Impact of radiation on teeth survival of head and neck cancer patients : a dosimetric-based retrospective study

Orientadores: Alan Roger dos Santos Silva, Mário Fernando de GoesTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de PiracicabaResumo: Objetivos: Caracterizar eventos dentários adversos (EDA) associados à extração pós-radioterapia (RT) e analisar o impacto da radiação na sobrevida dos dentes de pacientes com carcinomas espinocelulares (CEC) da cabeça e do pescoço. Métodos: Este é um estudo retrospectivo, baseado na distribuição dosimétrica dentária individual de pacientes com CEC da cabeça e do pescoço. O estudo caracterizou os EDA mais relevantes associados a extrações pós-RT, investigou o impacto de 3 gradientes de radiação dentária (60 Gy), assim como os grupos dentários anatômicos [anteriores (A), pré-molares (PM) e molares (M); ipsilaterais (i) ou contralaterais (c); maxilares (Max) ou mandibulares (Man)] na sobrevida de dentes pós-RT por meio da análise de sobrevida de Kaplan-Meier e o teste de log-rank. Por fim, o risco de extração dentária pós-RT para cada gradiente de radiação foi calculado por meio do odds ratio (OR) com intervalos de confiança (IC) de 95%. Resultados: 1.071 dentes, de 66 pacientes que concluíram a RT para o tratamento de CEC da cabeça e do pescoço, foram incluídos neste estudo. A cárie-relacionada à radioterapia (CRR) foi o EDA mais frequentemente (67.8%) associado a extrações pós-RT. A prevalência de CRR e periodontite apical variou de modo estatisticamente significativo (p60 Gy) foram 44.4%, 37.1% e 18.8%, respectivamente, e a sobrevida média dentária específica por gradiente de radiação foi de 38,6 meses (IC: 36.1-41.2), 39,6 meses (IC: 37.7-41.5) e 30,5 meses (IC: 25.0-36.1), respectivamente (p=0.004). Considerando-se os grupos dentários anatômicos, os resultados revelaram a seguinte distribuição da sobrevida média dentária: MiMax 60 Gy (IC: 1.56-5.35; p60 Gy apresentaram menor sobrevida pós-RTAbstract: Purpose: To characterize the dental adverse events (DAE) associated with post-head and neck radiotherapy (HNRT) teeth extractions and to investigate the impact of radiation on teeth survival in head and neck squamous cell carcinoma (HNSCC) patients. Methods: A retrospective dosimetric-based analysis of individual post-HNRT tooth from HNSCC patients was conducted. The most prevalent DAE affecting post-HNRT extracted teeth were categorized and the impact of 3 different radiation dose tiers (60 Gy) as well as the anatomical teeth groups [anterior teeth (A), premolars (PM), and molars (M); ipsilateral (i) or contralateral (c); maxillary (Max) or mandibular (Man) teeth] on teeth survival was analyzed, using the Kaplan-Meier analysis and the log-rank test. The risk assessment, odds ratio (OR), for post-HNRT tooth extraction was further calculated for each studied radiation dose tier with a 95% coincidence level set to test the significance. Results: 1,071 teeth, from 66 patients with HNSCC who underwent HNRT, were included in this study. Radiation-related caries (RRC) was the most frequent (67.8%) DAE associated with post-HNRT teeth extractions. The prevalence of RRC and apical periodontitis significantly differed among teeth subjected to the different studied radiation dose tiers (p60 Gy) were 44.4%, 37.1% and 18.8%, respectively. Following the same radiation dose tiers distribution, mean teeth survival was 38.6 (CI: 36.1-41.2) months, 39.6 (CI: 37.7-41.5) months and 30.5 (CI: 25.0-36.1), respectively (p=0.004). In terms of anatomical teeth groups, the results showed that mean teeth survival was: MiMax 60 Gy (CI: 1.56-5.35; p60 Gy presented reduced survivalDoutoradoPatologiaDoutor em Estomatopatologi

VOCAL REPERTORY OF TWO SPECIES OF THE LEPTODACTYLUS PENTADACTYLUS GROUP (ANURA, LEPTODACTYLIDAE)

Among frogs, vocalizations play important roles in their social interactions. Herein we describefi ve new types of vocalizations for two foam-nesting species of the Leptodactylus pentadactylusgroup, L. syphax and L. labyrinthicus. Behavioral observations and recordings were done in fourlocalities within the Cerrado biome, at southeast and central Brazil. Before emitting advertisementcalls, males of L. syphax often started producing a sequence of notes, which gradually turned into theadvertisement call. These different notes may be an introductory call, which would serve to preparethe vocal structures for the emission of the high-frequency/amplitude advertisement calls. A male ofL. syphax was emitting advertisement calls when a female approached and started to emit brief andlow-amplitude calls; these vocalizations probably are reciprocation calls. Males of L. labyrinthicusinvolved in agonistic interactions can emit vocal cracks (encounter call) and deep rough sounds (territorialcalls). Five courting males of L. labyrinthicus released screams with their mouth slightly openedin response to the approach of human observers. We conclude that these screams do not representdistress or territorial calls

Sugarcane nutrition for food and environmental security/ Nutrição da cana-de-açúcar para segurança alimentar e ambiental

Sugarcane is an important cash crop cultivated globally from temperate to tropical regions. Improving cane yield and recovery sustainably is an important research area for improving livelihoods of the cane farmers. Among different approaches sill judicious and integrated use of nutrients as per plant needs holds the special place. Further, applying need based N management through optical gadgets viz. Leaf color chart (LCC), SPAD, Green seeker, integrated nutrient management, fertigation, special focus on for improving the efficiency of different fertilizers through different state of art technologies. For having higher fertilizer use efficiency in sugarcane, some aspects of fertilization especially How much? What type of? When to add? Is it worth? Number of splits? Mode of action? must be considered both for seed or ratoon. Further, soil textural class and climatic conditions on one side while on changing climatic conditions also affected it a lot. Further, inherent fertility status of the soils is also an important factor which affects the fate of applied fertilizers. There is a need to create awareness in between the farmers for not to applying huge quantity of different fertilizers as per their neighboring farmers, rather farmer should be smart enough to adopt different technologies in a smart way for having better benefits and thus livelihoods as the purpose is to fed the canes but not the soil. In the present review an attempt being made to compare the comparative performance of sugarcane with respect to fertilization for finally guiding the sugarcane cultivars. Idea is to enlighten them regarding need based sustainable fertilization with an aim to improve the fertilizer use efficiencies for having improved yield and quality parameters instead of loading the soil with much of fertilizers which further have environmental concerns.  

Uma recusa ao servir: processos de libertação na Ética de Spinoza

This article aims to emphasize the processes of liberation in Spinoza’s ethics by problematizing how it is possible that man, who is not born free, becomes free, even in the face of his conditions more prone to servitude and the strength of affects, as well as as being a finite mode of the Substance (God), as the Dutch seventeenth-century ontology is based on.Este artigo tem o objetivo de enfatizar os processos de libertação na ética de Spinoza ao problematizar como é possível que o homem, que não nasce livre, torna-se livre, mesmo diante de suas condições mais propensas à servidão e à força dos afetos, bem como por ser um modo finito da Substância (Deus), conforme fundamenta a ontologia do seiscentista holandês

OCORRÊNCIA DE Lycopodiella cernnua (L.) PICHI-SERMOLLI (PTERIDOPHYTA: LYCOPODIOPSIDA: LYCOPODIACEAE) NAS BORDAS DE MANGUEZAL, SÃO LUÍS – MARANHÃO - BRASIL

  The occurrence of Lycopodiella cernnua (L.) Pichi-Sermolli (Pteridophyte: Lycopodiopsida: Lycopodiaceae) on mangrove bordering areas, São Luís – MA - Brazil.   The Pteridophyte division is represented by vascular criptogams of very varied habits, which may range from arborescent forms, of erect stems and large leaves up to small size, almost microscopic forms.  Lycopodiella cernnua specimens were collected, on the margins of Parna Açu’s mangrove, located in the southwest of the São Luís Island. Pteridophytes specimens were observed with great frequency on a hillside located on the bordering area of this mangrove where high humidity rates were recorded. Regarding the habitat, they are terrestrial, of open and humid sites, such as ravines; they are virtually cosmopolitan and very variable.   Key words: Pteridophyte, Lycopodiella cernnua, mangrove.

In situ analysis of gelatinolytic activity in human dentin

Matrix metalloproteinases (MMPs) such as gelatinases are differentially expressed in human tissues. These enzymes cleave specific substrates involved in cell signaling, tissue development and remodeling and tissue breakdown. Recent evidences show that gelatinases are crucial for normal dentin development and their activity is maintained throughout the entire tooth function in the oral cavity. Due to the lack of information about the exact location and activity of gelatinases in mature human dentin, the present study was designed to examine gelatinolytic levels In sound dentin. In situ zymography using confocal microscopy was performed on both mineralized and demineralized dentin samples. Sites presenting gelatinase activity were identified throughout the entire biological tissue pursuing different gelatinolytic levels for distinct areas: predentin and dentinal tubule regions presented higher gelatinolytic activity compared to intertubular dentin. Dentin regions with higher gelatinolytic activity immunohistochemically were partially correlated with MMP-2 expression. The maintenance of gelatinolytic activity in mature dentin may have biological implications related to biomineralization of predentin and tubular/peritubular dentinal regions, as well as regulation of defensive mechanisms of the dentin-pulp complex.Peer reviewe

An assessment of the level of knowledge of secondary school students from the State of Pernambuco, Brazil, regarding Human Papillomavirus (HPV) and prophylactic vaccinations/ Uma avaliação do nível de conhecimento de estudantes do ensino médio do estado de Pernambuco, Brasil, sobre o Papilomavírus Humano (HPV) e as vacinas profiláticas

The aim of this study was to assess the knowledge of high school students about HPV and their awareness that a vaccine is available as prophylactic treatment. Nine hundred and eighty-six students were surveyed—the gender distribution being 61.5% female and 38.5% male. Of those surveyed, 67.1% said they had heard of HPV, but only 53.3% of those familiar with the virus knew a prophylactic treatment was available. Female students knew more about HPV than did their male counterparts (71.6% v. 60%), consequently fewer males knew of the vaccine (58.3% v. 50.7%). The students’ acceptance of the HPV vaccine as prophylactic treatment was correlated with both prior knowledge of the virus and the vaccine. Therefore, the study concluded that it is necessary to increase public awareness about HPV and with the availability of a the vaccine as preventative treatment. That is important due to a great level of resistance to vaccination in several states of Brazil. This study highlights the need for new public health policies.

Nutritional status, nutrient accumulation and yield of corn grown in Yellow-Red Oxisol

Corn extracts and accumulates high amounts of soil nutrients due to its high forage yield. The aim of this study was to evaluate nutritional status, nutrient accumulation, and forage yield of corn hybrid BM 3066 PRO2, as well as primary macronutrient balance in the soil-plant system. Thus, a systematic sampling was carried out in seven crop areas of corn grown in a Yellow-Red Oxisol. Plants did not show nutrient deficiency. Leaf contents had the following decreasing order of concentration N> K> Ca> P> S> Mg> Fe = Mn> Zn> B> Cu. Biometric evaluations were carried out and we found average plant height and first ear insertion height of 2.42m and 1.52m, respectively. Fresh and dry biomass yields were 57.17 and 18.36 t ha-1, respectively. The accumulation of primary macronutrients in plant shoot biomass was 235.95 kg ha-1 N, 36.99 kg ha-1 P and 225.53 kg ha-1 K. Nutrient balance was positive for nitrogen (9.1 kg) and phosphorus (22 kg), but negative for potassium (-15 kg)

Peixes pescados e esculpidos: zoomorfos e haliêutica nos sambaquis do sul do Brasil

Este artigo versa sobre a presença e distribuição de esculturas zoomórficas (e antropomórficas) de estilo sambaquiano no Rio Grande do Sul e sua eventual relação com o conhecimento etnoictiológico dos pescadores contemporâneos. A partir dessa perspectiva, acredita-se ser possível propor novas inferências na interpretação destas esculturas, na dinâmica da ocupação sambaquieira no Estado e aferir uma continuidade da atividade humana com o ambiente litorâneo e os recursos costeiros

Evolução da Produção Científica em Contabilidade no Brasil: Uma análise da IES no período de 2010 a 2018: Evolution of Scientific Production in Accounting in Brazil: An analysis of the IES in the period from 2010 to 2018

Este artigo analisa e pontua o perfil de publicação das dissertações de mestrado de uma IES no período de 2010 a 2018. Para a elaboração fez-se o uso de uma metodologia descritiva, quantitativa, bibliográfica e documental, além de ser caracterizado como estudo bibliométrico. Do total de 206 dissertações publicadas e defendidas, 118 foram identificadas como de contabilidade. A análise indicou que o gênero predominante nas publicações é o masculino, os orientadores com maior número de orientações são Dr Ivam R. Peleias, Dr Marcos R. S. Pertes e Dr Claudio Parisi. A pesquisa apresentou 19 categorias de assunto, predominando Contabilidade Gerencial, Societária e Educação e Ensino. Na metodologia evidenciou-se um maior número de pesquisas com abordagem qualitativa. Identificou-se ainda 46 categorizações e combinações dos procedimentos metodológicos