N-body simulations of galaxies and groups of galaxies with the Marseille GRAPE systems

I review the Marseille GRAPE systems and the N-body simulations done with them. I first describe briefly the available hardware and software, their possibilities and their limitations. I then describe work done on interacting galaxies and groups of galaxies. This includes simulations of the formation of ring galaxies, simulations of bar destruction by massive compact satellites, of merging in compact groups and of the formation of brightest members in clusters of galaxies.Comment: 13 pages, 5 figures, to be published in "Non-linear Dynamics and Chaos in Astrophysics", eds. J.R. Buchler, S. Gottesman, J. Hunter and H. Kandrup, Annals of the New York Academy of Science

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to inhibit cell survival in a subset of these, making it an attractive target for cancer treatment. We present crystal structures of the helicase domain of human Polθ in the presence and absence of bound nucleotides, and a characterization of its DNA-binding and DNA-stimulated ATPase activities. Comparisons with related helicases from the Hel308 family identify several unique features. Polθ exists as a tetramer both in the crystals and in solution. We propose a model for DNA binding to the Polθ helicase domain in the context of the Polθ tetramer, which suggests a role for the helicase domain in strand annealing of DNA templates for subsequent processing by the polymerase domain

Neutrino oscillation constraints on neutrinoless double beta decay

We have studied the constraints imposed by the results of neutrino oscillation experiments on the effective Majorana mass || that characterizes the contribution of Majorana neutrino masses to the matrix element of neutrinoless double-beta decay. We have shown that in a general scheme with three Majorana neutrinos and a hierarchy of neutrino masses (which can be explained by the see-saw mechanism), the results of neutrino oscillation experiments imply rather strong constraints on the parameter ||. From the results of the first reactor long-baseline experiment CHOOZ and the Bugey experiment it follows that || < 3x10^{-2} eV if the largest mass-squared difference is smaller than 2 eV^2. Hence, we conclude that the observation of neutrinoless double-beta decay with a probability that corresponds to || > 10^{-1} eV would be a signal for a non-hierarchical neutrino mass spectrum and/or non-standard mechanisms of lepton number violation.Comment: 20 pages, including 4 figure

Four Light Neutrinos in Singular Seesaw Mechanism with Abelian Flavor Symmetry

The four light neutrino scenario, which explains the atmosphere, solar and LSND neutrino experiments, is studied in the framework of the seesaw mechanism. By taking both the Dirac and Majorana mass matrix of neutrinos to be singular, the four neutrino mass spectrum consisting of two almost degenerate pairs separated by a mass gap $\sim 1$ eV is naturally generated. Moreover the right-handed neutrino Majorana mass can be at $\sim 10^{14}$ GeV scale unlike in the usual singular seesaw mechanism. Abelian flavor symmetry is used to produce the required neutrino mass pattern. A specific example of the flavor charge assignment is provided to show that maximal mixings between the $\nu_\mu-\nu_\tau$ and $\nu_e-\nu_s$ are respectively attributed to the atmosphere and solar neutrino anomalies while small mixing between two pairs to the LSND results. The implication in the other fermion masses is also discussed.Comment: Firnal version to appear in PR

Future ντ\nu_\tau Oscillation Experiments and Present Data

Our goal in this paper is to examine the discovery potential of laboratory experiments searching for the oscillation $\nu_\mu(\nu_e) \rightarrow \nu_\tau$, in the light of recent data on solar and atmospheric neutrino experiments, which we analyse together with the most restrictive results from laboratory experiments on neutrino oscillations. In order to explain simultaneously $all$ present results we use a four-neutrino framework, with an additional sterile neutrino. Our predictions are rather pessimistic for the upcoming experiments NOMAD and CHORUS, which, we find, are able to explore only a small area of the oscillation parameter space. On the other hand, the discovery potential of future experiments is much larger. We consider three examples. E803, which is approved to operate in the future Fermilab main injector beam line, MINOS, a proposed long-baseline experiment also using the Fermilab beam, and NAUSICAA, an improved detector which improves by an order of magnitude the performance of CHORUS/NOMAD and can be operated either at CERN or at Fermilab beams. We find that those experiments can cover a very substantial fraction of the oscillation parameter space, having thus a very good chance of discovering $both$ $\nu_\mu \rightarrow \nu_\tau$ and $\nu_e \rightarrow \nu_\tau$ oscillation modes.Comment: Latex file using ReVTeX and epsifig.sty. 40 Pages. Revised version includes new references and changed Fig.

Status of four-neutrino mass schemes: a global and unified approach to current neutrino oscillation data

We present a unified global analysis of neutrino oscillation data within the framework of the four-neutrino mass schemes (3+1) and (2+2). We include all data from solar and atmospheric neutrino experiments, as well as information from short-baseline experiments including LSND. If we combine only solar and atmospheric neutrino data, (3+1) schemes are clearly preferred, whereas short-baseline data in combination with atmospheric data prefers (2+2) models. When combining all data in a global analysis the (3+1) mass scheme gives a slightly better fit than the (2+2) case, though all four-neutrino schemes are presently acceptable. The LSND result disfavors the three-active neutrino scenario with only $\Delta m^2_{sol}$ and $\Delta m^2_{atm}$ at 99.9% CL with respect to the four-neutrino best fit model. We perform a detailed analysis of the goodness of fit to identify which sub-set of the data is in disagreement with the best fit solution in a given mass scheme.Comment: 32 pages, 8 Figures included, REVTeX4.Improved discussion in sec. XI, references added, version accepted by Phys. Rev.

Neutrinoless double-beta decay with three or four neutrino mixing

Considering the scheme with mixing of three neutrinos and a mass hierarchy that can accommodate the results of solar and atmospheric neutrino experiments, it is shown that the results of solar neutrino experiments imply a lower bound for the effective Majorana mass in neutrinoless double-beta decay, under the natural assumptions that massive neutrinos are Majorana particles and there are no unlikely fine-tuned cancellations among the contributions of the different neutrino masses. Considering the four-neutrino schemes that can accommodate also the results of the LSND experiment, it is shown that only one of them is compatible with the results of neutrinoless double-beta decay experiments and with the measurement of the abundances of primordial elements produced in Big-Bang Nucleosynthesis. It is shown that in this scheme, under the assumptions that massive neutrinos are Majorana particles and there are no cancellations among the contributions of the different neutrino masses, the results of the LSND experiment imply a lower bound for the effective Majorana mass in neutrinoless double-beta decay.Comment: 18 pages including 2 figures, RevTe

Global Search for New Physics with 2.0/fb at CDF

Data collected in Run II of the Fermilab Tevatron are searched for indications of new electroweak-scale physics. Rather than focusing on particular new physics scenarios, CDF data are analyzed for discrepancies with the standard model prediction. A model-independent approach (Vista) considers gross features of the data, and is sensitive to new large cross-section physics. Further sensitivity to new physics is provided by two additional algorithms: a Bump Hunter searches invariant mass distributions for "bumps" that could indicate resonant production of new particles; and the Sleuth procedure scans for data excesses at large summed transverse momentum. This combined global search for new physics in 2.0/fb of ppbar collisions at sqrt(s)=1.96 TeV reveals no indication of physics beyond the standard model.Comment: 8 pages, 7 figures. Final version which appeared in Physical Review D Rapid Communication

Observation of Orbitally Excited B_s Mesons

We report the first observation of two narrow resonances consistent with states of orbitally excited (L=1) B_s mesons using 1 fb^{-1} of ppbar collisions at sqrt{s} = 1.96 TeV collected with the CDF II detector at the Fermilab Tevatron. We use two-body decays into K^- and B^+ mesons reconstructed as B^+ \to J/\psi K^+, J/\psi \to \mu^+ \mu^- or B^+ \to \bar{D}^0 \pi^+, \bar{D}^0 \to K^+ \pi^-. We deduce the masses of the two states to be m(B_{s1}) = 5829.4 +- 0.7 MeV/c^2 and m(B_{s2}^*) = 5839.7 +- 0.7 MeV/c^2.Comment: Version accepted and published by Phys. Rev. Let