1,145 research outputs found
AiguĂšze â Grotte aux Points
Date de l'opĂ©ration : 1994 (SU) Inventeur(s) : Galant Philippe (SDA) ; Colomer Albert (SRA) ; Chauvet Jean-Marie ; Deschamps Eliette ; Hillaire Christian C'est au cours d'un travail d'inventaire systĂ©matique des cavitĂ©s naturelles des gorges de l'ArdĂšche, que Jean-Marie Chauvet, Ăliette Deschamps et Christian Hillaire ont constatĂ© la prĂ©sence de signes peints Ă l'ocre rouge, dans une partie profonde de la grotte aux Points (AiguĂšze). Il s'agit d'une grotte qui se prĂ©sente sous la forme d'un ..
Revealing a third dissolved-phase Xenon-129 resonance in blood caused by hemoglobin glycation
Hyperpolarized (HP) xenon-129 (Xe), when dissolved in blood, has two NMR resonances: one in red blood cells (RBC) and one in plasma. The impact of numerous blood components on these resonances, however, has not yet been investigated. This study evaluates the effects of elevated glucose levels on the chemical shift (CS) and T* relaxation times of HP Xe dissolved in sterile citrated sheep blood for the first time. HP Xe was mixed with sheep blood samples premixed with a stock glucose solution using a liquidâgas exchange module. Magnetic resonance spectroscopy was performed on a 3T clinical MRI scanner using a custom-built quadrature dual-tuned Xe/H coil. We observed an additional resonance for the RBCs (Xe-RBC1) for the increased glucose levels. The CS of Xe-RBC1 and Xe-plasma peaks did not change with glucose levels, while the CS of Xe-RBC2 (original RBC resonance) increased linearly at a rate of 0.015 ± 0.002 ppm/mM with glucose level. Xe-RBC1 T* values increased nonlinearly from 1.58 ± 0.24 ms to 2.67 ± 0.40 ms. As a result of the increased glucose levels in blood samples, the novel additional HP Xe dissolved phase resonance was observed in blood and attributed to the Xe bound to glycated hemoglobin (HbA)
Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration
Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration (FTLD), ascertained within the European Early-Onset Dementia consortium. As control dataset, we sequenced 1,625 European control individuals and analyzed whole-exome sequence data of 2,274 German individuals (total n = 3,899). Association of rare SQSTM1 mutations was calculated in a meta-analysis of 4,332 FTLD and 10,240 control alleles. We identified 25 coding variants in FTLD patients of which 10 have not been described. Fifteen mutations were absent in the control individuals (carrier frequency < 0.00026) whilst the others were rare in both patients and control individuals. When pooling all variants with a minor allele frequency < 0.01, an overall frequency of 3.2 % was calculated in patients. Rare variant association analysis between patients and controls showed no difference over the whole protein, but suggested that rare mutations clustering in the UBA domain of SQSTM1 may influence disease susceptibility by doubling the risk for FTLD (RR = 2.18 [95 % CI 1.24-3.85]; corrected p value = 0.042). Detailed histopathology demonstrated that mutations in SQSTM1 associate with widespread neuronal and glial phospho-TDP-43 pathology. With this study, we provide further evidence for a putative role of rare mutations in SQSTM1 in the genetic etiology of FTLD and showed that, comparable to other FTLD/ALS genes, SQSTM1 mutations are associated with TDP-43 pathology
Search for muon-neutrino emission from GeV and TeV gamma-ray flaring blazars using five years of data of the ANTARES telescope
The ANTARES telescope is well-suited for detecting astrophysical transient
neutrino sources as it can observe a full hemisphere of the sky at all times
with a high duty cycle. The background due to atmospheric particles can be
drastically reduced, and the point-source sensitivity improved, by selecting a
narrow time window around possible neutrino production periods. Blazars, being
radio-loud active galactic nuclei with their jets pointing almost directly
towards the observer, are particularly attractive potential neutrino point
sources, since they are among the most likely sources of the very high-energy
cosmic rays. Neutrinos and gamma rays may be produced in hadronic interactions
with the surrounding medium. Moreover, blazars generally show high time
variability in their light curves at different wavelengths and on various time
scales. This paper presents a time-dependent analysis applied to a selection of
flaring gamma-ray blazars observed by the FERMI/LAT experiment and by TeV
Cherenkov telescopes using five years of ANTARES data taken from 2008 to 2012.
The results are compatible with fluctuations of the background. Upper limits on
the neutrino fluence have been produced and compared to the measured gamma-ray
spectral energy distribution.Comment: 27 pages, 16 figure
All-sky Search for High-Energy Neutrinos from Gravitational Wave Event GW170104 with the ANTARES Neutrino Telescope
Advanced LIGO detected a significant gravitational wave signal (GW170104)
originating from the coalescence of two black holes during the second
observation run on January 4, 2017. An all-sky high-energy
neutrino follow-up search has been made using data from the ANTARES neutrino
telescope, including both upgoing and downgoing events in two separate
analyses. No neutrino candidates were found within s around the GW
event time nor any time clustering of events over an extended time window of
months. The non-detection is used to constrain isotropic-equivalent
high-energy neutrino emission from GW170104 to less than
erg for a spectrum
The ANTARES Collaboration: Contributions to ICRC 2017 Part I: Neutrino astronomy (diffuse fluxes and point sources)
Papers on neutrino astronomy (diffuse fluxes and point sources, prepared for
the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by
the ANTARES Collaboratio
Performance of the First ANTARES Detector Line
In this paper we report on the data recorded with the first Antares detector
line. The line was deployed on the 14th of February 2006 and was connected to
the readout two weeks later. Environmental data for one and a half years of
running are shown. Measurements of atmospheric muons from data taken from
selected runs during the first six months of operation are presented.
Performance figures in terms of time residuals and angular resolution are
given. Finally the angular distribution of atmospheric muons is presented and
from this the depth profile of the muon intensity is derived.Comment: 14 pages, 9 figure
The ANTARES Collaboration: Contributions to ICRC 2017 Part II: The multi-messenger program
Papers on the ANTARES multi-messenger program, prepared for the 35th
International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the
ANTARES Collaboratio
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