Designing game-based myoelectric prosthesis training

A myoelectric prosthesis (myo) is a dexterous artificial limb controlled by muscle contractions. Learning to use a myo can be challenging, so extensive training is often required to use a myo prosthesis effectively. Signal visualizations and simple muscle-controlled games are currently used to help patients train their muscles, but are boring and frustrating. Furthermore, current training systems require expensive medical equipment and clinician oversight, restricting training to infrequent clinical visits. To address these limitations, we developed a new game that promotes fun and success, and shows the viability of a low-cost myoelectric input device. We adapted a user-centered design (UCD) process to receive feedback from patients, clinicians, and family members as we iteratively addressed challenges to improve our game. Through this work, we introduce a free and open myo training game, provide new information about the design of myo training games, and reflect on an adapted UCD process for the practical iterative development of therapeutic games

Computational fluid dynamics as a tool for urban drainage system analysis: a review of applications and best practice

Computational Fluid Dynamics (CFD) can be applied to gain insights into most fluid processes and associated phenomena and so presents potential to add value in the analysis of urban drainage systems. This paper presents a review of CFD studies carried out in this field, with the objective of developing an appreciation of how and where it can be applied. Existing work has tended to focus around the analysis of four types of urban drainage structure, including Combined Sewer Overflows (CSOs), storage and attenuation systems, stormwater sediment interceptors and sewerage conveyance structures. Within the respective studies, the prediction of flowfields, particulate behaviour, water surface profiles and Residence Time Distributions (RTDs) are found to form the main focus, and as such, these are considered in most detail in the paper. It is concluded that CFD presents a number of opportunities in urban drainage system analysis, and that the scope of this opportunity will further develop as both computational hardware and software resources become more advanced

Parker/buoyancy instabilities with anisotropic thermal conduction, cosmic rays, and arbitrary magnetic field strength

We report the results of a local stability analysis for a magnetized, gravitationally stratified plasma containing cosmic rays. We account for cosmic-ray diffusion and thermal conduction parallel to the magnetic field and allow beta to take any value, where p is the plasma pressure and B is the magnetic field strength. We take the gravitational acceleration to be in the -z-direction and the equilibrium magnetic field to be in the y-direction, and we derive the dispersion relation for small-amplitude instabilities and waves in the large-|k_x| limit. We use the Routh-Hurwitz criterion to show analytically that the necessary and sufficient criterion for stability in this limit is n k_B dT/dz + dp_cr/dz + (1/8pi)dB^2/dz > 0, where T is the temperature, n is the number density of thermal particles, and p_cr is the cosmic-ray pressure. We present approximate analytical solutions for the normal modes in the low- and high-diffusivity limits, show that they are consistent with the derived stability criterion, and compare them to numerical results obtained from the full, unapproximated, dispersion relation. Our results extend earlier analyses of buoyancy instabilities in galaxy-cluster plasmas to the beta <= 1 regime. Our results also extend earlier analyses of the Parker instability to account for anisotropic thermal conduction, and show that the interstellar medium is more unstable to the Parker instability than was predicted by previous studies in which the thermal plasma was treated as adiabatic.Comment: 36 pages, 2 figures, Accepted for publication in Ap

An open-hardware platform for optogenetics and photobiology

In optogenetics, researchers use light and genetically encoded photoreceptors to control biological processes with unmatched precision. However, outside of neuroscience, the impact of optogenetics has been limited by a lack of user-friendly, flexible, accessible hardware. Here, we engineer the Light Plate Apparatus (LPA), a device that can deliver two independent 310 to 1550 nm light signals to each well of a 24-well plate with intensity control over three orders of magnitude and millisecond resolution. Signals are programmed using an intuitive web tool named Iris. All components can be purchased for under $400 and the device can be assembled and calibrated by a non-expert in one day. We use the LPA to precisely control gene expression from blue, green, and red light responsive optogenetic tools in bacteria, yeast, and mammalian cells and simplify the entrainment of cyanobacterial circadian rhythm. The LPA dramatically reduces the entry barrier to optogenetics and photobiology experiments

Gauge Invariance in Simplicial Gravity

The issue of local gauge invariance in the simplicial lattice formulation of gravity is examined. We exhibit explicitly, both in the weak field expansion about flat space, and subsequently for arbitrarily triangulated background manifolds, the exact local gauge invariance of the gravitational action, which includes in general both cosmological constant and curvature squared terms. We show that the local invariance of the discrete action and the ensuing zero modes correspond precisely to the diffeomorphism invariance in the continuum, by carefully relating the fundamental variables in the discrete theory (the edge lengths) to the induced metric components in the continuum. We discuss mostly the two dimensional case, but argue that our results have general validity. The previous analysis is then extended to the coupling with a scalar field, and the invariance properties of the scalar field action under lattice diffeomorphisms are exhibited. The construction of the lattice conformal gauge is then described, as well as the separation of lattice metric perturbations into orthogonal conformal and diffeomorphism part. The local gauge invariance properties of the lattice action show that no Fadeev-Popov determinant is required in the gravitational measure, unless lattice perturbation theory is performed with a gauge-fixed action, such as the one arising in the lattice analog of the conformal or harmonic gauges.Comment: LaTeX, 68 pages, 24 figure

Observable consequences of kinetic and thermal AGN feedback in elliptical galaxies and galaxy clusters

We have constructed an analytical model of AGN feedback and studied its implications for elliptical galaxies and galaxy clusters. The results show that momentum injection above a critical value will eject material from low mass elliptical galaxies, and leads to an X-ray luminosity, $L_{\rm X}$, that is $\propto$ $\sigma^{8-10}$, depending on the AGN fuelling mechanism, where $\sigma$ is the velocity dispersion of the hot gas. This result agrees well with both observations and semi-analytic models. In more massive ellipticals and clusters, AGN outflows quickly become buoyancy-dominated. This necessarily means that heating by a central cluster AGN redistributes the intracluster medium (ICM) such that the mass of hot gas, within the cooling radius, should be $\propto L_{\rm X}(<r_{\rm cool})/[g(r_{\rm cool})\sigma]$, where $g(r_{\rm cool})$ is the gravitational acceleration at the cooling radius. This prediction is confirmed using observations of seven clusters. The same mechanism also defines a critical ICM cooling time of $\sim 0.5$ Gyr, which is in reasonable agreement with recent observations showing that star formation and AGN activity are triggered below a universal cooling time threshold.Comment: Accepted for publication in MNRAS, 11 pages, 2 figures and 2 table

Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study

ObjectiveWhile several studies have reported on the relation of diabetes status with pancreatic cancer risk, the predictive value of this disorder for other malignancies is unclear. Methods: The Whitehall study, a 25year follow-up for mortality experience of 18,006 men with data on post-challenge blood glucose and self-reported diabetes, allowed us to address these issues. Results: There were 2158 cancer deaths at follow-up. Of the 15 cancer outcomes, diabetes status was positively associated with mortality from carcinoma of the pancreas and liver, while the relationship with lung cancer was inverse, after controlling for a range of potential covariates and mediators which included obesity and socioeconomic position. After excluding deaths occurring in the first 10years of follow-up to examine the effect of reverse causality, the magnitude of the relationships for carcinoma of the pancreas and lung was little altered, while for liver cancer it was markedly attenuated. Conclusions: In the present study, diabetes status was related to pancreatic, liver, and lung cancer risk. Cohorts with serially collected data on blood glucose and covariates are required to further examine this area