1,313 research outputs found
An Infinite-Dimensional Family of Black-Hole Microstate Geometries
We construct the first explicit, smooth, horizonless black-hole microstate
geometry whose moduli space is described by an arbitrary function of one
variable and is thus infinite-dimensional. This is achieved by constructing the
scalar Green function on a simple D6 anti-D6 background, and using this Green
function to obtain the fully back-reacted solution for a supertube with varying
charge density in this background. We show that this supertube can store
parametrically more entropy than in flat space, confirming the entropy
enhancement mechanism that was predicted using brane probes. We also show that
all the local properties of the fully back-reacted solution can, in fact, be
obtained using the DBI action of an appropriate brane probe. In particular, the
supergravity and the DBI analysis yield identical functional bubble equations
that govern the relative locations of the centers. This indicates that there is
a non-renormalization theorem that protects these functional equations as one
moves in moduli space. Our construction creates configurations that are beyond
the scope of recent arguments that appear to put strong limits on the entropy
that can be found in smooth supergravity solutions.Comment: 46 pages, 1 figure, LaTe
Holographic renormalization as a canonical transformation
The gauge/string dualities have drawn attention to a class of variational
problems on a boundary at infinity, which are not well defined unless a certain
boundary term is added to the classical action. In the context of supergravity
in asymptotically AdS spaces these problems are systematically addressed by the
method of holographic renormalization. We argue that this class of a priori ill
defined variational problems extends far beyond the realm of holographic
dualities. As we show, exactly the same issues arise in gravity in non
asymptotically AdS spaces, in point particles with certain unbounded from below
potentials, and even fundamental strings in flat or AdS backgrounds. We show
that the variational problem in all such cases can be made well defined by the
following procedure, which is intrinsic to the system in question and does not
rely on the existence of a holographically dual theory: (i) The first step is
the construction of the space of the most general asymptotic solutions of the
classical equations of motion that inherits a well defined symplectic form from
that on phase space. The requirement of a well defined symplectic form is
essential and often leads to a necessary repackaging of the degrees of freedom.
(ii) Once the space of asymptotic solutions has been constructed in terms of
the correct degrees of freedom, then there exists a boundary term that is
obtained as a certain solution of the Hamilton-Jacobi equation which
simultaneously makes the variational problem well defined and preserves the
symplectic form. This procedure is identical to holographic renormalization in
the case of asymptotically AdS gravity, but it is applicable to any Hamiltonian
system.Comment: 37 pages; v2 minor corrections in section 2, 2 references and a
footnote on Palatini gravity added. Version to appear in JHE
Supersymmetric Solutions in Six Dimensions: A Linear Structure
The equations underlying all supersymmetric solutions of six-dimensional
minimal ungauged supergravity coupled to an anti-self-dual tensor multiplet
have been known for quite a while, and their complicated non-linear form has
hindered all attempts to systematically understand and construct BPS solutions.
In this paper we show that, by suitably re-parameterizing these equations, one
can find a structure that allows one to construct supersymmetric solutions by
solving a sequence of linear equations. We then illustrate this method by
constructing a new class of geometries describing several parallel spirals
carrying D1, D5 and P charge and parameterized by four arbitrary functions of
one variable. A similar linear structure is known to exist in five dimensions,
where it underlies the black hole, black ring and corresponding microstate
geometries. The unexpected generalization of this to six dimensions will have
important applications to the construction of new, more general such
geometries.Comment: v2: Eqs. (2.1), (2.39) corrected, references added. v3: minor
correction
Physical Activity Characteristics across GOLD Quadrants Depend on the Questionnaire Used
BACKGROUND:The GOLD multidimensional classification of COPD severity combines the exacerbation risk with the symptom experience, for which 3 different questionnaires are permitted. This study investigated differences in physical activity (PA) in the different GOLD quadrants and patient's distribution in relation to the questionnaire used. METHODS:136 COPD patients (58±21% FEV1 predicted, 34F/102M) completed COPD assessment test (CAT), clinical COPD questionnaire (CCQ) and modified Medical Research Council (mMRC) questionnaire. Exacerbation history, spirometry and 6MWD were collected. PA was objectively measured for 2 periods of 1 week, 6 months apart, in 5 European centres; to minimise seasonal and clinical variation the average of these two periods was used for analysis. RESULTS:GOLD quadrants C+D had reduced PA compared with A+B (3824 [2976] vs. 5508 [4671] steps.d-1, p<0.0001). The choice of questionnaire yielded different patient distributions (agreement mMRC-CAT κ = 0.57; CCQ-mMRC κ = 0.71; CCQ-CAT κ = 0.72) with different clinical characteristics. PA was notably lower in patients with an mMRC score ≥2 (3430 [2537] vs. 5443 [3776] steps.d-1, p <0.001) in both the low and high risk quadrants. CONCLUSIONS:Using different questionnaires changes the patient distribution and results in different clinical characteristics. Therefore, standardization of the questionnaire used for classification is critical to allow comparison of different studies using this as an entry criterion. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov NCT01388218
Degenerate Stars and Gravitational Collapse in AdS/CFT
We construct composite CFT operators from a large number of fermionic primary
fields corresponding to states that are holographically dual to a zero
temperature Fermi gas in AdS space. We identify a large N regime in which the
fermions behave as free particles. In the hydrodynamic limit the Fermi gas
forms a degenerate star with a radius determined by the Fermi level, and a mass
and angular momentum that exactly matches the boundary calculations. Next we
consider an interacting regime, and calculate the effect of the gravitational
back-reaction on the radius and the mass of the star using the
Tolman-Oppenheimer-Volkoff equations. Ignoring other interactions, we determine
the "Chandrasekhar limit" beyond which the degenerate star (presumably)
undergoes gravitational collapse towards a black hole. This is interpreted on
the boundary as a high density phase transition from a cold baryonic phase to a
hot deconfined phase.Comment: 75 page
Can subtle changes in gene expression be consistently detected with different microarray platforms?
Background: The comparability of gene expression data generated with different microarray platforms is still a matter of concern. Here we address the performance and the overlap in the detection of differentially expressed genes for five different microarray platforms in a challenging biological context where differences in gene expression are few and subtle. Results: Gene expression profiles in the hippocampus of five wild-type and five transgenic δC-doublecortin-like kinase mice were evaluated with five microarray platforms: Applied Biosystems, Affymetrix, Agilent, Illumina, LGTC home-spotted arrays. Using a fixed false discovery rate of 10% we detected surprising differences between the number of differentially expressed genes per platform. Four genes were selected by ABI, 130 by Affymetrix, 3,051 by Agilent, 54 by Illumina, and 13 by LGTC. Two genes were found significantly differentially expressed by all platforms and the four genes identified by the ABI platform were found by at least three other platforms. Quantitative RT-PCR analysis confirmed 20 out of 28 of the genes detected by two or more platforms and 8 out of 15 of the genes detected by Agilent only. We observed improved correlations between platforms when ranking the genes based on the significance level than with a fixed statistical cut-off. We demonstrate significant overlap in the affected gene sets identified by the different platforms, although biological processes were represented by only partially overlapping sets of genes. Aberrances in GABA-ergic signalling in the transgenic mice were consistently found by all platforms. Conclusion: The different microarray platforms give partially complementary views on biological processes affected. Our data indicate that when analyzing samples with only subtle differences in gene expression the use of two different platforms might be more attractive than increasing the number of replicates. Commercial two-color platforms seem to have higher power for finding differentially expressed genes between groups with small differences in expression
Stop Making Sense(s) : Some late medieval and very late medieval views on faculty psychology
Peer reviewe
Implications of CTL-Mediated Killing of HIV-Infected Cells during the Non-Productive Stage of Infection
Patients infected with HIV exhibit orders of magnitude differences in their set-point levels of the plasma viral load. As to what extent this variation is due to differences in the efficacy of the cytotoxic T lymphocyte (CTL) response in these patients is unclear. Several studies have shown that HIV-infected CD4+ T cells also present viral epitopes that are recognized by CTLs before the productive stage of infection, i.e., during the intracellular eclipse phase before the infected cell starts to produce new viral particles. Here, we use mathematical modeling to investigate the potential impact of early killing of HIV-infected cells on viral replication. We suggest that the majority of CTL-mediated killing could occur during the viral eclipse phase, and that the killing of virus-producing cells could be substantially lower at later stages due to MHC-I-down-regulation. Such a mechanism is in agreement with several experimental observations that include CD8+ T cell depletion and antiretroviral drug treatment. This indicates a potentially important role of CTL-mediated killing during the non-productive stage of HIV-infected cells
Enhancing return-to-work in cancer patients, development of an intervention and design of a randomised controlled trial
ABSTRACT: BACKGROUND: Compared to healthy controls, cancer patients have a higher risk of unemployment, which has negative social and economic impacts on the patients and on society at large. Therefore, return-to-work of cancer patients needs to be improved by way of an intervention. The objective is to describe the development and content of a work-directed intervention to enhance return-to-work in cancer patients and to explain the study design used for evaluating the effectiveness of the intervention. METHODS: Development and content of the intervention The work-directed intervention has been developed based on a systematic literature review of work-directed interventions for cancer patients, factors reported by cancer survivors as helping or hindering their return-to-work, focus group and interview data for cancer patients, health care professionals, and supervisors, and vocational rehabilitation literature. The work-directed intervention consists of: 1) 4 meetings with a nurse at the treating hospital department to start early vocational rehabilitation, 2) 1 meeting with the participant, occupational physician, and supervisor to make a return-to-work plan, and 3) letters from the treating physician to the occupational physician to enhance communication. Study design to evaluate the intervention The treating physician or nurse recruits patients before the start of initial treatment. Patients are eligible when they have a primary diagnosis of cancer, will be treated with curative intent, are employed at the time of diagnosis, are on sick leave, and are between 18 and 60 years old. After the patients have given informed consent and have filled out a baseline questionnaire, they are randomised to either the control group or to the intervention group and receive either care as usual or the work-directed intervention, respectively. Primary outcomes are return-to-work and quality of life. The feasibility of the intervention and direct and indirect costs will be determined. Outcomes will be assessed by a questionnaire at baseline and at 6, 12, 18, and 24 months after baseline. DISCUSSION: This study will provide information about the effectiveness of a work-directed intervention for cancer patients. The intention is to implement the intervention in normal care if it has been shown effective. Trial registration: NTR165
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