamental que toca no solo aspectos teóricos del diseño, si no también aspectos prácticos de una temática que se aplica día a día a nuevos campos y nuevas tecnologías

Mutations in TRAPPC11 are associated with a congenital disorder of glycosylation.

Congenital disorders of glycosylation (CDG) are a heterogeneous and rapidly growing group of diseases caused by abnormal glycosylation of proteins and/or lipids. Mutations in genes involved in the homeostasis of the endoplasmic reticulum (ER), the Golgi apparatus (GA), and the vesicular trafficking from the ER to the ER-Golgi intermediate compartment (ERGIC) have been found to be associated with CDG. Here, we report a patient with defects in both N- and O-glycosylation combined with a delayed vesicular transport in the GA due to mutations in TRAPPC11, a subunit of the TRAPPIII complex. TRAPPIII is implicated in the anterograde transport from the ER to the ERGIC as well as in the vesicle export from the GA. This report expands the spectrum of genetic alterations associated with CDG, providing new insights for the diagnosis and the understanding of the physiopathological mechanisms underlying glycosylation disorders

Serum amyloid a1/toll-like receptor-4 Axis, an important link between inflammation and outcome of TBI patients

Traumatic brain injury (TBI) is one of the leading causes of mortality and disability world-wide without any validated biomarker or set of biomarkers to help the diagnosis and evaluation of the evolution/prognosis of TBI patients. To achieve this aim, a deeper knowledge of the biochemical and pathophysiological processes triggered after the trauma is essential. Here, we identified the serum amyloid A1 protein-Toll-like receptor 4 (SAA1-TLR4) axis as an important link between inflammation and the outcome of TBI patients. Using serum and mRNA from white blood cells (WBC) of TBI patients, we found a positive correlation between serum SAA1 levels and injury severity, as well as with the 6-month outcome of TBI patients. SAA1 levels also correlate with the presence of TLR4 mRNA in WBC. In vitro, we found that SAA1 contributes to inflammation via TLR4 activation that releases inflammatory cytokines, which in turn increases SAA1 levels, establishing a positive proinflammatory loop. In vivo, post-TBI treatment with the TLR4-antagonist TAK242 reduces SAA1 levels, improves neurobehavioral outcome, and prevents blood–brain barrier disruption. Our data support further evaluation of (i) post-TBI treatment in the presence of TLR4 inhibition for limiting TBI-induced damage and (ii) SAA1-TLR4 as a biomarker of injury progression in TBI patientsThis work was supported by grants from Fundación Mutua Madrileña and Fondo de Investigaciones Sanitarias (FIS) (ISCIII/FEDER) (Programa Miguel Servet CP14/00008; CPII19/00005; PI16/00735; PI19/00082) to JE, RYC2019-026870-I to JMR and PI18/01387 to A

Líquenes silicícolas de Sierra Morena, I.

Ofrecemos en este primer trabajo sobre Sierra Morena, los resultados floristicos de la exploración de 9 localidades situadas al N de las provincias de Huelva (Comarca de Aracena) y Sevilla (Comarca Sierra Norte). En conjunto se citan 95 táxones y se ofrece la descripción de las más criticas, poco conocidas o escasamente citadas. Destacamos entre ellas las incluidas en el resumen en inglés.Floristisc results of research in 9 localities of Sevilla and Huelva Provinces (Comarca de Aracena and Comarca Sierra Norte) are given. 95 taxa are cited, with description of critical, incompletely know or scarcely reported ones. Amongst them we can point out: Rhizocarpon tetrasporum, Caloplaca furax, C. xerica, Acarospora impresula var. hospitans Acarospora smaragdula var. scyphulifera, Trapelia mooreana, Pyrenopsis triptococca, Leptogium albociliatum, Polyschidium muscicola and Diploschistes lichenicola

Algunos líquenes silicícolas de la Sierra del Aljibe (provincia de Cádiz, Sur de España)

[ES] Se ofrecen en este trabajo los primeros resultados florísticos de la exploración de la zona culminai de la Sierra del Aljibe (Cádiz, S. de España). Damos cuenta del hallazgo de 29 táxones.[EN] 29 taxa from the summit of the Aljibe Range (Cádiz, S. of Spain) are given

Patient satisfaction with remote monitoring of cardiac implantable electronic devices : the V questionnaire

Remote monitoring of cardiac implantable electronic devices (CIEDs) has demonstrated substantial benefits. Treatment guidelines have therefore endorsed its use and is being increasingly adopted in the clinical setting, but the level of satisfaction they convey remains still unknown. We developed and validated a questionnaire to measure patient satisfaction with remote monitoring using Medtronic CareLink® Network and assessed its internal reliability and dimensional validity. After a thorough literature review, cognitive debriefing of 18 patients, and an expert panel discussion, a 30-item instrument was proposed and grouped into 5 dimensions (items): 1- Information on cardiac condition (3), 2- Device convenience (3), 3- Transmission process (6), 4- Satisfaction with medical monitoring (8), and 5- General opinions (10). Correlation with the visual analog scale (VAS), overall health related quality of life (HRQoL) measured by the EuroQoL-5D accompanied by the VAS as well as with the Medical Outcomes Study (MOS) SF-36 were assessed. Psychometric properties, exploratory factor analysis and a second order confirmatory factor analysis (a hierarchical CFA with a general common factor explaining the relations between the first order common factors, See Figure 1) were estimated. Models were assessed based on item loading size, sign and statistical significance, and goodness-of-fit statistics. A total of 186 patients (77% male) with a mean age of 66.03 (SD = 13.94) years were assessed. 48% had implantable cardioverter-defibrillators, 24% had pacemakers, and 29% had cardiac resynchronization therapy devices. An overall Cronbach's α = 0.893 was achieved, with acceptable reliabilities for isolated dimensions. Correlations with corresponding VAS scales were meaningful and significant (p < 0.01). The second order factor solution yielded good goodness-of-fit indexes (χ 2 /df = 1.44, CFI = 0.96, TLI = 0.95, RMSEA = 0.05). Satisfaction with remote monitoring was not related to HRQoL (r < 0.05), except for the correlation between the SF-36 mental component and the information on cardiac condition dimension (r = 0.263, p < 0.001). The 30-item questionnaire showed good reliability and validity to assess satisfaction with remote monitoring in patients with CIEDs

Patient satisfaction with remote monitoring of cardiac implantable electronic devices : the V questionnaire

Remote monitoring of cardiac implantable electronic devices (CIEDs) has demonstrated substantial benefits. Treatment guidelines have therefore endorsed its use and is being increasingly adopted in the clinical setting, but the level of satisfaction they convey remains still unknown. We developed and validated a questionnaire to measure patient satisfaction with remote monitoring using Medtronic CareLink® Network and assessed its internal reliability and dimensional validity. After a thorough literature review, cognitive debriefing of 18 patients, and an expert panel discussion, a 30-item instrument was proposed and grouped into 5 dimensions (items): 1- Information on cardiac condition (3), 2- Device convenience (3), 3- Transmission process (6), 4- Satisfaction with medical monitoring (8), and 5- General opinions (10). Correlation with the visual analog scale (VAS), overall health related quality of life (HRQoL) measured by the EuroQoL-5D accompanied by the VAS as well as with the Medical Outcomes Study (MOS) SF-36 were assessed. Psychometric properties, exploratory factor analysis and a second order confirmatory factor analysis (a hierarchical CFA with a general common factor explaining the relations between the first order common factors, See Figure 1) were estimated. Models were assessed based on item loading size, sign and statistical significance, and goodness-of-fit statistics. A total of 186 patients (77% male) with a mean age of 66.03 (SD = 13.94) years were assessed. 48% had implantable cardioverter-defibrillators, 24% had pacemakers, and 29% had cardiac resynchronization therapy devices. An overall Cronbach's α = 0.893 was achieved, with acceptable reliabilities for isolated dimensions. Correlations with corresponding VAS scales were meaningful and significant (p < 0.01). The second order factor solution yielded good goodness-of-fit indexes (χ 2 /df = 1.44, CFI = 0.96, TLI = 0.95, RMSEA = 0.05). Satisfaction with remote monitoring was not related to HRQoL (r < 0.05), except for the correlation between the SF-36 mental component and the information on cardiac condition dimension (r = 0.263, p < 0.001). The 30-item questionnaire showed good reliability and validity to assess satisfaction with remote monitoring in patients with CIEDs