167 research outputs found
Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder
Recent emotion dysregulationmodels of generalized anxiety disorder (GAD) propose chronic worry in GAD functions as a maladaptive attempt to regulate anxiety related to uncertain or unpredictable outcomes. Emotion acceptance is an adaptive emotion regulation strategy increasingly incorporated into newer cognitive behavioral therapy (CBT) approaches to GAD to counter chronic worry. The current study explores themechanisms of emotion acceptance as an alternate emotion regulation strategy to worry or emotion suppression using functionalmagnetic resonance imaging. Twenty-one female participants diagnosed with GAD followed counterbalanced instructions to regulate responses to personally relevant worry statements by engaging in either emotion acceptance, worry or emotion suppression. Emotion acceptance resulted in lower ratings of distress than worry and was associated with increased dorsal anterior cingulate cortex (dACC) activation and increased ventrolateral prefrontal cortex (VLPFC)-amygdala functional connectivity. In contrast, worry showed significantly greater distress ratings than acceptance or suppression and was associated with increased precuneus, VLPFC, amygdala and hippocampal activation. Suppression did not significantly differ fromacceptance in distress ratings or amygdala recruitment, but resulted in significantly greater insula and VLPFC activation and decreased VLPFC-amygdala functional connectivity. Emotion acceptance closely aligned with activation and connectivity patterns reported in studies of contextual extinction learning and mindful awareness.National Institute of Mental Health (U.S.) (Grant F31 MH084422
Functional Brain Basis of Hypnotizability
Context Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known.
Objective To investigate the brain basis of hypnotizability.
Design Cross-sectional, in vivo neuroimaging study performed from November 2005 through July 2006.
Setting Academic medical center at Stanford University School of Medicine.
Patients Twelve adults with high and 12 adults with low hypnotizability.
Main Outcome Measures Functional magnetic resonance imaging to measure functional connectivity networks at rest, including default-mode, salience, and executive-control networks; structural T1 magnetic resonance imaging to measure regional gray and white matter volumes; and diffusion tensor imaging to measure white matter microstructural integrity.
Results High compared with low hypnotizable individuals had greater functional connectivity between the left dorsolateral prefrontal cortex, an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex, anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information using independent component analysis. Seed-based analysis confirmed elevated functional coupling between the dorsal anterior cingulate cortex and the dorsolateral prefrontal cortex in high compared with low hypnotizable individuals. These functional differences were not due to any variation in brain structure in these regions, including regional gray and white matter volumes and white matter microstructure.
Conclusions Our results provide novel evidence that altered functional connectivity in the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted
HyTI: Thermal Infrared Spectroscopy from a 6U Platform
The HyTI (Hyperspectral Thermal Imager) mission, funded by NASA’s Earth Science Technology Office InVEST (In-Space Validation of Earth Science Technologies) program, will demonstrate how high spectral and spatial long-wave infrared image data can be acquired from a 6U CubeSat platform. The mission will use a spatially modulated interferometric imaging technique to produce spectro-radiometrically calibrated image cubes, with 25 channels between 8-10.7 μm, at 13 cm-1 resolution), at a ground sample distance of ~60 m. The HyTI performance model indicates narrow band NE∆Ts of \u3c 0.3 K. The small form factor of HyTI is made possible via the use of a no-moving-parts Fabry-Perot interferometer, and JPL’s cryogenically-cooled HOT-BIRD FPA technology. Launch is scheduled for no earlier than Fall 2021. The value of HyTI to Earth scientists will be demonstrated via on-board processing of the raw instrument data to generate L1 and L2 products, with a focus on rapid delivery of data regarding volcanic degassing, land surface temperature, and precision agriculture metrics.
In this presentation we will provide an overview of the HyTI measurement approach, the onboard data reduction approach and the spacecraft design. We will also provide an update on HyTI integration and testing
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Home-ownership as a social norm and positional good: subjective well-being evidence from panel data
Much attention has been devoted to examining the absolute benefits
of home-ownership (e.g. security and autonomy). This paper by contrast is
concerned with conceptualising and testing the relative benefits of homeownership;
those benefits that depend on an individual’s status in society.
Home-ownership has previously been analysed as a social norm, implying that
the relative benefits (costs) associated with being an owner (renter) are
positively related to relevant others’ home-ownership values. The theoretical
contribution of this paper is to additionally conceptualise home-ownership as a
positional good, implying that the status of both home-owners and renters is
negatively related to relevant others’ home-ownership consumption.
The empirical contribution of this paper is to quantitatively test for these relative
benefits in terms of subjective well-being. We run fixed effects regressions on
three waves of the British Household Panel Study. We find that i) a strengthening
of relevant others’ home-ownership values is associated with increases
(decreases) in the subjective well-being of home-owners (renters), and ii) an
increase in relevant others’ home-ownership consumption decreases the life
satisfaction of owners but has no effect for renters.
Overall our findings suggest that i) the relative benefit of home-ownership are
both statistically significant and of a meaningful magnitude, and ii) homeownership
is likely to be both a social norm and a positional good. Without
explicitly recognising these relative benefits, policymakers risk overestimating
the contribution of home-ownership to societal well-being
The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito anopheles gambiae
Molecular interactions between male and female factors during mating profoundly affect the reproductive behavior and physiology of female insects. In natural populations of the malaria mosquito Anopheles gambiae, blood-fed females direct nutritional resources towards oogenesis only when inseminated. Here we show that the mating-dependent pathway of egg development in these mosquitoes is regulated by the interaction between the steroid hormone 20-hydroxy-ecdysone (20E) transferred by males during copulation and a female Mating-Induced Stimulator of Oogenesis (MISO) protein. RNAi silencing of MISO abolishes the increase in oogenesis caused by mating in blood-fed females, causes a delay in oocyte development, and impairs the function of male-transferred 20E. Co-immunoprecipitation experiments show that MISO and 20E interact in the female reproductive tract. Moreover MISO expression after mating is induced by 20E via the Ecdysone Receptor, demonstrating a close cooperation between the two factors. Male-transferred 20E therefore acts as a mating signal that females translate into an increased investment in egg development via a MISO-dependent pathway. The identification of this male–female reproductive interaction offers novel opportunities for the control of mosquito populations that transmit malaria
Live face-to-face interaction during fMRI: A new tool for social cognitive neuroscience
Cooperative social interaction is critical for human social development and learning. Despite the importance of social interaction, previous neuroimaging studies lack two fundamental components of everyday face-to-face interactions: contingent responding and joint attention. In the current studies, functional MRI data were collected while participants interacted with a human experimenter face-to-face via live video feed as they engaged in simple cooperative games. In Experiment 1, participants engaged in a live interaction with the experimenter (“Live”) or watched a video of the same interaction (“Recorded”). During the “Live” interaction, as compared to the Recorded conditions, greater activation was seen in brain regions involved in social cognition and reward, including the right temporoparietal junction (rTPJ), anterior cingulate cortex (ACC), right superior temporal sulcus (rSTS), ventral striatum, and amygdala. Experiment 2 isolated joint attention, a critical component of social interaction. Participants either followed the gaze of the live experimenter to a shared target of attention (“Joint Attention”) or found the target of attention alone while the experimenter was visible but not sharing attention (“Solo Attention”). The right temporoparietal junction and right posterior STS were differentially recruited during Joint, as compared to Solo, attention. These findings suggest the rpSTS and rTPJ are key regions for both social interaction and joint attention. This method of allowing online, contingent social interactions in the scanner could open up new avenues of research in social cognitive neuroscience, both in typical and atypical populations.Simons FoundationNational Institutes of Health (Postdoctoral National Research Service Award
Does study duration have opposite effects on recognition and repetition priming?
We investigated whether manipulating the duration for which an item is studied has opposite effects on recognition memory and repetition priming, as has been reported by Voss and Gonsalves (2010). Robust evidence of this would support the idea that distinct explicit and implicit memory systems drive recognition and priming, and would constitute evidence against a single-system model (Berry, Shanks, Speekenbrink, & Henson, 2012). Across seven experiments using study durations ranging from 40 ms to 2250 ms, and two different priming tasks (a classification task in Experiments 1a, 2a, 3a, and 4, and a continuous identification with recognition (CID-R) task in Experiments 1b, 2b, and 3b), we found that although a longer study duration improved subsequent recognition in each experiment, there was either no detectable effect on priming (Experiments 1a, 2a, and 4) or a similar effect to that on recognition, albeit smaller in magnitude (Experiments 1b, 2b, 3a, and 3b). Our findings (1) question whether study duration has opposite effects on recognition and priming, and (2) are robustly consistent with a single-system model of recognition and priming
Anatomical connectivity patterns predict face selectivity in the fusiform gyrus
A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural connectivity, as measured through diffusion-weighted imaging, we were able to predict functional activation to faces in the fusiform gyrus. These predictions outperformed two control models and a standard group-average benchmark. The structure–function relationship discovered from the initial participants was highly robust in predicting activation in a second group of participants, despite differences in acquisition parameters and stimuli. This approach can thus reliably estimate activation in participants who cannot perform functional imaging tasks and is an alternative to group-activation maps. Additionally, we identified cortical regions whose connectivity was highly influential in predicting face selectivity within the fusiform, suggesting a possible mechanistic architecture underlying face processing in humans.United States. Public Health Service (DA023427)National Institute of Mental Health (U.S.) (F32 MH084488)National Eye Institute (T32 EY013935)Poitras FoundationSimons FoundationEllison Medical Foundatio
Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist)
Neurofeedback has begun to attract the attention and scrutiny of the scientific and medical mainstream. Here, neurofeedback researchers present a consensus-derived checklist that aims to improve the reporting and experimental design standards in the field.</p
Priming Picture Naming with a Semantic Task: An fMRI Investigation
Prior semantic processing can enhance subsequent picture naming performance, yet the neurocognitive mechanisms underlying this effect and its longevity are unknown. This functional magnetic resonance imaging study examined whether different neurological mechanisms underlie short-term (within minutes) and long-term (within days) facilitation effects from a semantic task in healthy older adults. Both short- and long-term facilitated items were named significantly faster than unfacilitated items, with short-term items significantly faster than long-term items. Region of interest results identified decreased activity for long-term facilitated items compared to unfacilitated and short-term facilitated items in the mid-portion of the middle temporal gyrus, indicating lexical-semantic priming. Additionally, in the whole brain results, increased activity for short-term facilitated items was identified in regions previously linked to episodic memory and object recognition, including the right lingual gyrus (extending to the precuneus region) and the left inferior occipital gyrus (extending to the left fusiform region). These findings suggest that distinct neurocognitive mechanisms underlie short- and long-term facilitation of picture naming by a semantic task, with long-term effects driven by lexical-semantic priming and short-term effects by episodic memory and visual object recognition mechanisms
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