114 research outputs found
Salt-driven assembly of magnetic silica microbeads with tunable porosity.
HYPOTHESIS: Porous magnetic silica beads are promising materials for biological and environmental applications due to their enhanced adsorption and ease of recovery. This work aims to develop a new, inexpensive and environmentally friendly approach based on agglomeration of nanoparticles in aqueous droplets. The use of an emulsion as a geometrical constraint is expected to result in the formation of spherical beads with tunable composition depending on the aqueous phase content. EXPERIMENTS: Magnetic silica beads are produced at room temperature by colloidal destabilization induced by addition of CaCl2 to a water-in-oil emulsion containing SiO2 and Fe3O4 nanoparticles. The impact of the salt concentration, emulsification method, concentration of hydrophobic surfactant as well as silica content is presented in this paper. FINDINGS: This method enables the production of spherical beads with diameters between 1 and 9 µm. The incorporation of magnetic nanoparticles inside the bead's structure is confirmed using Energy Dispersive X-ray spectrometry (EDX) and Scanning Transmission Electron Microscopy (STEM) and results in the production of magnetic responsive beads with a preparation yield up to 84%. By incorporating the surfactant Span 80 in the oil phase it is possible to tune the roughness and porosity of the beads.W D Armstrong Studentship (internal Cambridge award
Filling of three-dimensional space by two-dimensional sheet growth.
Models of three-dimensional space filling based on growth of two-dimensional sheets are proposed. Beginning from planar Eden-style growth of sheets, additional growth modes are introduced. These enable the sheets to form layered or disordered structures. The growth modes can also be combined. An off-lattice kinetic Monte Carlo-based computer algorithm is presented and used to study the kinetics of the new models and the resulting structures. It is possible to study space filling by two-dimensional growth in a three-dimensional domain with arbitrarily oriented sheets; the results agree with previously published models where the sheets are only able to grow in a limited set of directions. The introduction of a bifurcation mechanism gives rise to complex disordered structures that are of interest as model structures for the mesostructure of calcium silicate hydrate in hardened cement paste.This research was supported by the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement 264448. AFR was supported by EPSRC grant EP/H035397/1.This is the author accepted manuscript. The final version is available from APS via http://dx.doi.org/10.1103/PhysRevE.92.04210
Asymptotic behaviour of zeros of exceptional Jacobi and Laguerre polynomials
The location and asymptotic behaviour for large n of the zeros of exceptional
Jacobi and Laguerre polynomials are discussed. The zeros of exceptional
polynomials fall into two classes: the regular zeros, which lie in the interval
of orthogonality and the exceptional zeros, which lie outside that interval. We
show that the regular zeros have two interlacing properties: one is the natural
interlacing between consecutive polynomials as a consequence of their
Sturm-Liouville character, while the other one shows interlacing between the
zeros of exceptional and classical polynomials. A generalization of the
classical Heine-Mehler formula is provided for the exceptional polynomials,
which allows to derive the asymptotic behaviour of their regular zeros. We also
describe the location and the asymptotic behaviour of the exceptional zeros,
which converge for large n to fixed values.Comment: 19 pages, 3 figures, typed in AMS-LaTe
Environmental responses to the 9.7 and 8.2 cold events at two ecotonal sites in the Dovre mountains, mid-Norway
Under embargo until: 2020-12-17We found strong signals of two cooling events around 9700 and 8200 cal yrs. BP in lakes Store Finnsjøen and Flåfattjønna at Dovre, mid-Norway. Analyses included pollen in both lakes, and C/N-ratio, biomarkers (e.g. alkanes and br-GDGTs), and XRF scanning in Finnsjøen. The positions of these lakes close to ecotones (upper forest-lines of birch and pine, respectively) reduced their resilience to cold events causing vegetation regression at both sites. The global 8.2 event reflects the collapse of the Laurentide Ice Sheet. The 9.7 event with impact restricted to Scandinavia and traced by pollen at Dovre only, reflects the drainage of the Baltic Ancylus Lake. More detailed analysis in Finnsjøen shows that the events also caused increased allochtonous input (K, Ca), increased sedimentation rate, and decreased sediment density and aquatic production. br-GDGT-based temperatures indicate gradual cooling through the early Holocene. In Finnsjøen, ca. 3100 maxima-minima couplets in sediment density along the analysed sequence of ca. 3100 calibrated years show the presence of varves for the first time in Norway. Impact of the 9.7 and 8.2 events lasted ca. 60 and 370 years, respectively. Pine pollen percentages were halved and re-established in less than 60 years, indicating the reduction of pine pollen production and not vegetative growth during the 9.7 event. The local impact of the 8.2 event sensu lato (ca. 8420–8050 cal yrs. BP) divides the event into a precursor, an erosional phase, and a recovery phase. At the onset of the erosional phase, summer temperatures increased.acceptedVersio
An extended class of orthogonal polynomials defined by a Sturm-Liouville problem
We present two infinite sequences of polynomial eigenfunctions of a
Sturm-Liouville problem. As opposed to the classical orthogonal polynomial
systems, these sequences start with a polynomial of degree one. We denote these
polynomials as -Jacobi and -Laguerre and we prove that they are
orthogonal with respect to a positive definite inner product defined over the
the compact interval or the half-line , respectively, and
they are a basis of the corresponding Hilbert spaces. Moreover, we prove
a converse statement similar to Bochner's theorem for the classical orthogonal
polynomial systems: if a self-adjoint second order operator has a complete set
of polynomial eigenfunctions , then it must be either the
-Jacobi or the -Laguerre Sturm-Liouville problem. A Rodrigues-type
formula can be derived for both of the polynomial sequences.Comment: 25 pages, some remarks and references adde
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis. However, the precise neuronal populations and cellular mechanisms involved are unclear. The effects of long-term manipulation of hypothalamic AMPK on energy balance are also unknown. To directly address such issues, we generated POMC alpha 2KO and AgRP alpha 2KO mice lacking AMPK alpha 2 in proopiomelanocortin- (POMC-) and agouti-related protein-expressing (AgRP-expressing) neurons, key regulators of energy homeostasis. POMC alpha 2KO mice developed obesity due to reduced energy expenditure and dysregulated food intake but remained sensitive to leptin. in contrast, AgRPa2KO mice developed an age-dependent lean phenotype with increased sensitivity to a melanocortin agonist. Electrophysiological studies in AMPK alpha 2-deficient POMC or AgRP neurons revealed normal leptin or insulin action but absent responses to alterations in extracellular glucose levels, showing that glucose-sensing signaling mechanisms in these neurons are distinct from those pathways utilized by leptin or insulin. Taken together with the divergent phenotypes of POMC alpha 2KO and AgRP alpha 2KO mice, our findings suggest that while AMPK plays a key role in hypothalamic function, it does not act as a general sensor and integrator of energy homeostasis in the mediobasal hypothalamus
Surgical Management of Paratesticular Rhabdomyosarcoma: A Consensus Opinion from the Children’s Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe
A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma
Jen Jen Yeh and colleagues developed and validated a six-gene signature in patients with pancreatic ductal adenocarcinoma that may be used to better stage the disease in these patients and assist in treatment decisions
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