Estrategia de gestion del conocimiento y actitud innovadora en empresas de Castilla-La Mancha: Un estudio exploratorio

This paper analyses, from a Knowledge-based View of the Firm, how companies formulate and implement their knowledge management strategies (KMS). Specifically, we try to explore if certain specific KMS patterns exist as a function of the established objectives, knowledge management tools that are used by the company, and the importance that it is given to certain strategic implementation aspects. Moreover, the study tries to identify particular innovative postures in firms related to the KMS that is developed and the existence of differences in relation to the financial performance achieved by these. A questionnaire was sent to a set of companies from the region of Castilla-La Mancha (Spain) in order to carry out the empirical study. The results of the study show the existence of significant differences in relation to the way that KMS are designed and implemented, as well as divergences in innovative postures and financial performance in these firms

The dependence of the sub-stellar IMF on the initial conditions for star formation

Abridged: We have undertaken a series of hydrodynamical simulations of multiple star formation in small turbulent molecular clouds. Our goal is to determine the sensitivity of the properties of the resulting stars and brown dwarfs to variations in the initial conditions imposed. In this paper we report on the results obtained by applying two different initial turbulent velocity fields. The slope of the turbulent power-law spectrum alpha is set to -3 in half of the calculations and to -5 in the other half. We find that, whereas the stellar mass function seems to only be weakly dependent on the value of alpha, the sub-stellar mass function turns out to be more sensitive to the initial slope of the velocity field. We argue that, since the role of turbulence is to create substructure from which gravitational instabilities may grow, variations in other initial conditions that also determine the fragmentation process are likely to affect the shape of the sub-stellar mass function as well. The absence of many planetary mass `free-floaters' in our simulations, especially in the mass range 1-10 MJ, suggests that, if these objects are abundant, they are likely to form by similar mechanisms to those thought to operate in quiescent accretion discs, instead of via instabilities in gravitationally unstable discs. Finally, we find that multiple and single stars share comparable kinematical properties, both populations being able to attain velocities in the range 1-10 km/s. From these values we draw the conclusion that only low-mass star-forming regions such as Taurus-Auriga or Ophiuchus, where the escape speed is low, might have suffered some depletion of its single and binary stellar population.Comment: 13 pages, 6 figures, accepted by MNRA

Evaluation of Aloe Vera Coated Polylactic Acid Scaffolds for Bone Tissue Engineering

3D-printed polylactic acid (PLA) scaffolds have been demonstrated as being a promising tool for the development of tissue-engineered replacements of bone. However, this material lacks a suitable surface chemistry to efficiently interact with extracellular proteins and, consequently, to integrate into the surrounding tissue when implanted in vivo. In this study, aloe vera coatings have been proposed as a strategy to improve the bioaffinity of this type of structures. Aloe vera coatings were applied at three different values of pH (3, 4 and 5), after treating the surface of the PLA scaffolds with oxygen plasma. The surface modification of the material has been assessed through X-ray photoelectron spectroscopy (XPS) analysis and water contact angle measurements. In addition, the evaluation of the enzymatic degradation of the structures showed that the pH of the aloe vera extracts used as coating influences the degradation rate of the PLA-based scaffolds. Finally, the cell metabolic activity of an in vitro culture of human fetal osteoblastic cells on the samples revealed an improvement of this parameter on aloe vera coated samples, especially for those treated at pH 3. Hence, these structures showed potential for being applied for bone tissue regeneration

A Hubble Space Telescope ACS Search for Brown Dwarf Binaries in the Pleiades Open Cluster

We present the results of a high-resolution imaging survey for brown dwarf binaries in the Pleiades open cluster. The observations were carried out with the Advance Camera for Surveys onboard the Hubble Space Telescope. Our sample consists of 15 bona-fide brown dwarfs. We confirm 2 binaries and detect their orbital motion, but we did not resolve any new binary candidates in the separation range between 5.4AU and 1700AU and masses in the range 0.035--0.065~Msun. Together with the results of our previous study (Martin et al., 2003), we can derive a visual binary frequency of 13.3$^{+13.7}_{-4.3}$\% for separations greater than 7~AU masses between 0.055--0.065~M_{\sun} and mass ratios between 0.45--0.9$<q<$1.0. The other observed properties of Pleiades brown dwarf binaries (distributions of separation and mass ratio) appear to be similar to their older counterparts in the field.Comment: 29 pages, 7 figures, 6 tables, accepted for publication in Ap

Efectos del acotamiento al pastoreo en pastizales de montaña de la Sierra del Segura (Albacete)

Fencing influence on overgrazed ranges of the Sierra del Segura is studied, over two fenced plots, during three years. An important increment of cover in herbaceous plants of elevated pastoral value, mainly perennial legumes, is observated. Uncovered soil ratio decreased by effect of fencing. Woody species of elevated pastoral value increment their cover. An important increment in floral richness and diversity is produced during the first year after fencing. Appearance species ratio decreased after the first year.Se estudia la influencia del acotamiento al pastoreo en pastizales esquilmados de la Sierra del Segura sobre dos parcelas acotadas y muestreadas tres años post-acotamiento. Se observa un importante incremento de cobertura en especies herbáceas de interés pastoral, principalmente de leguminosas vivaces, así como de la cobertura de suelo recubierto de vegetación. Las leñosas incrementan ligeramente su cobertura apareciendo diversas especies de interés pastoral. Se produce un importante incremento en la riqueza y diversidad florísticas durante el primer año post-acotamiento, ralentizándose posteriormente la tasa de aparición de especies

On the circum(sub)stellar environment of brown dwarfs in Taurus

Aims : We want to investigate whether brown dwarfs (BDs) form like stars or are ejected embryos. We study the presence of disks around BDs in the Taurus cloud, and discuss implications for substellar formation models. Methods : We use photometric measurements from the visible to the far infrared to determine the spectral energy distributions (SEDs) of Taurus BDs. Results: We use Spitzer color indices, Halpha as an accretion indicator, and models fit to the SEDs in order to estimate physical parameters of the disks around these BDs. We study the spatial distribution of BDs with and without disks across the Taurus aggregates, and we find that BDs with and without disks are not distributed regularly across the Taurus cloud. Conclusions: We find that 48%+/- 14% of Taurus BDs have a circumstellar disk signature, a ratio similar to recent results from previous authors in other regions. We fit the SEDs and find that none of the disks around BDs in Taurus can be fitted convincingly with a flaring index beta = 0, indicating that heating by the central object is efficient and that the disks we observe retain a significant amount of gas. We find that BDs with disks are proportionally more numerous in the northern Taurus filament, possibly the youngest filament. We do not find such a clear segregation for classical T Tauri stars (CTTS) and weak-lined T Tauri stars (WTTS), suggesting that, in addition to the effects of evolution, any segregation effects could be related to the mass of the object. A by-product of our study is to propose a recalibration of the Barrado y Navascues & Martin (2003) accretion limit in the substellar domain. The global shape of the limit fits our data points if it is raised by a factor 1.25-1.30.Comment: 11 pages, 5 figures, A&A accepte

Global and decomposition evolutionary support vector machine approaches for time series forecasting

Multi-step ahead Time Series Forecasting (TSF) is a key tool for support- ing tactical decisions (e.g., planning resources). Recently, the support vector machine emerged as a natural solution for TSF due to its nonlinear learning capabilities. This paper presents two novel Evolutionary Support Vector Machine (ESVM) methods for multi-step TSF. Both methods are based on an Estimation Distribution Algorithm (EDA) search engine that automatically performs a simultaneous variable (number of inputs) and model (hyperparameters) selection. The Global ESVM (GESVM) uses all past patterns to fit the support vector machine, while the Decomposition ESVM (DESVM) separates the series into trended and stationary effects, using a distinct ESVM to forecast each effect and then summing both predictions into a sin- gle response. Several experiments were held, using six time series. The proposed approaches were analyzed under two criteria and compared against a recent Evolu- tionary Artificial Neural Network (EANN) and two classical forecasting methods, Holt-Winters and ARIMA. Overall, the DESVM and GESVM obtained competitive and high quality results. Furthermore, both ESVM approaches consume much less computational effort when compared with EANN.The authors wish to thank Ramon Sagarna for introducing the subject of EDA. The work of P. Cortez was supported by FEDER (program COMPETE and FCT) under project FCOMP-01-0124-FEDER-022674

Exposure and impact of a mass media campaign targeting sexual health amongst Scottish men who have sex with men: an outcome evaluation

Background: This paper explores the exposure and impact of a Scottish mass media campaign: Make Your Position Clear. It ran from October 2009 to July 2010, targeted gay men and other men who have sex with men (MSM), and had two key aims: to promote regular sexual health and HIV testing every 6 months, and to promote the use of appropriate condoms and water-based lubricant with each episode of anal intercourse. Methods: A cross-sectional survey (anonymous and self-report) was conducted 10 months after the campaign was launched (July 2010). Men were recruited from commercial venues. Outcome measures included use of lubricant, testing for sexually transmitted infections and HIV, and intentions to seek HIV testing within the following six months. Linear-by-linear chi-square analysis and binary logistic regressions were conducted to explore the associations between the outcome measures and campaign exposure. Results: The total sample was 822 men (62.6% response rate). Men self-identifying as HIV positive were excluded from the analysis (n = 38). Binary logistic analysis indicated that those with mid or high campaign exposure were more likely to have been tested for HIV in the previous six months when adjusted for age, area of residence and use of the “gay scene” (AOR = 1.96, 95% CI = 1.26 to 3.06, p = .003), but were not more likely to be tested for STIs (AOR = 1.37, 95% CI = 0.88 to 2.16, p = .167). When adjusted for previous HIV testing, those with mid or high campaign exposure were not more likely to indicate intention to be tested for HIV in the following six months (AOR = 1.30, 95% CI = 0.73 to 2.32, p = .367). Those with no campaign exposure were less likely than those with low exposure to have used appropriate lubricant with anal sex partners in the previous year (AOR = 0.42, 95% CI = 0.23 to 0.77, p = .005). Conclusions: The campaign had demonstrable reach. The analysis showed partial support for the role of mass media campaigns in improving sexual health outcomes. This suggests that a role for mass media campaigns remains within combination HIV prevention

On the properties of young multiple stars

Abridged/ We present numerical results on the properties of young binary and multiple stellar systems. Our analysis is based on a series of SPH + Nbody simulations of the fragmentation of small molecular clouds, that fully resolve the opacity limit for fragmentation. We have produced a statistically significant number of stable multiple systems, with components separations in the range 1-1000 AU. At the end of the hydrodynamical evolution (0.5 Myr) we find that ~60% of stars and brown dwarfs are members of multiples systems, with about a third of these being low mass, weakly bound outliers in wide eccentric orbits. Our results imply that in the stellar regime most stars are in multiples (~80%) and that this fraction is an increasing function of primary mass. After Nbody integration to 10.5 Myr, the percentage of bound objects has dropped to ~40%, as most very low mass stars and brown dwarfs have been released to the field. Brown dwarfs are never found to be very close companions to stars (brown dwarf desert at very small separations), but one case exists of a brown dwarf companion at intermediate separations (10 AU). Our simulations can accommodate the existence of brown dwarf companions at large separations, but only if the primaries of these systems are themselves multiples. We have compared the outcome of our simulations with the properties of real stellar systems as deduced from the IR CM diagram of the Praesepe cluster and from spectroscopic and high-resolution imaging surveys of young clusters and the field.Comment: 14 pages, 4 figures, 1 table, accepted by MNRA

The role of retinal fluid location in atrophy and fibrosis evolution of patients with neovascular age-related macular degeneration long-term treated in real world

Purpose: To assess the effect of clinical factors on the development and progression of atrophy and fibrosis in patients with neovascular age-related macular degeneration (nAMD) receiving long-term treatment in the real world. Methods: An ambispective 36-month multicentre study, involving 359 nAMD patients from 17 Spanish hospitals treated according to the Spanish Vitreoretinal Society guidelines, was designed. The influence of demographic and clinical factors, including the presence and location of retinal fluid, on best-corrected visual acuity (BCVA) and progression to atrophy and/or fibrosis were analysed. Results: After 36 months of follow-up and an average of 13.8 anti-VEGF intravitreal injections, the average BCVA gain was +1.5 letters, and atrophy and/or fibrosis were present in 54.8% of nAMD patients (OR = 8.54, 95% CI = 5.85-12.47, compared to baseline). Atrophy was associated with basal intraretinal fluid (IRF) (OR = 1.87, 95% CI = 1.09-3.20), whereas basal subretinal fluid (SRF) was associated with a lower rate of atrophy (OR = 0.40, 95% CI = 0.23-0.71) and its progression (OR = 0.44, 95% CI = 0.26-0.75), leading to a slow progression rate (OR = 0.34, 95% CI = 0.14-0.83). Fibrosis development and progression were related to IRF at any visit (p < 0.001). In contrast, 36-month SRF was related to a lower rate of fibrosis (OR = 0.49, 95% CI = 0.29-0.81) and its progression (OR = 0.50, 95% CI = 0.31-0.81). Conclusion: Atrophy and/or fibrosis were present in 1 of 2 nAMD patients treated for 3 years. Both, especially fibrosis, lead to vision loss. Subretinal fluid (SRF) was associated with good visual outcomes and lower rates of atrophy and fibrosis, whereas IRF yields worse visual results and a higher risk of atrophy and especially fibrosis in routine clinical practice