Is Low-Level Laser Therapy Effective for Pain Reduction in Patients with Chronic Low Back Pain?

OBJECTIVE: The objective of this selective EBM review is to determine whether or not lowlevel laser therapy is effective for pain reduction in patients with chronic low back pain. STUDY DESIGN: Two randomized controlled trials published in 2010 and 2017 and one nonrandomized placebo-controlled clinical trial published in 2018. DATA SOURCES: Sources were written in English and published in peer-reviewed journal articles comparing low-level laser therapy (LLLT) to groups consisting of a combined laser therapy regimen or placebo in patients with chronic low back pain, found using PubMed. OUTCOMES MEASURED: Low back pain was assessed using the visual analog scale (VAS). The statistics used to assess significance of the outcome measured were P-values, change in mean from baseline, and SD. RESULTS: The first study (Ay S, Doğan Ş, Evcik D. J Back Musculoskelet Rehabil. 2017;30(2):235-240. doi: 10.3233/BMR-160739) compared two treatment groups who received LLLT for the treatment of chronic low back pain (CLBP). Improvements in pain were statistically significant in both groups (p-value \u3c0.01), but no difference was found between the two LLLT regimens. Another study (Ay S, Doğan Ş, Evcik D. Clin Rheumatol. 2010;29(8):905- 910. doi: 10.1007/s10067-010-1460-0) compared LLLT vs placebo in patients with CLBP, in addition to analyzing LLLT vs placebo in acute pain management. A statistically significant improvement in pain severity (p-value \u3c0.001) was observed in LLLT and placebo groups for CLBP. A third study (Taradaj J, Rajfur K, Shay B, et al. Clin Interv Aging. 2018;13:1445- 1455. doi: 10.2147/CIA.S168094) again compared LLLT to placebo for CLBP, in addition to analyzing high-intensity laser therapy (HILT) to placebo. In the LLLT and LLLT sham groups, a statistically significant (p\u3c0.01) decrease in pain was noted. CONCLUSION: These results superficially indicate that LLLT is an effective means of reducing pain associated with CLBP. However, comparison between sham groups and actual treatment groups seem to suggest a significant influence of placebo in the efficacy of LLLT. This evidence suggests that the general experience of undergoing laser therapy is what causes a reduction of pain, rather than science behind the laser therapy itself. The evidence provided is therefore not sufficient enough to support the claim that LLLT is an effective, appropriate or advisable treatment of CLBP. Future studies should directly compare the statistical difference in decreased pain scores between LLLT and placebo alone

Harmony Or Discord: Disordered Eating and Personality Traits of College Music Majors

Personality traits, such as neuroticism, perfectionism, and a narrow self-concept have been identified as risk factors for eating disorders or have been found at higher rates in those with eating disorders (e.g., Brannan & Petrie, 2008; Cash & Deagle, 1997; Cervera et al., 2003). Musicians exhibit many of these personality traits associated with eating disorders (e.g., Kemp, 1981), however eating disorder prevalence has not been studied in musicians. The present study examined the prevalence of eating disorders and pathogenic weight control behaviors among college music majors. This study also compared personality traits (i.e., neuroticism, perfectionism, musician identity) between music majors and nonmajors and examined which personality traits best predicted bulimic symptomatology. Participants were 93 female and 126 male undergraduate students majoring in music and a nonmusician comparison group of 310 women 140 men from the same university. Music majors and nonmajors did not differ from each other with regards to eating disorder prevalence rates. Exercising and fasting/strict dieting were the primary means of weight control amongst all participants. With regards to personality traits, female and male music majors reported higher levels of perfectionism than their nonmajor counterparts and male music majors reported higher levels of neuroticism than male nonmajors. After controlling for BMI, neuroticism and doubts about actions predicted bulimic symptoms in female music majors, whereas concern over mistakes predicted bulimic symptomatology among men majoring in music. Findings suggest that any additional appearance-based pressures from the music environment do not translate into increased levels of eating pathology. Music majors higher levels of perfectionism and neuroticism may help them to succeed within the music and perform at a high level. Lastly, personality dimensions of neuroticism and concern over making mistakes predict disordered eating in all students

Comparison between conjugated linoleic acid and essential fatty acids in preventing oxidative stress in bovine mammary epithelial cells

Some in vitro and in vivo studies have demonstrated protective effects of conjugated linoleic acid (CLA) isomers against oxidative stress and lipid peroxidation. However, only a few and conflicting studies have been conducted showing the antioxidant potential of essential fatty acids. The objectives of the study were to compare the effects of CLA to other essential fatty acids on the thiol redox status of bovine mammary epithelia cells (BME-UV1) and their protective role against oxidative damage on the mammary gland by an in vitro study. The BME-UV1 cells were treated with complete medium containing 50 μM of cis-9,trans-11 CLA, trans-10,cis-12 CLA, α-linolenic acid, γ-linolenic acid, and linoleic acid. To assess the cellular antioxidant response, glutathione, NADPH, and γ-glutamyl-cysteine ligase activity were measured 48 h after addition of fatty acids (FA). Intracellular reactive oxygen species and malondialdehyde production were also assessed in cells supplemented with FA. Reactive oxygen species production after 3 h of H2O2 exposure was assessed to evaluate and to compare the potential protection of different FA against H2O2-induced oxidative stress. All FA treatments induced an intracellular GSH increase, matched by high concentrations of NADPH and an increase of γ-glutamyl-cysteine ligase activity. Cells supplemented with FA showed a reduction in intracellular malondialdehyde levels. In particular, CLA isomers and linoleic acid supplementation showed a better antioxidant cellular response against oxidative damage induced by H2O2 compared with other FA

4-Chloro-7-hydr­oxy-6-methyl-1,7-naphthyridin-8(7H)-one

The title compound, C9H7ClN2O2, was prepared by reaction of methyl 4-chloro-3-(prop-1-yn­yl)picolinate with hydroxy­l­amine in MeOH/KOH solution. The two essentially planar mol­ecules which make up the asymmetric unit have almost identical geometries and and are linked into dimeric aggregates via pairs of O—H⋯O hydrogen bonds. These aggregates have almost perfect inversion symmetry; however, quite unusually, the inversion center of the dimer does not coincide with the crystallographic inversion center

Are prices of new dwellings different? A spectral analysis of UK property vintages

The work makes two contributions to Hui’s (2011) dynamic house price classification. First, a house price ripple in cycles from Modern to Older dwellings is revealed and, second, as New housing is shown to have lower volatility than the other two. Using spectral analysis, it is argued that there is a 7½-year repeat buyer-second-hand cycle and a five year, first time buyer-New housing cycle, common to three house price vintages. These cycles reinforce each other every fifteen years, which corresponds with a Minsky super-cycle in housing finance. The equity of the owner-occupier is fortified by higher house prices whereas new builds extract embedded equity from the market. Government should support builders and facilitate access to market to first time buyers and through programmes like Help-to-Buy 1. However, to address the greater price instability that should follow, Government should impose a capital gains tax on the house seller

Hydrologic indicators of hot spots and hot moments of mercury methylation potential along river corridors

The authors acknowledge financial support from the National Science Foundation: EAR-1226741 (to M.B.S.) and EAR-1225630 (to J.D.B.), and from the REG Trust (to M.B.S.).The biogeochemical cycling of metals and other contaminants in river-floodplain corridors is controlled by microbial activity responding to dynamic redox conditions. Riverine flooding thus has the potential to affect speciation of redox-sensitive metals such as mercury (Hg). Therefore, inundation history over a period of decades potentially holds information on past production of bioavailable Hg. We investigate this within a Northern California river system with a legacy of landscape-scale 19th century hydraulic gold mining. We combine hydraulic modeling, Hg measurements in sediment and biota, and first-order calculations of mercury transformation to assess the potential role of river floodplains in producing monomethylmercury (MMHg), a neurotoxin which accumulates in local and migratory food webs. We identify frequently inundated floodplain areas, as well as floodplain areas inundated for long periods. We quantify the probability of MMHg production potential (MPP) associated with hydrology in each sector of the river system as a function of the spatial patterns of overbank inundation and drainage, which affect long-term redox history of contaminated sediments. Our findings identify river floodplains as periodic, temporary, yet potentially important, loci of biogeochemical transformation in which contaminants may undergo change during limited periods of the hydrologic record. We suggest that inundation is an important driver of MPP in river corridors and that the entire flow history must be analyzed retrospectively in terms of inundation magnitude and frequency in order to accurately assess biogeochemical risks, rather than merely highlighting the largest floods or low-flow periods. MMHg bioaccumulation within the aquatic food web in this system may pose a major risk to humans and waterfowl that eat migratory salmonids, which are being encouraged to come up these rivers to spawn. There is a long-term pattern of MPP under the current flow regime that is likely to be accentuated by increasingly common large floods with extended duration.PostprintPeer reviewe

Satellite estimates of shortwave surface radiation and atmospheric meteorology for the BOREAS experiment region

This report provides background data for the Boreal Ecosystem Atmosphere Study (BOREAS) sites, including daily, seasonal, interannual, and spatial variability of shortwave (SW) radiation at the Earth's surface. This background data, from the Version 1.1 SW data set, was provided by the Surface Radiation Budget (SRB) Climatology Project established by the World Climate Research Program (WCRP)

(-)-Epigallocatechin-3-gallate and hydroxytyrosol improved antioxidative and anti-inflammatory responses in bovine mammary epithelial cells

(-)-Epigallocatechin-3-gallate and hydroxytyrosol improved antioxidative and anti-inflammatory responses in bovine mammary epithelial cells L. Basiricò1, P. Morera1, D. Dipasquale1, R. Bernini1, L. Santi1, A. Romani2, N. Lacetera1 and U. Bernabucci1† 1Dipartimento di Scienze Agrarie e Forestali (DAFNE), Università degli Studi della Tuscia, via San Camillo de Lellis, 01100, Viterbo, Italy; 2Dipartimento di Statistica, Informatica, Applicazioni (DiSiA) “Giuseppe Parenti”, Università degli Studi di Firenze, via Morgagni 59, 50134, Firenze, Italy (-)-Epigallocatechin-3-gallate (EGCG), the major phenolic compound of green tea, and hydroxytyrosol (HTyr), a phenol found in olive oil, have received attention due to their wide-ranging health benefits. To date, there are no studies that report their effect in bovine mammary gland. Therefore, the aim of this study was to evaluate the anti-oxidative and anti-inflammatory effects of EGCG and HTyr in bovine mammary epithelial cell line (BME-UV1) and to compare their antioxidant and anti-inflammatory in vitro efficacy. Sample of EGCG was obtained from a commercially available green tea extract while pure HTyr was synthetized in our laboratories. The mammary oxidative stress and inflammatory responses were assessed by measuring the oxidative stress biomarkers and the gene expression of inflammatory cytokines. To evaluate the cellular antioxidant response, glutathione (GSH/ GSSH), γ-glutamylcysteine ligase activity, reactive oxygen species and malondialdehyde (MDA) production were measured after 48-h incubation of 50 μM EGCG or 50 μM of HTyr. Reactive oxygen species production after 3 h of hydrogen peroxide (50 μM H2O2) or lipopolysaccharide (20 μM LPS) exposure was quantified to evaluate and to compare the potential protection of EGCG and HTyr against H2O2-induced oxidative stress and LPS-induced inflammation. The anti-inflammatory activity of EGCG and HTyr was investigated by the evaluation of pro and anti-inflammatory interleukins (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-10) messenger RNA abundance after treatment of cells for 3 h with 20 μM of LPS. Data were analyzed by one-way ANOVA. (-)-Epigallocatechin-3-gallate or HTyr treatments induced higher concentrations of intracellular GSH compared to control cells, matched by an increase of γ-glutamylcysteine ligase activity mainly in cells treated with HTyr. Interestingly, EGCG and HTyr prevented oxidative lipid damage in the BME-UV1 cells by a reduction of intracellular MDA levels. (-)-Epigallocatechin-3-gallate and HTyr were able to enhance cell resistance against H2O2-induced oxidative stress. It was found that EGCG and HTyr elicited a reduction of the three inflammatory cytokines TNF-α, IL-1β, IL-6 and an increase of the anti-inflammatory cytokine IL-10. Hydroxytyrosol has proved to be a strong antioxidant compound, and EGCG has shown mainly an anti-inflammatory profile. These results indicated that EGCG and HTyr may provide dual protection because they were able to attenuate oxidative stress and inflammatory responses, suggesting that these phenolic compounds are potential natural alternatives to be used in dairy cattle as feed supplement for reducing the development of oxidative and inflammatory processes related to parturition or as topical treatments for the control of bovine intramammary inflammation. Animal (2019), 13:12, pp 2847–2856Ministry for education, University and Research of Italy (MIUR) for financial support (Law 232/216, Departments of Excellence)