The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

ANALISIS KINERJA SISTEM PENGENDALI LEVEL DI CONDENSER DENGAN IDENTIFIKASI SISTEM KALANG TERTUTUP (STUDI KASUS DI CONDENSER PEMBANGKIT LISTRIK TENAGA PANAS BUMI UNIT IV PT.PERTAMINA GEOTHERMAL ENERGY AREA KAMOJANG)

System Identification is a method for determining the dynamic model of a system from input and output measurements of the system. Knowing a model system is needed to design and implement control systems with optimal performance. System identification is an experimental approach for determining the dynamic model of a system. Based on the results of closed-loop identification with algorithm closed-loop output error (CLOE) condenser system plant model is obtained and the control valve is of second order system. Analysis of responses transient and steady state of model in a closed loop system with exciting controller in the plant showed a fast oscillating with a settling time 4.28 seconds, peak time 3.58 seconds, rise time 0.756 seconds and no error steady state. Re-tuning control system gives the best results in response system using proportional-integral controller (PI) with the principle of ISE. The aim of re-tuning is to find the controllers constant that provides optimum performance and gives safety of the system especially in the actuator and the final element. Simulation results using MATLAB software shows the settling time of 24.7 seconds, peak time 3.57 seconds, rise time of 1.03 seconds and no steady state error occured. Controller constants the results of the re-tuning proportional band (K) is 260.34%, integral time (Ti) is 0.36 seconds and the time derivative (Td) 0 seconds

Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions (SCAI) 2021 think tank

The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture that brings together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community annually for high‐level field‐wide discussions. The 2021 Think Tank was organized into four parallel sessions reflective of the field of interventional cardiology: (a) coronary intervention, (b) endovascular medicine, (c) structural heart disease, and (d) congenital heart disease. Each session was moderated by a senior content expert and co‐moderated by a member of SCAI's Emerging Leader Mentorship program. This document presents the proceedings to the wider cardiovascular community in order to enhance participation in this discussion, create additional dialog from a broader base, and thereby aid SCAI, the industry community and external stakeholders in developing specific action items to move these areas forward

Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions (SCAI) 2021 think tank

The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture that brings together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community annually for high-level field-wide discussions. The 2021 Think Tank was organized into four parallel sessions reflective of the field of interventional cardiology: (a) coronary intervention, (b) endovascular medicine, (c) structural heart disease, and (d) congenital heart disease. Each session was moderated by a senior content expert and co-moderated by a member of SCAI\u27s Emerging Leader Mentorship program. This document presents the proceedings to the wider cardiovascular community in order to enhance participation in this discussion, create additional dialog from a broader base, and thereby aid SCAI, the industry community and external stakeholders in developing specific action items to move these areas forward