Sheridan School of Architectural Technology Volume 3 [W2018+S2018]

This volume shows the work of the graduating students of the Architectural Technology programme. Once again, their hard work over three years of study shows both in the variety and in the quality of their work. The work presented here was prepared in a single course but it draws from all the courses in the programme. It reflects their capabilities in design, building science, legislation, regulations, graphical representation and technology. Each piece of work represents the individual blend of these that each student possesses. As they leave Sheridan they take with them a range of knowledge and skills that will start their careers. As their careers develop some will do exactly what they thought and more will move in completely new and unexpected directions. Please enjoy the work presented here and think of the future to come.https://source.sheridancollege.ca/fast_books/1005/thumbnail.jp

Genome sequence of the parainfluenza virus 5 strain that persistently infects AGS cells

This work, including the efforts of Richard E Randall, was funded by Wellcome Trust (101788/Z/13/Z). This work, including the efforts of Steve Goodbourn, was funded by Wellcome Trust (101792/Z/13/Z).We have sequenced the parainfluenza virus 5 strain that persistently infects the commonly used AGS human cell line without causing cytopathology. This virus is most closely related to human strains, indicating that it may have originated from biopsy material or from laboratory contamination during generation of the cell line.Publisher PDFPeer reviewe

Atmospheric deposition at groundwater dependent wetlands phase 2 : nutrient source apportionment case studies from England and Wales

Groundwater dependent terrestrial ecosystems (GWDTEs) face multiple pressures from both atmospheric and terrestrial sources, resulting in the loss of protected habitats and biodiversity. One of the most critical issues facing GWDTEs in England and Wales is anthropogenic pollution from nutrients. Anthropogenic nutrients can originate from a wide range of sources including industry and agriculture, and can be transmitted via multiple pathways including; surface waters, catchment runoff, groundwater, and atmospheric deposition. These multiple pathways pose a problem for environmental regulators and managers. In order to reduce nutrient damage to wetlands, environmental regulators must first have the tools to identify the dominant sources and pathways (source attribution) of nutrients. Environmental regulators need cost effective tools to identify the most common source of nutrients in order to implement effective measures to reduce pressures. However there are a lack of source apportionment studies for GWDTEs, and no framework by which to assess multiple sources of nitrogen. This report aims to bridge that gap by considering both atmospheric and terrestrial sources of nitrogen in one study. Three GWDTEs were studied all characterised during previous Water Framework Directive investigations; Wybunbury Moss, Newbald Becksies and Cors Bodeilio. Each site benefited from existing monitoring data and an evidenced based conceptual model, significantly reducing costs to this project. Field data collection included; inorganic chemistry of groundwater, surface water and rainfall, nitrogen and oxygen isotopes and CFC /SF6 and NH3 /NO2 diffusion tubes deployed to quantify atmospheric dry gaseous deposition. Desk based analysis included; modeled atmospheric source apportionment from www.APIS.ac.uk, catchment nutrient modelling using the ‘Farmscoper’ tool and calculation and comparison of nutrient fluxes against site relevant critical loads from both modeled and measured atmospheric deposition data. We found that; Modelled atmospheric deposition data (www.APIS.ac.uk) was broadly comparable to our monthly on-site data collected at the three GWDTEs, but individual sites showed differing variability in ammonia concentrations compared with the national data. Modeled data provides a reliable way to quickly assess atmospheric loading at GWDTEs for national scale assessments, however site specific assessments should undertake their own measurements of ammonia concentrations. Detailed on site assessments of the pressure from atmospheric deposition to individual habitats are possible using National Vegetation Classification (NVC) mapping combined with Critical Load thresholds and modelled atmospheric deposition. Together these can provide a high resolution picture at site scale, provided vegetation mapping is available Open access modelling tool FarmScoper (ADAS) was successfully applied, however in both examples the modelling shows that even with land use changes the reduction in terrestrial nitrate would not be significant enough to meet the proposed groundwater ‘threshold’ values for nitrate

People of the British Isles: preliminary analysis of genotypes and surnames in a UK control population

There is a great deal of interest in fine scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to play a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. Here we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK control population that can be used as a resource by the research community as well as providing fine scale genetic information on the British population. So far, some 4,000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3,865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1,057 samples demonstrates the value of these samples for investigating fine scale population structure within the UK, and shows how this can be enhanced by the use of surnames

Tribute to Professor David Bruck

A tribute to Professor David I. Bruck, who served on the faculty of the Washington and Lee University School of Law from 2004 to 2020. Bruck directed W&L\u27s death penalty defense clinic, the Virginia Capital Case Clearinghouse, also known as VC3 . He became Professor of Law, Emeritus in 2020

Discriminating between the origins of remotely sensed circular structures:carbonate mounds, diapirs or periclinal folds? Purbeck Limestone Group, Weymouth Bay, UK

Many sedimentary rock successions contain plan-view circular structures, such as impacts, diapirs and carbonate build-ups. When remotely sensed, it can be difficult to discriminate between their formation mechanisms. Here we examine this problem by assessing the origins of circular structures imaged in high-resolution multibeam bathymetric data from Weymouth Bay, UK. The imagery shows 30–150 m across, concave-down structures within the upper Purbeck Limestone Group on the southern limb of the Purbeck Anticline. Similar structures have not been identified in the extensive outcrops around the bay. The morphology and geological setting of the structures are consistent with three different interpretations: carbonate mounds, periclinal folds and evaporite diapirs. However, none of these structures has been previously recorded in the upper Purbeck Limestone Group outcrops of this internationally renowned geological region. We apply a scoring system to 25 features of the circular structures to discriminate between these three alternative interpretations. This analysis indicates that evaporite diapirs are the least likely and carbonate mounds the most likely origin of the structures. The presence of carbonate mounds revises the upper Purbeck palaeofacies distribution in its type area and provides an analogue for the exploration for hydrocarbon reservoirs in lacustrine mounds

Sustainable computational science: the ReScience initiative

Computer science o ers a large set of tools for prototyping, writing, running, testing, validating, sharing and reproducing results, however computational science lags behind. In the best case, authors may provide their source code as a compressed archive and they may feel con dent their research is reproducible. But this is not exactly true. Jonathan Buckheit and David Donoho proposed more than two decades ago that an article about computational results is advertising, not scholarship. e actual scholarship is the full so ware environment, code, and data that produced the result. is implies new work ows, in particular in peer-reviews. Existing journals have been slow to adapt: source codes are rarely requested, hardly ever actually executed to check that they produce the results advertised in the article. ReScience is a peer-reviewed journal that targets computational research and encourages the explicit replication of already published research, promoting new and open-source implementations in order to ensure that the original research can be replicated from its description. To achieve this goal, the whole publishing chain is radically di erent from other traditional scienti c journals. ReScience resides on GitHub where each new implementation of a computational study is made available together with comments, explanations, and so ware tests