False discovery rate analysis of brain diffusion direction maps

Diffusion tensor imaging (DTI) is a novel modality of magnetic resonance imaging that allows noninvasive mapping of the brain's white matter. A particular map derived from DTI measurements is a map of water principal diffusion directions, which are proxies for neural fiber directions. We consider a study in which diffusion direction maps were acquired for two groups of subjects. The objective of the analysis is to find regions of the brain in which the corresponding diffusion directions differ between the groups. This is attained by first computing a test statistic for the difference in direction at every brain location using a Watson model for directional data. Interesting locations are subsequently selected with control of the false discovery rate. More accurate modeling of the null distribution is obtained using an empirical null density based on the empirical distribution of the test statistics across the brain. Further, substantial improvements in power are achieved by local spatial averaging of the test statistic map. Although the focus is on one particular study and imaging technology, the proposed inference methods can be applied to other large scale simultaneous hypothesis testing problems with a continuous underlying spatial structure.Comment: Published in at http://dx.doi.org/10.1214/07-AOAS133 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Measurement of Noise Reduction from Acoustic Casing Treatments Installed Over a Subscale High Bypass Ratio Turbofan Rotor

NASA is continuing to develop over-the-rotor acoustic liners for turbofan applications. A series of low Technology Readiness Level experiments were conducted to better understand the acoustic and aerodynamic effects of these acoustic liners. The final experiment included the evaluation of four acoustic casing treatment concepts and two baseline configurations in an internal flow axial compressor facility with a 1.5 pressure-ratio high-bypass turbofan rotor. An inlet in-duct array was utilized to extract sound power levels propagating forward from the turbofan rotor. The effect of a circumferentially grooved relative to a hardwall fan case was found to reduce the in-duct sound power level by about 1.5dB for frequencies less than 2kHz while increasing noise from 4 to 8kHz by as much as 7.5dB at low fan speeds. The four acoustic treatment concepts were incorporated into the bottoms of the circumferential grooves and found to provide an additional 1 to 2dB sound power level reduction under 2kHz. The sound power level reduction was found to be even greater, 2.5 to 3.5dB, when evaluating the reduction on rotor alone duct modes (co-rotating modes). The acoustic treatments also appeared to reduce multiple pure tone noise at transonic fan speeds. Depending on the acoustic treatment concept, the high-frequency noise created by the circumferential grooves was reduced by 1.5 to 5 dB. The total noise reduction from acoustic treatments embedded into the bottoms of circumferential grooves relative to a hardwall baseline was found to be 2.5 to 3.5dB sound power level. The sound power level reduction for rotor alone (co-rotating) modes was found to be 3.5 to 4.5dB. These results show the potential for significant turbofan noise reduction by incorporating acoustic treatments over-the-rotor

Evaluating Varieties of Alfalfa and Tall Fescue for Tolerance to Over-Grazing by Cattle

Cultivars of alfalfa (Medicago sativa L.) and tall fescue (Festuca arundinacea Schreb.) were seeded in small (1.5 m x 4.6 m) plots and harvested for estimating yield the following spring. Plots were then grazed by cattle continuously for the remainder of the season so as to keep stand heights at 7.5 cm or less. This procedure was repeated for one or two more grazing seasons, depending on stand survival. Stands were visually rated for stand in the fall and spring. Marked differences in grazing tolerance were observed among alfalfa cultivars, following closely the commercial designations as grazing-type or hay-type alfalfa. Some cultivars of endophyte-free tall fescue were as grazing tolerant as endophyte-infected Kentucky 31 tall fescue

The <i>Castalia</i> mission to Main Belt Comet 133P/Elst-Pizarro

We describe Castalia, a proposed mission to rendezvous with a Main Belt Comet (MBC), 133P/Elst-Pizarro. MBCs are a recently discovered population of apparently icy bodies within the main asteroid belt between Mars and Jupiter, which may represent the remnants of the population which supplied the early Earth with water. Castalia will perform the first exploration of this population by characterising 133P in detail, solving the puzzle of the MBC’s activity, and making the first in situ measurements of water in the asteroid belt. In many ways a successor to ESA’s highly successful Rosetta mission, Castalia will allow direct comparison between very different classes of comet, including measuring critical isotope ratios, plasma and dust properties. It will also feature the first radar system to visit a minor body, mapping the ice in the interior. Castalia was proposed, in slightly different versions, to the ESA M4 and M5 calls within the Cosmic Vision programme. We describe the science motivation for the mission, the measurements required to achieve the scientific goals, and the proposed instrument payload and spacecraft to achieve these

First bounds on the high-energy emission from isolated Wolf-Rayet binary systems

High-energy gamma-ray emission is theoretically expected to arise in tight binary star systems (with high mass loss and high velocity winds), although the evidence of this relationship has proven to be elusive so far. Here we present the first bounds on this putative emission from isolated Wolf-Rayet (WR) star binaries, WR 147 and WR 146, obtained from observations with the MAGIC telescope.Comment: (Authors are the MAGIC Collaboration.) Manuscript in press at The Astrophysical Journal Letter

Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players

Importance: Microglia, the resident immune cells of the central nervous system, play an important role in the brain\u27s response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single and repeated traumatic brain injury, possibly through sports-related concussive and subconcussive injuries. Limited in vivo brain imaging studies months to years after individuals experience a single moderate to severe traumatic brain injury suggest widespread persistent microglial activation, but there has been little study of persistent glial cell activity in brains of athletes with sports-related traumatic brain injury. Objective: To measure translocator protein 18 kDa (TSPO), a marker of activated glial cell response, in a cohort of National Football League (NFL) players and control participants, and to report measures of white matter integrity. Design, Setting, and Participants: This cross-sectional, case-control study included young active (n = 4) or former (n = 10) NFL players recruited from across the United States, and 16 age-, sex-, highest educational level-, and body mass index-matched control participants. This study was conducted at an academic research institution in Baltimore, Maryland, from January 29, 2015, to February 18, 2016. Main Outcomes and Measures: Positron emission tomography-based regional measures of TSPO using [11C]DPA-713, diffusion tensor imaging measures of regional white matter integrity, regional volumes on structural magnetic resonance imaging, and neuropsychological performance. Results: The mean (SD) ages of the 14 NFL participants and 16 control participants were 31.3 (6.1) years and 27.6 (4.9) years, respectively. Players reported a mean (SD) of 7.0 (6.4) years (range, 1-21 years) since the last self-reported concussion. Using [11C]DPA-713 positron emission tomographic data from 12 active or former NFL players and 11 matched control participants, the NFL players showed higher total distribution volume in 8 of the 12 brain regions examined (P \u3c .004). We also observed limited change in white matter fractional anisotropy and mean diffusivity in 13 players compared with 15 control participants. In contrast, these young players did not differ from control participants in regional brain volumes or in neuropsychological performance. Conclusions and Relevance: The results suggest that localized brain injury and repair, indicated by higher TSPO signal and white matter changes, may be associated with NFL play. Further study is needed to confirm these findings and to determine whether TSPO signal and white matter changes in young NFL athletes are related to later onset of neuropsychiatric symptoms