Réinsertion sociale des délinquants âgés : défis à relever

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal

Le centenaire de la Grande Guerre au prisme des médias : le cas des quotidiens The Guardian, Le Monde et die Süddeutsche Zeitung

Cette recherche montre que l’espace médiatique, en temps de commémoration, est un lieu privilégié pour un.e historien.ne qui souhaite capturer les dynamiques mémorielles d’une collectivité. Notre cas d’étude est la couverture médiatique du centenaire de la Première Guerre mondiale au prisme du The Guardian, Le Monde et Die Süeddeutsche Zeitung. Dans les sections en ligne First world war, Centenaire 14-18 et Erster Weltkrieg, nous avons analysé la couverture de presse sur une période allant de juin 2014 à juillet 2017. Cette étude utilise une définition opératoire de la mémoire collective qui nous aide à comprendre qu’il est nécessaire en histoire de la mémoire d’étudier le journalisme non pas comme une simple source d’archives, mais aussi comme un espace discursif où diverses représentations complexes du passé se rencontrent et communiquent afin de se redéfinir. Cet espace discursif possède deux points de jonction : l’histoire pratiquée et le mythistoire. Ce sont les dynamiques dans cet espace qui ont été étudiées pour chaque média dans ce mémoire. Nous identifions d’abord les grandes configurations historiographiques de la Grande Guerre, le rôle des historiens dans la couverture et tentons de voir dans quelle mesure ces configurations s’expriment dans les trois journaux étudiés. Pour terminer, les intentions commémoratives des journaux sont identifiées et mise à l’épreuve au moyen d’une étude des flux de nouvelles et des champs lexicaux de la couverture médiatique.This mémoire aims to show that media space, in times of commemoration, is a privileged place for historians who want to capture the dynamics of a community’s memory. Our case study is the media coverage of the centenary of the First World War through the lens of The Guardian, Le Monde and Die Süeddeutsche Zeitung. We analysed in these newspapers the press coverage from June 2014 to July 2017 in the online sections First world war, Centenaire 14-18 and Erster Weltkrieg. This study uses an operative definition of collective memory that allows us to understand the necessity, in the history of memory field, to study journalism not simply as an archive, but also as a discursive space where various complex representations of the past meet and communicate in order to redefine themselves. This discursive space has two points of junction: Practiced history and “mythistory”. The dynamics of this space have been studied for each publication in this research. First, we identify the major historical configurations of the Great War, the role of historians in the coverage, and try to see to which extent these configurations are expressed in the three newspapers studied. Finally, the commemorative intentions of the newspapers are identified and then tested through a study of news-flow and an analysis of the lexical fields of the respective media coverage

Étude de la cyclisation de lactones à 9 membres par réaction de métathèse et formation catalytique de liens benzyliques asymétriques

Préalablement, une synthèse de l’aliskiren, un inhibiteur de la rénine développé pour le traitement de l’hypertension, a été réalisée auprès du groupe Hanessian. Durant cette synthèse, une réaction clé de cyclisation par métathèse, menant à la formation de lactone à neuf membres, a été réalisée. Durant cette réaction, nous avons observé une différence de réactivité entre les diastéréomères, menant à la formation de monolactones et de dilactones, générant ainsi de l’intérêt pour l’étude des facteurs en cause. Le présent mémoire rapporte et détaille les résultats de cette analyse quant à la formation de monomères versus celle de dimères par cyclisation à l’aide de catalyseurs de Grubbs et l’impact de différentes conditions réactionnelles et la diastéréochimie relative sur la réaction. Un intérêt pour la formation de liens benzyliques nous a incité à approfondir notre compréhension d’une méthodologie de substitution nucléophile diastéréosélective catalysée par des acides. Le rationnel mit de l’avant par les groupes Bach et Olah a procuré une compréhension du mécanisme réactionnel sur lequel nous avons basé nos observations subséquentes. Nous avons porté notre attention sur l’alkylation d’arènes, de phénols et de sulfonamides. Diverses régiosélectivités et diastéréosélectivités ont pu être observées en présence de substrats dérivés de la synthèse de l’aliskiren, de nitroalcools ainsi que de azidoalcools en utilisant plusieurs acides de Lewis et de Brønsted.Previously, a synthesis of aliskiren, a renin inhibitor developed for the treatment of hypertension, was developed in the Hanessian group. As part of that synthesis, they used a ring-closing metathesis which led to the formation of a nine-membered lactone, a key intermediate of the synthesis. During the reaction, we observed a difference in reactivity between the various diastereoisomers leading to the formation of mono- and dilactones, inciting us to study the various factors involved. The present master’s thesis reports and details the results of the study of monomers versus dimers formation by cyclization using Grubbs’s catalysts and the effect of various reaction conditions and relative configuration on the reaction. An interest for the formation of benzylic bonds drove us to deepen our comprehension of a methodology of diastereselective nucleophilic substitution catalysed by acids. The rational brought forth by the Bach and Olah groups served as a basis for our understanding of the mechanism involved upon which we based our following observations. We focused our attention on the alkylation of arenes, phenols and sulfonamides. Various regioselectivities and diastereoselectivities were observed on substrates derived from the aliskiren’s synthesis, nitroaocohols and azidoalcohols while using various Lewis and Brønsted acids

Offre de livres numériques à destination des bibliothèques de lecture publique : un regard international (L\u27)

Cet événement international analyse la situation du livre numérique en bibliothèque de lecture publique en France et à l\u27étranger. Plusieurs experts du domaine partageront les résultats d’études réalisées en Amérique du Nord et en Europe. Ce séminaire interroge : - L’articulation entre l’offre éditoriale commerciale et celles des bibliothèques : à l’instar du livre papier, quels modèles économiques et législatifs seront nouvellement définis pour le livre numérique ? Quel dialogue entre éditeurs et bibliothèques ? - Les modalités d’acquisitions : dans le marché du livre numérique, quelle place tiendront les librairies ? - Le financement des acquisitions de livres numériques, les modalités de l’intervention publique ; - Les compétences professionnelles des bibliothécaires : technicité, formats, supports de lecture mais aussi politiques d’acquisition ; - La bibliothèque comme acteur politique et culturel de la médiation de collections de livres numériques

Analysis of Virion Structural Components Reveals Vestiges of the Ancestral Ichnovirus Genome

Many thousands of endoparasitic wasp species are known to inject polydnavirus (PDV) particles into their caterpillar host during oviposition, causing immune and developmental dysfunctions that benefit the wasp larva. PDVs associated with braconid and ichneumonid wasps, bracoviruses and ichnoviruses respectively, both deliver multiple circular dsDNA molecules to the caterpillar. These molecules contain virulence genes but lack core genes typically involved in particle production. This is not completely unexpected given that no PDV replication takes place in the caterpillar. Particle production is confined to the wasp ovary where viral DNAs are generated from proviral copies maintained within the wasp genome. We recently showed that the genes involved in bracovirus particle production reside within the wasp genome and are related to nudiviruses. In the present work we characterized genes involved in ichnovirus particle production by analyzing the components of purified Hyposoter didymator Ichnovirus particles by LC-MS/MS and studying their organization in the wasp genome. Their products are conserved among ichnovirus-associated wasps and constitute a specific set of proteins in the virosphere. Strikingly, these genes are clustered in specialized regions of the wasp genome which are amplified along with proviral DNA during virus particle replication, but are not packaged in the particles. Clearly our results show that ichnoviruses and bracoviruses particles originated from different viral entities, thus providing an example of convergent evolution where two groups of wasps have independently domesticated viruses to deliver genes into their hosts

From Sea to Sea: Canada's Three Oceans of Biodiversity

Evaluating and understanding biodiversity in marine ecosystems are both necessary and challenging for conservation. This paper compiles and summarizes current knowledge of the diversity of marine taxa in Canada's three oceans while recognizing that this compilation is incomplete and will change in the future. That Canada has the longest coastline in the world and incorporates distinctly different biogeographic provinces and ecoregions (e.g., temperate through ice-covered areas) constrains this analysis. The taxonomic groups presented here include microbes, phytoplankton, macroalgae, zooplankton, benthic infauna, fishes, and marine mammals. The minimum number of species or taxa compiled here is 15,988 for the three Canadian oceans. However, this number clearly underestimates in several ways the total number of taxa present. First, there are significant gaps in the published literature. Second, the diversity of many habitats has not been compiled for all taxonomic groups (e.g., intertidal rocky shores, deep sea), and data compilations are based on short-term, directed research programs or longer-term monitoring activities with limited spatial resolution. Third, the biodiversity of large organisms is well known, but this is not true of smaller organisms. Finally, the greatest constraint on this summary is the willingness and capacity of those who collected the data to make it available to those interested in biodiversity meta-analyses. Confirmation of identities and intercomparison of studies are also constrained by the disturbing rate of decline in the number of taxonomists and systematists specializing on marine taxa in Canada. This decline is mostly the result of retirements of current specialists and to a lack of training and employment opportunities for new ones. Considering the difficulties encountered in compiling an overview of biogeographic data and the diversity of species or taxa in Canada's three oceans, this synthesis is intended to serve as a biodiversity baseline for a new program on marine biodiversity, the Canadian Healthy Ocean Network. A major effort needs to be undertaken to establish a complete baseline of Canadian marine biodiversity of all taxonomic groups, especially if we are to understand and conserve this part of Canada's natural heritage

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

Épisodes d’inactivité et revenus criminels dans une trajectoire de délinquance

L’instabilité de l’activité criminelle dans le temps est déjà bien documentée. On connaît toutefois peu les circonstances qui expliquent ces variations à court terme. Une meilleure connaissance de ces facteurs est souhaitable puisqu’il est possible que les transitions et les changements à court terme précèdent les points tournants des carrières criminelles. Les conditions qui rendent compte d’une interruption temporaire des activités peuvent, par exemple, contribuer à expliquer un désistement définitif. L’étude se fonde sur les trajectoires de 172 délinquants impliqués dans des crimes à but lucratif et analyse les variations mensuelles de leurs revenus criminels ainsi que les épisodes d’inactivité criminelle à l’intérieur d’une période fenêtre de 36 mois. La méthode des calendriers d’histoire de vie combinée aux modèles hiérarchiques permet d’examiner conjointement le rôle de facteurs statiques (les caractéristiques individuelles des sujets) et dynamiques (les circonstances de vie). Les résultats mettent en évidence l’importance des événements qui marquent le style de vie des délinquants et des paramètres qui caractérisent l’engagement criminel dans la compréhension des variations dans les trajectoires à l’étude. Ils soulignent également l’importance de la finalité derrière les activités criminelles pour expliquer la décision des délinquants de cesser temporaire leurs activités illicites

Effect of different sampling designs and methods on the estimation of secondary production : a simulation

This article reports the results of a simulation study designed to investigate the effect of several sampling design factors on the accuracy and precision of various estimates of secondary production. Whereas most previous studies of this sort were concerned with freshwater fauna (e.g., insects), the hypothetical population used here reflects the characteristics of marine mussels from cold-temperate and subarctic regions. It features the simultaneous presence of different cohorts, gradual recruit arrival, seasonal growth oscillation, and quadratdependent population density, as well as random individual variation both in survival and in weight gain. For this population, the percentage relative bias (PRB) and relative root mean squared error (RRMSE) of 4 classic cohort-based methods, 3 size-based methods, and several variants thereof were computed as a function of sampling frequency, distribution of sampling dates, number of quadrats sampled per occasion, inclusion or omission of the last sampling date, and coarseness of the size classes and sieve aperture. Although most methods performed reasonably well, non-negligible differences were observed among them. A version of Allen's curve technique and a mass-specific growth rate method gave the best results for cohort- and size-based method groups, respectively. Sampling effort, in terms of both frequency of sampling and number of samples per date, had the largest documented influence on both PRB and RRMSE. Recommendations are made for the best compromises between methods and sampling designs to achieve reliable production estimates for populations with similar characteristics