Distinguishing between True and False Stories using various Linguistic Features

This paper analyzes what linguistic features differentiate true and false stories written in Hebrew. To do so, we have defined four feature sets containing 145 features: POS-tags, quantitative, repetition, and special expressions. The examined corpus contains stories that were composed by 48 native Hebrew speakers who were asked to tell both false and true stories. Classification experiments on all possible combinations of these four feature sets using five supervised machine learning methods have been applied. The Part of Speech (POS) set was superior to all others and has been found as a key component. The best accuracy result (89.6%) has been achieved by a combination of sixteen POS-tags and one quantitative feature.

ENTREVISTA INEDITA A PREBISCH: LOGROS Y DEFICIENCIAS DE LA CEPAL

En este número de la Revista de la CEPAL se rinde homenaje a la influencia perdurable que han tenido las ideas y políticas de Raúl Prebisch sobre el desarrollo de América Latina y del tercer mundo en general. Las tesis del intercambio desigual que propugnaba Prebisch y su concepto de la economía mundial organizada sobre la base de una relación entre un centro y una periferia, por controvertidos que fueran, le merecieron un lugar reconocido en la historia del pensamiento económico. A través de la CEPAL y luego de la UNCTAD las ideas de Prebisch afectaron a los gobiernos e instituciones de toda América Latina y de todo el mundo. Los orígenes teóricos y la evolución del pensamiento de Prebisch han sido analizados extensamente por economistas e historiadores.1 En cambio, no se ha discutido casi nada cómo Prebisch formó a su equipo ni cómo difundió su tesis en la región y en el plano internacional. La siguiente entrevista fue concedida por Prebisch a David Pollock, su asistente y amigo de mucho tiempo, y viene a colmar ese vacío. En esta conversación, Prebisch pasa revista a algunos de los momentos más importantes de su vida y  de la CEPAL. El material abarca el período 1948-1963, desde el ingreso de Prebisch a la organización hasta los albores del decenio de 1960, cuando dejó la CEPAL para convertirse en el primer Director General de la Conferencia de las Naciones Unidas sobre Comercio y Desarrollo (UNCTAD)

Entrevista inedita a Prebisch: logros y deficiencias de la CEPAL

En este número de la Revista de la CEPAL se rinde homenaje a la influencia perdurable que han tenido las ideas y políticas de Raúl Prebisch sobre el desarrollo de América Latina y del tercer mundo en general. Las tesis del intercambio desigual que propugnaba Prebisch y su concepto de la economía mundial organizada sobre la base de una relación entre un centro y una periferia, por controvertidos que fueran, le merecieron un lugar reconocido en la historia del pensamiento económico. A través de la CEPAL y luego de la UNCTAD las ideas de Prebisch afectaron a los gobiernos e instituciones de toda América Latina y de todo el mundo. Los orígenes teóricos y la evolución del pensamiento de Prebisch han sido analizados extensamente por economistas e historiadores.1 En cambio, no se ha discutido casi nada cómo Prebisch formó a su equipo ni cómo difundió su tesis en la región y en el plano internacional. La siguiente entrevista fue concedida por Prebisch a David Pollock, su asistente y amigo de mucho tiempo, y viene a colmar ese vacío. En esta conversación, Prebisch pasa revista a algunos de los momentos más importantes de su vida y de la CEPAL. El material abarca el período 1948-1963, desde el ingreso de Prebisch a la organización hasta los albores del decenio de 1960, cuando dejó la CEPAL para convertirse en el primer Director General de la Conferencia de las Naciones Unidas sobre Comercio y Desarrollo (UNCTAD)

Traffic Equations and Granular Convection

We investigate both numerically and analytically the convective instability of granular materials by two dimensional traffic equations. In the absence of vibrations the traffic equations assume two distinctive classes of fixed bed solutions with either a spatially uniform or nonuniform density profile. The former one exists only when the function V(\rho) that monitors the relaxation of grains assumes a cut off at the closed packed density, \rho_c, with V(\rho_c)=0, while the latter one exists for any form of V. Since there is little difference between the uniform and nonuniform solution deep inside the bed, the convective instability of the bulk may be studied by focusing on the stability of the uniform solution. In the presence of vibrations, we find that the uniform solution bifurcates into a bouncing solution, which then undergoes a supercritical bifurcation to the convective instability. We determine the onset of convection as a function of control parameters and confirm this picture by solving the traffic equations numerically, which reveals bouncing solutions, two convective rolls, and four convective rolls. Further, convective patterns change as the aspect ratio changes: in a vertically long container, the rolls move toward the surface, and in a horizontally long container, the rolls move toward the walls. We compare these results with those reported previously with a different continuum model by Hayakawa, Yue and Hong[Phys. Rev. Lett. 75,2328, 1995]. Finally, we also present a derivation of the traffic equations from Enskoq equation.Comment: 34 pages, 10 figure

Schwarzschild Geometry Emerging from Matrix Models

We demonstrate how various geometries can emerge from Yang-Mills type matrix models with branes, and consider the examples of Schwarzschild and Reissner-Nordstroem geometry. We provide an explicit embedding of these branes in R^{2,5} and R^{4,6}, as well as an appropriate Poisson resp. symplectic structure which determines the non-commutativity of space-time. The embedding is asymptotically flat with asymptotically constant \theta^{\mu\nu} for large r, and therefore suitable for a generalization to many-body configurations. This is an illustration of our previous work arXiv:1003.4132, where we have shown how the Einstein-Hilbert action can be realized within such matrix models.Comment: 21 pages, 1 figur

Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring

International audienceA new miniaturized glucose oxidase based needle-type glu¬ cose mlcrosensor has been developed for subcutaneous glu¬ cose monitoring. The sensor Is equivalent In shape and size to a 26-gauge needle (0.45-mm o.d.) and can be Implanted with ease without any Incision. The novel configuration greatly facilitates the deposition of enzyme and polymer films so that sensors with characteristics suitable for In vivo use (upper limit of linear range > 15 mM, response time 60%). The sensor response is largely Independent of ox¬ ygen tension In the normal physiological range. It also ex¬ hibits good selectivity against common interferences except for the exogenous drug acetaminophen

Comprehensive analysis of temporal alterations in cellular proteome of bacillus subtilis under curcumin treatment

Curcumin is a natural dietary compound with antimicrobial activity against various gram positive and negative bacteria. This study aims to investigate the proteome level alterations in Bacillus subtilis due to curcumin treatment and identification of its molecular/cellular targets to understand the mechanism of action. We have performed a comprehensive proteomic analysis of B. subtilis AH75 strain at different time intervals of curcumin treatment (20, 60 and 120 min after the drug exposure, three replicates) to compare the protein expression profiles using two complementary quantitative proteomic techniques, 2D-DIGE and iTRAQ. To the best of our knowledge, this is the first comprehensive longitudinal investigation describing the effect of curcumin treatment on B. subtilis proteome. The proteomics analysis revealed several interesting targets such UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, putative septation protein SpoVG and ATP-dependent Clp protease proteolytic subunit. Further, in silico pathway analysis using DAVID and KOBAS has revealed modulation of pathways related to the fatty acid metabolism and cell wall synthesis, which are crucial for cell viability. Our findings revealed that curcumin treatment lead to inhibition of the cell wall and fatty acid synthesis in addition to differential expression of many crucial proteins involved in modulation of bacterial metabolism. Findings obtained from proteomics analysis were further validated using 5-cyano-2,3-ditolyl tetrazolium chloride (CTC) assay for respiratory activity, resazurin assay for metabolic activity and membrane integrity assay by potassium and inorganic phosphate leakage measurement. The gene expression analysis of selected cell wall biosynthesis enzymes has strengthened the proteomics findings and indicated the major effect of curcumin on cell division

Effects of Engineered Nanoparticles on the Assembly of Exopolymeric Substances from Phytoplankton

The unique properties of engineered nanoparticles (ENs) that make their industrial applications so attractive simultaneously raise questions regarding their environmental safety. ENs exhibit behaviors different from bulk materials with identical chemical compositions. Though the nanotoxicity of ENs has been studied intensively, their unintended environmental impacts remain largely unknown. Herein we report experimental results of EN interactions with exopolymeric substances (EPS) from three marine phytoplankton species: Amphora sp., Ankistrodesmus angustus and Phaeodactylum tricornutum. EPS are polysaccharide-rich anionic colloid polymers released by various microorganisms that can assemble into microgels, possibly by means of hydrophobic and ionic mechanisms. Polystyrene nanoparticles (23 nm) were used in our study as model ENs. The effects of ENs on EPS assembly were monitored with dynamic laser scattering (DLS). We found that ENs can induce significant acceleration in Amphora sp. EPS assembly; after 72 hours EN-EPS aggregation reached equilibrium, forming microscopic gels of ∼4–6 µm in size. In contrast, ENs only cause moderate assembly kinetic acceleration for A. angustus and P. tricornutum EPS samples. Our results indicate that the effects of ENs on EPS assembly kinetics mainly depend on the hydrophobic interactions of ENs with EPS polymers. The cycling mechanism of EPS is complex. Nonetheless, the change of EPS assembly kinetics induced by ENs can be considered as one potential disturbance to the marine carbon cycle

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls.Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls.Peer reviewe