Group-Conditional Conformal Prediction via Quantile Regression Calibration for Crop and Weed Classification

As deep learning predictive models become an integral part of a large spectrum of precision agricultural systems, a barrier to the adoption of such automated solutions is the lack of user trust in these highly complex, opaque and uncertain models. Indeed, deep neural networks are not equipped with any explicit guarantees that can be used to certify the system's performance, especially in highly varying uncontrolled environments such as the ones typically faced in computer vision for agriculture.Fortunately, certain methods developed in other communities can prove to be important for agricultural applications. This article presents the conformal prediction framework that provides valid statistical guarantees on the predictive performance of any black box prediction machine, with almost no assumptions, applied to the problem of deep visual classification of weeds and crops in real-world conditions. The framework is exposed with a focus on its practical aspects and special attention accorded to the Adaptive Prediction Sets (APS) approach that delivers marginal guarantees on the model's coverage. Marginal results are then shown to be insufficient to guarantee performance on all groups of individuals in the population as characterized by their environmental and pedo-climatic auxiliary data gathered during image acquisition.To tackle this shortcoming, group-conditional conformal approaches are presented: the ''classical'' method that consists of iteratively applying the APS procedure on all groups, and a proposed elegant reformulation and implementation of the procedure using quantile regression on group membership indicators. Empirical results showing the validity of the proposed approach are presented and compared to the marginal APS then discussed

DO PARADIGMA DO VER AO DO TOCAR. O DEVIR HÁPTICO NA CRIAÇÃO ARTÍSTICA CONTEMPORÂNEA

[EN] The issue of the primacy of the visual perception of new technologies and the role of the haptic perception, through the intensification of sensory stimulation of digital culture, constitute a landmark reference in analysis and critical reflection in the field of aesthetics. A large part of the contemporary artistic discourses operates on the body, in search of new dimensions through the senses, promoting a cognitive agency out of the interstices of the rational-mediation logic. This research assumes that the digital image leaves the Cartesian tradition and demand a response in which the phenomenological technological images find their primary sense in the body. In this way, the body appears as a center of the most avant-garde arrangements of artistic objects in the video art and contemporary visual arts. Of the time-image, image-body, fluid and interactive. It is in this framework that the concepts linked to the speech has undergone a profound Visual recontextualization in contemporary art and that new approaches claim in rupture with the models of representation based on realism of the image. Thus, video art has questioned the perception of reality through sensory consciousness and is a preferred mean of exploration of the new regime of haptic Visuality, as a ultimate symbol of the apotheosis of postmodernism. Emerges from the metamorphosis of the body and of the visual objects a proposition video-body, which integrates the experiences of transgressive haptic arrangements of the new media. The video- haptic arises, in this context, as promoter of the perceptive interweaving of synesthetic intertranslations of the sensory modalities within the contemporary art. The haptic territories of the video are therefore seen as instances that establish their own construction video processing. This research focuses on the current scenario of haptic perception in contemporary art and the new fields of action on the border of the video-haptics and outlines the relocation to a haptic aesthetics in contemporary art.[ES] La cuestión de la primacía de la percepción visual con las nuevas tecnologías y el papel de la percepción háptica mediante la intensificación de los estímulos sensoriales de la cultura digital, se constituyen como un marco referencial en análisis y reflexiones críticas en el ámbito de la estética. Gran parte de los discursos artísticos contemporáneos trabajan sobre el cuerpo, en busca de nuevas dimensiones a través de los sentidos, promoviendo una apropiación cognitiva fuera de los límites de la mediación racional-lógica. Esta investigación parte de ese presupuesto, de que la imagen digital abandona la tradición cartesiana y busca una respuesta fenomenológica en la cual las imágenes tecnológicas encuentran su sentido primario en el cuerpo. De este modo, el cuerpo se nos aparece como el centro de los logros más vanguardistas en prácticas artísticas, tanto en los discursos del videoarte como en las artes visuales contemporáneas. De la imagen-tiempo pasamos a la imagen-interfaz, una imagen-cuerpo, fluida e interactiva. Es en este marco, donde los conceptos vinculados al discurso videográfico han sufrido una profunda recontextualización en el arte contemporáneo y donde las nuevas propuestas se plantean como forma de ruptura con los modelos de representación basados en el no-realismo de la imagen. Así, el videoarte ha cuestionado la percepción de la realidad a través de la consciencia sensorial y se constituye como un medio privilegiado de exploración del nuevo régimen de visualidad háptica, como un símbolo máximo de apoteosis del pos-modernismo. Emerge de la metamorfosis del cuerpo y de los objetos virtuales una proposición de video-cuerpo que integra las experiencias transgresivas de la potencialidad háptica de los nuevos media. Lo video-háptico surge, en este contexto, como promotor del cruce perceptivo y de las inter-traducciones sinestésicas de las modalidades sensoriales en el seno del arte contemporáneo. Los territorios hápticos del video son, por tanto, vistos como instancias que se establecen en el procesamiento de la propia construcción videográfica. Esta investigación incide sobre el actual escenario de la percepción háptica en el arte contemporáneo y los nuevos campos de actuación en la frontera de lo video-háptico y anuncia la deslocalización para una estética háptica en el arte contemporáneo.[CA] La qüestió de la primacia de la percepció visual amb les noves tecnologies i el paper de la percepció hàptica mitjançant la intensificació dels estímuls sensorials de la cultura digital, es constitueixen com un marc referencial en anàlisi i reflexions crítiques en l'àmbit de l'estètica. Gran part dels discursos artístics contemporanis treballen sobre el cos, a la recerca de noves dimensions a través dels sentits, promovent una apropiació cognitiva fos dels límits de la mediació racional-lògica. Aquesta recerca parteix d'aquest pressupost, que la imatge digital abandona la tradició cartesiana i busca una resposta fenomenològica en la qual les imatges tecnològiques troben el seu sentit primari en el cos. D'aquesta manera, el cos se'ns apareix com el centre dels assoliments més avantguardistes en pràctiques artístiques, tant en els discursos del videoart com en les arts visuals contemporànies. De la imatge-temps passem a la imatge-interfície, una imatge-cos, fluïda i interactiva. És en aquest marc, on els conceptes vinculats al discurs videogràfic han sofert una profunda recontextualització en l'art contemporani i on les noves propostes es plantegen com a forma de ruptura amb els models de representació basats en el no-realisme de la imatge. Així, el videoart ha qüestionat la percepció de la realitat a través de la consciència sensorial i es constitueix com un mitjà privilegiat d'exploració del nou règim de visualitat hàptica, com un símbol màxim d'apoteosi del postmodernisme. Emergeix de la metamorfosi del cos i dels objectes virtuals una proposició de video-cos que integra les experiències transgressives de la potencialitat hàptica dels nous mitjans. El video-hàptic sorgeix, en aquest context, com a promotor de l'encreuament perceptiu i de les inter-traduccions sinestésiques de les modalitats sensorials en el si de l'art contemporani. Els territoris hàptics del video són, per tant, vists com a instàncies que s'estableixen en el processament de la pròpia construcció videogràfica Aquesta recerca incideix sobre l'actual escenari de la percepció hàptica en l'art contemporani i els nous camps d'actuació a la frontera del video-hàptic i anuncia la deslocalització per a una estètica hàptica en l'art contemporani.Aguês Da Cruz Silva, SD. (2016). DO PARADIGMA DO VER AO DO TOCAR. O DEVIR HÁPTICO NA CRIAÇÃO ARTÍSTICA CONTEMPORÂNEA [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/61441TESI

Childhood Cryptosporidiosis: A Case Report

Cryptosporidium has emerged as an important cause of diarrheal illness worldwide, especially amongst young children and patients with infectious or iatrogenic immune deficiencies. The authors describe a case of mild cryptosporidiosis in a well-nourished, immunocompetent, one-year-old child. Rapid clinical and parasitological improvement was observed after a 3-day course of nitazoxanide

Nova crise nos Grandes Lagos da África Central: o surgimento da Segunda Guerra Mundial Africana?

A new crisis in Central Africa has recently emerged, involving the rise of a Congolese armed group accused of being supported by Rwanda. The crisis brings fears of the outbreak of a new conflagration in the proportions of the so-called Africa’s World War. The article discusses the crisis and its possible outcomes and solutions.  Uma nova crise na África Central surgiu recentemente, envolvendo a ascensão de um grupo armado congolês acusado de ser apoiado por Ruanda. A crise traz temores da explosão de uma nova conflagração nas proporções da chamada Guerra Mundial Africana. O artigo discute a crise e seus possíveis desfechos e soluções

How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions?

The development of acquired protective immunity to Plasmodium falciparum infection in young African children is considered in the context of three current strategies for malaria prevention: insecticide-impregnated bed nets or curtains, anti-sporozoite vaccines and intermittent preventive therapy. Evidence is presented that each of these measures may permit attenuated P. falciparum blood-stage infections, which do not cause clinical malaria but can act as an effective blood-stage "vaccine". It is proposed that the extended serum half-life, and rarely considered liver-stage prophylaxis provided by the anti-folate combination sulphadoxine-pyrimethamine frequently lead to such attenuated infections in high transmission areas, and thus contribute to the sustained protection from malaria observed among children receiving the combination as intermittent preventative therapy or for parasite clearance in vaccine trials

A crise da Costa do Marfim: a desconstrução do projeto nacional e o neo-intervencionismo francês

In recent months we witnessed a serious political crisis in Ivory Coast, which has historical and structural origins. This article analyzes the internal and external factors related to the crisis and questions the sustainability of the solution, namely the employ of extra-regional interventionism.Nos últimos meses presenciou-se uma grave crise política na Costa do Marfim, a qual possui origens históricas e estruturais. Este texto busca analisar os fatores internos e externos relacionados à crise e questionar sobre a sustentabilidade da solução adotada, a saber, o recurso ao intervencionismo extra-regional

Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor

Funding Information: We acknowledge the BioISI/FCUL Microscopy Facility, a node of the Portuguese Platform of BioImaging supported by FEDER funds (Ref. PPBI-POCI-01-0145-FEDER-022122). The mass spectrometry-based proteomics approach was performed at the i3S Proteomics Scientific Platform with the assistance of Hugo Osório, and had support from the Portuguese Mass Spectrometry Network, integrated in the National Roadmap of Research Infrastructures of Strategic Relevance (ROTEIRO/0028/2013; LISBOA-01-0145-FEDER-022125). FH was supported by Project LISBOA-01-0145-FEDER-007660 (Cellular Structural and Molecular Microbiology) funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI). FH, FRP and MSR were supported by Centre grants from Fundação para a Ciência e Tecnologia to the BioISI Research Unit (Refs. UIDB/04046/2020 and UIDP/04046/2020, https://doi.org/10.54499/UIDB/04046/2020 ) and by individual grants through Fundação para a Ciência e Tecnologia (PTDC/MED-NEU/31417/2017 to FH and PTDC/FIS-MAC/2741/2021 to MSR, https://doi.org/10.54499/PTDC/FIS-MAC/2741/2021 ). MD was supported by a research contract under FCT grant Ref. PTDC/MED-NEU/31417/2017. RV, FM and AAC were supported by PhD fellowships from Fundação para a Ciência e Tecnologia (Refs. PD/BD/128163/2016, SFRH/BD/133220/2017 and UI/BD/153051/2022, respectively). Funded by the European Union (TWIN2PIPSA, GA 101079147). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Research Executive Agency (REA). Neither the European Union nor the granting authority can be held responsible for them. Funding Information: We acknowledge the BioISI/FCUL Microscopy Facility, a node of the Portuguese Platform of BioImaging supported by FEDER funds (Ref. PPBI-POCI-01-0145-FEDER-022122). Mass spectrometry was carried out with support from the Portuguese Mass Spectrometry Network, integrated in the National Roadmap of Research Infrastructures of Strategic Relevance (ROTEIRO/0028/2013; LISBOA-01-0145-FEDER-022125). FH was supported by Project LISBOA-01-0145-FEDER-007660 (Cellular Structural and Molecular Microbiology) funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI). FH, FRP and MSR were supported by Centre grants from Fundação para a Ciência e Tecnologia to the BioISI Research Unit (Refs. UIDB/04046/2020 and UIDP/04046/2020, https://doi.org/10.54499/UIDB/04046/2020 ) and by individual grants through Fundação para a Ciência e Tecnologia (PTDC/MED-NEU/31417/2017 to FH and PTDC/FIS-MAC/2741/2021 to MSR, https://doi.org/10.54499/PTDC/FIS-MAC/2741/2021 ). MD was supported by a research contract under FCT grant Ref. PTDC/MED-NEU/31417/2017. RV, FM and AAC were supported by PhD fellowships from Fundação para a Ciência e Tecnologia (Refs. PD/BD/128163/2016, SFRH/BD/133220/2017 and UI/BD/153051/2022, respectively). Funded by the European Union (TWIN2PIPSA, GA 101079147). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Research Executive Agency (REA). Neither the European Union nor the granting authority can be held responsible for them. Publisher Copyright: © The Author(s) 2023.STAT3 is a pleiotropic transcription factor overactivated in 70% of solid tumours. We have recently reported that inactivating mutations on residues susceptible to post-translational modifications (PTMs) in only one of the monomers (i.e. asymmetric) caused changes in the cellular distribution of STAT3 homodimers. Here, we used more controlled experimental conditions, i.e. without the interference of endogenous STAT3 (STAT3-/- HeLa cells) and in the presence of a defined cytokine stimulus (Leukemia Inhibitory Factor, LIF), to provide further evidence that asymmetric PTMs affect the nuclear translocation of STAT3 homodimers. Time-lapse microscopy for 20 min after LIF stimulation showed that S727 dephosphorylation (S727A) and K685 inactivation (K685R) slightly enhanced the nuclear translocation of STAT3 homodimers, while K49 inactivation (K49R) delayed STAT3 nuclear translocation. Our findings suggest that asymmetrically modified STAT3 homodimers could be a new level of STAT3 regulation and, therefore, a potential target for cancer therapy.publishersversionpublishe

Window screening, ceilings and closed eaves as sustainable ways to control malaria in Dar es Salaam, Tanzania.

BACKGROUND\ud \ud Malaria transmission in Africa occurs predominantly inside houses where the primary vectors prefer to feed. Human preference and investment in blocking of specific entry points for mosquitoes into houses was evaluated and compared with known entry point preferences of the mosquitoes themselves.\ud \ud METHODS\ud \ud Cross-sectional household surveys were conducted in urban Dar es Salaam, Tanzania to estimate usage levels of available options for house proofing against mosquito entry, namely window screens, ceilings and blocking of eaves. These surveys also enabled evaluation of household expenditure on screens and ceilings and the motivation behind their installation.\ud \ud RESULTS\ud \ud Over three quarters (82.8%) of the 579 houses surveyed in Dar es Salaam had window screens, while almost half (48.9%) had ceilings. Prevention of mosquito entry was cited as a reason for installation of window screens and ceilings by 91.4% (394/431) and 55.7% (127/228) of respondents, respectively, but prevention of malaria was rarely cited (4.3%, 22/508). The median cost of window screens was between US $21-30 while that of ceilings was between US$301-400. The market value of insecticide-treated nets, window screening and ceilings currently in use in the city was estimated as 2, 5 and 42 million US$. More than three quarters of the respondents that lacked them said it was too expensive to install ceilings (82.2%) or window screens (75.5%).\ud \ud CONCLUSION\ud \ud High coverage and spending on screens and ceilings implies that these techniques are highly acceptable and excellent uptake can be achieved in urban settings like Dar es Salaam. Effective models for promotion and subsidization should be developed and evaluated, particularly for installation of ceilings that prevent entry via the eaves, which are the most important entry point for mosquitoes that cause malaria, a variety of neglected tropical diseases and the nuisance which motivates uptake

Experience and Challenges from Clinical Trials with Malaria Vaccines in Africa.

Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort by many groups over the last few decades. Despite this, there is currently no licensed malaria vaccine. Researchers, clinical trialists and vaccine developers have been working on many approached to make malaria vaccine available.African research institutions have developed and demonstrated a great capacity to undertake clinical trials in accordance to the International Conference on Harmonization-Good Clinical Practice (ICH-GCP) standards in the last decade; particularly in the field of malaria vaccines and anti-malarial drugs. This capacity is a result of networking among African scientists in collaboration with other partners; this has traversed both clinical trials and malaria control programmes as part of the Global Malaria Action Plan (GMAP). GMAP outlined and support global strategies toward the elimination and eradication of malaria in many areas, translating in reduction in public health burden, especially for African children. In the sub-Saharan region the capacity to undertake more clinical trials remains small in comparison to the actual need.However, sustainability of the already developed capacity is essential and crucial for the evaluation of different interventions and diagnostic tools/strategies for other diseases like TB, HIV, neglected tropical diseases and non-communicable diseases. There is urgent need for innovative mechanisms for the sustainability and expansion of the capacity in clinical trials in sub-Saharan Africa as the catalyst for health improvement and maintained

Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger

<p>Abstract</p> <p>Background</p> <p>Over the last years, significant progress has been made in the comprehension of the molecular mechanism of malaria resistance to drugs. Together with <it>in vivo </it>tests, the molecular monitoring is now part of the survey strategy of the <it>Plasmodium </it>sensitivity. Currently, DNA-microarray analysis allows the simultaneous study of many single nucleotide polymorphisms (SNP) of <it>Plasmodium </it>isolates. In December 2005, the International Federation of the Red Cross distributed two million three hundred thousand long-lasting insecticide nets to pregnant women and mothers of under five years children in the whole Niger. Then, Niger adopted artemisinin-based combination therapy as first-line treatment.</p> <p>Methods</p> <p>Thirty four SNPs of <it>pfcrt, pfdhfr, pfdhps, pfmdr </it>and <it>pfATPase </it>were analysed by DNA-microarray and PCR/RFLP in two villages – Zindarou and Banizoumbou – with different durations of malaria transmission. The main objective of the study was to measure the dynamics <it>of Plasmodium falciparum </it>resistant strains and associated factors.</p> <p>Results</p> <p>This study shows a global and clear increase of the drug-resistance associated molecular markers frequencies during a relatively short-time period of four years. Markers associated with resistance to chloroquine and sulphonamids were more frequently found in the short transmission zone than in the long transmission one. The <it>pfcrt76T </it>mutation is significantly more present at Banizoumbou than Zindarou (38.3% vs 25.2%, p = 0.013).</p> <p>This work allowed the screening of several field strains for five SNPs of <it>PfATPase6 </it>gene. The <it>pfATPase6S769N</it>, candidate mutation of resistance to artemisinin was not found. However the <it>pfATPsaeA623E </it>mutation was found in 4.7% of samples.</p> <p>Conclusion</p> <p>A significant increase of several SNPs frequencies was highlighted over a four-year period. The polymorphism of five <it>PfATPase6 </it>gene SNPs was described. The global, large and fast increase of the molecular resistance is discussed in the context of current changes of health policy and malaria control in Niger.</p