346 research outputs found
Impact of Nucleon Mass Shift on the Freeze Out Process
The freeze out of a massive nucleon gas through a finite layer with time-like
normal is studied. The impact of in-medium nucleon mass shift on the freeze out
process is investigated. A considerable modification of the thermodynamical
variables temperature, flow-velocity, energy density and particle density has
been found. Due to the nucleon mass shift the freeze out particle distribution
functions are changed noticeably in comparison with evaluations, which use
vacuum nucleon mass.Comment: submitted to Physical Review
Transient trimethylaminuria related to menstruation
BACKGROUND: Trimethylaminuria, or fish odor syndrome, includes a transient or mild malodor caused by an excessive amount of malodorous trimethylamine as a result of body secretions. Herein, we describe data to support the proposal that menses can be an additional factor causing transient trimethylaminuria in self-reported subjects suffering from malodor and even in healthy women harboring functionally active flavin-containing monooxygenase 3 (FMO3). METHODS: FMO3 metabolic capacity (conversion of trimethylamine to trimethylamine N-oxide) was defined as the urinary ratio of trimethylamine N-oxide to total trimethylamine. RESULTS: Self-reported Case (A) that was homozygous for inactive Arg500stop FMO3, showed decreased metabolic capacity of FMO3 (i.e., ~10% the unaffected metabolic capacity) during 120 days of observation. For Case (B) that was homozygous for common [Glu158Lys; Glu308Gly] FMO3 polymorphisms, metabolic capacity of FMO3 was almost ~90%, except for a few days surrounding menstruation showing < 40% metabolic capacity. In comparison, three healthy control subjects that harbored heterozygous polymorphisms for [Glu158Lys; Glu308Gly] FMO3 or homozygous for wild FMO3 showed normal (> 90%) metabolic capacity, however, on days around menstruation the FMO3 metabolic capacity was decreased to ~60–70%. CONCLUSION: Together, these results indicate that abnormal FMO3 capacity is caused by menstruation particularly in the presence, in homozygous form, of mild genetic variants such as [Glu158Lys; Glu308Gly] that cause a reduced FMO3 function
ost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism
Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The human 17β-hydroxysteroid dehydrogenase 10 (HSD10) is a moonlighting enzyme with at least two structurally and catalytically unrelated functions. HSD10 disease was originally described as a disorder of isoleucine metabolism, but the clinical manifestations were subsequently shown to be linked to impaired mtDNA transcript processing due to deficient function of HSD10 in the mtRNase P complex. A surprisingly large number of other, mostly enzymatic and potentially clinically relevant functions have been attributed to HSD10. Recently, HSD10 was reported to exhibit phospholipase C-like activity towards cardiolipins (CL), important mitochondrial phospholipids. To assess the physiological role of the proposed CL-cleaving function, we studied CL architectures in living cells and patient fibroblasts in different genetic backgrounds and lipid environments using our well-established LC–MS/MS cardiolipidomic pipeline. These experiments revealed no measurable effect on CLs, indicating that HSD10 does not have a physiologically relevant function towards CL metabolism. Evolutionary constraints could explain the broad range of reported substrates for HSD10 in vitro. The combination of an essential structural with a non-essential enzymatic function in the same protein could direct the evolutionary trajectory towards improvement of the former, thereby increasing the flexibility of the binding pocket, which is consistent with the results presented here
Rho - Omega Splitting and Mixing in Nuclear Matter
We investigate the splitting and mixing of and mesons in
nuclear matter. The calculations were performed on the basis of QCD sum rules
and include all operators up to mass dimension-6 twist-4 and up to first order
in the coupling constants. Special attention is devoted to the impact of the
scalar 4-quark condensates on both effects. In nuclear matter the Landau
damping governs the mass splitting while the scalar 4-quark
condensates govern the strenght of individual mass shifts. A strong in-medium
mass splitting causes the disappearance of the mixing.Comment: 28 pages, 8 figures, Phys. Rev. C 70 (2004) 03520
Study of in-medium meson properties in Ap, pA and AA collisions
We propose to investigate the in-medium properties of vector mesons
at the normal nuclear density in Ap(pA) collisions and at higher density in AA
collisions at the ITEP accelerator facility TWAC. Using of the inverse Ap
kinematics will permit us to study the meson production in a wide
momentum interval included the not yet explored range of small meson momenta
relative to the projectile nuclei where the mass modification effect in nuclear
matter is expected to be the strongest. Momentum dependence of the in-medium
meson width will be studied in the traditional pA kinematics. We
intend to use the electromagnetic calorimeter for reconstruction of the
meson invariant mass by detecting photons from the decay. The model calculations and simulations with
RQMD generator show feasibility of the proposed experiment. Available now
intensity of the ion beams provides a possibility to collect large statistics
and make decisive conclusion about the meson properties at density of
normal nuclei. At the second stage of the investigation the meson
properties will be studied in AA collisions at higher density. Interpretation
of these measurements will be based on the results obtained in Ap(pA)
interactions. Further investigation of the in-medium properties of light
unflavored and charmed mesons can be performed at ITEP and at GSI(FAIR) where
higher ion energies will be accessible in near future.Comment: 26 pages, 10 figures, 2 table
Absorption of phi mesons in near-threshold proton-nucleus reactions
In the framework of the nuclear spectral function approach for incoherent
primary proton--nucleon and secondary pion--nucleon production processes we
study the inclusive meson production in the interaction of 2.83 GeV
protons with nuclei. In particular, the A-dependences of the absolute and
relative meson yields are investigated within the different scenarios
for its in-medium width as well as for the cross section ratio . Our model calculations take into account
the acceptance window of the ANKE facility used in a recent experiment
performed at COSY. They show that the pion--nucleon production channel
contributes distinctly to the creation in heavy nuclei in the chosen
kinematics and, hence, has to be taken into consideration on close examination
of the dependences of the phi meson yields on the target mass number with the
aim to get information on its width in the medium. They also demonstrate that
the experimentally unknown ratio has a weak effect on the A-dependence of the relative meson
production cross section at incident energy of present interest, whereas it is
found to be appreciably sensitive to the phi in-medium width, which means that
this relative observable can indeed be useful to help determine the above width
from the direct comparison the results of our calculations with the future data
from the respective ANKE-at-COSY experiment.Comment: 16 pages, 9 figure
Analysis of the doubly heavy baryons in the nuclear matter with the QCD sum rules
In this article, we study the doubly heavy baryon states ,
, and in the nuclear matter using the QCD
sum rules, and derive three coupled QCD sum rules for the masses, vector
self-energies and pole residues. The predictions for the mass-shifts in the
nuclear matter , , and
can be confronted with the
experimental data in the future.Comment: 10 pages, 4 figure
Operator Product Expansion and Quark-Hadron Duality: Facts and Riddles
We review the status of the practical operator product expansion (OPE), when
applied to two-point correlators of QCD currents which interpolate to mesonic
resonances, in view of the violations of local quark-hadron duality. Covered
topics are: a mini-review of mesonic QCD sum rules in vacuum, at finite
temperature, or at finite baryon density, a comparison of model calculations of
current-current correlation functions in 2D and 4D with the OPE expression, a
discussion of meson distribution amplitudes in the light of nonperturbatively
nonlocal modifications of the OPE, and a reorganization of the OPE which
(partially) resums powers of covariant derivatives.Comment: now 68 pages, 29 figures (1 figure added), habilitation thesis, mild
restructuring, typos corrected, about 30 references and corresponding text
added, version to be published in Prog. Part. Nucl. Phy
The Large Enriched Germanium Experiment for Neutrinoless Double Beta Decay (LEGEND)
The observation of neutrinoless double-beta decay (0)
would show that lepton number is violated, reveal that neutrinos are Majorana
particles, and provide information on neutrino mass. A discovery-capable
experiment covering the inverted ordering region, with effective Majorana
neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with
excellent energy resolution and extremely low backgrounds, at the level of
0.1 count /(FWHMtyr) in the region of the signal. The
current generation Ge experiments GERDA and the MAJORANA DEMONSTRATOR
utilizing high purity Germanium detectors with an intrinsic energy resolution
of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in
the 0 signal region of all 0
experiments. Building on this success, the LEGEND collaboration has been formed
to pursue a tonne-scale Ge experiment. The collaboration aims to develop
a phased 0 experimental program with discovery potential
at a half-life approaching or at years, using existing resources as
appropriate to expedite physics results.Comment: Proceedings of the MEDEX'17 meeting (Prague, May 29 - June 2, 2017
The first search for bosonic super-WIMPs with masses up to 1 MeV/c with GERDA
We present the first search for bosonic super-WIMPs as keV-scale dark matter
candidates performed with the GERDA experiment. GERDA is a neutrinoless
double-beta decay experiment which operates high-purity germanium detectors
enriched in Ge in an ultra-low background environment at the Laboratori
Nazionali del Gran Sasso (LNGS) of INFN in Italy. Searches were performed for
pseudoscalar and vector particles in the mass region from 60 keV/c to 1
MeV/c. No evidence for a dark matter signal was observed, and the most
stringent constraints on the couplings of super-WIMPs with masses above 120
keV/c have been set. As an example, at a mass of 150 keV/c the most
stringent direct limits on the dimensionless couplings of axion-like particles
and dark photons to electrons of and
at 90% credible interval,
respectively, were obtained.Comment: 6 pages, 3 figures, submitted to Physical Review Letters, added list
of authors, updated ref. [21
- …