352 research outputs found
Characterizing unknown systematics in large scale structure surveys
Photometric large scale structure (LSS) surveys probe the largest volumes in
the Universe, but are inevitably limited by systematic uncertainties. Imperfect
photometric calibration leads to biases in our measurements of the density
fields of LSS tracers such as galaxies and quasars, and as a result in
cosmological parameter estimation. Earlier studies have proposed using
cross-correlations between different redshift slices or cross-correlations
between different surveys to reduce the effects of such systematics. In this
paper we develop a method to characterize unknown systematics. We demonstrate
that while we do not have sufficient information to correct for unknown
systematics in the data, we can obtain an estimate of their magnitude. We
define a parameter to estimate contamination from unknown systematics using
cross-correlations between different redshift slices and propose discarding
bins in the angular power spectrum that lie outside a certain contamination
tolerance level. We show that this method improves estimates of the bias using
simulated data and further apply it to photometric luminous red galaxies in the
Sloan Digital Sky Survey as a case study.Comment: 24 pages, 6 figures; Expanded discussion of results, added figure 2;
Version to be published in JCA
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Bone Marrow–on–a–Chip Replicates Hematopoietic Niche Physiology in Vitro
Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex functions of living bone marrow; hence, most translational studies relevant to the hematologic system are conducted in live animals. Here we describe a method for fabricating 'bone marrow–on–a–chip' that permits culture of living marrow with a functional hematopoietic niche in vitro by first engineering new bone in vivo, removing it whole and perfusing it with culture medium in a microfluidic device. The engineered bone marrow (eBM) retains hematopoietic stem and progenitor cells in normal in vivo–like proportions for at least 1 week in culture. eBM models organ-level marrow toxicity responses and protective effects of radiation countermeasure drugs, whereas conventional bone marrow culture methods do not. This biomimetic microdevice offers a new approach for analysis of drug responses and toxicities in bone marrow as well as for study of hematopoiesis and hematologic diseases in vitro.Engineering and Applied Science
The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey : cosmological implications of the full shape of the clustering wedges in the data release 10 and 11 galaxy samples
We explore the cosmological implications of the angle-averaged correlation function, ξ(s), and the clustering wedges, ξ⊥(s) and ξ∥(s), of the LOWZ and CMASS galaxy samples from Data Releases 10 and 11 of the Sloan Digital Sky Survey III (SDSS-III) Baryon Oscillation Spectroscopic Survey. Our results show no significant evidence for a deviation from the standard Λ cold dark matter model. The combination of the information from our clustering measurements with recent data from the cosmic microwave background is sufficient to constrain the curvature of the Universe to Ωk = 0.0010 ± 0.0029, the total neutrino mass to ∑mν < 0.23 eV (95 per cent confidence level), the effective number of relativistic species to Neff = 3.31 ± 0.27 and the dark energy equation of state to wDE = −1.051 ± 0.076. These limits are further improved by adding information from Type Ia supernovae and baryon acoustic oscillations from other samples. In particular, this data set combination is completely consistent with a time-independent dark energy equation of state, in which case we find wDE = −1.024 ± 0.052. We explore the constraints on the growth rate of cosmic structures assuming f(z) = Ωm(z)γ and obtain γ = 0.69 ± 0.15, consistent with the predictions of general relativity of γ = 0.55.Publisher PDFPeer reviewe
The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: single-probe measurements from CMASS anisotropic galaxy clustering
With the largest spectroscopic galaxy survey volume drawn from the SDSS-III
Baryon Oscillation Spectroscopic Survey (BOSS), we can extract cosmological
constraints from the measurements of redshift and geometric distortions at
quasi-linear scales (e.g. above 50 Mpc). We analyze the broad-range
shape of the monopole and quadrupole correlation functions of the BOSS Data
Release 12 (DR12) CMASS galaxy sample, at the effective redshift , to
obtain constraints on the Hubble expansion rate , the angular-diameter
distance , the normalized growth rate , and the
physical matter density . We obtain robust measurements by
including a polynomial as the model for the systematic errors, and find it
works very well against the systematic effects, e.g., ones induced by stars and
seeing. We provide accurate measurements ,
, , = , , , ,
where is the comoving sound horizon at the drag epoch and
Mpc is the sound scale of the fiducial cosmology used in
this study. The parameters which are not well constrained by our galaxy
clustering analysis are marginalized over with wide flat priors. Since no
priors from other data sets, e.g., cosmic microwave background (CMB), are
adopted and no dark energy models are assumed, our results from BOSS CMASS
galaxy clustering alone may be combined with other data sets, i.e., CMB, SNe,
lensing or other galaxy clustering data to constrain the parameters of a given
cosmological model. The uncertainty on the dark energy equation of state
parameter, , from CMB+CMASS is about 8 per cent. The uncertainty on the
curvature fraction, , is 0.3 per cent. We do not find deviation from
flat CDM.Comment: 15 pages, 11 figures. The latest version matches and the accepted
version by MNRAS. A bug in the first version has been identified and fixed in
the new version. We have redone the analysis with newest data (BOSS DR12
Ameliorating Systematic Uncertainties in the Angular Clustering of Galaxies: A Study using SDSS-III
We investigate the effects of potential sources of systematic error on the
angular and photometric redshift, z_phot, distributions of a sample of redshift
0.4 < z < 0.7 massive galaxies whose selection matches that of the Baryon
Oscillation Spectroscopic Survey (BOSS) constant mass sample. Utilizing over
112,778 BOSS spectra as a training sample, we produce a photometric redshift
catalog for the galaxies in the SDSS DR8 imaging area that, after masking,
covers nearly one quarter of the sky (9,913 square degrees). We investigate
fluctuations in the number density of objects in this sample as a function of
Galactic extinction, seeing, stellar density, sky background, airmass,
photometric offset, and North/South Galactic hemisphere. We find that the
presence of stars of comparable magnitudes to our galaxies (which are not
traditionally masked) effectively remove area. Failing to correct for such
stars can produce systematic errors on the measured angular auto-correlation
function, w, that are larger than its statistical uncertainty. We describe how
one can effectively mask for the presence of the stars, without removing any
galaxies from the sample, and minimize the systematic error. Additionally, we
apply two separate methods that can be used to correct the systematic errors
imparted by any parameter that can be turned into a map on the sky. We find
that failing to properly account for varying sky background introduces a
systematic error on w. We measure w, in four z_phot slices of width 0.05
between 0.45 < z_phot < 0.65 and find that the measurements, after correcting
for the systematic effects of stars and sky background, are generally
consistent with a generic LambdaCDM model, at scales up to 60 degrees. At
scales greater than 3 degrees and z_phot > 0.5, the magnitude of the
corrections we apply are greater than the statistical uncertainty in w.Comment: Accepted by MNRA
A Simple Likelihood Method for Quasar Target Selection
We present a new method for quasar target selection using photometric fluxes
and a Bayesian probabilistic approach. For our purposes we target quasars using
Sloan Digital Sky Survey (SDSS) photometry to a magnitude limit of g=22. The
efficiency and completeness of this technique is measured using the Baryon
Oscillation Spectroscopic Survey (BOSS) data, taken in 2010. This technique was
used for the uniformly selected (CORE) sample of targets in BOSS year one
spectroscopy to be realized in the 9th SDSS data release. When targeting at a
density of 40 objects per sq-deg (the BOSS quasar targeting density) the
efficiency of this technique in recovering z>2.2 quasars is 40%. The
completeness compared to all quasars identified in BOSS data is 65%. This paper
also describes possible extensions and improvements for this techniqueComment: Updated to accepted version for publication in the Astrophysical
Journal. 10 pages, 10 figures, 3 table
Low-Dose Antithymocyte Globulin Has No Disadvantages to Standard Higher Dose in Pediatric Kidney Transplant Recipients: Report from the Pediatric Nephrology Research Consortium
Introduction Rabbit antithymocyte globulin (rATG) dosing strategies for induction in pediatric kidney transplantation vary between centers. It is not known whether a lower rATG induction dose provides safe and effective immunosuppression compared with a “standard” higher dose.
Methods We performed a retrospective multicenter study of all isolated first-time kidney transplant recipients \u3c 21 years old who received rATG induction between 1 January 2010 and 31 December 2014 at 9 pediatric centers. An a priori cutoff of a 4.5-mg/kg cumulative rATG dose was used to identify low (≤ 4.5 mg/kg) and standard (\u3e 4.5 mg/kg) exposure groups. Outcomes examined included 12 months posttransplant graft function (estimated glomerular filtration rate [eGFR]); the occurrence of acute rejection, donor-specific antibody (DSA), neutropenia, and viral infection (cytomegalovirus [CMV], Epstein-Barr virus [EBV], and BK virus); and 24-month outcomes of posttransplant lymphoproliferative disorder (PTLD) occurrence and patient and graft survival.
Results Two hundred thirty-five patients were included. Baseline features of the low and standard rATG dose groups were similar. By 12 months, the rATG dose group had no significant impact on the occurrence of neutropenia, positive DSA, or viral polymerase chain reaction (PCR). Graft function was similar. Acute rejection rates were similar at 17% (low dose) versus 19% (standard dose) (P = 0.13). By 24 months, graft survival (96.4% vs. 94.6%) and patient survival (100% vs. 99.3%) were similar between the low- and standard-dose groups (P = 0.54 and 0.46), whereas the occurrence of PTLD trended higher in the standard-dose group (0% vs. 2.6%, P = 0.07).
Conclusion A low rATG induction dose ≤ 4.5 mg/kg provided safe and effective outcomes in this multicenter low immunologic risk pediatric cohort. Prospective studies are warranted to define the optimal rATG induction dose in pediatric kidney transplantation
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