12 research outputs found
Dark Matter Searches with the ANTARES Neutrino Telescope
[EN] The MOSCAB experiment (Materia OSCura A Bolle) uses the Geyser technique for dark matter search. The results of the first 0.5 kg mass prototype detector using superheated C3F8 liquid were very encouraging, achieving a 5 keV nuclear recoil threshold with high insensitivity to gamma radiation. Additionally, the technique seems to be easily scalable to higher masses for both in terms of complexity and costs, resulting in a very competitive technique for direct dark matter search, especially for the spin dependent case. Here, we report as well in the construction and commissioning of the big detector of 40 kg at the Milano-Bicocca University. The detector, the calibration tests and the evaluation of the background will be presented. Once demonstrated the functionality of the detector, it will be operated at the Gran Sasso National Laboratory in 2015.We acknowledge the financial support of the Spanish Ministerio de Ciencia e Innovación (MICINN) and Ministerio de Economía y Competitividad (MINECO), Grants FPA2012-37528-C02-02, and Consolider MultiDark CSD2009-00064, and of the Generalitat Valenciana, Grants ACOMP/2014/153 and PrometeoII/2014/079.Ardid Ramírez, M. (2016). Dark Matter Searches with the ANTARES Neutrino Telescope. Nuclear and Particle Physics Proceedings. 273:378-382. https://doi.org/10.1016/j.nuclphysbps.2015.09.054S37838227
The ANTARES Optical Module
The ANTARES collaboration is building a deep sea neutrino telescope in the
Mediterranean Sea. This detector will cover a sensitive area of typically 0.1
km-squared and will be equipped with about 1000 optical modules. Each of these
optical modules consists of a large area photomultiplier and its associated
electronics housed in a pressure resistant glass sphere. The design of the
ANTARES optical module, which is a key element of the detector, has been
finalized following extensive R & D studies and is reviewed here in detail.Comment: 26 pages, 15 figures, to be published in NI
Centrosome abnormalities are frequently observed in non-small-cell lung cancer and are associated with aneuploidy and cyclin E overexpression
Centrosome abnormalities are observed in human cancers and have been
associated with aneuploidy, a driving force in tumour progression.
However, the exact pathways that tend to cause centrosome abnormalities
have not been fully elucidated in human tumours. Using a series of 68
non-small-cell lung carcinomas and an array of in vitro experiments, the
relationship between centrosome abnormalities, aneuploidy, and the
status of key G1 to S-phase transition cell-cycle molecules, involved in
the regulation of centrosome duplication, was investigated. Centrosome
amplification and structural abnormalities were common (53%), were
strongly related to aneuploidy, and, surprisingly, were even seen in
adjacent hyperplastic regions, suggesting the possibility that these are
early lesions in lung carcinogenesis. Cyclin E and E2F1 overexpression,
but not p53 mutation, was observed to correlate with centrosome
abnormalities in vivo (p = 0.029 andp = 0.015, respectively). This was
further strengthened by the observation that cyclin E was specifically
present in the nucleus and/or cytoplasm of the cells that contained
centrosome aberrations. The cytoplasmic cyclin E signal may be
attributed, in part, to the presence of truncated low-molecularweight
isoforms of cyclin E. In order to isolate the effect of cyclin E on the
appearance of centrosome abnormalities, a U20S tetracycline-repressible
cyclin E cell line that has a normal centrosome profile by default was
used. With this system, it was confirmed in vitro that persistent cyclin
E overexpression is sufficient to cause the appearance of centrosome
abnormalities. Copyright (c) 2006 Pathological Society of Great Britain
and Ireland. Published by John Wiley & Sons, Ltd
Immunocytological and Preliminary Immunohistochemical Studies of Prothymosin α, a Human Cancer–associated Polypeptide, With a Well-characterized Polyclonal Antibody
Prothymosin α (ProTα) is a nuclear polypeptide of great biological and, possibly clinical, importance, because its expression levels have been associated with early diagnosis/prognosis of human cancer. It is therefore interesting to raise easily available and cost-effective antibodies that would be applied to develop reliable ProTα immunodiagnostics. In this study, New Zealand white rabbits and laying hens were parallel immunized against intact ProTα or the synthetic fragments ProTα[1-28], ProTα[87-109], and ProTα[101-109], all conjugated to keyhole limpet hemocyanin (KLH). The corresponding antibodies G and Y were immunochemically evaluated in parallel with ELISA and Western blot systems and applied to fluorescence immunocytology experiments using various cancer cell lines and normal cells. The antibody G raised against ProTα[101-109]/KLH had excellent functional characteristics in the Western blot and immunocytology experiments, where the fluorescent signal was almost exclusively shown in the cell nucleus independently of the cells assayed. The above antibody has been applied to preliminary IHC staining of human cancer prostate tissues, leading to a high percentage of clearly and intensively stained nuclei in the adenocarcinoma tissue; this antibody can be further used in cancer tissue immunostaining and in research concerning the role of ProTα in tumorigenesis. (J Histochem Cytochem 56:1023–1031, 2008
The ANTARES optical module
The ANTARES collaboration is building a deep sea neutrino telescope in the Mediterranean Sea. This detector will cover a sensitive area of typically 0.1 km2 and will be equipped with about 1000 optical modules. Each of these optical modules consists of a large area photomultiplier and its associated electronics housed in a pressure resistant glass sphere. The design of the ANTARES optical module, which is a key element of the detector, has been finalized following extensive R&D studies and is reviewed here in detail. © 2001 Elsevier Science B.V. All rights reserved
Transmission of light in deep sea water at the site of the ANTARES neutrino telescope
The Antares neutrino telescope is a large photomultiplier array designed to detect neutrino-induced upward-going muons by their Cherenkov radiation. Understanding the absorption and scattering of light in the deep Mediterranean is fundamental to optimising the design and performance of the detector. This paper presents measurements of blue and UV light transmission at the Antares site taken between 1997 and 2000. The derived values for the scattering length and the angular distribution of particulate scattering were found to be highly correlated, and results are therefore presented in terms of an absorption length λabs and an effective scattering length λscteff. The values for blue (UV) light are found to be λabs ≃ 60(26) m, λscteff ≃ 265(122)m , with significant (∼15%) time variability. Finally, the results of A ntares simulations showing the effect of these water properties on the anticipated performance of the detector are presented. © 2004 Elsevier B.V. All rights reserved