Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Entire Life Time Monitoring of Filament Wound Composite Cylinders Using Bragg Grating Sensors: III. In-Service External Pressure Loading

International audienceThis article is the third of three papers describing a study of the monitoring of filament wound composite cylinders for underwater applications. Part I described the technological issues and the development of specimens instrumented with embedded gratings and thermocouples, with the aim of monitoring the temperature and strain changes during the cylinder manufacturing presented in Part II. Residual strains are not negligible, over 1,000 axial micro-strain at the end of the curing cycle. Part III describes the response of these cylinders to hydrostatic pressure loading. The same embedded fiber optical Bragg gratings (FBGs) used for parts I and II of the study are here used as strain gauges. Their response is compared to that of classical resistive strain gages bonded to the inner surface of the tube. Results from these initial tests demonstrate the embedded FBG sensor's capability to monitor structural health of an underwater structure from fabrication throughout its service life. Embedded instrumentation records strains during pressure cycles up to final failure, without affecting the cylinder response