Strengtheningtheunderstanding and production of texts, use of research as a pedagogicalstrategy, withsupport in information and communicationtechnologies

Este artículo presenta resultados derivados de la investigación acerca del desarrollo de la comprensión lectora y la producción escrita, comocompetencias necesarias en la formación integral de los estudiantes, no sólo del área del lenguaje, sino en todo su quehacer comunicativo e intelectual, en favor de un aprendizaje significativo. El propósito es generar procesos para fortalecer una práctica pedagógica que promuevael desarrollo de aprendizajes basados en la investigación como estrategia pedagógica y la incorporación de los avances de las tecnologías de la información y la comunicación. Se desarrolló la investigación con estudiantes de la Institución Educativa Departamental Agropecuaria Nuestra Señora de las Mercedes, ubicada en Magdalena, Pivijay, Colombia. Se generaron orientaciones para la integración curricular de la investigación y las tecnologías de información y comunicación, para orientar innovaciones necesarias para redefinir las estrategias que adoptan los docentes en su quehacer pedagógicoThisarticlepresentsresultsderivedfromresearchonthedevelopment of readingcomprehension and writtenproduction, as necessarycompetences in the integral formation of students, notonly in thearea of language, but in alltheircommunicative and intellectualwork, in favor of a significantlearningThepurposeistogenerateprocessestostrengthen a pedagogicalpracticethatpromotesthedevelopment of learningbasedonresearch as a pedagogicalstrategy and theincorporation of advances in information and communicationtechnologies.TheresearchwasdevelopedwithstudentsfromtheAgriculturalDepartmentalInstitution of Our Lady of Mercy, located in Magdalena, Pivijay, Colombia. Guidelinesforthe curricular integration of research and information and communicationtechnologiesweregeneratedto guide innovationsnecessaryto redefine thestrategiesadoptedbyteachers in theirpedagogicalwor

Information and communication technologies as strategies to strengthen the Interpretation and production of texts

La interpretación y producción de textos siempre ha sido una temática de gran interés investigativo a nivel nacional, debido a los problemas vinculados con los bajos resultados obtenidos en las diferentes pruebas establecidas. Partiendo de esto el propósito de la investigación está dirigido a fortalecer en los estudiantes la competencia Interpretativa y productiva de textos a través de las Tecnologías de la información y comunicación. Se asume un abordaje metodológico desde la investigación cualitativa, orientada desde la investigación acción. La unidad de análisis estuvo constituida por 132 estudiantes de los grados 4 y 5, entre las edades de 0 a 19 años, que conforman las diferentes sedes de la IED Agropecuaria Nuestra Señora de las Mercedes. Los resultados arrojados dejaron ene videncia que al trabajar los temas referentes a la interpretación y producción de textos, se generó un incremento significado en los resultados académicos de los estudiantes; entregando productos de calidad en contenido e interpretación textual.The interpretation and production of texts has always been a topic of great research interest at the national level, due to the problems associated with the low results obtained in the different tests established. Based on this, the purpose of the research is aimed at strengthening students’ interpretive and productive competence in texts through information and communication technologies. It assumes a methodological approach from qualitative research, oriented from the action research. The analysis unit consisted of 132 students of grades 4 and 5, between the ages of 0 to 19 years, which make up the different venues of the IED Farming Our Lady of Mercy. The results thrown away showed that by working on issues related to the interpretation and production of texts, a significant increase in the students’ academic results was generated; delivering quality products in content and textual interpretation

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Electrophoretic characterization of soluble proteins from dental tissues (polyphyodonts and diphyodonts species)

The developmental processes related to odontogenesis are similar in all vertebrates and they occur during embryogenesis. The dental papilla can exercises directive morphogenetic role on epithelia of different phylogenetic origin. In our laboratory we have previously shown that cultured heterologous tissue recombinations between adult lizards dental papillae and quail epithelia were capable of producing odontogenesis and amelogenesis. Employing sodium dodecyl‐sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE) according to Laemmli ('70, Nature, 227:680–685.) and two‐dimensional polyacrylamide gel electrophoresis (2‐D PAGE) (O'Farrell, '75, J. Biol. Chem., 250:4007–4021.), we have examined the distribution of soluble proteins with respect to isoelectric point and molecular weight of dental papillae isolated from tooth germs at bell stage of adult lizard Liolaemus tenuis tenuis (polyphyodont species) and dog fetuses Canis familiaris (diphyodont species). A comparison was also made wit

Miscelánea matemática

El proyecto, en el que colaboran cuatro institutos de Torrejón de Ardoz, quiere sacar las matemáticas fuera del aula con la organización de actividades lúdicas. Los objetivos son acercar las matemáticas a los alumnos; realizar una exposición de materiales didácticos; y utilizar las nuevas tecnologías e internet para difundir las matemáticas. Los profesores entregan los materiales al CPR que los distribuye entre los participantes para que estos organicen y renueven cada quince días la exposición con cuatro biografías y fotos, tres problemas y láminas o puzzles. Además con los materiales elaborados se confecciona la web. Se evalúa la participación de los alumnos, el grado de satisfacción de profesores y la calidad de los materiales.Madrid (Comunidad Autónoma). Consejería de EducaciónMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES