AN EFFECT OF SPORT ON INDIAN ECONOMY AND SOCIETY

The prime motive of this Research study is to understand and measure the impact of Sports on the Indian Economy and Society. According to this research the sport works as a tool for improvement and betterment of the Society. All the theoretical and statistical data required for the present study is collected by using various Primary and Secondary Sources of the Data. The statistical information required is collected by administering Closed Ended Questionnaires to the peoples living in Pune District and the theoretical information required is collected through various Reference Books, Journals, Websites, Newspapers, Magazines, Research Papers, Theses etc. After collecting the necessary data, it is analyzed with the help of MS-Excel Software. From this study is found that most of the respondents plays sports because they want to gain new skills (Mean-2.65)

CUSTOMER RELATIONSHIP MANAGEMENT IN BANKING SECTOR: A STUDY

In India as well as world banking system is the core of all financial activities including lending and depositing money, providing loans to institutions and private players and institutions. Intoday’s competitive scenario, companies pursuit for consumers to satisfy them in every respect and offer them the best services.†Customer is everything “is the new realization of every profit – making company because they are the revenue and profits. This paper helps to understand the concept and meaning of CRM, current scenario in Indian Banking System and also enables the researcher to know the steps involved in implementation of CRM in Banking Sector. This Paper also tried to identify the factors influencing the Customer Relationship Management practices (CRM) in Bank in Pune District. Total 250 samples were taken and correlation and mean scores were calculated to analyze the data

Effect of crystallographic orientation on the pitting corrosion resistance of laser surface melted AISI 304L austenitic stainless steel

The localized corrosion behavior of laser surface melted 304L austenitic stainless steel was studied by potentiodynamic polarization test. The extent of improvement in corrosion resistance was governed by the preferred orientation and the percentage of delta ferrite present on the surface of the laser melted sample. It was established by orientation imaging microscopy that the highest pitting potential value was obtained when grains were oriented in the most close- packed [101] direction compared to the random distribution of the base metal and other laser surface melted samples oriented in [001] direction. The sample with lower percentage of ferrite had good pitting resistance

Impact of Cardiovascular Diseases on the Outcome of Patients with COVID-19

The prevalence of COVID 19 disease cases in India stands too high; this disease is caused by the coronavirus called SARS-CoV-2. Noval coronavirus virus was firstly detected in a group of people suffering from Pneumonia in Wuhan, China. Several studies are conducted to understand the different aspects of novel coronavirus SARS-CoV-2 in causing severe respiratory infections. However, the impact of risk factors on the severity of the symptoms and outcome of COVID 19 is not clearly understood. Similarly, most studies reported that patients who suffer from comorbidities with COVID 19 had a poor prognosis. Most COVID 19 patients who had preexisting medical conditions such as hypertension, diabetes, obesity, smoking habit, etc., required ICU admission and mechanical ventilation. On the other hand, studies reported that COVID 19 infection is responsible for causing the predominant cardiovascular diseases due to myocardial damage, thromboembolism arrhythmias, and ACS

Synthesis of Modified Peptidoglycan Precursor Analogues for the Inhibition of Glycosyltransferase.

The peptidoglycan glycosyltransferases (GTs) are essential enzymes that catalyze the polymerization of glycan chains of the bacterial cell wall from lipid II and thus constitute a validated antibacterial target. Their enzymatic cavity is composed of a donor site for the growing glycan chain (where the inhibitor moenomycin binds) and an acceptor site for lipid II substrate. In order to find lead inhibitors able to fill this large active site, we have synthesized a series of substrate analogues of lipid I and lipid II with variations in the lipid, the pyrophosphate, and the peptide moieties and evaluated their biological effect on the GT activity of E. coli PBP1b and their antibacterial potential. We found several compounds able to inhibit the GT activity in vitro and cause growth defect in Bacillus subtilis . The more active was C16-phosphoglycerate-MurNAc-(l-Ala-d-Glu)-GlcNAc, which also showed antibacterial activity. These molecules are promising leads for the design of new antibacterial GT inhibitors

Response of nutrient management practices through organic substances on rice var. GR-11 in North Konkan Coastal zone of Maharashtra

The management of soil organic matter is crucial to maintain a productive organic farming system. No one source of nutrient usually fulfills to maintain productivity and quality control in organic system.In addition, the inputs to supplement nutrient availability are often not uniform presenting additional challenges in meeting the nutrient requirements of crops in organic system.With this concept, a field experiment was conducted at the research farm of ASPEE Agricultural Research and Development Foundation, Tansa Farm, At Nare, Taluka Wada, Dist. Palghar, Maharashtra, during Kharif 2016-17 in rice.Different treatments comprising organic amendments such as Azotobacter, Banana Pseudostem sap 2%, Vermiwash 2% and Panchgavya 2% each applied alone or in all possible combinations were tried in organic crop production.These treatments were compared with absolute control (No biofertilizer+ No Spray). Recommended dose of chemical fertilizer 100:50:50 kg NPK ha-1. A Rice variety ‘GR-11\u27 was taken.Results revealed a significant enhancement in grain yield of rice over absolute control due to the application of different organic amendments applied alone or in combinations. Rice grain yield increased by 35.5% over absolute control when organic amendments viz., Seedling deep in Azotobacter + Vermiwash 2% + Banana Pseudostem Sap 2% were applied together.The rice grain yield (5.7 t ha-1) obtained under combined application of above three organic amendments was at par with the yield recorded under seedling deep in Azotobacter + Vermiwash 2% + Panchgavya 2%.An interesting observation recorded was that there was no serious attack of any insects pest or disease in organically grown crop.The study revealed that addition of four organic amendments viz. seedling deep in Azotobacter, vermiwash 2%, Panchgavya 2% and Banana Pseudostem Sap 2% could give the optimum yield of organic rice var. GR-11

Critical-Sized Bone Defects: Sequence and Planning.

Bone defects associated with open fractures require a careful approach and planning. At initial presentation, an emergent irrigation and debridement is required. Immediate definitive fixation is frequently safe, with the exception of those injuries that normally require staged management or very severe type IIIB and IIIC injuries. Traumatic wounds that can be approximated primarily should be closed at the time of initial presentation. Wounds that cannot be closed should have a negative pressure wound therapy dressing applied. The need for subsequent debridements remains a clinical judgment, but all nonviable tissue should be removed before definitive coverage. Cefazolin remains the standard of care for all open fractures, and type III injuries also require gram-negative coverage. Both induced membrane technique with staged bone grafting and distraction osteogenesis are excellent options for bony reconstruction. Soft tissue coverage within 1 week of injury seems critical

Microwave Hydrothermal Carbonization of Rice Straw: Optimization of Process Parameters and Upgrading of Chemical, Fuel, Structural and Thermal Properties.

The process parameters of microwave-induced hydrothermal carbonization (MIHTC) play an important role on the hydrothermal chars (hydrochar) yield. The effect of reaction temperature, reaction time, particle size and biomass to water ratio was optimized for hydrochar yield by modeling using the central composite design (CCD). Further, the rice straw and hydrochar at optimum conditions have been characterized for energy, chemical, structural and thermal properties. The optimum condition for hydrochar synthesis was found to be at a 180 °C reaction temperature, a 20 min reaction time, a 1:15 weight per volume (w/v) biomass to water ratio and a 3 mm particle size, yielding 57.9% of hydrochar. The higher heating value (HHV), carbon content and fixed carbon values increased from 12.3 MJ/kg, 37.19% and 14.37% for rice straw to 17.6 MJ/kg, 48.8% and 35.4% for hydrochar. The porosity, crystallinity and thermal stability of the hydrochar were improved remarkably compared to rice straw after MIHTC. Two characteristic peaks from XRD were observed at 2? of 15° and 26°, whereas DTG peaks were observed at 50?150 °C and 300?350 °C for both the materials. Based on the results, it can be suggested that the hydrochar could be potentially used for adsorption, carbon sequestration, energy and agriculture applications

Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers

Although several synthetic or xenobiotic nucleic acids (XNAs) have been shown to be viable genetic materials in vitro, major hurdles remain for their in vivo applications, particularly orthogonality. The availability of XNAs that do not interact with natural nucleic acids and are not affected by natural DNA processing enzymes, as well as specialized XNA processing enzymes that do not interact with natural nucleic acids, is essential. Here, we report 3′–2′ phosphonomethyl-threosyl nucleic acid (tPhoNA) as a novel XNA genetic material and a prime candidate for in vivo XNA applications. We established routes for the chemical synthesis of phosphonate nucleic acids and phosphorylated monomeric building blocks, and we demonstrated that DNA duplexes were destabilized upon replacement with tPhoNA. We engineered a novel tPhoNA synthetase enzyme and, with a previously reported XNA reverse transcriptase, demonstrated that tPhoNA is a viable genetic material (with an aggregate error rate of approximately 17 × 10–3 per base) compatible with the isolation of functional XNAs. In vivo experiments to test tPhoNA orthogonality showed that the E. coli cellular machinery had only very limited potential to access genetic information in tPhoNA. Our work is the first report of a synthetic genetic material modified in both sugar and phosphate backbone moieties and represents a significant advance in biorthogonality toward the introduction of XNA systems in vivo

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases

Six 1′,5′-anhydrohexitol uridine triphosphates were synthesized with aromatic substitutions appended via a carboxamide linker to the 5-position of their bases. An improved method for obtaining such 5-substituted hexitol nucleosides and nucleotides is described. The incorporation profile of the nucleotide analogues into a DNA duplex overhang using recently evolved XNA polymerases is compared. Long, mixed HNA sequences featuring the base modifications are generated. The apparent binding affinity of four of the nucleotides to the enzyme, the rate of the chemical step and of product release, plus the specificity constant for the incorporation of these modified nucleotides into a DNA duplex overhang using the HNA polymerase T6G12_I521L are determined via pre-steady-state kinetics. HNA polymers displaying aromatic functional groups could have significant impact on the isolation of stable and high-affinity binders and catalysts, or on the design of nanomaterials