Projeto e dimensionamento de um sistema de freio aplicado a um protótipo de veículo para competição fora de estrada

This course work aims to present the brake system design of a baja SAE prototype, presenting all the stages of the project, as well as a justification of the selection of each of the components of the system. To reduce the expenses of the system were used cost optimization tools. The brakes can be activated in different ways, with the hydraulic drive being the most used. The disc brake was selected for the design. Along with floating type brake calipers, which has the advantage of compensating small bores on the disc. For the development of the low SAE prototype, the Modular Function Deployment (MFD) was applied, which allows the designer to choose the modular design from the reasons specified in the design. The Quality Function Deployment (QFD) was applied in the improvement and improvement of the product, the Engineering and Value Analysis (EAV) was applied, making it possible to determine the components that have a high cost in relation to the function they perform. Finally the Design for Manufacturing and Assembly (DFMA) was ideal to make a design of manufacture, assembly of components during the assembly and maintenance of the system. The parts selection was used as a parallel measurement with the design, to suit the needs of the project. The present study made it possible to apply the knowledge acquired during the period in which I was part of the Baja da Peste team, as well as everything that was seen in the classroom during the course of mechanical engineering, thus contributing to my training.Este trabalho de conclusão de curso tem por objetivo apresentar o dimensionamento do sistema de freio de um protótipo baja SAE, apresentando todas as etapas do projeto, bem como a justificativa da seleção de cada componente deste sistema. Para redução das despesas do sistema foram utilizadas ferramentas de otimização de custos. Os freios podem ser acionados de diversas formas, sendo o acionamento hidráulico o mais utilizado. O freio a disco foi o selecionado para o projeto. Juntamente com pinças do tipo flutuante, que tem como vantagem compensar pequenos empenos no disco. Para desenvolvimento do protótipo baja SAE foi aplicado o Desdobramento da Função Modular (MFD), que permite que o projetista escolha o design modular a partir das razões especificadas no projeto. O Desdobramento da Função Qualidade (QFD), foi aplicado no desenvolvimento e melhoria do produto, a Engenharia e Análise do Valor (EAV) foi aplicada, possibilitando determinar os componentes que tem custo elevado em relação a função que eles exercem. Por fim o Projeto para Manutenção e Montagem (DFMA) foi aplicado ao projeto a fim de facilitar a fabricação, minimizar os erros durante a montagem e manutenção do sistema. A seleção das peças a serem utilizadas foi feita de forma paralela com o dimensionamento, de modo que atendessem as necessidades do projeto. O presente estudo possibilitou aplicar os conhecimentos adquiridos no período em que fiz parte da equipe Baja da Peste, bem como tudo que foi visto em sala de aula durante o curso de engenharia mecânica, contribuindo assim para a minha formação

Support to woman by a companion of her choice during childbirth: a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>To evaluate the effectiveness and safety of the support given to women by a companion of their choice during labor and delivery.</p> <p>Methods</p> <p>A total of 212 primiparous women were enrolled in a randomized controlled clinical trial carried out between February 2004 and March 2005. One hundred and five women were allocated to the group in which support was permitted and 107 to the group in which there was no support. Variables regarding patient satisfaction and events related to obstetrical care, neonatal results and breastfeeding were evaluated. Student's t-test or Wilcoxon's test, chi-square or Fisher's exact test, risk ratios, and their respective 95% confidence intervals were used in the statistical analysis.</p> <p>Results</p> <p>Overall, the women in the support group were more satisfied with labor (median 88.0 versus 76.0, p < 0.0001) and delivery (median 91.4 versus 77.1, p < 0.0001). During labor, patient satisfaction was associated with the presence of a companion (RR 8.06; 95%CI: 4.84 – 13.43), with care received (RR 1.11; 95%CI: 1.01 – 1.22) and with medical guidance (RR 1.14 95%CI: 1.01 – 1.28). During delivery, satisfaction was associated with having a companion (RR 5.57, 95%CI: 3.70 – 8.38), with care received (RR 1.11 95%CI: 1.01 – 1.22) and with vaginal delivery (RR 1.33 95%CI:1.02 – 1.74). The only factor that was significantly lower in the support group was the occurrence of meconium-stained amniotic fluid (RR 0.51; 95%CI: 0.28 – 0.94). There was no statistically significant difference between the two groups with respect to any of the other variables.</p> <p>Conclusion</p> <p>The presence of a companion of the woman's choice had a positive influence on her satisfaction with the birth process and did not interfere with other events and interventions, with neonatal outcome or breastfeeding.</p

Existem relações entre tamanho e morfoecogenicidade do corpo lúteo detectados pelo ultra-som e os teores de progesterona plasmática em receptoras de embriões eqüinos?

Corpus luteum (CL) synthesizes progesterone (P4), which has a major function in maintenance of pregnancy in equine females and also enables the application of biotechnologies of reproduction. Considering the importance of the CL and its anatomical and physiological features to achieve normal pregnancy, our aims were to determine the size and morphoechogenicity (ME), as well as plasma P4 concentrations of corpus luteum from recipient mares for nine days after ovulation (D0). Therefore, 57 recipient mares were examined daily by transrectal ultrasonography (US) from early signals of estrus to D9. CLs were measured and their ME classified according to a 1 to 6 scale (1=anechogenic; 6=hiperechogenic). Blood samples were collected daily and progesterone concentrations assessed by radioimmunoassay. Pregnancies were checked by US 13 and 25 days after ovulation. Corpus luteum echogenicity had a tendency to increase from D0 to D9. Progesterone concentrations were &lt; 2,16 ng/ml until D3, but there was a significant elevation from D4 to D9 (3,41 to 4,33 ng/ml). There were no differences in CL size, except between D2 (31,54 mm) and D8 (25,95 mm); p &lt; 0,05). Thus, an increase in mean luteal ME is accompanied by an increase in plasmatic P4 concentration, but this event seems independent of luteal size. There were no differences between ME, size and P4 levels from D0 to D9 in recipient mares that became pregnant or not after embryo transfer.O corpo lúteo (CL) é a glândula produtora de progesterona (P4), hormônio cuja secreção contínua é essencial para o início e a manutenção da gestação em fêmeas eqüinas, e, conseqüentemente, para a aplicabilidade de inúmeras biotécnicas de reprodução. Considerando-se a importância do CL para a manutenção de uma gestação normal e suas características anatomofisiológicas, objetivou-se determinar por ultra-sonografia (US) o tamanho e a morfoecogenicidade (ME) do CL em receptoras de embriões eqüinos desde a ovulação (D0) até nove dias após (D9), bem como os níveis plasmáticos de P4 produzida no mesmo período. Para tanto, 57 éguas receptoras de um programa de transferência de embriões foram examinadas diariamente por US transretal desde a primeira detecção dos sinais de estro até o D9. A cada exame, os CL foram mensurados e sua ME registrada segundo escore de 1 a 6 (1=anecóico; 6=hiperecóico). Amostras de sangue foram colhidas diariamente e a P4 dosada por radioimunoensaio. O diagnóstico de gestação foi realizado por US aos 13 e 25 dias após a ovulação. Houve uma tendência de os corpos lúteos apresentarem ME crescente (de 1 a 5) desde o dia da ovulação até o D9. Os níveis de P4 foram &lt; 2,16 ng/ml até o D3, com conseqüente elevação e manutenção em níveis de diestro entre D4 e D9 (3,41 a 4,33 ng/ml). O tamanho luteínico não diferiu, com exceção das médias extremas durante o período (D2 = 31,54 mm versus D8 = 25,95mm; p &lt; 0,05). Assim, o aumento da ME média dos CLs avaliados por US é acompanhado por aumento na concentração plasmática de P4 em receptoras de embriões, mas este evento parece não ser dependente do tamanho da glândula luteínica. Não existe diferença na ME, no tamanho dos corpos lúteos, nem nos níveis de P4 circulante do D0 ao D9 em receptoras de embriões eqüinos que se tornaram gestantes ou não após a transferência de embriões

Singular Fermi Liquids

An introductory survey of the theoretical ideas and calculations and the experimental results which depart from Landau Fermi-liquids is presented. Common themes and possible routes to the singularities leading to the breakdown of Landau Fermi liquids are categorized following an elementary discussion of the theory. Soluble examples of Singular Fermi liquids (often called Non-Fermi liquids) include models of impurities in metals with special symmetries and one-dimensional interacting fermions. A review of these is followed by a discussion of Singular Fermi liquids in a wide variety of experimental situations and theoretical models. These include the effects of low-energy collective fluctuations, gauge fields due either to symmetries in the hamiltonian or possible dynamically generated symmetries, fluctuations around quantum critical points, the normal state of high temperature superconductors and the two-dimensional metallic state. For the last three systems, the principal experimental results are summarized and the outstanding theoretical issues highlighted.Comment: 170 pages; submitted to Physics Reports; a single pdf file with high quality figures is available from http://www.lorentz.leidenuniv.nl/~saarloo

New Emigration and Portuguese Society: Transnationalism and Return

This chapter addresses the theme of transnationalism and return in recent Portuguese emigration, namely the flows that occurred after the turn of the century. It starts with a brief theoretical overview on those topics, which constitute two relatively neglected characteristics of Portuguese emigration. Next, based on a survey carried out in 2014–2015 to more than 6000 recent emigrants, it reveals some of the links that they maintain with their home country, as well as their plans for the future, which include settlement in the destination country, return and re-emigration. Lastly, it examines data on returning emigrants – especially those that returned between 2001 and 2011 – extracted from the 2011 Census. The evidence reveals a significant number of returns, including individuals at both working and retirement ages and at all skill levels, thus exposing the unexpected complexity of movements. The results are based on the research project “Back to the future: new emigration and links with Portuguese society” (REMIGR), which aimed to ascertain the extent and characteristics of the new emigration wave. The project included an overview of emigration and return to and from all regions of the world, as well as case studies in UK, France, Luxembourg, Angola, Mozambique and Brazil.info:eu-repo/semantics/publishedVersio

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts