974 research outputs found

    De l\u27ombre à la lumière : l\u27iconographie de la lectrice dans la peinture française (1700-1789)- Annexes

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    Annexes du mémoire du Master 1 Cultures de l\u27écrit et de l\u27image portant sur la figure de la lectrice dans la peinture française du XVIIIe siècle

    High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma

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    Activin A (ActA)/follistatin (FST) signaling has been shown to be deregulated in different tumor types including lung adenocarcinoma (LADC). Here, we report that serum ActA protein levels are significantly elevated in LADC patients (n=64) as compared to controls (n=46, p=0.015). ActA levels also correlated with more advanced disease stage (p<0.0001) and T (p=0.0035) and N (p=0.0002) factors. M1 patients had significantly higher ActA levels than M0 patients (p<0.001). High serum ActA level was associated with poor overall survival (p<0.0001) and was confirmed as an independent prognostic factor (p=0.004). Serum FST levels were increased only in female LADC patients (vs. female controls, p=0.031). Two out of five LADC cell lines secreted biologically active ActA, while FST was produced in all of them. Transcripts of both type I and II ActA receptors were detected in all five LADC cell lines. In conclusion, our study does not only suggest that measuring blood ActA levels in LADC patients might improve the prediction of prognosis, but also indicates that this parameter might be a novel non-invasive biomarker for identifying LADC patients with organ metastases

    Les objets religieux dans les inventaires après décès à Marseille (1539-1629)

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    L’étude des inventaires après-décès de la très catholique ville de Marseille permet de mieux connaître les expressions de la foi dans un cadre privé. Du XVIe au XVIIe siècle, le nombre de foyers ainsi que celui d’objets religieux progressent peu. On note le triomphe de l’iconographie, en général placée dans la salle commune. Ces représentations révèlent une tripartition presque parfaite entre le Christ, la Vierge et les saints. Les tableaux du Christ sont ceux dont le nombre augmente le plus, tout particulièrement ceux de la Passion, alors que ceux de Marie connaissent une évolution plus qualitative que quantitative. Quant aux images de saints, elles se diversifient aux dépens de Marie-Madeleine. Deux principaux types de comportements se dégagent : ceux qui possèdent peu d’objets, mais de natures différentes (comme tableau et chapelet) ; ceux qui détiennent plusieurs objets similaires. Au-delà du niveau de vie des propriétaires, ces écarts témoignent de choix personnels dans la façon d’exprimer sa foi. Le catholicisme marseillais est loin d’être uniforme.The study of after death inventories in the notoriously Roman Catholic city of Marseilles is improving our knowledge of how people expressed their faith in privacy. All along the 16th and 17th centuries, families as well as devotional objects increased very little in numbers. We notice that iconographic items, generally placed in the common room, had the prevailing part. Such representations show an almost perfect tripartite distribution between Christ, the Virgin Mary and the saints. Pictures of Jesus Christ were those increasing the most, especially scenes of the Passion, whereas those of Mary evolved more in quality than quantity. As to the pictures of saints, they became more diverse at the expense of Mary Magdalen. Two main behavioural types stand out: a category with few objects of different types (such as picture and beads) and people with several objects of the same nature. Beyond social level, such discrepancies reveal the owners’ personal choices in the way they expressed their faith. Roman Catholicism in Marseilles was far from uniform

    De l\u27ombre à la lumière : l\u27iconographie de la lectrice dans la peinture française (1700-1789)

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    Mémoire du Master 1 Cultures de l\u27écrit et de l\u27image portant sur la figure de la lectrice dans la peinture française du XVIIIe siècle

    Alterações ultrassonógráficas de 2° e 3° trimestres observadas em 143 fetos submetidos ao estudo cromossômico e acompanhados no Centro de Medicina Fetal / UFMG

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    Purpose: To describe the ultrasonographic findings observed in 143 fetuses, associating them with the main chromosomal anomalies and verifying if there is a typical ultrasonographic alteration that could be related to a particular chromosomopathy. Method: A retrospective and descriptive study was carried out including 143 fetuses with ultrasonographic abnormalities followed up from January 1997 to June 2003. Charyotyping was made in all cases. The material used was obtained by invasive techniques. Results: The cordocentesis was the most common invasive technique performed with 103 punctures. Of the followed 143 fetuses, 66 (46,1%) had chromosomal disease. Themost common chromosomal anomaly in our experience was trisomy 18, with 22 cases (33,3%) followed by trisomy 21, with 15 cases (22,7%). 45% of the fetuses with two or more ultrasonographic abnormalities had a chromosomal anomaly. 78% had cromosomopaties when seven or more structural defects were observed by ultrasound. The cardiac anomalies (especially ventricular septal defects) were the most frequentfinding in fetuses with trisomy 21 (46,7%). At the trisomy 18 the polyhydramnios (72,7%) and intrauterine growth restriction (63,3%) were the most frequent ultrasonographic finding. The cleft lip (88,9%) and the intrauterine growth restriction (55%) were more frequent in fetuses with trisomy 13. Conclusions: The risk of chromosomal diseases increases according to the growth in the number of abnormalities seen by ultrasound examinations.Objetivo: Descrever os achados ultrassonográficos observados em 143 fetos, associando-os às principais anomalias cromossômicas e verificar se existe uma alteração ultrassonográfica típica que se associe a uma cromossomopatia em particular. Métodos: Foi realizado um estudo retrospectivo e descritivo de 143 fetos portadores de malformações diagnosticadas ao exame ultrassonográfico, entre janeiro de 1997 e junho de 2003. Em todos os casos foi realizado cariótipo fetal, cujo material foi obtido por procedimento invasivo. Resultados: A cordocentese foi o procedimento invasivo mais realizado com 103punções. Dos 143 casos acompanhados 66 (46,1%) possuíam doença cromossômica. A trissomia do 18, com 22 casos (33,3%) seguida da trissomia do 21, com 15 casos (22,7%), foram os defeitos cromossômicos mais freqüentes. 45% dos fetos com duas ou mais alterações ultrassonográficas eram portadores de anomalia cromossômica, 78% dos fetos possuíam cromossomopatias quando observamos sete ou mais defeitos morfológicos ao ultrassom. As anomalias cardíacas (principalmente os defeitos de septo ventricular) foram as mais encontradas nos feto com trissomia do 21 (46,7%). Na trissomia do 18 o polihidrâmnio (72,7%) e o crescimento intra-uterino restrito (63,3%) foram as alterações ultrassonográficas observadas. O lábio leporino (88,9%) e o crescimento intra-uterino restrito(55%) foram mais frequentes nos fetos com trissomia do 13. Conclusões: O risco de doenças cromossômicas aumenta de acordo com o aumento nonúmero de alterações vistas no exame ultrassonográfico. Apesar das principais anomalias cromossômicas apresentarem alterações morfológicas detectáveis ao exame de ultra-som não identificamos nenhum achado ultrassonográfico específico que identifique com segurança um tipo particular de cromossomopatia

    Démographie, structures: Restructuration foncière par échanges aimables multilatéraux

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    The regrouping of land by voluntary exchanges because of its adaptability and rapidity is the best way of improving land structures. The low cost to those farmers who exchange land leads to the investment expenses being recouped very quickly. For the State the results show a balance of additional income and expenses

    Development of an ERL RF Control System

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    The Mainz Energy-recovering Superconducting Accelerator (MESA), currently under construction at Johannes Gutenberg-Universität Mainz, requires a newly designed digital low-level radio frequency (LLRF) system. Challenging requirements have to be fulfilled to ensure high beam quality and beam parameter stability. First, the layout with two recirculations and the requirements will be shown from an LLRF point of view. Afterwards, different options for the control system are presented. This includes the generator-driven system, the self-excited loop and classical PID controller as well as more sophisticated solutions

    Longitudinal Beam Stabilization at FAIR by Means of a Derivative Estimation

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    During acceleration in SIS18/SIS100 at GSI/FAIR longitudinal beam-oscillations are expected to occur. To reduce emittance blow-up, dedicated LLRF beam feedback systems are planned. To date longitudinal beam oscillations have been damped in machine experiments with a finite-impulse-response (FIR) filter controller with 3 filter taps. An alternative approach implementing the FIR filter as a derivative estimator controller is simulated and tested. This approach shares the same controller topology and can therefore be easily integrated in the system. It exploits the fact that the sampling rate of the feedback hardware is considerably higher than the frequency of the beam oscillations. It is therefore capable of damping oscillations without overshoot within one oscillation period
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