189 research outputs found
Finite element model to simulate impact on a soft tissue simulant
A finite element model of an impact test on a soft tissue simulant, used as part of a shoulder surrogate, was developed in Ansys© LS-DYNA®. The surrogate consisted of a metal hemicylindrical core, with a diameter of 75 mm, covered with a 15 mm thick relaxed muscle simulant. The muscle simulant consisted of a 14 mm thick layer of silicone covered with 1 mm thick chamois leather to represent skin. The material properties of the silicone were obtained via quasi-static compression testing (curve fit with hyperelastic models) and compressive stress relaxation testing (curve fit with a Prony series). Outputs of the finite element models were compared against experimental data from impact tests on the shoulder surrogate at energies of 4.9, 9.8 and 14.7 J. The accuracy of the finite element models was assessed using four parameters: peak impact force, maximum deformation, impact duration and impulse. A 5-parameter Mooney-Rivlin material model combined with a 2-term Prony series was found to be suitable for modelling the soft tissue simulant of the shoulder surrogate. This model had under 10% overall mean deviation from the experimental values for the four assessment parameters across the three impact energies. Overall, the model provided a repeatable test method that can be adapted to help predict injuries to skin tissue and the performance/efficacy of personal protective equipment
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Optimized, Competitive Supercritical-CO2 Cycle GFR for Gen IV Service
An overall plant design was developed for a gas-cooled fast reactor employing a direct supercritical Brayton power conversion system. The most important findings were that (1) the concept could be capital-cost competitive, but startup fuel cycle costs are penalized by the low core power density, specified in large part to satisfy the goal of significatn post-accident passive natural convection cooling; (2) active decay heat removal is preferable as the first line of defense, with passive performance in a backup role; (3) an innovative tube-in-duct fuel assembly, vented to the primpary coolant, appears to be practicable; and (4) use of the S-Co2 GFR to support hydrogen production is a synergistic application, since sufficient energy can be recuperated from the product H2 and 02 to allow the electrolysis cell to run 250 C hotter than the reactor coolant, and the water boilers can be used for reactor decay heat removal. Increasing core poer density is identified as the top priority for future work on GFRs of this type
Parity nonconservation in deuteron photoreactions
We calculate the asymmetries in parity nonconserving deuteron
photodisintegration due to circularly polarized photons gamma+d to n+p with the
photon laboratory energy ranging from the threshold up to 10 MeV and the
radiative capture of thermal polarized neutrons by protons n+p to gamma+d. We
use the leading order electromagnetic Hamiltonian neglecting the smaller
nuclear exchange currents. Comparative calculations are done by using the
Reid93 and Argonne v18 potentials for the strong interaction and the DDH and
FCDH "best" values for the weak couplings in a weak one-meson exchange
potential. A weak NDelta transition potential is used to incorporate also the
Delta(1232)-isobar excitation in the coupled-channels formalism.Comment: 14 pages, 13 figures (18 eps files), LaTeX2
Parity Violation in Proton-Proton Scattering at 221 MeV
TRIUMF experiment 497 has measured the parity violating longitudinal
analyzing power, A_z, in pp elastic scattering at 221.3 MeV incident proton
energy. This paper includes details of the corrections, some of magnitude
comparable to A_z itself, required to arrive at the final result. The largest
correction was for the effects of first moments of transverse polarization. The
addition of the result, A_z=(0.84 \pm 0.29 (stat.) \pm 0.17 (syst.)) \times
10^{-7}, to the pp parity violation experimental data base greatly improves the
experimental constraints on the weak meson-nucleon coupling constants
h^{pp}_\rho and h^{pp}_\omega, and has implications for the interpretation of
electron parity violation experiments.Comment: 17 pages RevTeX, 14 PostScript figures. Revised version with
additions suggested by Phys. Rev.
CDMS, Supersymmetry and Extra Dimensions
The CDMS experiment aims to directly detect massive, cold dark matter
particles originating from the Milky Way halo. Charge and lattice excitations
are detected after a particle scatters in a Ge or Si crystal kept at ~30 mK,
allowing to separate nuclear recoils from the dominating electromagnetic
background. The operation of 12 detectors in the Soudan mine for 75 live days
in 2004 delivered no evidence for a signal, yielding stringent limits on dark
matter candidates from supersymmetry and universal extra dimensions. Thirty Ge
and Si detectors are presently installed in the Soudan cryostat, and operating
at base temperature. The run scheduled to start in 2006 is expected to yield a
one order of magnitude increase in dark matter sensitivity.Comment: To be published in the proceedings of the 7th UCLA symposium on
sources and detection of dark matter and dark energy in the universe, Marina
del Rey, Feb 22-24, 200
Structural and Biochemical Evaluation of the Interaction of the Phosphatidylinositol 3-Kinase p85a Src Homology 2 Domains with Phosphoinositides and Inositol Polyphosphates
Macromolecular Biochemistr
Nuclear Parity-Violation in Effective Field Theory
We reformulate the analysis of nuclear parity-violation (PV) within the
framework of effective field theory (EFT). To order Q, the PV nucleon-nucleon
(NN) interaction depends on five a priori unknown constants that parameterize
the leading-order, short-range four-nucleon operators. When pions are included
as explicit degrees of freedom, the potential contains additional medium- and
long-range components parameterized by PV piNN couplings. We derive the form of
the corresponding one- and two-pion-exchange potentials. We apply these
considerations to a set of existing and prospective PV few-body measurements
that may be used to determine the five independent low-energy constants
relevant to the pionless EFT and the additional constants associated with
dynamical pions. We also discuss the relationship between the conventional
meson-exchange framework and the EFT formulation, and argue that the latter
provides a more general and systematic basis for analyzing nuclear PV.Comment: 67 Page Latex file with typos correcte
Genomic and Genic Deletions of the FOX Gene Cluster on 16q24.1 and Inactivating Mutations of FOXF1 Cause Alveolar Capillary Dysplasia and Other Malformations
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare, neonatally lethal developmental disorder of the lung with defining histologic abnormalities typically associated with multiple congenital anomalies (MCA). Using array CGH analysis, we have identified six overlapping microdeletions encompassing the FOX transcription factor gene cluster in chromosome 16q24.1q24.2 in patients with ACD/MPV and MCA. Subsequently, we have identified four different heterozygous mutations (frameshift, nonsense, and no-stop) in the candidate FOXF1 gene in unrelated patients with sporadic ACD/MPV and MCA. Custom-designed, high-resolution microarray analysis of additional ACD/MPV samples revealed one microdeletion harboring FOXF1 and two distinct microdeletions upstream of FOXF1, implicating a position effect. DNA sequence analysis revealed that in six of nine deletions, both breakpoints occurred in the portions of Alu elements showing eight to 43 base pairs of perfect microhomology, suggesting replication error Microhomology-Mediated Break-Induced Replication (MMBIR)/Fork Stalling and Template Switching (FoSTeS) as a mechanism of their formation. In contrast to the association of point mutations in FOXF1 with bowel malrotation, microdeletions of FOXF1 were associated with hypoplastic left heart syndrome and gastrointestinal atresias, probably due to haploinsufficiency for the neighboring FOXC2 and FOXL1 genes. These differences reveal the phenotypic consequences of gene alterations in cis
ZMYND11‐related syndromic intellectual disability: 16 patients delineating and expanding the phenotypic spectrum
Pathogenic variants in ZMYND11, which acts as a transcriptional repressor, have been associated with intellectual disability, behavioural abnormalities and seizures. Only 11 affected individuals have been reported to‐date, and the phenotype associated with pathogenic variants in this gene have not been fully defined.
Here, we present 16 additional patients with predicted pathogenic heterozygous variants in ZMYND11, including four individuals from the same family, to further delineate and expand the genotypic and phenotypic spectrum of ZMYND11‐related syndromic intellectual disability. The associated phenotype includes developmental delay, particularly affecting speech, mild‐moderate intellectual disability, significant behavioural abnormalities, seizures, and hypotonia. There are subtle shared dysmorphic features, including prominent eyelashes and eyebrows, depressed nasal bridge with bulbous nasal tip, anteverted nares, thin vermilion of the upper lip and wide mouth. Novel features include brachydactyly and tooth enamel hypoplasia.
Most identified variants are likely to result in premature truncation and/or nonsense mediated decay. Two ZMYND11 variants located in the final exon ‐ p.(Gln586*) (likely escaping nonsense‐mediated decay) and p.(Cys574Arg) ‐ are predicted to disrupt the MYND‐type zinc finger motif and likely interfere with binding to its interaction partners. Hence, the homogeneous phenotype likely results from a common mechanism of loss‐of‐function
Comment on Spracklandus Hoser, 2009 (Reptilia, Serpentes, ELAPIDAE): request for confirmation of the availability of the generic name and for the nomenclatural validation of the journal in which it was published
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