Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation

Source at https://doi.org/10.1038/s42003-018-0068-9. Most sequence variants identified hitherto in genome-wide association studies (GWAS) of atrial fibrillation are common, non-coding variants associated with risk through unknown mechanisms. We performed a meta-analysis of GWAS of atrial fibrillation among 29,502 cases and 767,760 controls from Iceland and the UK Biobank with follow-up in samples from Norway and the US, focusing on low-frequency coding and splice variants aiming to identify causal genes. We observe associations with one missense (OR = 1.20) and one splice-donor variant (OR = 1.50) in RPL3L, the first ribosomal gene implicated in atrial fibrillation to our knowledge. Analysis of 167 RNA samples from the right atrium reveals that the splice-donor variant in RPL3L results in exon skipping. We also observe an association with a missense variant in MYZAP (OR = 1.38), encoding a component of the intercalated discs of cardiomyocytes. Both discoveries emphasize the close relationship between the mechanical and electrical function of the heart

Basic Teachers' sense of coherence in teaching : A study teachers' sense of coherence in the work of extraordinary adaptations for students with ADHD

Syftet med vår studie var att få en inblick i hur grundskolelärarna får en känsla av sammanhang (KASAM) i arbetet med extra anpassningar inom ordinarie undervisning för att stödja elever med ADHD. Våra frågeställningar var, vilken begriplighet har lärarna i sitt arbete med extra anpassningar för att stödja elever med ADHD, hur förklarar lärarna att de hanterar extra anpassningar, och vilka extra anpassningar anser lärarna som mest meningsfulla att använda i undervisningen? Vi har använt oss av en kvalitativ metod där sex olika intervjuer utfördes med hjälp av en intervjuguide. Vår teoretiska utgångspunkt i studien var KASAM. Vi har kopplat det tre komponenterna, begriplighet, hanterbarhet och meningsfullhet till vår diskussion och vårt resultat. Vårt resultat visar att de sex intervjuade lärarna hanterar extra anpassningar i undervisningen. Lärarna använder många olika extra anpassningar som kan stödja elever med ADHD. Betydelsefulla extra anpassningar är bland annat struktur, planering och rutiner

Sweden's largest Facebook study

The emergence of the Internet has made it easier for people to socially interact than ever before. Today, the most popular channel is Facebook with over 845 million users world wide. In Sweden, the number of users amount to approximately half of the population. We had two aims with this study. First, we investigate which areas of Facebook usage that Swedish Facebook users consider more important vis-a-vis less important. We were also interested in how users convey their persona through their status updates, including what they status update about, and the underlying reasons for updating one’s status. Second, we investigate what psychological effects Facebook may induce. More specifically, we look at the psychological constructs self-esteem and well-being in relation to Facebook usage. We surveyed 1011 Swedish Facebook users with our questionnaires, measuring respondents’ Facebook usage patterns, well-being and self-esteem. Our analyses revealed that on average Swedish women spend 81 minutes per day on Facebook, whereas Swedish men are logged on to the site about 64 minutes per day. Generally, Facebook is used for social network maintenance, such as maintaining contact with people one doesn’t meet so often. However, Facebook is seldom used for meeting new people. Another finding is that Facebook users generally tend to update their status about positive events, major events and when they are feeling well, rather than negative events and when they are feeling bad. Women seem to be more engaged and active on Facebook than men, agreeing that a vast number of uses is significantly more important. Furthermore, women tend to write more about their thoughts and feelings, whereas twice as many men state that they provoke others on Facebook. Pertaining to Facebook’s psychological effects, the amount of time spent on Facebook had no relationship with self-esteem when controlling for gender, age, education and income. $is result runs counter to previous findings. However, women who spend more time on Facebook report feeling less happy and feel less content with their lives. For men, this relationship was not evident.$e study teaches that Facebook is used as a tool for affiliating with friends and family, as well as a personal showcase, where users show their positive sides. Herein lies also a danger. When Facebook users compare their own lives with others’ seemingly more successful careers and happy relationships, they may feel that their own lives are less successful in comparison

FOCUS - Food Knowledge Community Skåne-Blekinge : förstudie 2016

Focus förstudieprojekt syftar till att utreda förutsättningarna för att stärka och utveckla innovationsinfrastrukturen för livsmedelssystemet i Skåne och Blekinge, för att bidra till ökad tillväxt, sysselsättning, attraktionskraft och långsiktig hållbarhet. Utifrån syftet ovan och ambitionen att stärka samarbetet mellan lärosätena i Skåne och Blekinge inom livsmedelsområdet ska förstudien besvara följande frågeställningar: 1. Hur ser förutsättningarna ut för forskning, utbildning och samverkan/innovation inom livsmedelsområdet i Skåne och Blekinge? 2. Vilka är de mest angelägna behoven avseende forskning, utbildning och samverkan/innovation för livsmedelsnäringen och offentliga aktörer? 3. Hur kan regionala framtidssatsningar och strategier inom forskning, utbildning och samverkan inom livsmedelsområdet utformas, för att bidra till ett samlat utbud av akademisk kompetens riktat till företag och andra aktörer i hela livsmedelssystemet

The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis

In recent years, the concept of distinct subpopulations of human neutrophils has attracted much attention. One bona fide subset marker, exclusively expressed by a proportion of circulating neutrophils in a given individual, and therefore dividing neutrophils in two distinct subpopulations, is the glycoprotein CD177. CD177 is expressed on the plasma and granule membranes of 0-100% of circulating neutrophils depending on the donor. Several in vitro studies have linked CD177 to neutrophil transmigration, yet very few have looked at the role of CD177 for tissue recruitment in vivo. We investigate whether the CD177(+)and CD177(-)neutrophil subsets differ in their propensity to migrate to both aseptic- and microbe-triggered inflamed human tissues. Microbe-triggered neutrophil migration was evaluated in samples of gingival crevicular fluid (GCF) from patients with periodontitis, whereas neutrophil migration to aseptic inflammation was evaluated in synovial fluid from patients with inflammatory arthritis, as well as in exudate from experimental skin chambers applied on healthy donors. We found that the proportion of CD177(+)neutrophils was significantly higher in GCF from patients with periodontitis, as compared to blood from the same individuals. Such accumulation of CD177(+)neutrophils was not seen in the two models of aseptic inflammation. Moreover, the proportion of CD177(+)neutrophils in circulation was significantly higher in the periodontitis patient group, as compared to healthy donors. Our data indicate that the CD177(+)neutrophil subset is preferentially recruited to the gingival crevice of periodontitis patients, and may imply that this subtype is of particular importance for situations of microbe-driven inflammation.Funding Agencies|Swedish Research CouncilSwedish Research Council [201600982]; Swedish Heart-Lung FoundationSwedish Heart-Lung Foundation [20180218]; King Gustaf V Memorial Foundation [FAI-2017-0368]; Patent Revenue Fund Research in Preventive Odontology; Swedish state under the TUA agreement [TUAGBG-628751]</p