Reproductive performance of resident and migrant males, females and pairs in a partially migratory bird

We thank everyone from the Centre for Ecology & Hydrology (CEH) who contributed to data collection, and Scottish Natural Heritage for access to the Isle of May National Nature Reserve. We thank the Scottish Ornithologists’ Club (SOC) for their support, and all volunteer observers, particularly Raymond Duncan, Moray Souter and Bob Swann. HG was funded by a Natural Environment Research Council (NERC) CASE studentship supported by CEH and SOC, FD, SW, MPH, MN and SB were funded by NERC and the Joint Nature Conservation Committee, and JMR was part-funded by the Royal Society. Finally, we thank the Associate Editor and two reviewers for constructive comments on the manuscript. The data are available from the Dryad Digital Repository https://doi.org/10.5061/dryad.532j0 (Grist et al., 2017)Peer reviewedPublisher PD

Impacts of climate change on seabirds, relevant to the coastal and marine environment around the UK

• The seabird declines that commenced at the end of the last century have continued during the last two decades. • Further research into the causes of these declines is required if we are to fully understand the complex mechanisms operating, which are known to vary geographically. Climate change is considered to be one of the main causes of the declines. The principal mechanism is the effect of climate warming on food supply. • There is growing evidence that short-term weather conditions have an important effect, including extreme weather events. Climate models predict further warming and increased severity and frequency of extreme weather events in UK waters. • Seabirds face an uncertain future and may decline further in the coming decades, as the interacting effects of new and existing influences will pose additional challenges

p53-Dependent Transcriptional Responses to Interleukin-3 Signaling

p53 is critical in the normal response to a variety of cellular stresses including DNA damage and loss of p53 function is a common feature of many cancers. In hematological malignancies, p53 deletion is less common than in solid malignancies but is associated with poor prognosis and resistance to chemotherapy. Compared to their wild-type (WT) counterparts, hematopoietic progenitor cells lacking p53 have a greater propensity to survive cytokine loss, in part, due to the failure to transcribe Puma, a proapoptotic Bcl-2 family member. Using expression arrays, we have further characterized the differences that distinguish p53−/− cells from WT myeloid cells in the presence of Interleukin-3 (IL-3) to determine if such differences contribute to the increased clonogenicity and survival responses observed in p53−/− cells. We show that p53−/− cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway. Contrastingly, we find that p53−/− cells are independent on AKT for their survival. Thus, loss of p53 in myeloid cells results in an altered transcriptional and kinase signaling environment that favors enhanced cytokine signaling

First high-resolution infrared spectra of 2–13C-propane:Analyses of the ν26 (B2) c-type and ν9 (A1) b-type bands

International audienc

The development and evaluation of mini-GEMs: a short, focused, online e-learning videos in geriatric medicine

Mini Geriatric E-Learning Modules (Mini-GEMs) are short, focused, e-learning videos on geriatric medicine topics, hosted on YouTube, which are targeted at junior doctors working with older people. This study aimed to explore how these resources are accessed and used. The authors analyzed the viewing data from 22 videos published over the first 18 months of the Mini-GEM project. We conducted a focus group of U.K. junior doctors considering their experiences with Mini-GEMS. The Mini-GEMs were viewed 10,291 times over 18 months, equating to 38,435 minutes of total viewing time. The average viewing time for each video was 3.85 minutes. Learners valued the brevity and focused nature of the Mini-GEMs and reported that they watched them in a variety of settings to supplement clinical experiences and consolidate learning. Watching the videos led to an increase in self-reported confidence in managing older patients. Mini-GEMs can effectively disseminate clinical teaching material to a wide audience. The videos are valued by junior doctors due to their accessibility and ease of use

Among-individual and within-individual variation in seasonal migration covaries with subsequent reproductive success in a partially migratory bird

Acknowledgements: We thank Raymond Duncan (Grampian Ringing Group), whose insatiable enthusiasm for ringing was inspirational. We thank everyone who contributed to fieldwork, especially Mike Harris and David Hunter; Roger Pradel for generous advice on CMR mixture models; and UK Natural Environment Research Council for funding (NE/R000859/1, NE/P009719/1). Data accessibility Data are available from the Dryad Digital Repository: https://doi.org/10.5061/dryad.pvmcvdnhv [46]. Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.5054649.Peer reviewedPostprin

Metallic Xenon, Molecular Condensates, and Superconductivity

A possibility of explaining the light absorption observed to occur under pressure-induced xenon metallization as due to the transition to the superconducting state is analyzed. The mechanism of the van der Waals bonding is discussed.Comment: LaTeX 2.09 (RevTeX), 4 pages, 4 PostScript figures included in tex

Between-individual variation in nematode burden among juveniles in a wild host:Variation in nematode burdens of juvenile birds

Parasite infection in young animals can affect host traits related to demographic processes such as survival and reproduction, and is therefore crucial to population viability. However, variation in infection among juvenile hosts is poorly understood. Experimental studies have indicated that effects of parasitism can vary with host sex, hatching order and hatch date, yet it remains unclear whether this is linked to differences in parasite burdens. We quantified gastrointestinal nematode burdens of wild juvenile European shags (Phalacrocorax aristotelis) using two in situ measures (endoscopy of live birds and necropsy of birds that died naturally) and one non-invasive proxy measure (fecal egg counts (FECs)). In situ methods revealed that almost all chicks were infected (98%), that infections established at an early age and that older chicks hosted more worms, but FECs underestimated prevalence. We found no strong evidence that burdens differed with host sex, rank or hatch date. Heavier chicks had higher burdens, demonstrating that the relationship between burdens and their costs is not straightforward. In situ measures of infection are therefore a valuable tool in building our understanding of the role that parasites play in the dynamics of structured natural populations

Hierarchical variation in phenotypic flexibility across timescales and associated survival selection shape the dynamics of partial seasonal migration

We thank everyone from UK Centre for Ecology & Hydrology and University of Aberdeen (UoA) who contributed to data collection, particularly Hannah Grist and Jenny Sturgeon; NatureScot for access to the Isle of May National Nature Reserve; Scottish Ornithologists' Club (SOC) for their support; and all volunteer observers, particularly Raymond Duncan and Moray Souter. This work was funded by Natural Environment Research Council (NERC; award NE/R000859/1 and award NE/R016429/1 as part of the UK-SCaPE programme delivering National Capability), Norwegian Research Council (SFF-III grant 223257), NTNU, UK Royal Society, Marine Alliance for Science and Technology for Scotland (MASTS), SOC and UoA.Peer reviewedPostprin

Study to examine the impact of climate change on seabird species off the east coast of Scotland and potential implications for environmental assessments

This study investigated the potential impacts of climate change on seabird distribution, abundance and demography off the east coast of Scotland, and examined integration of these climate models into standard population forecast models used in assessments for offshore wind developments