Cold Fermi-gas with long range interaction in a harmonic trap

We study equilibrium density and spin density profiles for a model of cold one-dimensional spin 1/2 fermions interacting via inverse square interaction and exchange in an external harmonic trap. This model is the well-known spin-Calogero model (sCM) and its fully nonlinear collective field theory description is known. We extend the field theory description to the presence of an external harmonic trap and obtain analytic results for statics and dynamics of the system. For instance, we find how the equilibrium density profile changes upon tuning the interaction strength. The results we obtain for equilibrium configurations are very similar to the ones obtained recently by Ma and Yang [1] for a model of fermions with short ranged interactions. Our main approximation is the neglect of the terms of higher order in spatial derivatives in equations of motion - gradientless approximation [2]. Within this approximation the hydrodynamic equations of motion can be written as a set of decoupled forced Riemann-Hopf equations for the dressed Fermi momenta of the model. This enables us to write analytical solutions for the dynamics of spin and charge. We describe the time evolution of the charge density when an initial non-equilibrium profile is created by cooling the gas with an additional potential in place and then suddenly removing the potential. We present our results as a simple "single-particle" evolution in the phase-space reminiscing a similar description of the dynamics of non-interacting one-dimensional fermions.Comment: 11 pages, 5 figures (figure typo corrected and references added

Identification of small-molecule inhibitors of the antiapoptotic protein myeloid cell leukaemia-1 (Mcl-1)

Protein–protein interactions (PPIs) control many cellular processes in cancer and tumour growth. Of significant interest is the role PPIs play in regulating apoptosis. The overexpression of the antiapoptosis regulating Bcl-2 family of proteins is commonly observed in several cancers, leading to resistance towards both radiation and chemotherapies. From this family, myeloid cell leukemia-1 (Mcl-1) has proven the most difficult to target, and one of the leading causes of treatment resistance. Exploiting the selective PPI between the apoptosis-regulating protein Noxa and Mcl-1, utilising a fluorescence polarization assay, we have identified four small molecules with the ability to modulate Mcl-1. The identified compounds were computationally modelled and docked against the Mcl-1 binding interface to obtain structural information about their binding sites allowing for future analogue design. When examined for their activity towards pancreatic cell lines that overexpress Mcl-1 (MiaPaCa-2 and BxPC-3), the identified compounds demonstrated growth inhibition, suggesting effective Mcl-1 modulation

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration

Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated administration of cisplatin. In this study, we assessed whether a low (subclinical) dose of cisplatin could be utilized as a model of nausea and emesis in the dog while decreasing the severity of adverse events to allow repeated administration. The emetic, nausea-like behavior and potential biomarker response to both the clinical dose (70 mg/m2) and low dose (15 mg/m2) of cisplatin was assessed. Plasma creatinine concentrations and granulocyte counts were used to assess adverse effects on the kidneys and bone marrow, respectively. Nausea-like behavior and emesis was induced by both doses of cisplatin, but the latency to onset was greater in the low-dose group. No significant change in plasma creatinine was detected for either dose groups. Granulocytes were significantly reduced compared with baseline (P = 0.000) following the clinical, but not the low-dose cisplatin group. Tolerability of repeated administration was assessed with 4 administrations of an 18 mg/m2 dose cisplatin. Plasma creatinine did not change significantly. Cumulative effects on the granulocytes occurred, they were significantly decreased (P = 0.03) from baseline at 3 weeks following cisplatin for the 4th administration only. Our results suggest that subclinical doses (15 and 18 mg/m2) of cisplatin induce nausea-like behavior and emesis but have reduced adverse effects compared with the clinical dose allowing for repeated administration in crossover studies

Shorter constant work rate cycling tests as proxies for longer tests in highly trained cyclists

Severe-intensity constant work rate (CWR) cycling tests simulate the high-intensity competition environment and are useful for monitoring training progression and adaptation, yet impose significant physiological and psychological strain, require substantial recovery, and may disrupt athlete training or competition preparation. A brief, minimally fatiguing test providing comparable information is desirable. Purpose To determine whether physiological variables measured during, and functional decline in maximal power output immediately after, a 2-min CWR test can act as a proxy for 4-min test outcomes. Methods Physiological stress (VO _2 kinetics, heart rate, blood lactate concentrations ([La-]b)) was monitored and performance fatigability was estimated (as pre-to-post-CWR changes in 10-s sprint power) during 2- and 4-min CWR tests in 16 high-level cyclists (VO _2peak ¼ 64:4 ± 6:0 ml·kg-1·min-1). The relationship between the 2- and 4-min CWR tests and the physiological variables that best relate to the performance fatigability were investigated. Results The 2-min CWR test evoked a smaller decline in sprint mechanical power (32% vs. 47%, p \u3c 0.001). Both the physiological variables (r = 0.66–0.96) and sprint mechanical power (r = 0.67–0.92) were independently and strongly correlated between 2- and 4-min tests. Differences in VO _2peak and [La-]b in both CWR tests were strongly associated with the decline in sprint mechanical power. Conclusion Strong correlations between 2- and 4-min severe-intensity CWR test outcomes indicated that the shorter test can be used as a proxy for the longer test. A shorter test may be more practical within the elite performance environment due to lower physiological stress and performance fatigability and should have less impact on subsequent training and competition preparation

Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study

Nausea is a subjective sensation which is difficult to measure in non-verbal species. The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure change in potential nausea biomarkers arginine vasopressin (AVP) and cortisol. A four period cross-over blinded study was conducted in eight healthy beagle dogs of both genders. Dogs were administered 18 mg/m2 cisplatin intravenously, followed 45 min later by a 15 min infusion of either placebo (saline) or antiemetic treatment with ondansetron (0.5 mg/kg; 5-HT3 antagonist), maropitant (1 mg/kg; NK1 antagonist) or metoclopramide (0.5 mg/kg; D2 antagonist). The number of vomits and nausea associated behaviours, scored on a visual analogue scale, were recorded every 15 min for 8 h following cisplatin administration. Plasma samples were collected to measure AVP, cortisol and antiemetic drug concentrations

Creating corroborated crisis reports from social media data through formal concept analysis

During a crisis citizens reach for their smart phones to report, comment and explore information surrounding the crisis. These actions often involve social media and this data forms a large repository of real-time, crisis related information. Law enforcement agencies and other first responders see this information as having untapped potential. That is, it has the capacity extend their situational awareness beyond the scope of a usual command and control centre. Despite this potential, the sheer volume, the speed at which it arrives, and unstructured nature of social media means that making sense of this data is not a trivial task and one that is not yet satisfactorily solved; both in crisis management and beyond. Therefore we propose a multi-stage process to extract meaning from this data that will provide relevant and near real-time information to command and control to assist in decision support. This process begins with the capture of real-time social media data, the development of specific LEA and crisis focused taxonomies for categorisation and entity extraction, the application of formal concept analysis for aggregation and corroboration and the presentation of this data via map-based and other visualisations. We demonstrate that this novel use of formal concept analysis in combination with context-based entity extraction has the potential to inform law enforcement and/or humanitarian responders about on-going crisis events using social media data in the context of the 2015 Nepal earthquake. Keywords : formal concept analysis, crisis management, disaster response, visualisation, entity extraction

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.

Hundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of cell lines is currently impractical, and such experiments are often difficult to control. Here we report a method called PRISM that allows pooled screening of mixtures of cancer cell lines by labeling each cell line with 24-nucleotide barcodes. PRISM revealed the expected patterns of cell killing seen in conventional (unpooled) assays. In a screen of 102 cell lines across 8,400 compounds, PRISM led to the identification of BRD-7880 as a potent and highly specific inhibitor of aurora kinases B and C. Cell line pools also efficiently formed tumors as xenografts, and PRISM recapitulated the expected pattern of erlotinib sensitivity in vivo

Visible-Light Photoredox Catalysis in Flow

Photoredox catalysis: A variety of organic transformations mediated by visible-light-active photoredox catalysts have been conducted in a photochemical flow reactor. The reactor design is very simple and can be easily implemented in any laboratory (see picture). In addition, this reactor afforded a marked increase in the reaction rate compared to those observed in typical batch (round bottom flask) reactors.National Science Foundation (U.S.) (Grant CHE-1056568)National Institutes of Health (U.S.) (NIGMS Grant R01-GM096129)Alfred P. Sloan FoundationAmgen Inc.Boehringer Ingelheim PharmaceuticalsAmgen Inc. (Graduate Fellowship)NMR (CHE-0619339)MS (CHE-0443618