Contrataciones del Estado y gestión administrativa, en una universidad estatal, región La Libertad, 2022

Esta investigación tuvo como objetivo determinar en qué medida se relacionan las Contrataciones del Estado con la Gestión Administrativa en una universidad Estatal, región La Libertad, 2022. La investigación es de tipo básica, tiene un diseño no experimental, de corte transversal, con un nivel de estudio descriptivo correlacional causal, manteniendo un enfoque cuantitativo y se utilizó una metodología hipotético deductiva. La población de estudio estuvo conformada por el personal de la universidad estatal, región La Libertad, que labora en las áreas de: Logística, Dirección General de Administración, Presupuesto, Rectorado, Contabilidad y Tesorería, donde se tomó como muestra a 48 personas, a quienes se les aplicó un cuestionario, basado en Ramos (2021). Los resultados establecieron una relación entre las variables, con un coeficiente de correlación de Pearson de ,661 y una significancia bilateral de .000. Concluyendo en la aprobación de las hipótesis planteadas, determinando una relación positiva alta entre las variables.TrujilloEscuela de PosgradoReforma y Modernización del EstadoEducación y calidad educativaApoyo a la reducción de brechas y carencias en la educación en todos sus nivelesEducación de calida

Contrataciones del Estado y gestión administrativa, en una universidad estatal, región La Libertad, 2022

Esta investigación tuvo como objetivo determinar en qué medida se relacionan las Contrataciones del Estado con la Gestión Administrativa en una universidad Estatal, región La Libertad, 2022. La investigación es de tipo básica, tiene un diseño no experimental, de corte transversal, con un nivel de estudio descriptivo correlacional causal, manteniendo un enfoque cuantitativo y se utilizó una metodología hipotético deductiva. La población de estudio estuvo conformada por el personal de la universidad estatal, región La Libertad, que labora en las áreas de: Logística, Dirección General de Administración, Presupuesto, Rectorado, Contabilidad y Tesorería, donde se tomó como muestra a 48 personas, a quienes se les aplicó un cuestionario, basado en Ramos (2021). Los resultados establecieron una relación entre las variables, con un coeficiente de correlación de Pearson de ,661 y una significancia bilateral de .000. Concluyendo en la aprobación de las hipótesis planteadas, determinando una relación positiva alta entre las variables

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.

iPSC-derived microglia offer a powerful tool to study microglial homeostasis and disease-associated inflammatory responses. Yet, microglia are highly sensitive to their environment, exhibiting transcriptomic deficiencies when kept in isolation from the brain. Furthermore, species-specific genetic variations demonstrate that rodent microglia fail to fully recapitulate the human condition. To address this, we developed an approach to study human microglia within a surrogate brain environment. Transplantation of iPSC-derived hematopoietic-progenitors into the postnatal brain of humanized, immune-deficient mice results in context-dependent differentiation into microglia and other CNS macrophages, acquisition of an ex vivo human microglial gene signature, and responsiveness to both acute and chronic insults. Most notably, transplanted microglia exhibit robust transcriptional responses to Aβ-plaques that only partially overlap with that of murine microglia, revealing new, human-specific Aβ-responsive genes. We therefore have demonstrated that this chimeric model provides a powerful new system to examine the in vivo function of patient-derived and genetically modified microglia

Outcomes among trauma patients with duodenal leak following primary versus complex repair of duodenal injuries: An Eastern Association for the Surgery of Trauma multicenter trial

BACKGROUND: Duodenal leak is a feared complication of repair, and innovative complex repairs with adjunctive measures (CRAM) were developed to decrease both leak occurrence and severity when leaks occur. Data on the association of CRAM and duodenal leak are sparse, and its impact on duodenal leak outcomes is nonexistent. We hypothesized that primary repair alone (PRA) would be associated with decreased duodenal leak rates; however, CRAM would be associated with improved recovery and outcomes when leaks do occur. METHODS: A retrospective, multicenter analysis from 35 Level 1 trauma centers included patients older than 14 years with operative, traumatic duodenal injuries (January 2010 to December 2020). The study sample compared duodenal operative repair strategy: PRA versus CRAM (any repair plus pyloric exclusion, gastrojejunostomy, triple tube drainage, duodenectomy). RESULTS: The sample (N = 861) was primarily young (33 years) men (84%) with penetrating injuries (77%); 523 underwent PRA and 338 underwent CRAM. Complex repairs with adjunctive measures were more critically injured than PRA and had higher leak rates (CRAM 21% vs. PRA 8%, p \u3c 0.001). Adverse outcomes were more common after CRAM with more interventional radiology drains, prolonged nothing by mouth and length of stay, greater mortality, and more readmissions than PRA (all p \u3c 0.05). Importantly, CRAM had no positive impact on leak recovery; there was no difference in number of operations, drain duration, nothing by mouth duration, need for interventional radiology drainage, hospital length of stay, or mortality between PRA leak versus CRAM leak patients (all p \u3e 0.05). Furthermore, CRAM leaks had longer antibiotic duration, more gastrointestinal complications, and longer duration until leak resolution (all p \u3c 0.05). Primary repair alone was associated with 60% lower odds of leak, whereas injury grades II to IV, damage control, and body mass index had higher odds of leak (all p \u3c 0.05). There were no leaks among patients with grades IV and V injuries repaired by PRA. CONCLUSION: Complex repairs with adjunctive measures did not prevent duodenal leaks and, moreover, did not reduce adverse sequelae when leaks did occur. Our results suggest that CRAM is not a protective operative duodenal repair strategy, and PRA should be pursued for all injury grades when feasible. LEVEL OF EVIDENCE: Therapeutic/Care Management; Level IV

Strategies and performance of the CMS silicon tracker alignment during LHC Run 2

The strategies for and the performance of the CMS silicon tracking system alignment during the 2015–2018 data-taking period of the LHC are described. The alignment procedures during and after data taking are explained. Alignment scenarios are also derived for use in the simulation of the detector response. Systematic effects, related to intrinsic symmetries of the alignment task or to external constraints, are discussed and illustrated for different scenarios