283 research outputs found
Separate cortical and hippocampal cell populations target the rat nucleus reuniens and mammillary bodies
Nucleus reuniens receives dense projections from both the hippocampus and the frontal cortices. Reflecting these connections, this nucleus is thought to enable executive functions, including those involving spatial learning. The mammillary bodies, which also support spatial learning, again receive dense hippocampal inputs, as well as lighter projections from medial frontal areas. The present study, therefore, compared the sources of these inputs to nucleus reuniens and the mammillary bodies. Retrograde tracer injections in rats showed how these two diencephalic sites receive projections from separate cell populations, often from adjacent layers in the same cortical areas. In the subiculum, which projects strongly to both sites, the mammillary body inputs originate from a homogenous pyramidal cell population in more superficial levels, while the cells that target nucleus reuniens most often originate from cells positioned at a deeper level. In these deeper levels, a more morphologically diverse set of subiculum cells contributes to the thalamic projection, especially at septal levels. While both diencephalic sites also receive medial frontal inputs, those to nucleus reuniens are especially dense. The densest inputs to the mammillary bodies appear to arise from the dorsal peduncular cortex, where the cells are mostly separate from deeper neurons that project to nucleus reuniens. Again, in those other cortical regions that innervate both nucleus reuniens and the mammillary bodies, there was no evidence of collateral projections. The findings support the notion that these diencephalic nuclei represent components of distinct, but complementary, systems that support different aspects of cognition
Bacterial genotoxins induce T cell senescence
Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms remain unclear. To address this issue, we investigated the effects of the most widely expressed bacterial genotoxin, the cytolethal distending toxin (CDT), on T cells—the key mediators of adaptive immunity. We show that CDT induces premature senescence in activated CD4 T cells in vitro and provide evidence suggesting that infection with genotoxin-producing bacteria promotes T cell senescence in vivo. Moreover, we demonstrate that genotoxin-induced senescent CD4 T cells assume a senescence-associated secretory phenotype (SASP) which, at least partly, is orchestrated by the ATM-p38 signaling axis. These findings provide insight into the immunomodulatory properties of bacterial genotoxins and uncover a putative link between bacterial infections and T cell senescence
Collateral rostral thalamic projections to prelimbic, infralimbic, anterior cingulate and retrosplenial cortices in the rat brain
As the functional properties of a cortical area partly reflect its thalamic inputs, the present study compared collateral projections arising from various rostral thalamic nuclei that terminate across prefrontal (including anterior cingulate) and retrosplenial areas in the rat brain. Two retrograde tracers, fast blue and cholera toxin B, were injected in pairs to different combinations of cortical areas. The research focused on the individual anterior thalamic nuclei, including the interanteromedial nucleus, nucleus reuniens and the laterodorsal nucleus. Of the principal anterior thalamic nuclei, only the anteromedial nucleus contained neurons reaching both the anterior cingulate cortex and adjacent cortical areas (prefrontal or retrosplenial), though the numbers were modest. For these same cortical pairings (medial prefrontal/anterior cingulate and anterior cingulate/retrosplenial), the interanteromedial nucleus and nucleus reuniens contained slightly higher proportions of bifurcating neurons (up to 11% of labelled cells). A contrasting picture was seen for collaterals reaching different areas within retrosplenial cortex. Here, the anterodorsal nucleus, typically provided the greatest proportion of bifurcating neurons (up to 15% of labelled cells). While individual neurons that terminate in different retrosplenial areas were also found in the other thalamic nuclei, they were infrequent. Consequently, these thalamo-cortical projections predominantly arise from separate populations of neurons with discrete cortical termination zones, consistent with the transmission of segregated information and influence. Overall, two contrasting medial-lateral patterns of collateral projections emerged, with more midline nuclei, for example, nucleus reuniens and the interoanteromedial nucleus innervating prefrontal areas, while more dorsal and lateral anterior thalamic collaterals innervated retrosplenial cortex
I. Flux and color variations of the quadruply imaged quasar HE 0435-1223
aims: We present VRi photometric observations of the quadruply imaged quasar
HE 0435-1223, carried out with the Danish 1.54m telescope at the La Silla
Observatory. Our aim was to monitor and study the magnitudes and colors of each
lensed component as a function of time. methods: We monitored the object during
two seasons (2008 and 2009) in the VRi spectral bands, and reduced the data
with two independent techniques: difference imaging and PSF (Point Spread
Function) fitting.results: Between these two seasons, our results show an
evident decrease in flux by ~0.2-0.4 magnitudes of the four lensed components
in the three filters. We also found a significant increase (~0.05-0.015) in
their V-R and R-i color indices. conclusions: These flux and color variations
are very likely caused by intrinsic variations of the quasar between the
observed epochs. Microlensing effects probably also affect the brightest "A"
lensed component.Comment: 10 pages, 8 figure
The Transiting System GJ1214: High-Precision Defocused Transit Observations and a Search for Evidence of Transit Timing Variation
Aims: We present 11 high-precision photometric transit observations of the
transiting super-Earth planet GJ1214b. Combining these data with observations
from other authors, we investigate the ephemeris for possible signs of transit
timing variations (TTVs) using a Bayesian approach.
Methods: The observations were obtained using telescope-defocusing
techniques, and achieve a high precision with random errors in the photometry
as low as 1mmag per point. To investigate the possibility of TTVs in the light
curve, we calculate the overall probability of a TTV signal using Bayesian
methods.
Results: The observations are used to determine the photometric parameters
and the physical properties of the GJ1214 system. Our results are in good
agreement with published values. Individual times of mid-transit are measured
with uncertainties as low as 10s, allowing us to reduce the uncertainty in the
orbital period by a factor of two.
Conclusions: A Bayesian analysis reveals that it is highly improbable that
the observed transit times is explained by TTV, when compared with the simpler
alternative of a linear ephemeris.Comment: Submitted to A&
High-precision photometry by telescope defocussing - VI. WASP-24, WASP-25 and WASP-26
The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013/) under grant agreement nos. 229517 and 268421. This publication was supported by grants NPRP 09-476-1-078 and NPRP X-019-1-006 from Qatar National Research Fund (a member of Qatar Foundation). TCH acknowledges financial support from the Korea Research Council for Fundamental Science and Technology (KRCF) through the Young Research Scientist Fellowship Programme and is supported by the KASI (Korea Astronomy and Space Science Institute) grant 2012-1-410-02/2013-9-400-00. SG, XW and XF acknowledge the support from NSFC under the grant no. 10873031. The research is supported by the ASTERISK project (ASTERoseismic Investigations with SONG and Kepler) funded by the European Research Council (grant agreement no. 267864). DR, YD, AE, FF (ARC), OW (FNRS research fellow) and J Surdej acknowledge support from the Communauté française de Belgique – Actions de recherche concertées – Académie Wallonie-Europe.We present time series photometric observations of 13 transits in the planetary systems WASP-24, WASP-25 and WASP-26. All three systems have orbital obliquity measurements, WASP-24 and WASP-26 have been observed with Spitzer, and WASP-25 was previously comparatively neglected. Our light curves were obtained using the telescope-defocussing method and have scatters of 0.5–1.2 mmag relative to their best-fitting geometric models. We use these data to measure the physical properties and orbital ephemerides of the systems to high precision, finding that our improved measurements are in good agreement with previous studies. High-resolution Lucky Imaging observations of all three targets show no evidence for faint stars close enough to contaminate our photometry. We confirm the eclipsing nature of the star closest to WASP-24 and present the detection of a detached eclipsing binary within 4.25 arcmin of WASP-26.Publisher PDFPeer reviewe
High-precision photometry by telescope defocussing. III. The transiting planetary system WASP-2
We present high-precision photometry of three transits of the extrasolar
planetary system WASP-2, obtained by defocussing the telescope, and achieving
point-to-point scatters of between 0.42 and 0.73 mmag. These data are modelled
using the JKTEBOP code, and taking into account the light from the
recently-discovered faint star close to the system. The physical properties of
the WASP-2 system are derived using tabulated predictions from five different
sets of stellar evolutionary models, allowing both statistical and systematic
errorbars to be specified. We find the mass and radius of the planet to be M_b
= 0.847 +/- 0.038 +/- 0.024 Mjup and R_b = 1.044 +/- 0.029 +/- 0.015 Rjup. It
has a low equilibrium temperature of 1280 +/- 21 K, in agreement with a recent
finding that it does not have an atmospheric temperature inversion. The first
of our transit datasets has a scatter of only 0.42 mmag with respect to the
best-fitting light curve model, which to our knowledge is a record for
ground-based observations of a transiting extrasolar planet.Comment: Accepted for publication in MNRAS. 9 pages, 3 figures, 10 table
OGLE-2009-BLG-092/MOA-2009-BLG-137: A Dramatic Repeating Event With the Second Perturbation Predicted by Real-Time Analysis
We report the result of the analysis of a dramatic repeating gravitational
microlensing event OGLE-2009-BLG-092/MOA-2009-BLG-137, for which the light
curve is characterized by two distinct peaks with perturbations near both
peaks. We find that the event is produced by the passage of the source
trajectory over the central perturbation regions associated with the individual
components of a wide-separation binary. The event is special in the sense that
the second perturbation, occurring days after the first, was
predicted by the real-time analysis conducted after the first peak,
demonstrating that real-time modeling can be routinely done for binary and
planetary events. With the data obtained from follow-up observations covering
the second peak, we are able to uniquely determine the physical parameters of
the lens system. We find that the event occurred on a bulge clump giant and it
was produced by a binary lens composed of a K and M-type main-sequence stars.
The estimated masses of the binary components are
and , respectively, and they are separated in
projection by . The measured distance to the
lens is . We also detect the orbital motion
of the lens system.Comment: 18 pages, 5 figures, 1 tabl
Characterizing Low-Mass Binaries From Observation of Long Time-scale Caustic-crossing Gravitational Microlensing Events
Despite astrophysical importance of binary star systems, detections are
limited to those located in small ranges of separations, distances, and masses
and thus it is necessary to use a variety of observational techniques for a
complete view of stellar multiplicity across a broad range of physical
parameters. In this paper, we report the detections and measurements of 2
binaries discovered from observations of microlensing events MOA-2011-BLG-090
and OGLE-2011-BLG-0417. Determinations of the binary masses are possible by
simultaneously measuring the Einstein radius and the lens parallax. The
measured masses of the binary components are 0.43 and 0.39
for MOA-2011-BLG-090 and 0.57 and 0.17 for
OGLE-2011-BLG-0417 and thus both lens components of MOA-2011-BLG-090 and one
component of OGLE-2011-BLG-0417 are M dwarfs, demonstrating the usefulness of
microlensing in detecting binaries composed of low-mass components. From
modeling of the light curves considering full Keplerian motion of the lens, we
also measure the orbital parameters of the binaries. The blended light of
OGLE-2011-BLG-0417 comes very likely from the lens itself, making it possible
to check the microlensing orbital solution by follow-up radial-velocity
observation. For both events, the caustic-crossing parts of the light curves,
which are critical for determining the physical lens parameters, were resolved
by high-cadence survey observations and thus it is expected that the number of
microlensing binaries with measured physical parameters will increase in the
future.Comment: 8 pages, 5 figures, 4 table
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