Probing the Emission States of PSR J1107−5907

The emission from PSR J1107−5907 is erratic. Sometimes the radio pulse is undetectable, at other times the pulsed emission is weak, and for short durations the emission can be very bright. In order to improve our understanding of these state changes, we have identified archival data sets from the Parkes radio telescope in which the bright emission is present, and find that the emission never switches from the bright state to the weak state, but instead always transitions to the "off" state. Previous work had suggested the identification of the "off" state as an extreme manifestation of the weak state. However, the connection between the "off" and bright emission reported here suggests that the emission can be interpreted as undergoing only two emission states: a "bursting" state consisting of both bright pulses and nulls, and the weak emission state

Unexpected high frequency of genital involvement in women with clinical and hostological features of oral lichen planus

The main aims of this cross-sectional study were: (i) to assess the frequency of genital (vulval) lichen planus (VLP) and vulval lichen sclerosus (VLS) in women affected with oral lichen planus (OLP), regardless of the genital symptoms reported; and (ii) to verify whether any demographic, clinical, or histological features of OLP are associated with a higher risk of vulvo-vaginal involvement. Fifty-five women, presenting OLP, consecutively underwent gynaecological examination and, if they demonstrated positive clinical signs of VLP, underwent biopsy. After a drop-out of 14 subjects, 31/41 (75.6%) were found to have signs of genital involvement, of which 13/31 (44.0%) were asymptomatic. Following genital biopsy, 27/31 (87.1%) had histologically confirmed VLP or VLS. Following both univariate and multivariate statistical analyses, no significant association was found between gynaecological concomitance and demographic, clinical, histological features of OLP. This unpredictably common genital involvement in females with OLP emphasizes the importance of routinely performing both oral and gynaecological examinations, to facilitate an early and correct therapeutic approach. © 2006 Acta Dermato-Venereologica

Highly Canalized MinD Transfer and MinE Sequestration Explain the Origin of Robust MinCDE-Protein Dynamics

Min-protein oscillations in Escherichia coli are characterized by the remarkable robustness with which spatial patterns dynamically adapt to variations of cell geometry. Moreover, adaption, and therefore proper cell division, is independent of temperature. These observations raise fundamental questions about the mechanisms establishing robust Min oscillations, and about the role of spatial cues, as they are at odds with present models. Here, we introduce a robust model based on experimental data, consistently explaining the mechanisms underlying pole-to-pole, striped, and circular patterns, as well as the observed temperature dependence of the oscillation period. Contrary to prior conjectures, the model predicts that MinD and cardiolipin domains are not colocalized. The transient sequestration of MinE and highly canalized transfer of MinD between polar zones are the key mechanisms underlying oscillations. MinD channeling enhances midcell localization and facilitates stripe formation, revealing the potential optimization process from which robust Min-oscillations originally arose

Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast

A model for replicative life span extension by calorie restriction (CR) in yeast has been proposed whereby reduced glucose in the growth medium leads to activation of the NAD(+)–dependent histone deacetylase Sir2. One mechanism proposed for this putative activation of Sir2 is that CR enhances the rate of respiration, in turn leading to altered levels of NAD(+) or NADH, and ultimately resulting in enhanced Sir2 activity. An alternative mechanism has been proposed in which CR decreases levels of the Sir2 inhibitor nicotinamide through increased expression of the gene coding for nicotinamidase, PNC1. We have previously reported that life span extension by CR is not dependent on Sir2 in the long-lived BY4742 strain background. Here we have determined the requirement for respiration and the effect of nicotinamide levels on life span extension by CR. We find that CR confers robust life span extension in respiratory-deficient cells independent of strain background, and moreover, suppresses the premature mortality associated with loss of mitochondrial DNA in the short-lived PSY316 strain. Addition of nicotinamide to the medium dramatically shortens the life span of wild type cells, due to inhibition of Sir2. However, even in cells lacking both Sir2 and the replication fork block protein Fob1, nicotinamide partially prevents life span extension by CR. These findings (1) demonstrate that respiration is not required for the longevity benefits of CR in yeast, (2) show that nicotinamide inhibits life span extension by CR through a Sir2-independent mechanism, and (3) suggest that CR acts through a conserved, Sir2-independent mechanism in both PSY316 and BY4742

Effects Of Circum-nuclear Disk Gas Evolution And The Spin Of Central Black Holes

Mass and spin are the only two parameters needed to completely characterize black holes in General Relativity. However, the interaction between black holes and their environment is where complexity lies, as the relevant physical processes occur over a large range of scales. That is particularly relevant in the case of super-massive black holes (SMBHs), hosted in galaxy centers, and surrounded by swirling gas and various generations of stars. These compete with the SMBH for gas consumption and affect both dynamics and thermodynamics of the gas itself. How the behavior of such fiery environment influence the angular momentum of the gas accreted onto SMBHs, and, hence, black-hole spins is uncertain. We explore the interaction between SMBHs and their environment via first 3D sub-parsec resolution simulations (ranging from 0.1 pc to 1 kpc scales) that study the evolution of the SMBH spin by including the effects of star formation, stellar feedback, radiative transfer, and metal pollution according to the proper stellar yields and lifetimes. This approach is crucial to investigate the impact of star formation processes and feedback effects on the angular momentum of the material that could accrete on the central hole. We find that star formation and feedback mechanisms can locally inject significant amounts of entropy in the surrounding medium, and impact on the inflow inclination angles and Eddington fractions. As a consequence, the resulting trends show upper-intermediate equilibrium values for the spin parameter, a, of about 0.6 - 0.9, corresponding to radiative efficiencies \epsilon = 9% - 15%. These results suggest that star formation feedback taking place in the circum-nuclear disk during the in-fall cannot induce alone very strong chaotic trends in the gas flow, quite independently from the different numerical parameters.Comment: Changes in title and updates in references. Inclusion of additional runs and parameter studies. Conclusions unaffected. Accepte

Parameterizing and Validating Existing Algorithms for Identifying Out-of-Bed Time Using Hip-Worn Accelerometer Data from Older Women

Objective: To parameterize and validate two existing algorithms for identifying out-of-bed time using 24-hour hip-worn accelerometer data from older women. Approach: Overall, 628 women (80±6 years old) wore ActiGraph GT3X+ accelerometers 24 hours/day for up to 7 days and concurrently completed sleep-logs. Trained staff used a validated visual analysis protocol to measure in-bed periods on accelerometer tracings (criterion). The Tracy and McVeigh algorithms were adapted for optimal use in older adults. A training set of 314 women was used to choose two key thresholds by maximizing the sum of sensitivity and specificity for each algorithm and data (vertical axis, VA, and vector magnitude, VM) combination. Data from the remaining 314 women were then used to test agreement in waking wear time (i.e., out-of-bed time while wearing the accelerometer) by computing sensitivity, specificity, and kappa comparing the algorithm output with the criterion. Waking wear time-adjusted means of sedentary time, light-intensity physical activity (light PA) and moderate-to-vigorous-intensity physical activity (MVPA) were then estimated and compared. Main results: Waking wear time agreement with the criterion was high for Tracy_VA, Tracy_VM, McVeigh_VA, and highest for McVeigh_VM. Compared to the criterion, McVeigh_VM had mean sensitivity=0.92, specificity=0.87, kappa=0.80, and overall mean difference (±SD) of -0.04±2.5 hours/day. Minutes of sedentary time, light PA, and MVPA adjusted for waking wear time using the criterion measure and McVeigh_VM were not statistically different (p \u3e0.43 | all). Significance: The McVeigh algorithm with optimal parameters using VM performed best compared to criterion sleep-log assisted visual analysis and is suitable for automated identification of waking wear time in older women when visual analysis is not feasible

Broad emission lines for negatively spinning black holes

We present an extended scheme for the calculation of the profiles of emission lines from accretion discs around rotating black holes. The scheme includes discs with angular momenta which are parallel and antiparallel with respect to the black hole's angular momentum, as both configurations are assumed to be stable (King et al., 2005). We discuss line shapes for such discs and present a code for modelling observational data with this scheme in X-ray data analysis programs. Based on a Green's function approach, an arbitrary radius dependence of the disc emissivity and arbitrary limb darkening laws can be easily taken into account, while the amount of precomputed data is significantly reduced with respect to other available models.Comment: 7 pages, 6 figures; accepted by MNRAS for Publication, now matches the proof read versio

New Spherically Symmetric Solutions in f(R)-gravity by Noether Symmetries

Spherical symmetry for f(R)-gravity is discussed by searching for Noether symmetries. The method consists in selecting conserved quantities in form of currents that reduce dynamics of f(R)-models compatible with symmetries. In this way we get a general method to obtain constants of motion without setting a priori the form of f(R). In this sense, the Noether symmetry results a physical criterium. Relevant cases are discussed.Comment: 9 pages, accepted for publication in General Relativity and Gravitatio

LETSGO: A spacecraft-based mission to accurately measure the solar angular momentum with frame-dragging

LETSGO (LEnse-Thirring Sun-Geo Orbiter) is a proposed space-based mission involving the use of a spacecraft moving along a highly eccentric heliocentric orbit perpendicular to the ecliptic. It aims to accurately measure some important physical properties of the Sun and to test some post-Newtonian features of its gravitational field by continuously monitoring the Earth-probe range. Preliminary sensitivity analyses show that, by assuming a cm-level accuracy in ranging to the spacecraft, it would be possible to detect, in principle, the Lense-Thirring effect on it at a 10^-3-10^-4 level over a timescale of 2 yr, while the larger Schwarzschild component of the solar gravitational field may be sensed with a relative accuracy of about 10^-8-10^-9 during the same temporal interval. The competing range perturbation due to the non-sphericity of the Sun would be a source of systematic error, but it turns out that all the three dynamical features of motion examined affect the Earth-probe range in different ways, allowing for a separation in data analyses. The high eccentricity would help in reducing the impact of the non-gravitational perturbations whose impact would certainly be severe when LETSGO would approach the Sun at just a few solar radii. Further studies should be devoted to investigate both the consequences of the non-conservative forces and the actual measurability of the effects of interest by means of extensive numerical data simulations, parameter estimations and covariance analyses. Also an alternative, fly-by configuration is worth of consideration.Comment: LaTex2e, double column, 19 pages, 3 figures, 3 tables, 97 references. Accepted for publication in Acta Astronautica. Proof corrections inserte