Using remote sensing to assess the relationship between crime and the urban layout

[EN] The link between place and crime is at the base of social ecology theories of crime that focus in the relationship of the characteristics of geographical areas and crime rates. The broken windows theory states that visible cues of physical and social disorder in a neighborhood can lead to an increase in more serious crime. The crime prevention through environmental design (CPTED) planning approach seeks to deter criminal behavior by creating defensible spaces. Based on the premise that a settlement's appearance is a reflection of the society, we ask whether a neighborhood's design has a quantifiable imprint when seen from space using urban fabric descriptors computed from very high spatial-resolution imagery. We tested which land cover, structure and texture descriptors were significantly related to intra-urban homicide rates in Medellin, Colombia, while controlling for socioeconomic confounders. The percentage of impervious surfaces other than clay roofs, the fraction of clay roofs to impervious surfaces, two structure descriptors related to the homogeneity of the urban layout, and the uniformity texture descriptor were all statistically significant. Areas with higher homicide rates tended to have higher local variation and less general homogeneity; that is, the urban layouts were more crowded and cluttered, with small dwellings with different roofing materials located in close proximity to one another, and these regions often lacked other homogeneous surfaces such as open green spaces, wide roads, or large facilities. These results seem to be in agreement with the broken windows theory and CPTED in the sense that more heterogeneous and disordered urban layouts are associated with higher homicide rates.This research was made possible by funding from EAFIT University (EAFIT-435-000060) and the Medellin City Hall EnlazaMundos program. The authors thank the anonymous reviewers and Hermilson Velazquez, Andr es Ramírez Hassan and Gustavo Canavire for their insightful observations and suggestions during the different stages of this projectPatiño Quinchía, JE.; Duque, JC.; Pardo Pascual, JE.; Ruiz Fernández, LÁ. (2014). Using remote sensing to assess the relationship between crime and the urban layout. Applied Geography. 55:48-60. https://doi.org/10.1016/j.apgeog.2014.08.016S48605

The CARMENES search for exoplanets around M dwarfs. Stellar atmospheric parameters of target stars with STEPARSYN

We determined effective temperatures, surface gravities, and metallicities for a sample of 343 M dwarfs observed with CARMENES, the double-channel, high-resolution spectrograph installed at the 3.5 m telescope at Calar Alto Observatory. We employed STEPARSYN, a Bayesian spectral synthesis implementation particularly designed to infer the stellar atmospheric parameters of late-type stars following a Markov chain Monte Carlo approach. We made use of the BT-Settl model atmospheres and the radiative transfer code turbospectrum to compute a grid of synthetic spectra around 75 magnetically insensitive Fe I and Ti I lines plus the TiO γ and ∈ bands. To avoid any potential degeneracy in the parameter space, we imposed Bayesian priors on Teff and logg based on the comprehensive, multi-band photometric data available for the sample. We find that this methodology is suitable down to M7.0 V, where refractory metals such as Ti are expected to condense in the stellar photospheres. The derived Teff, logg, and [Fe/H] range from 3000 to 4200 K, 4.5 to 5.3 dex, and -0.7 to 0.2 dex, respectively. Although our Teff scale is in good agreement with the literature, we report large discrepancies in the [Fe/H] scales, which might arise from the different methodologies and sets of lines considered. However, our [Fe/H] is in agreement with the metallicity distribution of FGK-type stars in the solar neighbourhood and correlates well with the kinematic membership of the targets in the Galactic populations. Lastly, excellent agreement in Teff is found for M dwarfs with interferometric angular diameter measurements, as well as in the [Fe/H] between the components in the wide physical FGK+M and M+M systems included in our sample. © 2021 ESO.CARMENES is an instrument for the Centro Astronomico Hispano en Andalucia at Calar Alto (CAHA). CARMENES is funded by the German Max-Plank Gesellschaft (MPG), the Spanish Consejo Superior de Investigaciones Cientificas (CSIC), the European Union through FEDER/ERF FICTS-2011-02 funds, and the members of the CARMENES Consortium (Max-Plank-Institut fur Astronomie, Instituto de Astrofisica de Andalucia, Landessternwarte Konigstuhl, Institut de Ciences de l'Espai, Institut fur Astrophysik Gottingen, Universidad Complutense de Madrid, Thuringer Landessternwarte Tautenberg, Instituto de Astrofisica de Canarias, Hamburger Sternwarte, Centro de Astrobiologia and Centro Astronomico Hispano-Andaluz), with additional contributions by the Spanish Ministry of Economy, the German Science Foundation through the Major Research Instrumentation Programme and DFG Research Unit FOR2544 "Blue Planets around Red Stars", the Klaus Tschira Stiftung, the states of BadenWurttemberg and Niedersachsen, and by the Junta de Andalucia. The authors acknowledge financial support from the Fundação para a Ciência e a Tecnologia (FCT) through the research grants UID/FIS/04434/2019, UIDB/04434/2020 and UIDP/04434/2020, national funds PTDC/FIS-AST/28953/2017, by FEDER (Fundo Europeu de Desenvolvimento Regional) through COMPETE2020 Programa Operacional Competitividade e Internacionalizacao (POCI-01-0145FEDER-028953), and the Spanish Ministerio de Ciencia, Innovacion y Universidades, Ministerio de Economia y Competitividad, the Universidad Complutense de Madrid, and the Fondo Europeo de Desarrollo Regional (FEDER/ERF) through fellowship FPU15/01476, and projects AYA2016-79425-C3-1/2/3-P, PID2019-109522GB-C5[1:4]/AEI/10.13039/501100011033, AYA2014-56359-P, BES-2017-080769, and RYC-2013-14875. The authors also acknowledge financial support from the Centre of Excellence "Severo Ochoa" and "Maria de Maeztu" awards to the Instituto de Astrofisica de Canarias (SEV-2015-0548), Instituto de Astrofisica de Andalucia (SEV-2017-0709), and Centro de Astrobiologia (MDM-2017-0737), and the Generalitat de Catalunya/CERCA programme. This work has made use of the VALD database, operated at Uppsala University, the Institute of Astronomy RAS in Moscow, and the University of Vienna, and of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium).Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. V.M.P. acknowledges financial support from NASA through grant NNX17AG24G. S.V.J. acknowledges the support of the DFG priority program SPP 1992 "Exploring the Diversity of Extrasolar Planets" (JE 701/5-1). E.M. would also like to warmly thank the staff at the Hamburger Sternwarte for their hospitality during his stay funded by project EST18/00162. Based on data from the CARMENES data archive at CAB (INTA-CSIC).Peer reviewe

Immediate vs. deferred switching from a boosted protease inhibitor (PI/r) based regimen to a Dolutegravir (DTG) based regimen in virologically suppressed patients with high cardiovascular risk or Age ≥50 years: final 96 weeks results of NEAT 022 study

Background Both immediate and deferred switching from a ritonavir-boosted protease inhibitor (PI/r)–based regimen to a dolutegravir (DTG)–based regimen may improve lipid profile. Methods European Network for AIDS Treatment 022 Study (NEAT022) is a European, open-label, randomized trial. Human immunodeficiency virus (HIV)–infected adults aged ≥50 years or with a Framingham score ≥10% were eligible if HIV RNA was <50 copies/mL. Patients were randomized to switch from PI/r to DTG immediately (DTG-I) or to deferred switch at week 48 (DTG-D). Week 96 endpoints were proportion of patients with HIV RNA <50 copies/mL, percentage change of lipid fractions, and adverse events (AEs). Results Four hundred fifteen patients were randomized: 205 to DTG-I and 210 DTG-D. The primary objective of noninferiority at week 48 was met. At week 96, treatment success rate was 92.2% in the DTG-I arm and 87% in the DTG-D arm (difference, 5.2% [95% confidence interval, –.6% to 11%]). There were 5 virological failures in the DTG-I arm and 5 (1 while on PI/r and 4 after switching to DTG) in the DTG-D arm without selection of resistance mutations. There was no significant difference in terms of grade 3 or 4 AEs or treatment-modifying AEs. Total cholesterol and other lipid fractions (except high-density lipoprotein) significantly (P < .001) improved both after immediate and deferred switching to DTG overall and regardless of baseline PI/r strata. Conclusions Both immediate and deferred switching from a PI/r to a DTG regimen in virologically suppressed HIV-infected patients ≥50 years old or with a Framingham score ≥10% was highly efficacious and well tolerated, and improved the lipid profile

The CARMENES search for exoplanets around M dwarfs

Context. The CARMENES instrument, installed at the 3.5 m telescope of the Calar Alto Observatory in Almería, Spain, was conceived to deliver high-accuracy radial velocity (RV) measurements with long-term stability to search for temperate rocky planets around a sample of nearby cool stars. Moreover, the broad wavelength coverage was designed to provide a range of stellar activity indicators to assess the nature of potential RV signals and to provide valuable spectral information to help characterise the stellar targets. Aims: We describe the CARMENES guaranteed time observations (GTO), spanning from 2016 to 2020, during which 19 633 spectra for a sample of 362 targets were collected. We present the CARMENES Data Release 1 (DR1), which makes public all observations obtained during the GTO of the CARMENES survey. Methods: The CARMENES survey target selection was aimed at minimising biases, and about 70% of all known M dwarfs within 10 pc and accessible from Calar Alto were included. The data were pipeline-processed, and high-level data products, including 18 642 precise RVs for 345 targets, were derived. Time series data of spectroscopic activity indicators were also obtained. Results: We discuss the characteristics of the CARMENES data, the statistical properties of the stellar sample, and the spectroscopic measurements. We show examples of the use of CARMENES data and provide a contextual view of the exoplanet population revealed by the survey, including 33 new planets, 17 re-analysed planets, and 26 confirmed planets from transiting candidate follow-up. A subsample of 238 targets was used to derive updated planet occurrence rates, yielding an overall average of 1.44 ± 0.20 planets with 1 M⊕ &lt; Mpl sin i &lt; 1000 M⊕ and 1 day &lt; Porb &lt; 1000 days per star, and indicating that nearly every M dwarf hosts at least one planet. All the DR1 raw data, pipeline-processed data, and high-level data products are publicly available online. Conclusions: CARMENES data have proven very useful for identifying and measuring planetary companions. They are also suitable for a variety of additional applications, such as the determination of stellar fundamental and atmospheric properties, the characterisation of stellar activity, and the study of exoplanet atmospheres

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Accuracy assessment of GE image classification results.

<p>Accuracy assessment of GE image classification results.</p

Regression coefficients.

<p>Regression coefficients.</p

Partial dependence plots for the four most relevant variables (Gradient Boost Regressor): RSF, percentage of vegetation and water, and RMM.

<p>Partial dependence plots for the four most relevant variables (Gradient Boost Regressor): RSF, percentage of vegetation and water, and RMM.</p

Rotated factor loadings (orthogonal Varimax rotation) of image spectral, texture and structure variables.

<p>Rotated factor loadings (orthogonal Varimax rotation) of image spectral, texture and structure variables.</p

Location of Liverpool city and LED index values at LSOA level, shown over a Stamen Terrain base map (base map tiles by Stamen Design, under a CC BY 3.0, data by OpenStreetMap, under CC BY SA).

<p>Location of Liverpool city and LED index values at LSOA level, shown over a Stamen Terrain base map (base map tiles by Stamen Design, under a CC BY 3.0, data by OpenStreetMap, under CC BY SA).</p