1,700 research outputs found
ASSESSEMENT OF FAMILIES OF CHILDREN WITH CONGENITAL HEART DISEASE AND NURSING INTERVENTION
RESUMOObjetivos: avaliar como a família é afetada pela descoberta de um caso de cardiopatia congênita em um de seus membros e; discutir a intervenção de enfermagem direcionada à família de criança portadora de cardiopatia congênita. Métodos: estudo descritivo, de abordagem qualitativa, executado através de um estudo de caso e utilização do método de análise de conteúdo, adotando como referencial teórico o Modelo Calgary de Avaliação e Intervenção na Família. Foram realizadas entrevistas semi-estruturadas e gravadas com 28 familiares de crianças portadoras de cardiopatia congênita e em tratamento ambulatorial pré-cirúrgico, em uma instituição hospitalar especializada em cardiopediatria no município do Rio de Janeiro. Resultados: os dados coletados possibilitaram a criação de tópicos que remetem à existência de uma reconfiguração familiar em uma situação de enfermidade agravada, muitas vezes, pela escassez dos recursos sócio-econômicos, mas que encontra na religião e espiritualidade o suporte necessário. Conclusão: Mais do que direcionar o cuidado à criança enferma, o olhar do enfermeiro deve estar ampliado para as relações familiares que influenciam a capacidade de participação de seus membros no processo terapêutico, incluindo tanto o cuidado físico como o emocional à criança portadora de cardiopatia congênita. Descritores: enfermagem; relações familiares; cuidado da criança; cardiopatias congênitas
The new cultural history as a methodology proposed for research in the nursing history field / A nova história cultural como proposta metodológica para pesquisas no campo da história da enfermagem
Objetivo: Discutir a utilização da Nova História Cultural como método para análise dos usos e costumes da enfermagem relacionados aos materiais impressos. Método: Pesquisa descritiva de natureza qualitativa, a partir da reflexão sobre os avanços teórico-metodológicos defendidos pelo historiador Chartier no campo da História Cultural. Para estabelecer nexos entre a Nova História Cultural, proposta pelo historiador, e a História da Enfermagem foram levantadas 02 teses e 03 dissertações produzidas no Laboratório de Abordagens Científicas na História da Enfermagem- LACENF/UNIRIO. Resultado: Os estudos apontaram que a metodologia proposta por Chartier está pautada na íntima relação entre representações e os efeitos produzidos pelas suas apropriações. Conclusão: As diferentes formas que adquirem o texto impresso ganham status de documento-objeto para os estudos da história cultural por permitirem que se tornem presentes um objeto, conceito ou pessoa ausente mediante sua substituição por uma imagem, capaz de representá-los adequadamente
Prion Protein Polymorphisms Affect Chronic Wasting Disease Progression
Analysis of the PRNP gene in cervids naturally infected with chronic wasting disease (CWD) suggested that PRNP polymorphisms affect the susceptibility of deer to infection. To test this effect, we orally inoculated 12 white-tailed deer with CWD agent. Three different PRNP alleles, wild-type (wt; glutamine at amino acid 95 and glycine at 96), Q95H (glutamine to histidine at amino acid position 95) and G96S (glycine to serine at position 96) were represented in the study cohort with 5 wt/wt, 3 wt/G96S, and 1 each wt/Q95H and Q95H/G96S. Two animals were lost to follow-up due to intercurrent disease. The inoculum was prepared from Wisconsin hunter-harvested homozygous wt/wt animals. All infected deer presented with clinical signs of CWD; the orally infected wt/wt had an average survival period of 693 days post inoculation (dpi) and G96S/wt deer had an average survival period of 956 dpi. The Q95H/wt and Q95H/G96S deer succumbed to CWD at 1,508 and 1,596 dpi respectively. These data show that polymorphisms in the PRNP gene affect CWD incubation period. Deer heterozygous for the PRNP alleles had extended incubation periods with the Q95H allele having the greatest effect
The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment
The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in
operation since July 2014. This paper describes the second data release from
this phase, and the fourteenth from SDSS overall (making this, Data Release
Fourteen or DR14). This release makes public data taken by SDSS-IV in its first
two years of operation (July 2014-2016). Like all previous SDSS releases, DR14
is cumulative, including the most recent reductions and calibrations of all
data taken by SDSS since the first phase began operations in 2000. New in DR14
is the first public release of data from the extended Baryon Oscillation
Spectroscopic Survey (eBOSS); the first data from the second phase of the
Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2),
including stellar parameter estimates from an innovative data driven machine
learning algorithm known as "The Cannon"; and almost twice as many data cubes
from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous
release (N = 2812 in total). This paper describes the location and format of
the publicly available data from SDSS-IV surveys. We provide references to the
important technical papers describing how these data have been taken (both
targeting and observation details) and processed for scientific use. The SDSS
website (www.sdss.org) has been updated for this release, and provides links to
data downloads, as well as tutorials and examples of data use. SDSS-IV is
planning to continue to collect astronomical data until 2020, and will be
followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14
happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov
2017 (this is the "post-print" and "post-proofs" version; minor corrections
only from v1, and most of errors found in proofs corrected
The natural history and management of hamstring injuries
Hamstring injuries in sport can be debilitating. The anatomical complexity of this muscle makes uniform assessment of injury epidemiology difficult and insures that post-injury management strategies must be individually focused. This article reviews the anatomy of the hamstring, its role in athletic movement, common mechanisms of injury, and management guidelines with the goal of return into sporting activity in mind
A Study of the Influence of Sex on Genome Wide Methylation
Sex differences in methylation status have been observed in specific gene-disease studies and healthy methylation variation studies, but little work has been done to study the impact of sex on methylation at the genome wide locus-to-locus level or to determine methods for accounting for sex in genomic association studies. In this study we investigate the genomic sex effect on saliva DNA methylation of 197 subjects (54 females) using 20,493 CpG sites. Three methods, two-sample T-test, principle component analysis and independent component analysis, all successfully identify sex influences. The results show that sex not only influences the methylation of genes in the X chromosome but also in autosomes. 580 autosomal sites show strong differences between males and females. They are found to be highly involved in eight functional groups, including DNA transcription, RNA splicing, membrane, etc. Equally important is that we identify some methylation sites associated with not only sex, but also other phenotypes (age, smoking and drinking level, and cancer). Verification was done through an independent blood cell DNA methylation data (1298 CpG sites from a cancer panel array). The same genomic site-specific influence pattern and potential confounding effects with cancer were observed. The overlapping rate of identified sex affected genes between saliva and blood cell is 81% for X chromosome, and 8% for autosomes. Therefore, correction for sex is necessary. We propose a simple correction method based on independent component analysis, which is a data driven method and accommodates sample differences. Comparison before and after the correction suggests that the method is able to effectively remove the potentially confounding effects of sex, and leave other phenotypes untouched. As such, our method is able to disentangle the sex influence on a genome wide level, and paves the way to achieve more accurate association analyses in genome wide methylation studies
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