Plan de responsabilidad social para la mejora de la compañía Alkosto

Anexo A E-Book de ética para la empresa Alkosto Link : https://editor-storage.reedsy.com/books/135368/exports/success/9355e084-0fb9- 4e34-9b07-28b4fe345e33/202004092354-codigo-de-etica-alkosto.zip Anexo B Diagnostico por observaciónLa empresa seleccionada es una cadena de tiendas en Colombia llamada Alkosto, se caracteriza por ser líder en el sector comercial compitiendo con sus precios bajos, además de comercializar todo tipo de elementos básicos para la satisfacción de una gran variedad de necesidades, por esto vemos una gran oportunidad en expandirnos enfocándonos para el año 2022 en tener mayor presencia a nivel nacional llevando a cada uno de nuestros clientes la mejor experiencia de compra para así fidelizarlos, esto iniciando desde varias de nuestras estrategias de marketing interno y externo, donde deseamos involucrar nuestros clientes y a su vez mejorar nuestra visibilidad mediante la potencialización de marketing digital y redes sociales que a su vez nos ayudara a disminuir publicidad física que genera desechos e impacto ambiental siendo eficaces en nuestro proceso de responsabilidad social, adicional buscamos generar inclusión y reconociendo a todas las personas que interactúen de manera directa o indirecta con la compañía impulsando una mejor calidad de vida, en aspectos económicos y ambientales mediante planes de acción que nos lleven a impactar positivamente y cumpliendo protocolos establecidos para nuestra excelencia, igualmente siempre enfocándonos en incentivar y organizar nuestro personal mediante las políticas de la compañía y cumplimiento estricto de normas para garantizar la calidad de nuestros productos, el buen funcionamiento de todos los almacenes y generando valores corporativos al personal encargado en todas las áreas, para alcanzar la excelencia en conjunto como compañía y transmitirla mediante la prestación de nuestros servicios logrando la satisfacción del cliente.The selected company is a chain of stores in Colombia called Alkosto, it is characterized by being a leader in the commercial sector competing with its low prices, in addition to marketing all kinds of basic elements to satisfy a wide variety of needs, for this we see a great opportunity to expand by focusing by 2022 on having a greater presence at the national level, bringing to each of our clients the best shopping experience in order to retain them, this starting from several of our internal and external marketing strategies, where we want to involve our clients and in turn improve our visibility through the enhancement of digital marketing and social networks that in turn will help us to reduce physical advertising that generates waste and environmental impact, being effective in our process of social responsibility, additionally we seek to generate inclusion and recognizing all people they interact man was direct or indirect with the company promoting a better quality of life, in economic and environmental aspects through action plans that lead us to positively impact and complying with established protocols for our excellence, also always focusing on incentivizing and organizing our personnel through the policies of the company and strict compliance with standards to guarantee the quality of our products, the proper functioning of all warehouses and generating corporate values for the personnel in charge in all areas, to achieve overall excellence as a company and transmit it through the provision of our services achieving customer satisfaction

MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment

Background: The bone marrow (BM) is the most common site of dissemination in patients with aggressive, metastatic neuroblastoma (NB). However, the molecular mechanisms underlying the aggressive behavior of NB cells in the BM niche are still greatly unknown. In the present study, we explored biological mechanisms that play a critical role in NB cell survival and progression in the BM and investigated potential therapeutic targets. Methods: Patient-derived bone marrow (BM) primary cultures were generated using fresh BM aspirates obtained from NB patients. NB cell lines were cultured in the presence of BM conditioned media containing cell-secreted factors, and under low oxygen levels (1% O2) to mimic specific features of the BM microenvironment of high-risk NB patients. The BM niche was explored using cytokine profiling assays, cell migration-invasion and viability assays, flow cytometry and analysis of RNA-sequencing data. Selective pharmacological inhibition of factors identified as potential mediators of NB progression within the BM niche was performed in vitro and in vivo. Results: We identified macrophage migration inhibitory factor (MIF) as a key inflammatory cytokine involved in BM infiltration. Cytokine profiling and RNA-sequencing data analysis revealed NB cells as the main source of MIF in the BM, suggesting a potential role of MIF in tumor invasion. Exposure of NB cells to BM-conditions increased NB cell-surface expression of the MIF receptor CXCR4, which was associated with increased cell viability, enhanced migration-invasion, and activation of PI3K/AKT and MAPK/ERK signaling pathways. Moreover, subcutaneous co-injection of NB and BM cells enhanced tumor engraftment in mice. MIF inhibition with 4-IPP impaired in vitro NB aggressiveness, and improved drug response while delayed NB growth, improving survival of the NB xenograft model. Conclusions: Our findings suggest that BM infiltration by NB cells may be mediated, in part, by MIF-CXCR4 signaling. We demonstrate the antitumor efficacy of MIF targeting in vitro and in vivo that could represent a novel therapeutic target for patients with disseminated high-risk NB

Evaluación de métodos para medir la actividad inhibitoria de extractos vegetales nativos del departamento de sucre sobre bacterias y levadura patógenas

The objective of this study was to evaluate the efficiency of two methods for measuring inhibitory activity of native ethanolic extracts plant of the Department of Sucre on bacteria and yeast human pathogenic. Sampling was conducted in the municipalities of Morroa and Sincelejo. The leaves of the plants Melia azederach, Sapium sp, Jatropha gossypilia, Psidium guajava, Origanum vulgare, Melissa officinalis, Eucalyptus sp and Cymbopogon citratus were processed using the methods of percolation and Soxhlet for the extraction of the extract. Methods were tested on agar hole method (Method 1) and the sensitive disk method (method 2) to measure the inhibitory effect on Pseudomonas aeruginosa, Klebsiella oxytoca, Enterococcus faecalis, Escherichia coli, and Bulkolderia glumaea Zygosaccharomyces microellipsoides. The results demonstrate that the method 2 allows greater efficiency and interpretation of results with regard to method 1 where there was diffusion of the extracts in the hole, which creates interference in the measurement. This is the first work in the department of Sucre where two methods are evaluated to determine inhibitory activity of a large group of native plants on pathogenic bacteria and yeast.El objetivo del presente trabajo fue evaluar la eficiencia de dos métodos para medir actividad inhibitoria de extractos vegetales etanólicos nativos del Departamento de Sucre sobre bacterias y levadura patógenas de humanos y plantas. Los muestreos se realizaron en los municipios de Morroa y Sincelejo. Las hojas de las plantas Melia Azederach, Sapium sp, Jatropha gossypilia, Psidium guajava, Origanum vulgare Melissa officinalis, Eucalyptus sp y Cymbopogon citratus fueron procesadas utilizando los métodos de percolación y de soxhlet para la extracción de los extractos. Se evaluaron los métodos de orificio sobre agar (método 1) y el método de disco sensitivos (método 2) para medir el efecto inhibitorio sobre Pseudomonas aeruginosa, Klebsiella oxytoca, Enterococcus faecalis, Escherichia coli, Bulkolderia glumaea y Zygosaccharomyces microellipsoides. Los resultados obtenidos demuestran que el método 2 permite una mayor eficacia e interpretación de los resultados con relación al método 1 donde se observó difusión de los extractos en el orificio, lo cual crea interferencia en la medición. Este es el primer trabajo en el departamento de Sucre donde se evalúan dos métodos para determinar actividad inhibitoria de un grupo amplio de plantas nativas sobre bacterias y levadura patógenas

Novel synthetic sulfoglycolipid IG20 facilitates exocytosis in chromaffin cells through the regulation of sodium channels

This is the peer reviewed version of the following article: Novel synthetic sulfoglycolipid IG20 facilitates exocytosis in chromaffin cells through the regulation of sodium channels: Journal of Neurochemistre, 135.5 (2015), which has been published in final form at http://dx.doi.org/10.1111/jnc.13357In searching for druggable synthetic lipids as potential modulators of synaptic transmission and plasticity, we synthesized sulfoglycolipid IG20 that stimulates neuritic outgrowth. Here we have explored its effects on ion channels and exocytosis in bovine chromaffin cells (BCCs). IG20 augmented the rate of basal catecholamine release. Such effect did not depend on Ca2+ mobilization from intracellular stores; rather, IG20-elicited secretion entirely dependent on Ca2+ entry through Lsubtype voltage-activated Ca2+ channels. Those channels were recruited by cell depolarization mediated by IG20 likely through its ability to enhance the recruitment of Na+ channels at more hyperpolarizing potentials. Confocal imaging with fluorescent derivative IG20-NBD revealed its rapid incorporation and confinement into the plasmalemma, supporting the idea that IG20 effects are exerted through a plasmalemmal-delimited mechanism. Thus, synthetic IG20 seems to mimic several physiological effects of endogenous lipids such as regulation of ion channels, Ca2+ signaling, and exocytosis. Therefore, sulfoglycolipid IG20 may become a pharmacological tool to investigate the role of the lipid environment on neuronal excitability, ion channels, neurotransmitter release, synaptic efficacy, and neuronal plasticity. It may also inspire the synthesis of druggable sulfoglycolipids aimed at increasing synaptic plasticity and efficacy in neurodegenerative diseases and traumatic brain – spinal cord injuryThis work was supported by grants from Ministerio de Economía y Competitividad, Spain (MINECO, SAF-2013-44108-P to AGG and LG; and FIS-PI11/01436 to AFM), Fundación Eugenio Rodríguez Pascual (to LG). We thank the continued support of Fundación Teófilo Hernando, Madrid, Spai

Diseño de metodologías online para asistir en la docencia de las prácticas de laboratorio de la asignatura de Física Aplicada a Farmacia

Objetivos propuestos en la presentación del proyecto: En este proyecto planteamos la realización de forma análoga de vídeos de las prácticas de la Asignatura de primero de Física Aplicada a Farmacia. De la experiencia del proyecto anterior (361) consideramos necesario implementar dos nuevos objetivos: 1. Adaptación de los materiales creados para la enseñanza en el sistema híbrido de docencia presencial-virtual 2. Ampliación de los contenidos que permitan la evaluación de las competencias adquiridas, así como para autoevaluación de los/as estudiantes. Además, seguiremos adaptando los contenidos a la plataforma nueva de Microsoft Teams y Google Meets y ayudando a la formación del profesorado universitario en competencias digitales, la innovación en recursos educativos en abierto y enseñanza virtual, el proceso de evaluación de la actividad docente e implementando la inserción laboral y el emprendimiento entre los estudiantes, así como, el fomento de una universidad inclusiva, accesible, diversa y enfocada a los objetivos de la Agenda 2030 para el desarrollo sostenible.Depto. de Química en Ciencias FarmacéuticasFac. de FarmaciaFALSEUniversidad Complutense de Madridsubmitte

Diseño de metodologías online para asistir en la docencia de las prácticas de laboratorio de la asignatura de Físico Química Farmacéutica

El proyecto de innovación docente realizó un diseño de metodologías online para asistir en la docencia de las prácticas de laboratorio de la asignatura de Físico Química Farmacéutica. Esta asignatura es obligatoria de segundo año del grado en Farmacia

Entramado productivo minero en San Juan. Herramientas de intervención desde un abordaje territorial.

Esta investigación es un proyecto de desarrollo tecnológico social (PDTS) orientado a generar por un lado, conocimiento sobre la dinámica socio-técnica de la principal actividad económica en la provincia y por otro, realizar propuestas innovadoras que aprovechen y fortalezcan las capacidades territoriales generadas y acumuladas por la minería en San Juan.EEA San JuanFil: Moscheni, Margarita. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Ureta, Adriana Alimé. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Checcarelli Pintor, Angelo Emmanuel. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Heredia Flores, Augusto Marcos. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: De la Torre, Delia Inés. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Funes Poblete, Eliana Gabriela. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Esquivel, Fabiana Eugenia. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Hernández, Juan Jesús. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Juan; ArgentinaFil: Neffa, Julio César. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: De los Ríos, Leonardo. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Doncel Ramallo, Lourdes Romina. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Perez, Marta Lidia. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Godoy, María Victoria. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Grimalt, Miguel. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Luna, Pedro. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Ortiz Flores, Renzo Federico. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; ArgentinaFil: Gili Diez, Valeria. Universidad Nacional de San Juan. Facultad de Ciencias Sociales; Argentin

Track A Basic Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138319/1/jia218438.pd

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700