Efficacy of Souroubea-Platanus Dietary Supplement Containing Triterpenes in Beagle Dogs Using a Thunderstorm Noise-Induced Model of Fear and Anxiety

A novel botanical dietary supplement, formulated as a chewable tablet containing a defined mixture of Souroubea spp. vine and Platanus spp. Bark, was tested as a canine anxiolytic for thunderstorm noise-induced stress (noise aversion). The tablet contained five highly stable triterpenes and delivered 10 mg of the active ingredient betulinic acid (BA) for an intended 1 mg/kg dose in a 10 kg dog. BA in tablets was stable for 30 months in storage at 23 °C. Efficacy of the tablets in reducing anxiety in dogs was assessed in a blinded, placebo-controlled study by recording changes in blood cortisol levels and measures of behavioral activity in response to recorded intermittent thunder. Sixty beagles were assigned into groups receiving: placebo, 0.5×, 1×, 2×, and 4× dose, or the positive control (diazepam), for five days. Reduction in anxiety measures was partially dose-dependent and the 1× dose was effective in reducing inactivity time (p = 0.0111) or increased activity time (p = 0.0299) compared with placebo, indicating a decrease in anxiety response. Cortisol measures also showed a dose-dependent reduction in cortisol in dogs treated with the test tablet

Expressions 1993-1994

https://openspace.dmacc.edu/expressions/1015/thumbnail.jp

Domestic Violence Outcome Measures Project

The Domestic Violence Outcome Project had a two-fold purpose: first, to identify the long-term outcomes and needs of those who receive services from domestic violence agencies, and second, to establish procedures for on-going evaluation within agencies. Working closely with 15 agencies that are members of the Chicago Metropolitan Battered Women's Network, the researchers developed a survey to evaluate services and identify client needs. The services evaluated included court advocacy (e.g., assistance from an advocate in obtaining an order of protection), legal services (assistance from a licensed attorney with divorce or other court proceedings), emergency shelter, and counseling

Efficacy of Souroubea-Platanus Dietary Supplement Containing Triterpenes in Beagle Dogs Using a Thunderstorm Noise-Induced Model of Fear and Anxiety

A novel botanical dietary supplement, formulated as a chewable tablet containing a defined mixture of Souroubea spp. vine and Platanus spp. Bark, was tested as a canine anxiolytic for thunderstorm noise-induced stress (noise aversion). The tablet contained five highly stable triterpenes and delivered 10 mg of the active ingredient betulinic acid (BA) for an intended 1 mg/kg dose in a 10 kg dog. BA in tablets was stable for 30 months in storage at 23 ◦C. Efficacy of the tablets in reducing anxiety in dogs was assessed in a blinded, placebo-controlled study by recording changes in blood cortisol levels and measures of behavioral activity in response to recorded intermittent thunder. Sixty beagles were assigned into groups receiving: placebo, 0.5×, 1×, 2×, and 4× dose, or the positive control (diazepam), for five days. Reduction in anxiety measures was partially dosedependent and the 1× dose was effective in reducing inactivity time (p = 0.0111) or increased activity time (p = 0.0299) compared with placebo, indicating a decrease in anxiety response. Cortisol measures also showed a dose-dependent reduction in cortisol in dogs treated with the test tablet.Un novedoso suplemento dietético botánico, formulado como una tableta masticable que contiene una mezcla definida de Souroubea spp. vid y Platanus spp. La corteza se probó como ansiolítico canino para el estrés inducido por el ruido de las tormentas (aversión al ruido). La tableta contenía cinco triterpenos altamente estables y liberaba 10 mg del ingrediente activo ácido betulínico (BA) para una dosis prevista de 1 mg / kg en un perro de 10 kg. BA en tabletas se mantuvo estable durante 30 meses en almacenamiento a 23 ◦C. La eficacia de los comprimidos para reducir la ansiedad en perros se evaluó en un estudio ciego controlado con placebo mediante el registro de cambios en los niveles de cortisol en sangre y medidas de actividad conductual en respuesta a truenos intermitentes registrados. Se asignaron sesenta beagles en grupos que recibieron: placebo, dosis de 0,5 ×, 1 ×, 2 × y 4 ×, o el control positivo (diazepam), durante cinco días. La reducción de las medidas de ansiedad fue parcialmente dependiente de la dosis y la dosis 1 × fue eficaz para reducir el tiempo de inactividad (p = 0,0111) o el aumento del tiempo de actividad (p = 0,0299) en comparación con el placebo, lo que indica una disminución en la respuesta de ansiedad. Las medidas de cortisol también mostraron una reducción dependiente de la dosis en el cortisol en perros tratados con la tableta de prueba.CanCog Technologies Inc, Canada.Educons University, SerbiaCanCog Technologies Inc, CanadaThe Aga Khan University, KenyaUniversidad Nacional, Costa RicaStonehedge Bioresources Inc, CanadaUniversity of Ottawa, CanadáEscuela de Ciencias Ambientale

GNU Radio

GNU Radio is a free & open-source software development toolkit that provides signal processing blocks to implement software radios. It can be used with readily-available, low-cost external RF hardware to create software-defined radios, or without hardware in a simulation-like environment. It is widely used in hobbyist, academic, and commercial environments to support both wireless communications research and real-world radio systems