Producción académica en torno a las NIC/NIIF en cuatro revistas colombianas, período 2009-2014

This document seeks to describe the research trends around IAS/IFRS in four scientific journals for the years 2009 to 2014 in Colombia. For this purpose, the identification of thematic clusters, types of articles, methodologies used, authors and institutions from which the research came from was made. The findings show the interest in publishing about the process of convergence, adoption and effects of the implementation of IAS/IFRS. Trends in IFRS application work in private companies, theoretical discussion and reflection work, but few literature review papers, and secondly, the use of qualitative methodologies are found.Este documento busca describir las tendencias de investigación en torno a las NIC/NIIF en cuatro revistas científicas para los años 2009 a 2014 en Colombia. Para tal efecto, se hizo la identificación de clústeres temáticos, tipologías de artículos, metodologías empleadas, autores e instituciones de donde provenían las investigaciones. Los hallazgos dejan ver el interés que había por publicar sobre el proceso de convergencia, adopción y efectos de la implementación de las NIC/NIIF. Se encuentran tendencias en trabajos de aplicación de las NIIF en empresas privadas, trabajos de discusión teórica y de reflexión, pero pocos trabajos de revisión de literatura y, en segundo lugar, se identifica el uso de metodologías de corte cualitativ

Study of the impact on the value of the square meter of land of priority interest housing projects developed in medium-stratum areas. Case study "Leaf Square"

El presente análisis se enfoca en la evolución del valor del metro cuadrado de terreno en los predios aledaños al proyecto de vivienda de interés prioritario denominado "Plaza de la Hoja" entre los años 2004 A 2019, con el fin de determinar la existencia de algún impacto de dicho proyecto en el valor de los terrenos. Este análisis se ejecuto con base a información propia de la Unidad Administrativa Especial de Catastro Distrital (UAECD), al empleo de herramientas de software Stata y paquete de Excel de Office y el análisis de datos con el test estadístico y econométrico denominado Test de Chow.This analysis focuses on the evolution of the value of the square meter of land in the properties adjacent to the priority housing project called " Leaf Square" between 2004 to 2019, in order to determine the existence of any impact of said project in the land value. This analysis was carried out based on information from the Special Administrative Unit of the District Cadastre (UAECD), the use of Stata software tools and the Excel Office package and the data analysis with the statistical and econometric test called the Chow Test.Unidad Administrativa Especial de Catastro Distrital (UAECD

Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance

Background & AimsDrug induced liver injury (DILI) is challenging because of the lack of biomarkers to predict mortality. Our aim was to describe miRNA changes in sera of subjects with acute idiosyncratic DILI and determine if levels of miRNAs were associated with 6 month mortality.MethodsClinical data and sera were collected from subjects enrolled in the Drug Induced Liver Injury Network prospective study. miRNAs were isolated from serum obtained from 78 subjects within 2 weeks of acute DILI and followed up for 6 months or longer. miRNAs were compared to 40 normal controls and 6 month survivors vs non‐survivors.ResultsThe mean age of the DILI cohort was 48 years, and 55% were female. Eleven (14.1%) subjects died, 10 within 6 months of DILI onset, 5 (45%) liver related. Lower levels of miRNAs‐122, ‐4463 and ‐4270 were associated with death within 6 months (P<.05). None of the subjects with miRNA‐122 greater than the median value died within 6 months for a sensitivity of 100% and specificity of 57%. In subjects with a serum albumin <2.8 g/dL and miR‐122<7.89 RFU the sensitivity, specificity, positive and negative predictive values for death within 6 months were 100%, 57%, 38% and 100% respectively.ConclusionsSerum miRNA‐122 combined with albumin accurately identified subjects who died within 6 months of drug induced liver injury. If confirmed prospectively, miRNA‐122 and albumin may be useful in identifying patients at high risk for mortality or liver transplantation.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136681/1/liv13312_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136681/2/liv13312.pd

Farmacovigilancia en promoción y prevención de no automedicación de antibióticos para prevenir reacciones adversas en niños menores de seis años en la droguería la Rebaja del barrio Santa Rita en la ciudad de Ibagué, Tolima

El proyecto tiene como fin educar a familiares de niños menores de 6 años en pro a prevenir prácticas de automedicación de antibióticos con el fin de que conozcan como su uso desmedido puede presentar problemas de salud y la presencia de eventos adversos, se ha evidenciado que en la droguería la rebaja ubicada en el barrio santa Rita en la ciudad de Ibagué se realizan compras de antibióticos pediátricos sin formula medica por ello nace la necesidad de estudiar los factores que promueven dichas prácticas y sus implicaciones en la salud, para su realización se usó una metodología de tipo aplicada con enfoque cualitativo, se implementaron encuestas a 50 personas entre padres de familia, cuidadores y familiares que compraron antibióticos sin formula médica, determinando su impacto en la presencia de eventos adverso, sé evidencio que la gran mayoría efectivamente automedican a sus infantes, no tienen conocimiento de las posibles RAM y no conocen los pasos para notificarla, para mitigar los casos de automedicación se implementó estrategias de promoción y prevención promoviendo el uso adecuado de los antibióticos para prevenir factores de riesgos derivados por su uso y promover el interés de la comunidad en participar en la farmacovigilancia y prevenir y reportar los reacciones adversas.The purpose of the project is to educate relatives of children under 6 years of age to prevent self-medication practices of antibiotics so that they know how their excessive use can cause health problems and the presence of adverse events. It has been shown that in The La Rebate drugstore located in the Santa Rita neighborhood in the city of Ibagué purchases of pediatric antibiotics without medical formula is made, which is why the need arises to study the factors that promote these practices. For its implementation, an applied methodology with a focus was used. qualitative, surveys were implemented among Fifty people among parents, caregivers and relatives who bought antibiotics without a medical formula, determining their impact on the presence of adverse events, it is evident that the vast majority effectively self-medicate their infants, they do not have knowledge of the possible ADRs and do not know the steps to notify them, to mitigate cases of self-medication, promotion and prevention strategies were implemented, promoting the appropriate use of antibiotics to prevent risk factors derived from their use and promote the community's interest in participating in the pharmacovigilance and preventing and reporting adverse reactions

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels

The mechanisms of allosteric action within pentameric ligand-gated ion channels (pLGICs) remain to be determined. Using crystallography, site-directed mutagenesis, and two-electrode voltage clamp measurements, we identified two functionally relevant sites in the extracellular (EC) domain of the bacterial pLGIC from Gloeobacter violaceus (GLIC). One site is at the C-loop region, where the NQN mutation (D91N, E177Q, and D178N) eliminated inter-subunit salt bridges in the open-channel GLIC structure and thereby shifted the channel activation to a higher agonist concentration. The other site is below the C-loop, where binding of the anesthetic ketamine inhibited GLIC currents in a concentration dependent manner. To understand how a perturbation signal in the EC domain, either resulting from the NQN mutation or ketamine binding, is transduced to the channel gate, we have used the Perturbation-based Markovian Transmission (PMT) model to determine dynamic responses of the GLIC channel and signaling pathways upon initial perturbations in the EC domain of GLIC. Despite the existence of many possible routes for the initial perturbation signal to reach the channel gate, the PMT model in combination with Yen's algorithm revealed that perturbation signals with the highest probability flow travel either via the β1-β2 loop or through pre-TM1. The β1-β2 loop occurs in either intra- or inter-subunit pathways, while pre-TM1 occurs exclusively in inter-subunit pathways. Residues involved in both types of pathways are well supported by previous experimental data on nAChR. The direct coupling between pre-TM1 and TM2 of the adjacent subunit adds new insight into the allosteric signaling mechanism in pLGICs. © 2013 Mowrey et al

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

Embryonic stem cell pluripotency, once achieved, triggers a switch in promoter affinity for Oct4, which leads to cardiogenesis

Prevalencia de infección por VIH/ SIDA en hombres que tienen sexo con hombres en Bucaramanga, Colombia

RESUMENINTRODUCCIÓN: La infección por VIH/SIDA continúa siendo un reto para la salud pública en términos de su prevención y control. El objetivo del estudio fue determinar la prevalencia de VIH/SIDA en el grupo de hombres que tienen sexo con hombres y los factores comportamentales que favorecen su transmisión. MATERIALES Y MÉTODOS: Estudio descriptivo trasversal con muestreo no probabilístico en sitios de encuentro frecuentados por esta población y en la cárcel. Se aplicó una encuesta estructurada y se realizó toma de muestra sanguínea anónima ligada por códigos para el diagnóstico de infección por VIH. RESULTADOS: Se encuestaron 336 hombres en 9 sitios con un promedio de 27,6 +/- 8,4 años. El 92,4% tenía estudios de secundaria o superiores, el 6% declaró vivir con pareja femenina y el 19,9% con pareja masculina estable. El 54,6% refrió que nunca o solo de forma ocasional utiliza preservativo con sus parejas sexuales. El 43% de los encuestados se había realizado prueba para VIH/SIDA y de éstos el 20,1% (29 hombres) ya tenían diagnóstico confirmatorio. Entre los 150 hombres tamizados se diagnosticaron 8 nuevos casos obteniendo una prevalencia general de 11,01%. CONCLUSIONES: Los hallazgos indican que la epidemia en el municipio corresponde a una de tipo concentrada. Aunque actualmente se recomiendan estrategias de prevención dirigidas a población general, en el municipio se recomienda continuar actividades específicas en este grupo de población que aún presenta conductas de riesgo para la trasmisión del VIH. Palabras clave: Prevalencia, HSH, tamizaje, diagnostico, VIH/SIDA ABSTRACT INTRODUCTION: Prevention and control of infection by HIV/AIDS is a challenge to public health. The aim of the study was to determine the prevalence of HIV/AIDS in men who have sex with men and the behavioral factors related with transmission in Bucaramanga, Colombia MATERIALS AND METHODS: Transversal descriptive serological survey with non probabilistic sampling in meeting and reclusion places. A structured interview and serum sample linked by codes was applied. RESULTS: 336 men with 27.6 +/- 8.4 age mean were studied in nine places. A 92.4% had secondary or upper education level. 6% were living with a female partner and 19.9% with a male partner. The 54.6% reported that never or occasionally used condom with their partners. The 43% of men had been tested for HIV and 20.1% of them (29 men) were already diagnosed as serum positive. Amongst 150 men screened, 8 new cases were diagnosed reaching 11.01% prevalence in general. CONCLUSIONS: Results show there is a concentrated epidemic HIV in Bucaramanga. In spite prevention strategies for general population currently carried out, it is recommended to continue specifc strategies for this population group to control risk behavior in the HIV transmission.  Keywords: Prevalence, MSM, Screening, diagnosis, HIV/AIDS

Prevalencia de infección por VIH/ SIDA en hombres que tienen sexo con hombres en Bucaramanga, Colombia

RESUMENINTRODUCCIÓN: La infección por VIH/SIDA continúa siendo un reto para la salud pública en términos de su prevención y control. El objetivo del estudio fue determinar la prevalencia de VIH/SIDA en el grupo de hombres que tienen sexo con hombres y los factores comportamentales que favorecen su transmisión. MATERIALES Y MÉTODOS: Estudio descriptivo trasversal con muestreo no probabilístico en sitios de encuentro frecuentados por esta población y en la cárcel. Se aplicó una encuesta estructurada y se realizó toma de muestra sanguínea anónima ligada por códigos para el diagnóstico de infección por VIH. RESULTADOS: Se encuestaron 336 hombres en 9 sitios con un promedio de 27,6 +/- 8,4 años. El 92,4% tenía estudios de secundaria o superiores, el 6% declaró vivir con pareja femenina y el 19,9% con pareja masculina estable. El 54,6% refrió que nunca o solo de forma ocasional utiliza preservativo con sus parejas sexuales. El 43% de los encuestados se había realizado prueba para VIH/SIDA y de éstos el 20,1% (29 hombres) ya tenían diagnóstico confirmatorio. Entre los 150 hombres tamizados se diagnosticaron 8 nuevos casos obteniendo una prevalencia general de 11,01%. CONCLUSIONES: Los hallazgos indican que la epidemia en el municipio corresponde a una de tipo concentrada. Aunque actualmente se recomiendan estrategias de prevención dirigidas a población general, en el municipio se recomienda continuar actividades específicas en este grupo de población que aún presenta conductas de riesgo para la trasmisión del VIH. Palabras clave: Prevalencia, HSH, tamizaje, diagnostico, VIH/SIDA ABSTRACT INTRODUCTION: Prevention and control of infection by HIV/AIDS is a challenge to public health. The aim of the study was to determine the prevalence of HIV/AIDS in men who have sex with men and the behavioral factors related with transmission in Bucaramanga, Colombia MATERIALS AND METHODS: Transversal descriptive serological survey with non probabilistic sampling in meeting and reclusion places. A structured interview and serum sample linked by codes was applied. RESULTS: 336 men with 27.6 +/- 8.4 age mean were studied in nine places. A 92.4% had secondary or upper education level. 6% were living with a female partner and 19.9% with a male partner. The 54.6% reported that never or occasionally used condom with their partners. The 43% of men had been tested for HIV and 20.1% of them (29 men) were already diagnosed as serum positive. Amongst 150 men screened, 8 new cases were diagnosed reaching 11.01% prevalence in general. CONCLUSIONS: Results show there is a concentrated epidemic HIV in Bucaramanga. In spite prevention strategies for general population currently carried out, it is recommended to continue specifc strategies for this population group to control risk behavior in the HIV transmission.  Keywords: Prevalence, MSM, Screening, diagnosis, HIV/AIDS

The transport mechanism of the mitochondrial ADP/ATP carrier

The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the mitochondrial matrix, which are key transport steps for oxidative phosphorylation in eukaryotic organisms. The transport protein belongs to the mitochondrial carrier family, a large transporter family in the inner membrane of mitochondria. It is one of the best studied members of the family and serves as a paradigm for the molecular mechanism of mitochondrial carriers. Structurally, the carrier consists of three homologous domains, each composed of two transmembrane α-helices linked with a loop and short α-helix on the matrix side. The transporter cycles between a cytoplasmic and matrix state in which a central substrate binding site is alternately accessible to these compartments for binding of ADP or ATP. On both the cytoplasmic and matrix side of the carrier are networks consisting of three salt bridges each. In the cytoplasmic state, the matrix salt bridge network is formed and the cytoplasmic network is disrupted, opening the central substrate binding site to the intermembrane space and cytosol, whereas the converse occurs in the matrix state. In the transport cycle, tighter substrate binding in the intermediate states allows the interconversion of conformations by lowering the energy barrier for disruption and formation of these networks, opening and closing the carrier to either side of the membrane in an alternating way. Conversion between cytoplasmic and matrix states might require the simultaneous rotation of three domains around a central translocation pathway, constituting a unique mechanism among transport proteins. This article is part of a Special Issue entitled: Mitochondrial Channels edited by Pierre Sonveaux, Pierre Maechler and Jean-Claude Martinou

General Anesthetics Predicted to Block the GLIC Pore with Micromolar Affinity

Although general anesthetics are known to modulate the activity of ligand-gated ion channels in the Cys-loop superfamily, there is at present neither consensus on the underlying mechanisms, nor predictive models of this modulation. Viable models need to offer quantitative assessment of the relative importance of several identified anesthetic binding sites. However, to date, precise affinity data for individual sites has been challenging to obtain by biophysical means. Here, the likely role of pore block inhibition by the general anesthetics isoflurane and propofol of the prokaryotic pentameric channel GLIC is investigated by molecular simulations. Microscopic affinities are calculated for both single and double occupancy binding of isoflurane and propofol to the GLIC pore. Computations are carried out for an open-pore conformation in which the pore is restrained to crystallographic radius, and a closed-pore conformation that results from unrestrained molecular dynamics equilibration of the structure. The GLIC pore is predicted to be blocked at the micromolar concentrations for which inhibition by isofluorane and propofol is observed experimentally. Calculated affinities suggest that pore block by propofol occurs at signifcantly lower concentrations than those for which inhibition is observed: we argue that this discrepancy may result from binding of propofol to an allosteric site recently identified by X-ray crystallography, which may cause a competing gain-of-function effect. Affinities of isoflurane and propofol to the allosteric site are also calculated, and shown to be 3 mM for isoflurane and for propofol; both anesthetics have a lower affinity for the allosteric site than for the unoccupied pore